The SNARE Machinery in Mast Cell Secretion

Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators. During an allergic response, the high-affinity IgE receptor, FcεRI, becomes cross-linked by receptor-bound IgE and antigen resulting in immediate release of pre-synthesized mediators – stored in granules – as well as in de novo synthesis of various mediators like cytokines and chemokines. Soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptors (SNARE) proteins were found to play a central role in regulating membrane fusion events during exocytosis. In addition, several accessory regulators like Munc13, Munc18, Rab GTPases, secretory carrier membrane proteins, complexins, or synaptotagmins were found to be involved in membrane fusion. In this review we summarize our current knowledge about the SNARE machinery and its mechanism of action in mast cell secretion

Management of anaphylaxis due to COVID-19 vaccines in the elderly

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.Peer reviewe

Etude de quelques fonctions phagocytaires impliquées dans le vieillissement et les pathologies dégénératives

AIX-MARSEILLE2-BU Sci.Luminy (130552106) / SudocSudocFranceF

Profil moléculaire de sensibilisation aux acariens domestiques dans une population marseillaise

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Thryptase et mastocyte (à la frontière entre allergie et immunité innée)

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Le test d'activation des basophiles dans le diagnostic in vitro de l'allergie (données cytométriques sur le basophile humain après activation par la voie IgE dépendante)

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Intérêt du test d'activation des basophiles dans le diagnostic des hypersensibilités médicamenteuses (cas de la Pristinamycine)

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Apport du test d'activation des basophiles dnas le diagnostic de l'allergie aux protéines de lait de vache de l'enfant

AIX-MARSEILLE2-BU Méd/Odontol. (130552103) / SudocSudocFranceF