Absorption Simulation ( ABSIM ) Software Development

Researchers working on air conditioning systems currently use a software called ABSIM ( Absorption Simulation ) to evaluate current absorption systems or simulate new system designs. ABSIM was developed at Oak Ridge National Labs in the 1980s and the latest platform it is compatible with is Windows XP. ABSIM is not compatible on newer platforms and is not very user friendly. A lot of the actions involved in using ABSIM aren’t very intuitive. The goal is to develop a more user friendly simulation program that is based off of ABSIM and see to it that the program can be deployed across different platforms. Storing and managing the data of the modular system was another issue that needed to be addressed. Putting together a user interface for the new program was achieved by using the application framework ‘Qt Creator’. To learn more about ‘Qt Creator’ and its uses, online research was primarily done on forums popular amongst app developers. A linked list was used to store and manage the data. A simulation program for absorption systems is currently being developed in C++ using ‘Qt Creator’. Using a linked list for storing and organizing data turned out to be the simplest and most efficient way to do so. ‘Qt Creator’ is the right tool used in the development of the simulation program because it allows a program to be deployed on any platform which has the necessary libraries

Down Regulation of Receptor like Kinase Gene in Apomictic \u3cem\u3eCenchrus ciliaris\u3c/em\u3e

Apomixis is a potential technology for agriculture to fix heterosis or hybrid vigor in hybrid plants. Cenchrus ciliaris which is a popular forage crop reproduces predominantly through apomixis and has been used as a model plant to understand genetic and molecular mechanisms controlling apomixis. A partial receptor like kinase gene (CcRLK) was isolated from apomictic C. ciliaris which showed exclusive expression in the embryo sacs of apomictic flowers compared to sexual embryo sacs during in situ hybridization analysis. This gene showed kinase and LRR domains implying its putative role in signaling pathways. In order to understand its functional significance, it was downregulated using RNAi approach

Atraumatic Restorative Treatment: Review and a Case Report

Atraumatic Restorative Treatment (ART), which was introduced as field trials, have gained popularity among clinicians for their ease, minimal use of instrumentation and hence can be done in remote areas with little or no resources and can be used in patients with special needs, anxious and apprehensive patients in the dental setting. The present paper presents a case of modified ART (ARTm) with full patient satisfaction after a 3 month follow up, with a review of the same and the differences between ART and ARTm

Sleep Deprivation and Neurological Disorders

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer\u27s disease and Parkinson\u27s disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended

Sleep deprivation and neurological disorders

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended

Current results and future prospects from PSR J1757-1854, a highly-relativistic double neutron star binary

Pulsars, rapidly-rotating highly-magnetised neutron stars, can serve as useful laboratories for probing aspects of fundamental physics. Binary pulsars, especially those in tight binary systems with massive, compact companions, are useful in testing different theories of gravity, the current paradigm being General Relativity (GR). Additionally, binary pulsars can also be utilised to explore other areas of fundamental physics, such as the behaviour of matter at ultra-high densities and the neutron star moment of inertia. A standout example is PSR J1757-1854, a 21.5-ms pulsar in a highly-eccentric (e=0.61), 4.4-hr orbit around a neutron star companion. This pulsar exhibits some of the most extreme relativistic parameters ever observed in a binary pulsar, reaching a maximum line-of-sight acceleration of close to 700 m/s/s and displaying among the strongest relativistic effects due to gravitational wave damping. To date, five post-Keplerian parameters have been measured in PSR J1757-1854, allowing for three independent tests of gravity to be conducted (of which GR passes all three) and for the component neutron star masses to be separated. The extreme properties of this system (particularly its high eccentricity) are expected to allow for future measurements of Lense-Thirring precession effects (allow for a measurement of the neutron star moment of inertia) and the relativistic deformation of the orbit, both of which remain almost completely unexplored by other binary systems. Although first discovered by the Parkes Radio Telescope in 2016 as part of the High Time Resolution Universe Southern Galactic Plane survey, it is ongoing observations with the Green Bank Telescope (GBT) which have provided the backbone of PSR J1757-1854’s continuing study. The large-bandwidth, high-precision observations afforded by the GBT played a fundamental role in delivering the science derived from the pulsar so far, and will be critical in allowing it to reach its full scientific potential going forward. In this talk I will provide a progress report on the ongoing timing of the system, including a review of the latest mass measurements and gravity tests, with an emphasis towards the future science which this pulsar will make possible

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17

Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664–711) of the 1830 (1797–1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76·1% (95% UI 71·6–80·7) of countries from 2000 to 2017, and in 53·9% (50·6–59·6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017. Interpretation: Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation

Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017

Correction:Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.Peer reviewe

Estimating global injuries morbidity and mortality : methods and data used in the Global Burden of Disease 2017 study

Background While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.Peer reviewe