Hypolipidemic effect of Achyranthes aspera on High fat diet induced atherogenic rats

ABSTRACT Present investigation was undertaken to evaluate the hypolipidemic activity of aqueous extract of Achyranthes aspera in high fat diet induced atherogenic rats. High fat diet produced a significant increase in total cholesterol, VLDL, LDL, PL, Triglycerides, Free fatty acids and decrease in HDL. It also increased HMG CoA reductase activity. Reduction in the activity of Lipo protein lipase was observed. High fat diet also decreased the levels of SOD, CAT and reduced glutathione with associated increase in lipid peroxidation. Treatment with Achyranthes aspera (200mg./kg b.wt.,) altered the deranged metabolic profile and was effective in producing hypolipidemia