Chitinozoan biozonation and new lithostratigraphical data in the upper Ordovician of the Fauquez and Aquempont areas (Brabant Massif, Belgium)

A chitinozoan biozonation is established for the Upper Ordovician rocks of the Sennette valley in the Fauquez area and the Asquempont area, revising the existing chitinozoan biozonation of the Brabant Massif. The chitinozoans of five formations (the Ittre, Bornival, Huet, Fauquez and Madot formations) are studied from 70 samples. The chitinozoan biozonation is correlated with Baltoscandia and the Avalonian Upper Ordovician type sections in the U.K. This correlation provides an accurate dating of the studied formations. A megaslumping event, affecting a part of the Ittre and Bornival Formation and causing the overturning of a pile of sediments estimated at minimum 200 m thick, may be placed in the mid Oandu (Cheneyan, middle Caradoc, early Stage 6"?). The volcanic rocks in the Fauquez area, formally thought to be restricted to the Ashgill, are confined to the late Caradoc - early Ashgill timespan. In addition to this, this paper presents new lithostratigraphical data on the Ittre Formation and the lower member of the Bornival Formation

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis between prognostic patient groups. Subsequently, methylationspecific PCR (MSP) assays were developed for 78 top-ranking differentially methylated regions and tested on two independent cohorts of 132 and 177 samples, respectively. Further, a new statistical framework was used to identify a robust set of MSP assays of which the methylation score (i.e. the percentage of methylated assays) allows accurate outcome prediction. Survival analyses were performed on the individual target level, as well as on the combined multimarker signature. As a result of the differential DNA methylation assessment by MBD sequencing, 58 of the 78 MSP assays were designed in regions previously unexplored in neuroblastoma, and 36 are located in non-promoter or non-coding regions. In total, 5 individual MSP assays (located in CCDC177, NXPH1, lnc-MRPL3-2, lnc-TREX1-1 and one on a region from chromosome 8 with no further annotation) predict event-free survival and 4 additional assays (located in SPRED3, TNFAIP2, NPM2 and CYYR1) also predict overall survival. Furthermore, a robust 58-marker methylation signature predicting overall and eventfree survival was established. In conclusion, this study encompasses the largest DNA methylation biomarker study in neuroblastoma so far. We identified and independently validated several novel prognostic biomarkers, as well as a prognostic 58-marker methylation signature

Wonen op historische grond. Archeologisch onderzoek naar nederzettingsresten uit de IJzertijd, Romeinse tijd en Middeleeuwen aan de Lostraat te Aalter.

Dit rapport werd ingediend bij het agentschap samen met een aantal afzonderlijke digitale bijlagen. Een aantal van deze bijlagen zijn niet inbegrepen in dit pdf document en zijn niet online beschikbaar. Sommige bijlagen (grondplannen, fotos, spoorbeschrijvingen, enz.) kunnen van belang zijn voor een betere lezing en interpretatie van dit rapport. Indien u deze bijlagen wenst te raadplegen kan u daarvoor contact opnemen met: [email protected]

Contemporary management of primary parapharyngeal space tumors

The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety of tumor types can develop in this location; most common are salivary gland neoplasm and neurogenic tumors. The management of these tumors has improved greatly owing to the developments in imaging techniques, surgery, and radiotherapy. Most tumors can be removed with a low rate of complications and recurrence. The transcervical approach is the most frequently used. In some cases, minimally invasive approaches may be used alone or in combination with a limited transcervical route, allowing large tumors to be removed by reducing morbidity of expanded approaches. An adequate knowledge of the anatomy and a careful surgical plan is essential to tailor management according to the patient and the tumor. The purpose of the present review was to update current aspects of knowledge related to this more challenging area of tumor occurrence.Peer reviewe

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP

Romeinse grafheuvels in IJsselstein : een inventariserend veldonderzoek in de vorm van proefsleuven en een booronderzoek

Lit.opg., bijl., verklarende woordenlijs

Chitinozoen

B

Ammonites from the latest Aalenian–earliest Bathonian of La Baume (Castellane area, SE France): palaeontology and biostratigraphy

Middle Jurassic strata are naturally exposed around the village called La Baume, near Castellane (Alpes de Haute Provence, SE France). We have realized both a detailed log and a bed-by-bed sampling for ammonite biostratigraphy in a 68 metres thick succession of subpelagic marls and limestones (“Calcaires à Zoophycos”) that spans the Middle Jurassic from uppermost Aalenian to lowermost Bathonian. The subpelagic succession can be roughly subdivided into three members. Ammonites from the Upper Aalenian Concavum Zone, all Lower Bajocian Zones (Discites Zone, Laeviuscula Zone including Ovale Subzone, Humpriesianum Zone), one Upper Bajocian Zone (Parkinsoni Zone) and probably one lower Bathonian Zone (Zigzag Zone) were found. A major gap of both the Niortense Zone and the Garantiana Zone, which was not previously described, was detected at the boundary between members 2 and 3. The main palaeontological interest of the ammonite fauna from La Baume is the richness and diversity of the family Sonniniidae, which is the subject of a systematic study and figurated along with some biostratigraphically significant forms. Biostratigraphical results and open problems are discussed

The latest Aalenian – earliest Bathonian ammonite faunas from La Baume (near Castellane, Alpes de Haute Provence, SE France): palaeontology and biostratigraphy.

International audienc