Single Molecule Studies of a Biological Motor F₁-ATPase: Interplay of Experiment, Analytic Theory and Computation

In this chapter we discuss the interaction between theory and single molecule experiments on a biological motor, F₁-ATPase. In particular, we consider an interplay between the experiment, analytical theory, and computer simulations. The complementarity of the millisecond and microsecond experiments is noted. For example, the limited experiments on the latter indicate that the ATP binding in one β subunit precedes an ADP release in another β subunit, whereas the millisecond experiments do not time-resolve the two steps