Anteriyor miyokart enfarktüs hastalarında sol ön inen koroner arterin sonlanım şeklinin (sarılı olan ve olmayan

Amaç: Primer perkütan koroner girişim ile başarılı tedavi edilen anteriyor miyokart enfarktüs (AME) hastalarında sol ön inen koroner arter (LAD) sonlanımının doku Doppler ekokardiyografi(DDE) bulgularına etkisinin değerlendirilmesi amaçlandı. Yöntemler: Çalışma enine kesitli gözlemsel prospektif olarak planlandı. Seksen dört hasta çalışmaya dahil edildi. Hastalara ilk üç gün içinde ekokardiyografik değerlendirme yapıldı. Klasik DDE parametreleri sağ ventrikül (RV) lateral duvar ve sol ventriküle (LV) ait dört duvardan alındı. DDE parametreleri olarak; sistolik fonsiyonların değerlendirilmesinde - DDE mitral annüler sistolik hız değeri - Sm, diyastolik fonksiyonların - DDE mitral annüler erken ve E/A değerleri, kombine sistolik ve diyastolik fonksiyonların değerlendirilmesinde - miyokart performans indeksi (MPI) değeri kullanıldı. LAD sonlanım özelliğine göre iki gruba (sarılı olan ve olmayan LAD) ayrıldı. İstatistiksel analizde Student-t, Mann-Whitney U ve Ki-kare testleri, Pearson ve Spearman bivaryasyon korelasyon analizleri kullanıldı. Bulgular: Hastaların demografik verileri ve bazal ekokardiyografik ölçümleri benzerdi. RV ve LV için 4 duvardan alınan anüler DDE parametrelerinden sadece anteriyor Sm değerinde (Ant Sm) istatistikî anlamlılık ortaya çıkarken, Em, Am ve MPI değerlerinde anlamlı değişiklik tespit edilmemiştir. LAD koroner arterin LV apikalde sonlanan, diyafragmatik yüze (sarılı olmayan) geçiş göstermeyen olgularda anteriyor duvarın Sm değeri LAD koroner arterin LV apikalde sonlanmayan, diyafragmatik yüze geçiş gösterdiği (sarılı olan) olgulara göre daha fazla etkilendiği ortaya çıkmıştır (6.701.66 and 7.441.66 cm/sn; p0.036). Anteriyor Sm değeri ile LAD uzunluğu arasında korelasyon tespit edildi (r236, p0.036). Sonuç: LAD sonlanımı primer perkütan koroner girişim ile başarılı tedavi edilen AME hastalarında, erken dönemde anteriyor duvarın sistolik fonksiyonları için önemli bir parametredir.Objective: We aimed to evaluate effect of termination property of left anterior descending (LAD) on tissue Doppler echocardiography (TDE) parameters in patients experiencing their first anterior myocardial infarction (AMI) who had undergone successful primary percutaneous coronary intervention (PCI) Methods: A prospective, cross-sectional observational study was performed. Eighty-four patients were enrolled in the study. Echocardiography was performed during the first three days of AMI. Conventional TDE measurements were obtained from right ventricular (RV) and four left ventricular (LV) walls: for the systolic function - mitral annular TDE systolic velocity - Sm, for diastolic function - mitral annular TDE early and late diastolic velocities - Em, Am, transmitral early and late diastolic velocities ratio - E/A, and combined systolic and diastolic function - myocardial performance index (MPI). Coronary arteries were evaluated and patients were divided into two groups (non-wrapped LAD and wrapped LAD) according to the termination properties. Student-t, Mann-Whitney U and Chi-square tests, bivariate Pearson and Spearman correlation analyses were used for statistical analysis. Results: Baseline characteristics and conventional echocardiographic parameters of the patients were similar. There was a statistically significant difference for the anterior wall Sm parameter, whereas there was no substantial difference for Em, Am and MPI values. The anterior wall Sm was more affected in patients with non wrapped LAD than in patients with wrapped LAD (6.70±1.66 and 7.44±1.66 cm/s; p0.036,).The anterior Sm parameter was uniquely correlated with LAD termination status when compared with other independent parameters (r0.236, p0.036). Conclusion: We showed that termination of LAD is important for the anterior wall systolic functions in the early stage of AMI treated successfully

Long-Term Effect of Bosentan Therapy on Cardiac Function and Symptomatic Benefits in Adult Patients With Eisenmenger Syndrome

Background: Bosentan improves symptoms in patients with Eisenmenger syndrome (ES). This study evaluated the effect of long-term bosentan therapy on cardiac function and its relation to symptomatic benefits in ES patients

The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

Purpose: The present study aimed to investigate the relationship between the severity of coronary artery disease (CAD) and level of Lipoprotein (LP)(a). Methods: The study included 52 CAD patients and a control group consisting of 38 individuals. The patients were classified into three groups based on the clinical form of CAD (stable angina pectoris, SAP, unstable angina pectoris,UAP, and myocardial infarction,MI), and were further divided into three groups based on CAD severity (1-, 2- and 3-vessel). Serum Lp(a) levels were monitored 4, 8, and 24 h, 10 and 30 days following acute MI in 18 patients. Results: Based on regression analysis, Lp(a) was not correlated with other lipoproteins or with risk factors of CAD, such as body mass index, smoking, family history, diabetes, age, gender, and hypertension (r = 0.08-0.22). 72% of the patients in the CAD group and 24% of the control group had an Lp(a) level > 30 mg dL–1 (P = 0.004), and Lp(a) levels were higher in 3-vessel patients than in 2-vessel and 1-vessel CAD patients (86% vs. 68%, P = 0.02 and 86% vs. 62%, P=0.01, respectively). Serum Lp(a) levels were higher in the UAP and MI groups than in the SAP group (48 ± 44.7 mg dL–1, 49 ± 36.1 mg dL–1 and 31.2 ± 22.3 mg dL–1 , respectively,P=0.02). Lp(a) levels increased after acute MI, and reached peak levels 10 days post-MI (41% increase, P=0.001) and remained considerably elevated (18%) 30 days post-MI (P=0.01). Conclusion: Serum Lp(a) was higher in the UAP and MI patients in comparison with the SAP patients, and was higher in 3-vessel CAD in comparison with 1- and 2-vessel CAD patients