kinematic elicitation of basic emotions a validation study in an italian sample

Video clips proved to effectively elicit different emotions. Hewig and colleagues (2005) developed a comprehensive set collecting 20 emotional film clips and investigated the basic emotions elicited in a German sample. In this study, we tested the reproducibility of their findings in Italian nonclinical adult subjects (N = 32) examined individually in an ecological setting; moreover, the differences between presentation modalities (with and without sound) were examined. Clips were rated on 10 emotional states (serene, amused, happy, surprised, sad, scared, angry, disgusted, indignant, tense) and on two bipolar dimensions of valence and intensity. Only little differences between presentation modalities were found; stories depicted proved to be clear enough. Film clips elicited the expected emotional profiles, and their rank order for each emotion is almost comparable with the German ones. However, all the clips elicited more than one emotion: ANCOVA proved that emotions were not fully independent and specific association patterns were found. Implications are discussed in the light of the complexity of emotional activation

PREDICTION OF ADHERENCE TO ANTIRETROVIRAL THERAPY: CAN PATIENTS' GENDER PLAY SOME ROLE? AN ITALIAN PILOT STUDY (AIDSIMPACT SPECIAL ISSUE)

International audienceRecent literature has shown that adherence to HAART is a multi-faceted phenomenon, which involves both behavioural and psychological features. Therefore, the results obtained so far, though promising, have not yet unambiguously identified the factors that could predict non-adherence. Since any support for strengthening the adherence should take into account the HIV+ patients' perception of both their state of health and their relational style, this study tried to identify some psychological characteristics involved in the adherence phenomenon. A self-administered battery of tests including the Attachment Style Questionnaire and the Multidimensional Health Locus of Control Form-C, was administered to an Italian sample. Results showed significant gender differences between non-adherent vs. adherent subjects. Specifically, the psychological profile of non-adherent males seemed focus less on relational aspects and perceived relevance of physicians and of ‘significant other people', whilst that of non-adherent females seemed more ‘relationship-oriented'. This study means to encourage clinicians to plan specific, gender- focused support for enhancing adherence

THE USEFULLNESS OF THE MULTIDIMENSIONAL HEALTH LOCUS OF CONTROL FORM C FOR HIV+ SUBJECTS: AN ITALIAN STUDY (AIDSIMPACT SPECIAL ISSUE)

International audienceIn the last few years, Highly Active Anti-Retroviral Therapy (HAART) has resulted in a remarkable decrease in HIV-related morbidity and mortality. This “new deal” encouraged clinical research in investigating patients' manifest behaviours and their beliefs regarding their health status, which likely influence not only their treatment-linked behaviours but also their quality of life. Locus of control has shown to be a construct that can predict and explain health-related behaviours. Multidimensional Health Locus of Control scale - Form C (MHLC-C) is a condition-specific locus of control scale that can be easily adapted for use with any medical or health-related condition. With the aim to enhance the knowledge about the HIV+ patients' point of view of their complex health condition, this study preliminarily investigated the psychometrics properties of the MHLC-C Italian version and its generalizability across samples defined both by being adherent or not and by gender. Two more samples of chronic patients (Cardiac Surgery and Cancer) were enrolled to better characterize the HIV+ patient's MHLC-C profile. The results showed the validity, reliability and generalizability of the 4-factor structure of MHLC-C. More interestingly, HIV+ subjects' revealed a peculiar pattern of beliefs regarding their health condition that clinicians should take into account when managing patients' complex bio-psychosocial condition

Gruppi Esperienziali Terapeutici (GET): un trattamento finalizzato alla regolazione emozionale

Il contributo illustra i fondamenti teorici dell'approccio terapeutico chiamato GET (Gruppi Esperienziali Terapeutici), un trattamento multilivello finalizzato alla regolazione emotiva. In particolare, viene approfondita la sua integrazione all'interno di un setting comunitario entro il quale l'esperienza condivisa - tra utenti e operatori - diventa fattore terapeutico centrale

The FERMI seeded-FEL facility: Status and perspectives

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Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

Although HAART suppresses HIV replication, it is often unable to restore immune homeostasis. Consequently, non-AIDS-defining diseases are increasingly seen in treated individuals. This is attributed to persistent virus expression in reservoirs and to cell activation. Of note, in CD4(+) T cells and monocyte-macrophages of virologically-suppressed individuals, there is continued expression of multi-spliced transcripts encoding HIV regulatory proteins. Among them, Tat is essential for virus gene expression and replication, either in primary infection or for virus reactivation during HAART, when Tat is expressed, released extracellularly and exerts, on both the virus and the immune system, effects that contribute to disease maintenance. Here we report results of an ad hoc exploratory interim analysis (up to 48 weeks) on 87 virologically-suppressed HAART-treated individuals enrolled in a phase II randomized open-label multicentric clinical trial of therapeutic immunization with Tat (ISS T-002). Eighty-eight virologically-suppressed HAART-treated individuals, enrolled in a parallel prospective observational study at the same sites (ISS OBS T-002), served for intergroup comparison. Immunization with Tat was safe, induced durable immune responses, and modified the pattern of CD4(+) and CD8(+) cellular activation (CD38 and HLA-DR) together with reduction of biochemical activation markers and persistent increases of regulatory T cells. This was accompanied by a progressive increment of CD4(+) T cells and B cells with reduction of CD8(+) T cells and NK cells, which were independent from the type of antiretroviral regimen. Increase in central and effector memory and reduction in terminally-differentiated effector memory CD4(+) and CD8(+) T cells were accompanied by increases of CD4(+) and CD8(+) T cell responses against Env and recall antigens. Of note, more immune-compromised individuals experienced greater therapeutic effects. In contrast, these changes were opposite, absent or partial in the OBS population. These findings support the use of Tat immunization to intensify HAART efficacy and to restore immune homeostasis. TRIAL REGISTRATION: ClinicalTrials.gov NCT0075159