12 research outputs found
Stereoretentive Pd-Catalyzed KumadaâCorriu Couplings of Alkenyl Halides at Room Temperature
Enantioâ, Regioâ and Chemoselective CopperâCatalyzed 1,2âHydroborylation of Acylsilanes
The enantioselective synthesis of synthetically significant ( -hydroxyallyl)silanes, ( -hydroxyaryl)silanes and ( hydroxyalkyl)silanes is reported. The present copper-catalysed 1,2hydroborylation of acylsilanes affords the aforementioned products in high yields and high enantiomeric excesses. This robust and scalable additive-free catalytic system relies on the use of low copper(II) acetate and diphosphine ligand loadings at room temperature in the presence of a commercially available and bench stable hydride source