1,253 research outputs found
Geiger-Mode Avalanche Photodiodes in Particle Detection
It is well known that avalanche photodiodes operated in the Geiger mode above
the breakdown voltage offer a virtually infinite sensitivity and time accuracy
in the picosecond range that can be used for single photon detection. However,
their performance in particle detection remains still unexplored. In this
contribution, we are going to expose the different steps that we have taken in
order to prove the efficiency of Geiger mode avalanche photodiodes in the
aforementioned field. In particular, we will present an array of pixels of
1mmx1mm fabricated with a standard CMOS technology for characterization in a
test beam.Comment: 7 pages, 2 figures, Proceedings of LCWS1
Development of high voltage-CMOS sensors within the CERN-RD50 collaboration
This paper presents work done by the CERN-RD50 collaboration to develop and study monolithic CMOS sensors for future hadron colliders, especially in terms of radiation tolerance, time resolution and granularity. Currently CERN-RD50 is completing the performance evaluation of RD50-MPW2 and has recently submitted RD50-MPW3, the second and third prototype sensor chips designed by the collaboration. The paper gives an overview of the main design aspects and performance evaluation results of the first two prototype chips RD50-MPW1 and RD50-MPW2, and details the design of the latest prototype RD50-MPW3. RD50-MPW2 is a small prototype with an 8 x 8 matrix of active pixels which implement analogue readout electronics only and solutions for low leakage currents. This prototype has been evaluated in the laboratory and also at proton and ion beam facilities, before and after irradiation with neutrons up to 2⋅1015 neq/cm 2. RD50-MPW3 is a more advanced prototype with a matrix of 64 x 64 pixels which integrate both analogue and digital readout electronics inside the sensing diodes. To alleviate routing congestion and minimise crosstalk noise, the pixels are serially configured and organised in a double column scheme. This prototype has optimised peripheral readout electronics for effective chip configuration, based on the I2C protocol, and fast data transmission
Characterisation of AMS H35 HV-CMOS monolithic active pixel sensor prototypes for HEP applications
Monolithic active pixel sensors produced in High Voltage CMOS (HV-CMOS)
technology are being considered for High Energy Physics applications due to the
ease of production and the reduced costs. Such technology is especially
appealing when large areas to be covered and material budget are concerned.
This is the case of the outermost pixel layers of the future ATLAS tracking
detector for the HL-LHC. For experiments at hadron colliders, radiation
hardness is a key requirement which is not fulfilled by standard CMOS sensor
designs that collect charge by diffusion. This issue has been addressed by
depleted active pixel sensors in which electronics are embedded into a large
deep implantation ensuring uniform charge collection by drift. Very first small
prototypes of hybrid depleted active pixel sensors have already shown a
radiation hardness compatible with the ATLAS requirements. Nevertheless, to
compete with the present hybrid solutions a further reduction in costs
achievable by a fully monolithic design is desirable. The H35DEMO is a large
electrode full reticle demonstrator chip produced in AMS 350 nm HV-CMOS
technology by the collaboration of Karlsruher Institut f\"ur Technologie (KIT),
Institut de F\'isica d'Altes Energies (IFAE), University of Liverpool and
University of Geneva. It includes two large monolithic pixel matrices which can
be operated standalone. One of these two matrices has been characterised at
beam test before and after irradiation with protons and neutrons. Results
demonstrated the feasibility of producing radiation hard large area fully
monolithic pixel sensors in HV-CMOS technology. H35DEMO chips with a substrate
resistivity of 200 cm irradiated with neutrons showed a radiation
hardness up to a fluence of ncm with a hit efficiency of
about 99% and a noise occupancy lower than hits in a LHC bunch
crossing of 25ns at 150V
DDR1 (discoidin domain receptor tyrosine kinase 1)
Review on DDR1 (discoidin domain receptor tyrosine kinase 1), with data on DNA, on the protein encoded, and where the gene is implicated
Atividade biológica das toxinas do Bt, Cry 1A(b) e Cry 1F em Spodoptera frugiperda (Smith) (Lepidoptera: noctuidae).
Atualmente, há duas diferentes toxinas do Bacillus thuringiensis (Bt) disponíveis em milho transgênico. Entretanto, há poucas informações sobre a toxicidade dessas proteínas puras Cry 1A(b) e Cry 1F para a lagarta-do-cartucho do milho (LCM), Spodoptera frugiperda, (Smith) usando o método de tratamento superficial da dieta. Os bioensaios foram conduzidos, usando um gradiente de concentração para as duas toxinas. Cada tratamento foi infestado artificialmente com larvas da LCM recém-eclodidas e mantidas sob temperatura constante e no escuro. Dez dias após a infestação, o número de larvas sobreviventes e a inibição de crescimento baseado na biomassa foram avaliados. Os dados de mortalidade foram submetidos à análise de "Probit". As CL50 estimadas para Cry1A(b) e Cry1F foram, respectivamente, 689,81 ng/cm2 e 36,46 ng/cm2. A CL50 foi suficiente para inibir o acúmulo de biomassa das larvas em 91,61% e 89,81% para Cry1Ab e Cry1F, respectivamente. As larvas que sobreviveram por dez dias nas dietas tratadas com o Cry 1A(b) foram transferidas para dieta não tratadas e observadas até a emergência dos adultos. Das larvas sobreviventes, 62,8% recuperaram seu desenvolvimento, acumulando a biomassa de uma pupa normal. Portanto, a atividade biológica da toxina do Bt vai além da simples toxicidade, incluindo uma significativa inibição de alimentação. Esse fato tem implicações importantes para o desenvolvimento de estratégias para o manejo da resistência
Selection of the fall armyworm Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae) for survival on Cry 1A (b) Bt toxin.
Plantas transgênicas que expressam toxinas da bactéria Bacillus thuringiensis (Bt) representam um importante avanço para o controle de lepidópteros-pragas de milho. Híbridos de milho Bt expressando a toxina Cry1A(b) têm mostrado significativo nível de resistência à lagarta-do-cartucho (LCM), Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae), embora larvas dessa espécie tenham sido observadas em campo e em laboratório sobrevivendo nesses híbridos. Resistência de S. frugiperda também tem sido registrada para diferentes inseticidas. Em bioensaios, seleção de insetos sobreviventes mostrou um aumento do nível de tolerância à toxina do Bt Cry1A(b) em populações da lagarta-do-cartucho, após quatro gerações, indicando que essa tolerância é herdada. Palavras-chave: Insecta, resistência, plantas transgênicas
Prototyping of an HV-CMOS demonstrator for the High Luminosity-LHC upgrade
HV-CMOS sensors can offer important advantages in terms of material budget, granularity and cost for large area tracking systems in high energy physics experiments. This article presents the design and simulated results of an HV-CMOS pixel demonstrator for the High Luminosity-LHC. The pixel demonstrator has been designed in the 0.35 μm HV-CMOS process from ams AG and submitted for fabrication through an engineering run. To improve the response of the sensor, different wafers with moderate to high substrate resistivities are used to fabricate the design. The prototype consists of four large analog and standalone matrices with several pixel flavours, which are all compatible for readout with the FE-I4 ASIC. Details about the matrices and the pixel flavours are provided in this article
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