557 research outputs found

    Dominance and Innovation

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    Do dominant or less dominant firms innovate more? Theoretically it has been shown that within an asymmetric mixed strategy game of a patent race, the less dominant firm invests more than the dominant firm. But the empirical data on patent races is divided. In this paper, we argue that the decisions that concern strategic choice in innovation may be influenced by expected relative returns. Our approach, which we call the returns-based beliefs approach, is based upon subjective probabilities. It combines a decision analytic solution concept and Luce’s (1959) probabilistic choice model. In particular, we show how the use of the returns-based beliefs approach provides support for the thesis that dominant firms invest more in R&D within an asymmetric mixed strategy game. Consequently, we argue that the returns-based beliefs approach is more in line with recent empirical studies of innovation. We also provide empirical evidence using UK R&D data across a range of industries from 2001-2006 that shows that firms’ spending on R&D is related more to their own profitability than that of their competitors, which is consistent with the returns-based beliefs approach. We discuss the managerial implications of our theoretical approach and the empirical findings

    Divine Competition: Religious Organisations and Service Provision in India

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    This paper examines religious and non-religious service provision by religious organisations in India. We present a stylized Hotelling-style model in which two religious organisations differentiate hemselves on the strength of religious beliefs in order to compete in attracting adherents. We show in the model two central predictions: first,that the organisations will differentiate themselves on the strength of religious beliefs. Second, that in equilibrium, economic inequality makes the organisations increase their provision of non-religious services. To test this, we present unique primary survey dataon the economics of religion, collected by us between 2006 and 2010 from 568 Hindu, Muslim, Christian, Sikh and Jain religious organisations spread across 7 Indian states. We use these data to demonstrate that the organisations have substantially increasedtheir provision of non-religious services. We also provide quantitative evidence based oneconometric testing to highlight that religious organisations are differenting themselves on the strength of religious beliefs with respect to other organisations, and are also providing higher education and health services as economic inequality increases in India

    Genetic variability, heritability and genetic advance of quantitative traits in black gram by effects of mutation in field trail

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    Genetic variation has led to an increase in the quantitative traits of crops. The variability on genome is induced by mutation, which enhances the productivity. We evaluated variability on quantitative characters such as, plant height, number of branches/plant, number of leaves/plant, number of fruit clusters/plant, number of pods/plant, number of seeds/pod, yield/plant and 100 seed weight of black gram in M2 generation by the effect of mutation by gamma rays. The results were shown high genetic variability, heritability and genetic advance with significant enhancement (P 0.05 and P 0.01) in growth and yield traits. Hence selection is effective for these traits could be possible through gamma rays. The speculation of effects of gamma rays on genome is that irradiation, induced addition, deletion in DNA pairs and also attributed large chromosomal  rearrangement. The result were shown significant enhancement in yield and related traits. It indicates that improvement in quantitative traits would be possible through gamma rays

    A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis

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    ATI earlier report from this Centre (Tuber-culosis Chemotherapy Centre, Madras, 1964) showed that a fully supervised twice-weekly regimen of streptomycin plus high-dosage isoniazid was highly effective in the treatment of patients with newly-diagnosed bacteriologi-cally confirmed pulmonary tuberculosis. How-ever, this regimen involves intramuscular injections of streptomycin and may not always be easy to organize, especially in rural areas and in developing countries with limited resources. For this reason, it was decided to investigate the possibility of replacing strepto-mycin in the twice-weekly regimen by two oral drugs, namely ethionamide and PAS. Ethiona-mide was chosen since, apart from isoniazid and streptomycin, it was the most potent drug available at the time, and PAS was included with a view to enhance the efficacy of the regimen. Finally, it was decided that the patients should be given an intensive phase of daily treatment with streptomycin, PAS and isoniazid for two weeks. Experiments in the guinea-pig had shown that the size of the individual dose of a drug needed to be increased as the interval between successive doses was increased (Dickinson & Mitchison, 1966). As PAS is bulky and the dosage of isoniazid in the twice-weekly regimen was already high, namely 15 mg./kg. body-weight, it was decided to explore the possibility of increasing the dosage of ethionamide to a level higher than that usually employed (0.5— 1.0 g.) in daily regimens. An investigation was therefore undertaken to determine the maximum tolerated dose of ethionamide. when administered twice-weekly together with isonia-zid plus PAS. Since the assessment of ethio-namide intolerance is largely subjective, the study was conducted ‘double-blind’ with respect to the dosage of ethionamide
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