169 research outputs found
Goal-directed use of balanced solutions for laparoscopic surgery in obese patients
Modern guidelines for infusion therapy in laparoscopic surgery of patients with obesity are ambiguous due to insufficient number of clinical researches.
The aim of our work was to evaluate the effect of goal-directed infusion therapy with balanced solutions on hemodynamics, electrolyte balance, renal function and incidence of perioperative complications of laparoscopic surgery in obese patients.
Materials and methods. The study included 54 obese patients (BMI >30 kg/m2) who were performed laparoscopic surgery in case of the diaphragmatic hernia, colon tumors, postoperative ventral hernia and morbid obesity. In the group A (n = 26) goal-directed infusion therapy by balanced solutions Gelaspan and Sterofundin (B. Braun, Germany) was used. Impedance measuring technology using the monitor Utas 300 (Ukraine) was used to determine the target stroke volume (SV). In the group B (n = 28) infusion therapy was performed by unbalanced solutions (6 % HES and 0.9 % NaCl), focusing on fluid deficiency according to changes in blood pressure (BP), heart rate (HR), and diuresis. The incidence of hypotension and total volume of infusion therapy (TVIT) were evaluated intraoperatively, changes in BP and HR were compared. After surgery diuresis, blood Na+, K+, Clβ and creatinine concentrations, diuretic use frequency and incidence of cardiac, respiratory, hemorrhagic and infectious complications were controlled. Statistical analysis was performed using the Statistica for Windows software version 6.0.
Results. The incidence of hypotension in the group B was almost 2 times more than in the group A (P 0.05). Intraoperative TVIT in the group B was 23 % higher due to crystalloid, and diuresis intensity was twice less than in the group A (P < 0.05). Concentrations of electrolytes and creatinine blood level did not change significantly in the study groups. After surgery in the group B 25 % of patients were prescribed diuretic and in the group A diuretic was not prescribed in any case (P < 0.05). In-hospital mortality in both groups was zero, no serious complications were observed.
Conclusions. Goal-directed infusion therapy with balanced solutions in laparoscopic surgery in obese patients halved the incidence of intraoperative hemodynamic instability, reduces the volume loading of crystalloids by 23 % during surgery and provides adequate perioperative diuresis without additional stimulation
Incentive spirometry as a way to prevent pulmonary atelectasis development
The purpose. The purpose of this study was to evaluate the effectiveness of incentive spirometry (IS) as a method of atelectasis prevention in patients with moderate or high risk of PPCs development after upper abdominal surgery.
Materials and methods. The study consisted of two stages. The first retrospective stage was to analyze the medical histories data of 51 inpatients, who were included in the comparison group. The prospective part of the study included 39 patients of the study group, who had sessions of the IS during the first 7 days of the postoperative period. Patients of both groups were operated on the upper abdominal organs by open procedure, operation time was more than 2 hours, all patients had an ARISCAT score β₯26 points. Pulmonary atelectasis development was monitored in the groups in the first week of the postoperative period. The statistical analysis of the data was performed using the Microsoft Excel 2013 and Statistica for Windows 6.0 programs. When comparing the groups according to the clinical outcome, the relative risk (RR) and odds ratio (OR) were determined and then confidence intervals (95 % CI) were calculated. Statistical significance of the results was determined depending on the CI values.
Results. During the first 7 days, 34 cases of pulmonary atelectasis (67 %) were recorded in the comparison group. In the study group, 9 patients (23 %) were diagnosed with pulmonary atelectasis. The analysis of clinical results showed that when applying incentive spirometry, there was a statistically significant decrease in the relative risk of atelectasis development within the first week of the postoperative period (RR = 0.346, 95 % CI [0.189; 0.634], P = 0.0006). The odds ratio of atelectasis development in the study group was statistically lower than in the group of retrospective study (OR = 0.150, 95 % CI [0.058, 0.386], P = 0.0001).
Conclusions. Incentive spirometry is an effective way to prevent pulmonary atelectasis in patients with a moderate or high risk for developing postoperative pulmonary complications according to the ARISCAT scale after upper abdominal surgery
AFM-based approach to establish structure/property type correlations for polymeric functional materials
This work was supported by the RSF (project No. 18-19-00453) and the RFBR (project No. 18-08-01356 A)
Atomic force microscopy in polymeric chemistryβs studies
This work was supported by the RSF (project No. 18-19-00453)
Torsional fluctuations in columnar DNA assemblies
In columnar assemblies of helical bio-molecules the azimuthal degrees of
freedom, i.e. rotations about the long axes of molecules, may be important in
determining the structure of the assemblies especially when the interaction
energy between neighbouring molecules explicitly depends on their relative
azimuthal orientations. For DNA this leads to a rich variety of mesophases for
columnar assemblies, each categorized by a specific azimuthal ordering. In a
preceding paper [A. Wynveen, D. J. Lee, and A. A. Kornyshev, Eur. Phys. J. E,
16, 303 (2005)] a statistical mechanical theory was developed for the
assemblies of torsionally rigid molecues in order to determine how thermal
fluctuations influence the structure of these mesophases. Here we extend this
theory by including torsional fluctuations of the molecules, where a DNA
molecule may twist about its long axis at the cost of torsional elastic energy.
Comparing this with the previous study, we find that inclusion of torsional
fluctuations further increases the density at which the transition between the
hexagonal structure and the predicted rhombic phase occurs and reduces the
level of distortion in the rhombic phase. As X-ray diffraction may probe the
2-D lattice structure of such assemblies and provide information concerning the
underlying interaction between molecules, we have also calculated correlation
functions for the azimuthal ordering which are manifest in an x-ray scattering
intensity profiles.Comment: 33 pages, 8 figure
Efficacy of regional analgesia techniques in abdominal surgery patients with obesity
Abstract
The use of regional anesthetic techniques in abdominal surgery is an essential component of the multimodal approach to perioperative analgesia, yet data on their use in obese patients remains limited.
The aim of this study is to determine the effectiveness of the epidural analgesia (EA) and the transversus abdominis plane block (TAP-block) in laparoscopic obese patients, as well as to evaluate the possibility of using the rectus sheath block (RSB) as a βrescueβ anesthetic technique after laparotomy in obese patients.
Materials and methods. The data on the 102 obese patients operated on esophageal hiatal diaphramgmatic hernia, colon tumor, postoperative ventral hernia, morbid obesity and choledocholithiasis were analyzed. In laparoscopic surgery 20 patients received EA (EA group), 21 patients β TAP-block (TAP group), 21 patients β opioids and non-steroidal anti-inflammatory drugs (NSAIDs) without any regional anesthesia techniques (group TIVA1). In laparotomic surgery 16 patients received RSB (RSB group) and 24 patients β only opioids and NSAIDs (TIVA2 group). After the surgery the following was estimated: the time of extubation, the total dose of opioids, the level of pain according to the 10-point numeric range score (NRS), the incidence of dyspnea using the monitor Utas 300 (Ukraine), the incidence of postoperative nausea and vomiting (PONV), the time of active patient mobilization, and the level of satisfaction with analgetic regimen. For the RSB group, the complexity of the RSB and the mean time to achieve adequate analgesia (pain intensity β€3 points per NRS) were determined additionally. The statistical analysis was performed using the Statistica for Windows version 6.0 software.
Results. In the EA group, the intraoperative dose of fentanyl was twice lower, and patients were extubated two times faster than in the TAP, TIVA1, RSB, TIVA2 groups (P < 0.05). At the same time, none of the patients in the EA group required the restoration of neuromuscular conduction with neostigmine (P < 0.05). After the surgery, the pain level was 2β3 times higher in the TIVA1, RSB, and TIVA2 groups than in the EA and TAP groups (P < 0.05). βRescueβ analgesia in the RSB group was performed from the first attempt in all the patients in 5β10 minutes and provided an adequate effect in 3 (2β4) min. The complexity level of RSB was defined as βeasyβ in 12 (75 %) patients, as βaverageβ in 4 (25 %) patients (P < 0.05). The incidence of dyspnea and opioid doses after surgery in the EA, TAP and RSB groups of patients were 2 times lower, and the incidence of PONV was 3 to 4 times lower than in the TIVA1 and TIVA2 patientsβ groups (P < 0.05). In the EA and TAP groups, patients became mobile after 8β13 hours after surgery, in the group TIVA1 β after 16β22 hours, in the group RSB β after 18β36 hours, in the group TIVA2 β after 48β96 hours (P < 0.05). 100 % of the respondents from the EA, TAP and RSB groups were satisfied with the analgesic regimen at the βexcellent β goodβ level. In the TIVA1 and TIVA2 groups, 20β25 % of respondents identified analgesic comfort as βgoodβ, 60β65 % of respondents β as βsatisfactorilyβ, about 15 % of respondents β as βunsatisfactorilyβ (P < 0.05).
Conclusions. In laparoscopic surgery the use of EA or TAP-block in obese patients significantly reduces the level of postoperative pain, the need for opioids, the incidence of dyspnea and PONV, which leads to the possibility of patientsβ mobilization within 8β13 hours after surgery. After laparotomic surgery in obese patients RSB effectively βrescuesβ from pain and prevents excessive use of opioids, which reduces the number of adverse reactions and increases satisfaction with the quality of analgesia
Atomic force microscopy in the modelβs development of polymeric functional materials formation on inert supports
This work was supported by the RFBR (project No. 18-08-01356 A)
ΠΡΠ΅Π΄ΡΠΏΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ Π²Π΅Π½ΠΎΠ·Π½ΠΎΠ³ΠΎ ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΠ·ΠΌΠ° Ρ Ρ ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ
ΠΠ΅Π½ΠΎΠ·Π½Π°Ρ ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΡ (ΠΠ’Π) β ΠΎΠ΄Π½Π° ΠΈΠ· ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΏΡΠΈΡΠΈΠ½ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ
ΠΈ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Ρ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π’Π°ΠΌ Π³Π΄Π΅ ΡΡΠΎ ΡΠΌΠ΅ΡΡΠ½ΠΎ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π° Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ²Π°Ρ
ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ, ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΠ’Π
ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΎ. ΠΠΆΠΈΡΠ΅Π½ΠΈΠ΅, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΌΠΎΡΠ±ΠΈΠ΄Π½ΠΎΠ΅, ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ
Π²ΡΡΠΎΠΊΠΈΠΌ ΡΠΈΡΠΊΠΎΠΌ ΠΠ’Π ΠΈ, ΠΊ ΡΠΎΠΆΠ°Π»Π΅Π½ΠΈΡ, ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π΄ΠΎΠ·Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡΠ΅ΠΌΡΡ
Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π΅ΡΡΠ°ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³Π΅ΠΏΠ°ΡΠΈΠ½Π°, Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
Π³Π΅ΠΏΠ°ΡΠΈΠ½ΠΎΠ² ΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΡΠ°ΠΊΡΠΎΡΠ° Π₯Π°, Π½Π΅ ΠΌΠΎΠ³ΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΉ
ΡΠΏΠΎΡΠΎΠ± ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΠ’Π Ρ ΡΡΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π£Π²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡΠΈΠΉΡΡ ΠΎΠ±ΡΠ΅ΠΌ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ² ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π΄Π»Ρ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠΊΠΎΠ°Π³ΡΠ»ΡΠ½ΡΠ° ΠΈ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΠ° ΠΠ’Π Π΄ΠΎΠ·Π°
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ Π΄ΠΎΠ»ΠΆΠ½Π° ΠΊΠΎΡΡΠΈΠ³ΠΈΡΠΎΠ²Π°ΡΡΡΡ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎ. ΠΠ»Ρ
ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ Π²ΠΎΠΏΡΠΎΡΠ° ΠΌΡ ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ βPoint of Careβ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³
Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π½ΠΈΠ·ΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΎΠΉ ΠΏΡΠ΅Π·ΠΎΡΡΠΎΠΌΠ±ΠΎΡΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΠΈ.Venous thromboembolism (VTE) is one of the main causes of morbidity and
mortality of hospitalized patients. Evidence-based prevention methods are used
where it is appropriate and the amount of VTE can be significantly reduced. Obesity is an independent risk factor for VTE for both men and women. This relates to
hemostasis disorders characterized in general as a prothrombotic state and requiring adequate perioperative correction to prevent VTE. Unfortunately, fixed doses
of recommended anticoagulants including unfractionated heparin, low-molecular
heparins and inhibitors of Xa factor canβt provide an optimal way to prevent VTE
in patients with obesity. Increasing amount of literature and evidences accumulation indicate that the dose of the drug in patients with obesity should be individually corrected to optimize pharmacodynamic activity of the anticoagulant and to reduce the risk of VTE, possibly by using βPoint of Careβ (POC) monitoring. However, thromboelastography (TEG) and rotational thromboelastomethry (ROTEM)
are not available in everyday practice and are used more often in critical situations.
To solve this issue we propose to use POC monitoring of hemostasis with low-frequency piezothromboelastography (LPTEG)
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠΏΠΈΠ΄ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π°Π½Π°Π»Π³Π΅Π·ΠΈΠΈ Π½Π° Π³Π΅ΠΌΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» ΠΏΠΎΡΠ»Π΅ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ
Current recommendations for the prevention of venous thromboembolism (VTE) in obese patients have a low level of evidence. Thatβs why the
use of other techniques of influence on hemostatic potential (GP) is actual.
Aim. To evaluate the effect of epidural analgesia (EA) on hemostatic system
parameters after laparoscopic operations in obese patients.
Material and methods. GP parameters were measured in 52 patients with
BMI>30 kg/m2 using the method of low-frequency piezoelectric thromboelastography (LPTEG). The initial GP level was determined and its changes were compared
on the 3rd day after surgery between the group of total intravenous anesthesia (TBA,
n=26) and EA-group (n=25). Statistical analysis was conducted using Statistica for
Windows version 6.0.
Results. The initial level of GP didnβt differ significantly between the study
groups. In TBA-group hypercoagulation and inhibition of fibrinolysis with a moderate decrease in platelet aggregation were present on the 3rd day after surgery
(p<0.05). In EA-group there was an improvement in coagulation and fibrinolysis
but aggregation rates reached the lower limit of the norm (p<0.05).
Conclusion. Perioperative use of EA in abdominal laparoscopic surgery of patients with obesity helps to normalize coagulation and fibrinolytic GP components
and reduces the aggregation of formed blood elements.Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ Π²Π΅Π½ΠΎΠ·Π½ΠΎΠ³ΠΎ ΡΡΠΎΠΌΠ±ΠΎΡΠΌΠ±ΠΎΠ»ΠΈΠ·ΠΌΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠ΅ΡΡ Π½ΠΈΠ·ΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΠΏΠΎΡΡΠΎΠΌΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄ΡΡΠ³ΠΈΡ
ΡΠ΅Ρ
Π½ΠΈΠΊ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π³Π΅ΠΌΠΎΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» (ΠΠ).
Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΏΠΈΠ΄ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π°Π½Π°Π»Π³Π΅Π·ΠΈΠΈ (ΠΠ) Π½Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΈΡΡΠ΅ΠΌΡ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° ΠΏΠΎΡΠ»Π΅ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΠ ΠΈΠ·ΠΌΠ΅ΡΡΠ»ΠΈ Ρ 52 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ
ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° > 30 ΠΊΠ³/ΠΌ2 Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ Π½ΠΈΠ·ΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΎΠΉ ΠΏΡΠ΅Π·ΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΎΠΌΠ±ΠΎΡΠ»Π°ΡΡΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΈΡΡ
ΠΎΠ΄Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΠΠ ΠΈ ΡΡΠ°Π²Π½ΠΈΠ²Π°Π»ΠΈ Π΅Π³ΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π½Π° 3-ΠΈ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΡΠΏΠΏΠΎΠΉ ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΉ
Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎΠΉ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΈ (Π’ΠΠ, n=26) ΠΈ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΠ (n=25). Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ
Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Statistica for Windows Π²Π΅ΡΡΠΈΡ 6.0.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡ
ΠΎΠ΄Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΠΠ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π½Π΅ ΡΠ°Π·Π»ΠΈΡΠ°Π»ΡΡ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. Π Π³ΡΡΠΏΠΏΠ΅ Π’ΠΠ Π³ΠΈΠΏΠ΅ΡΠΊΠΎΠ°Π³ΡΠ»ΡΡΠΈΡ ΠΈ ΡΠ³Π½Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ»ΠΈΠ·Π°
Π½Π° ΡΠΎΠ½Π΅ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π°Π³ΡΠ΅Π³Π°ΡΠΈΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ² ΡΠΎΡ
ΡΠ°Π½ΡΠ»ΠΈΡΡ Π½Π° 3-ΠΈ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ (p<0,05). Π Π³ΡΡΠΏΠΏΠ΅ ΠΠ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΠ»ΠΎ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠΎΠ°Π³ΡΠ»ΡΡΠΈΠΈ ΠΈ ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ»ΠΈΠ·Π°, Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π°Π³ΡΠ΅Π³Π°ΡΠΈΠΈ Π΄ΠΎΡΡΠΈΠ³Π»ΠΈ Π½ΠΈΠΆΠ½Π΅ΠΉ Π³ΡΠ°Π½ΠΈΡΡ Π½ΠΎΡΠΌΡ (p<0,05).
ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ΅ΡΠΈΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠ Π² Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΉ Ρ
ΠΈΡΡΡΠ³ΠΈΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ
ΠΊΠΎΠ°Π³ΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈ ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠ΅ΠΉ ΠΠ, Π½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ Π°Π³ΡΠ΅Π³Π°ΡΠΈΡ ΡΠΎΡΠΌΠ΅Π½Π½ΡΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ
Surface structuring features of polymeric membranes based on chitosan according to atomic force microscopy
Π‘ ΡΠ΅Π»ΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΡΡΡΠΊΡΡΡΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΡΡ
ΠΌΠ΅ΠΌΠ±ΡΠ°Π½ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Ρ
ΠΈΡΠΎΠ·Π°Π½Π° Π½Π° ΠΊΠ°ΠΆΠ΄ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π° Π°ΡΠΎΠΌΠ½ΠΎ-ΡΠΈΠ»ΠΎΠ²ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΈΠ·ΡΡΠ΅Π½Π° ΡΠ΅ΡΠΈΡ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ².For to reveal surface structuring mechanisms of modified polymeric membranes based on chitosan, a series of intermediate samples was studied using atomic force microscopy at each modification stage.Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΏΡΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠ³ΠΎ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ½Π΄Π° Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΏΡΠΎΠ΅ΠΊΡΠ° β 15-19-10057
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