Magmatic evolution of the Nevado del Ruiz volcano, Central Cordillera, Colombia : mineral chemistry and geochemistry

A partir de nouvelles données pétrographiques, minéralogiques et géochimiques, les auteurs réalisent une caractérisation géochimique des laves du Nevado del Ruiz (éruptions quaternaires, historiques et récentes) et des formations volcaniques du Pliocène des pentes de la Cordillère central

IoT-Enhanced Healthcare: A Patient Care Evaluation Using the IoT Healthcare Test

Empirical insights into the significant effects of IoT-Enhanced Healthcare on patient care and health outcomes are provided by this study. The transformational potential of IoT technology is shown by data generated from a varied patient group, which includes continuous monitoring of blood pressure, body temperature, heart rate, and blood glucose levels via IoT devices. The usage of IoT devices is directly correlated with greater cardiovascular stability, as shown by consistently normal vital signs, according to statistical assessments. Additionally, the data highlights how patients using IoT devices have better control over their blood glucose levels, as seen by fewer cases of increased glucose levels. Evaluations of the quality of patient care show improved levels of satisfaction, efficacy of therapy, and communication, highlighting the benefits of IoT-Enhanced Healthcare. The evaluation of the outcomes of the IoT Healthcare Test confirms the precision and dependability of IoT devices in medical diagnosis, highlighting the significance of IoT-Enhanced Healthcare in transforming patient care. Together, these results provide strong evidence of IoT's ability to improve patient outcomes, treatment quality, and patient health

Precision Agriculture and Sustainable Yields: Insights from IoT-Driven Farming and the Precision Agriculture Test

This study clarifies how precision agriculture powered by the Internet of Things may optimize agricultural productivity and sustainability. Important connections, like the positive association between agricultural output and soil moisture, are revealed by analyzing data from Internet of Things sensors. Test findings for Precision Agriculture show impressive production increases: 20% better yields for wheat, 15% higher yields for maize, and 5% higher yields for soybeans. Interestingly, these improvements come with significant resource savings, with a 10% to 20% reduction in the use of pesticides and fertilizers. The evaluation of sustainable yield highlights efficiency levels between 92% and 95%. These results demonstrate how precision agriculture has the potential to completely transform contemporary agricultural methods by maximizing crop output, promoting sustainability, and reducing environmental impact

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

OBJECTIVE— Melanocortin-4 receptor (MC4R) deficiency is the most frequent genetic cause of obesity. However, there is uncertainty regarding the degree of penetrance of this condition, and the putative impact of the environment on the development of obesity in MC4R mutation carriers is unknown

Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

<p>Abstract</p> <p>Background</p> <p>7B2 is a regulator/activator of the prohormone convertase 2 which is involved in the processing of numerous neuropeptides, including insulin, glucagon and pro-opiomelanocortin. We have previously described a suggestive genetic linkage peak with childhood obesity on chr15q12-q14, where the 7B2 encoding gene, <it>SGNE1 </it>is located. The aim of this study is to analyze associations of <it>SGNE1 </it>genetic variation with obesity and metabolism related quantitative traits.</p> <p>Methods</p> <p>We screened <it>SGNE1 </it>for genetic variants in obese children and genotyped 12 frequent single nucleotide polymorphisms (SNPs). Case control analyses were performed in 1,229 obese (534 children and 695 adults), 1,535 individuals with type 2 diabetes and 1,363 controls, all French Caucasians. We also studied 4,922 participants from the D.E.S.I.R prospective population-based cohort.</p> <p>Results</p> <p>We did not find any association between <it>SGNE1 </it>SNPs and childhood or adult obesity. However, the 5' region SNP -1,701A>G associated with higher area under glucose curve after oral glucose tolerance test (p = 0.0005), higher HOMA-IR (p = 0.005) and lower insulinogenic index (p = 0.0003) in obese children. Similar trends were found in obese adults. SNP -1,701A>G did not associate with risk of T2D but tends to associate with incidence of type 2 diabetes (HR = 0.75 95%CI [0.55–1.01]; p = 0.06) in the prospective cohort.</p> <p>Conclusion</p> <p><it>SGNE1 </it>genetic variation does not contribute to obesity and common forms of T2D but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity. Further molecular studies are required to understand the molecular bases involved in this process.</p