10 research outputs found
An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
- Author
- Aalfs Cora M.
- Aaltonen Kirsimari
- Adenis Claude
- Adlard Julian
- Agnarsson Bjarni A.
- Aittomäki Kristiina
- Alonso Rosario
- Amadori Alberto
- Andrulis Irene L.
- Angelakos Maggie
- Antoniou Antonis C.
- Ardern Jones Audrey
- Ardnor Christina Edwinsdotter
- Arnold Norbert
- Arun Banu K.
- Arver Brita
- Attard Virginia
- Ausems M. G. E. M.
- Balmaña J.
- Balogh Maria
- Bancroft Elizabeth
- Bardel Claire
- Bardsley Cathryn
- Barile Monica
- Barjhoux Laure
- Barouk Simonet Emmanuelle
- Barroso Alicia
- Barrowdale Daniel
- Barton David
- Barwell Julian
- Belotti Muriel
- Benitez Javier
- Berger Andreas
- Berlin Cheryl
- Berthet Pascaline
- Bignon Yves Jean
- Blanco Amie
- Blanco Ignacio
- Blein Sophie
- Blok M. J.
- Blomqvist Drs Carl
- Bonadona Valérie
- Bonanni Bernardo
- Bonnet Françoise
- Borg Ake
- Bourdon Violaine
- Bove Betsy
- Bozsik Aniko
- Bradshaw Nicola
- Brady Angela
- Breast Cancer Family Registry Null
- Bressac de Paillerets Brigitte
- Brewer Carole
- Brice Glen
- Bronner Myriam
- Bubien Virginie
- Buecher Bruno
- Bustinza Gisela Barbany
- Buys Saundra S.
- Caldes Trinidad
- Calender Alain
- Caligo Maria A.
- Capella Gabriel
- Capone Gabriele L.
- Caron Olivier
- Carter Jonathan
- Castro Elena
- Chan Salina
- Chenevix Trench Georgia
- Chung Wendy K.
- Claber Oonagh
- Claes Kathleen
- Colas Chrystelle
- Cole Trevor
- Collier Rebecca
- Collonge Rame Marie Agnès
- Collée J. M.
- Conejero Raquel Andrés
- Conrad Peggy
- Cook Jackie
- Corines Marina
- Coron Fanny
- Couch Fergus J.
- Coulet Florence
- Coupier Isabelle
- Cox David G.
- Craven Caroline
- Crawford Beth
- Crawford Gillian
- Damette Alexandre
- Damiola Francesca
- Danjean Vincent
- Davidson Rosemarie
- de Bock G. H.
- de la Hoya Miguel
- de Lange J. L.
- De Leeneer Kim
- de Pauw Antoine
- Del Valle Jesús
- Delatycki Martin
- della Puppa Lara
- Delnatte Capucine
- Demange Liliane
- Dennis Joe
- Devilee Peter
- Diez Orland
- Ding Chun
- Ding Yuan Chun
- Dishon Sara
- Disilvestro Paul A.
- Dite Gillian
- Ditsch Nina
- Dolcetti Riccardo
- Domchek Susan M.
- Domokos Gabriella
- Donaldson Alan
- Dorfling Cecilia M.
- Dorkins Huw
- Douglas Fiona
- Dreyfus Hélène
- Driessen Rebecca
- Drummond Sarah
- Dumont Martine
- Duncan Alexis
- Durda Katarzyna
- Durell Sarah
- Eason Jacqueline
- Easton Douglas F.
- Eccles Diana
- Eddy Charlotte
- Eeles Ros
- Eglitis Drs Janis
- Ehrencrona Hans
- Einbeigi Zakaria
- Eisinger François
- Ejlertsen Bent
- Ellis Ian
- Ellis Steve
- Emanuelsson Monica
- Embrace Null
- Engel Christoph
- Erkkilä Irja
- Evans D. Gareth
- Faivre Laurence
- Feillel Viviane
- Ferenczi Judit
- Ferrer Sandra Fert
- Fineberg Elena
- Fink Retter Anneliese
- Foo Claire
- Foretova Lenka
- Foulkes William
- Fournier Joëlle
- Franko Judit
- Fricker Jean Pierre
- Friedman Eitan
- Frost Debra
- Frénay Marc
- Garber Judy
- Gauthier Villars Marion
- Gayther Simon
- Gehrig Andrea
- Gerdes Anne Marie
- Gibson Sarah
- Gille J. J. P.
- Giraud Sophie
- Gladieff Laurence
- Glendon Gord
- Godwin Andrew K.
- Goff Sheila
- Goldgar David E.
- Golmard Lisa
- Goodman Selina
- Greene Mark H.
- Gregory Helen
- Griškevicius Laimonas
- Gronwald Jacek
- Guimbaud Rosine
- Gómez Garcia E. B.
- Halliday Dorothy
- Hamann Ute
- Handallou Sandrine
- Hansen Thomas V. O.
- Haque Eshika
- Harbst Katja
- Hardouin Agnès
- Harrington Patricia
- Harris Marion
- Healey Sue
- Henriksson Karin
- Hill Kathryn
- Hodgson Shirley
- Hoffman Jonathan
- Hogervorst Frans B. L.
- Hooning M. J.
- Houdayer Claude
- Houghton Catherine
- Houlston Richard
- Imyanitov Evgeny N.
- Isaacs Claudine
- Izatt Louise
- Jacobs Chris
- Jacobs Lauren
- Jager Agnes
- Jakubowska Anna
- James Margaret
- Janavicius Ramunas
- Jaworska Bieniek Katarzyna
- Jeffers Lisa
- Jensen Uffe Birk
- Jernström Helena
- Jobson Irene
- Karlan Beth Y.
- Karlsson Per
- Kast Karin
- Kaulich Daphne Geschwantler
- Kennedy M. John
- Kets Carolien M.
- Kientz Caroline
- Killick Emma
- Kivuva Emma
- Kleibl Zdenek
- Kohut Kelly
- Konstantopoulou Irene
- Krilova Anna
- Kristoffersson Ulf
- Kruse Torben A.
- Kuchenbaecker Karoline B.
- Kulkarni Anjana
- Kwan Lorna
- Laitman Yael
- Lalloo Fiona
- Lambo Rossana
- Langman Caroline
- Lasset Christine
- Lazaro Conxi
- Lebrun Marine
- Lee Andrew
- Lee Robin
- Lefol Cédrick
- Lehmann Anna
- Lejbkowicz Flavio
- Leroux Dominique
- Lester Jenny
- Lidereau Rosette
- Liedgren Sigrun
- Liljegren Annelie
- Lincoln Anne
- Lindblom Annika
- Lindeman Geoffrey
- Lindor Noralane M.
- Loman Niklas
- Longmuir Mark
- Longy Michel
- Loranger Kate
- Lubinski Jan
- Lucassen Anneke
- Lynch Henry T.
- Léone Mélanie
- Machackova Eva
- Mai Phuong L.
- Mak Julie
- Male Alison
- Manoukian Siranoush
- Markov Nadja Bogdanova
- Martayan Aline
- Martin Sue
- Maskiell Judi
- Maugard Christine
- Mazoyer Sylvie
- Mcbride Donna
- Mccann Emma
- Mcguffog Lesley
- Mcleod Diane
- Meijers Heijboer Hanne E. J.
- Meindl Alfons
- Melin Beatrice
- Mensenkamp A. R.
- Miedzybrodzka Zosia
- Mitchell Gillian
- Moncoutier Virginie
- Montagna Marco
- Morrison Patrick J.
- Mortemousque Isabelle
- Mourits M. J.
- Muller Danièle
- Mulligan Anna Marie
- Muranen Taru A.
- Murday Victoria
- Murray Alexandra
- Nathanson Katherine L.
- Neuhausen Susan L.
- Nevanlinna Heli
- Niederacher Dieter
- Niedermayr Eveline
- Nielsen Finn C.
- Niu Qun
- Noguchi Tetsuro
- Nogues Catherine
- Nordling Margareta
- Nussbaum Robert L.
- O'Conor Michelle
- Obdeijn I. M.
- Offit Kenneth
- Olah Edith
- Olopade Olufunmilayo I.
- Olsson Håkan
- Olswold Curtis
- Ong Kai Ren
- Oosterwijk Jan C.
- Orsulic Sandra
- Osorio Ana
- OTTINI LAURA
- Overbeek L. I. H.
- Page Elizabeth
- Palola Virpi
- Pankratz Vernon S.
- Papi Laura
- Papp Janos
- Paterson Joan
- Pedersen Inge Sokilde
- Peissel Bernard
- Peixoto Ana
- Pensotti Valeria
- Peterlongo Paolo
- Peyrat Jean Philippe
- Peysselon Magalie
- Pfeiler Georg
- Pharoah Paul D. P.
- Phelan Catherine M.
- Piedmonte Marion
- Pigg Maritta Hellström
- Pilato Brunella
- Pinchev Mila
- Pinto Pedro
- Pita Guillermo
- Platte Radka
- Plendl Hansjoerg
- Pocza Timea
- Pohlreich Petr
- Porteous Mary E.
- Preisler Adams Sabine
- Prieur Fabienne
- Pujol Pascal
- Pye Carole
- Quarrell Oliver
- Radice Paolo
- Rahman Nazneen
- Ramus Susan J.
- Rantala Johanna
- Rappaport Christine
- Rea Gillian
- Rebbeck Timothy R.
- Rebischung Christine
- Remenieras Audrey
- Rennert Gad
- Rhiem Kerstin
- Robson Mark
- Rocha Patrícia
- Rogers Mark T.
- Rookus Matti A.
- Rosenquist Richard
- Rouleau Etienne
- Rudaitis Vilius
- Révillion Françoise
- Santos Catarina
- Sawyer Sarah
- Schmidt M. K.
- Schmutzler Rita K.
- Scuvera Giulietta
- Searle Anne
- Segota Ena
- Seldon Joyce
- Senter Leigha
- Serra Feliu Gemma
- Sevenet Nicolas
- Seynaeve C.
- Shanley Susan
- Side Lucy E.
- Siesling S.
- Simard Jacques
- Singer Christian F.
- Sinilnikova Olga M.
- Smalley Sarah
- Snadden Lesley
- Snyder Carrie L.
- Sobol Hagay
- Sokolowska Johanna
- Soller Maria
- Sornin Valérie
- Soubrier Florent
- Soucy Penny
- Spurdle Amanda B.
- Stayner Barbara
- Steele Linda
- Steinemann Doris
- Stengrevics Aivars
- Stenmark Askmalm Marie
- Stewart Nicola
- Stoppa Lyonnet Dominique
- Sukiennicki Grzegorz
- Sutter Christian
- Sweet Kevin
- Szabo Csilla I.
- Taylor Amy
- Taylor Jane
- Tchatchou Sandrine
- Tea Muy Kheng
- Teixeira Manuel R.
- Terry Mary Beth
- Teulé Alex
- Thelander Margo
- Thomas Gilles
- Thomassen Mads
- Thompson Ella
- Thorne Heather
- Tibiletti Maria Grazia
- Tihomirova Laima
- Tirapo Carole
- Tischkowitz Marc
- Tobias Ed
- Toland Amanda Ewart
- Tollenaar R. A. E. M.
- Tommasi Stefania
- Toulas Christine
- Tranchant Martine
- Tripathi Vishakha
- Tsimiklis Helen
- Tung Nadine
- Uhrhammer Nancy
- van Asperen C. J.
- van Cronenburg T. C. T. E. F.
- van den Ouweland Ans M. W.
- van der Hout A. H.
- van der Luijt Rob B.
- van Deurzen C. H. M.
- Van Le Linda
- van Leeuwen Flora E.
- van Os T. A. M.
- van Rensburg Elizabeth J.
- van Roozendaal Kees E. P.
- Varesco Liliana
- Varon Mateeva Raymonda
- Vasen H. F.
- Vaszko Tibor
- Vennin Philippe
- Verhoef S.
- Verny Pierre Carole
- Viel Alessandra
- Vijai Joseph
- von Wachenfeldt Anna
- Vénat Bouvet Laurence
- Waisfisz Q.
- Walker Lisa
- Wang Gohrke Shan
- Wappenschmidt Barbara
- Watt Catherine
- Weaver Jo Ellen
- Weitzel Jeffrey N.
- Wiggins Jennifer
- Wijnands R.
- Wijnen J. T.
- Winchester Lizzie
- Wozniak Eva
- Yannoukakos Drakoulis
- Zaffaroni Daniela
- Zidan Jamal
- Zikan Michal
- Zvocec Cecilia
- Öfverholm Anna
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Introduction: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers. Methods: We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals. Results: We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. Conclusions: This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.Peer reviewe
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
- Author
- Aalfs C.M. (Cora)
- Adenis C. (Claude)
- Adlard J.W. (Julian)
- Agata S. (Simona)
- Agnarsson B.A. (Bjarni)
- Aittomäki K. (Kristiina)
- Andersen M.K. (Mette)
- Andrulis I.L. (Irene)
- Angelakos M. (Maggie)
- Antoniou A.C. (Antonis)
- Ardern-Jones A. (Audrey)
- Ardnor C.E. (Christina Edwinsdotter)
- Arnold N. (Norbert)
- Arun B.K. (Banu)
- Arver B. (Brita Wasteson)
- Asperen C.J. (Christi) van
- Attard V. (Virginia)
- Ausems M.G.E.M. (Margreet)
- Bacot F. (Francois)
- Bae-Jump V.L. (Victoria L.)
- Balmana J. (Judith)
- Bancroft E.K. (Elizabeth)
- Bardsley C. (Cathryn)
- Barjhoux L. (Laure)
- Barkardottir R.B. (Rosa)
- Barouk-Simonet E. (Emmanuelle)
- Barrowdale D. (Daniel)
- Barton D.E. (David)
- Barwell J. (Julian)
- Beattie M.S. (Mary)
- Belotti M. (Muriel)
- Benítez J. (Javier)
- Berlin C. (Cheryl)
- Berthet P. (Pascaline)
- Bignon Y.-J. (Yves-Jean)
- Bignon Y.-J. (Yves-Jean)
- Blanco I. (Ignacio)
- Blank S.V. (Stephanie)
- Blok M.J. (Marinus)
- Bock G.H. (Geertruida) de
- Bonadona V. (Valérie)
- Bonnani B. (Bernardo)
- Bonnet F. (Françoise)
- Borg Å. (Åke)
- Bourdon V. (Violaine)
- Bradshaw N. (Nicola)
- Brady A.F. (Angela)
- Bressac-de Paillerets B. (Brigitte)
- Brewer C. (C.)
- Brewer C. (Carole)
- Brice G. (Glen)
- Bronner M. (Myriam)
- Brunet J. (Joan)
- Bubien V. (Virginie)
- Buecher B. (Bruno)
- Bustinza G.B.
- Buys S.S. (Saundra)
- Caldes T. (Trinidad)
- Calender A. (Alain)
- Caligo M.A. (Maria)
- Campbell I. (Ian)
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- Claber O. (Oonagh)
- Claes K. (Kathleen)
- Cohn D.E. (David)
- Colas C. (Chrystelle)
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- Collier R. (Rebecca)
- Collée J.M. (Margriet)
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- Coulet F. (Florence)
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- Cronenburg T.C.T.E.F. van
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- Damiola F. (Francesca)
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- Deurzen C.H.M. (Carolien) van
- Devilee P. (Peter)
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- Diez O. (Orland)
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- Donaldson A. (Alan)
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- Dorkins H. (Huw)
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- Durda K. (Katarzyna)
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- Ehrencrona H. (Hans)
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- Ellis S. (Steve)
- Ellis S.D. (Steve)
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- Gadzicki D. (Dorothea)
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- Gehrig P.A. (Paola A.)
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- Guimbaud R. (Rosine)
- Gómez García E.B. (Encarna)
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- Hooning M.J. (Maartje)
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- Houghton C. (Catherine)
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- Hout A.H. (Annemarie) van der
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- Huo D. (Dezheng)
- Huzarski T. (Tomasz)
- Imyanitov E.N. (Evgeny)
- Izatt L. (Louise)
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- James P.A. (Paul )
- Janavicius R. (Ramunas)
- Jaworska K. (Katarzyna)
- Jeffers L. (Lisa)
- Jensen U.B.
- Jernström H. (H.)
- Jobson I. (Irene)
- John E.M. (Esther)
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- Karlan B.Y. (Beth)
- Karlsson P. (Per)
- Kast K. (Karin)
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- Kets C.M. (Marleen)
- Kientz C. (Caroline)
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- Kohut K. (Kelly)
- Kosel M. (Matthew)
- Kristoffersson U. (Ulf)
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- Kuchenbaecker K.B. (Karoline)
- Kulkarni A. (Anjana)
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- Lejbkowicz F. (Flavio)
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- Lester K.J. (Kathryn)
- Lidereau R. (Rosette)
- Liedgren S. (Sigrun)
- Ligtenberg M.J. (Marjolijn)
- Liljegren A. (Annelie)
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- Lindor N.M. (Noralane)
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- Longy M. (Michel)
- Loud J.T. (Jennifer)
- Lu K.H. (Karen)
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- Luijt R.B. (Rob) van der
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- Mai P.L. (Phuong)
- Male A. (Alison)
- Manoukian S. (Siranoush)
- Martin S. (Sue)
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- Mazoyer S. (Sylvie)
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- McGuffog L. (Lesley)
- McLeod D. (Diane)
- Meijers-Heijboer E.J. (Hanne)
- Meijers-Heijboer H. (Hanne)
- Meindl A. (Alfons)
- Melin B. (Beatrice)
- Melloni G. (Giulia)
- Melville S.A. (Scott)
- Mensenkamp A.R. (Arjen)
- Miedzybrodzka Z. (Zosia)
- Miron A. (Alexander)
- Moeller S.T. (Sanne Traasdahl)
- Moncoutier V. (Virginie)
- Montagna M. (Marco)
- Morrison P.J. (Patrick)
- Mortemousque I. (Isabelle)
- Mourits M.J. (Marjan)
- Muller D.W. (Danièle)
- Mulligan A.M. (Anna Marie)
- Muranen T.A. (Taru)
- Murday V. (Victoria)
- Murray A. (Alexandra)
- Murray A. (Anna)
- Narod S. (Steven)
- Nathanson K.L. (Katherine)
- Neuhausen S.L. (Susan)
- Nevanlinna H. (Heli)
- Niederacher D. (Dieter)
- Niedermayr E. (Eveline)
- Nielsen F.C. (Finn)
- Noguchi T. (Tetsuro)
- Nogues C. (Catherine)
- Nordling M. (Margareta)
- Offit K. (Kenneth)
- Olah E.
- Olopade O.I. (Olofunmilayo)
- Olsson H.
- Olswold C. (Curtis)
- Ong K.-R. (Kai-Ren)
- Oosterwijk J.C. (Jan)
- Orsulic S. (Sandra)
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- Osorio A. (Ana)
- Ottini L. (Laura)
- Ouweland A.M.W. (Ans) van den
- Ozcelik H. (Hilmi)
- Page E. (Elizabeth)
- Pankratz V.S. (Shane)
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- Pedersen I.S. (Inge Sokilde)
- Peissel B. (Bernard)
- Pensotti V. (Valeria)
- Peock S. (Susan)
- Peterlongo P. (Paolo)
- Peyrat J.-P.
- Peysselon M. (Magalie)
- Pfeiler G. (Georg)
- Phelan C. (Catherine)
- Piedmonte M. (Marion)
- Pigg M.H. (Maritta )
- Platte R. (Radka)
- Plendl H. (Hansjoerg)
- Porteous M.E. (Mary)
- Preisler-Adams S. (Sabine)
- Prieur F. (Fabienne)
- Pujana M.A. (Miguel)
- Pujol P. (Pascal)
- Quarrell O. (Oliver)
- Radice P. (Paolo)
- Rahman N. (Nazneen)
- Ramus S.J. (Susan)
- Randhawa K. (Kashmir)
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- Remenieras A. (Audrey)
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- Rensburg E.J. (Elizabeth) van
- Rhiem K. (Kerstin)
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- Romero A. (Alfonso)
- Rookus M.A. (M.)
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- Rouleau E. (Etienne)
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- Shanley S. (Susan)
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- Sinilnikova O. (Olga)
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- Slager S. (Susan)
- Small L. (Laurie)
- Smalley S. (Sarah)
- Snadden L. (Lesley)
- Snyder C.L. (Carrie)
- Sobol H. (Hagay)
- Sobol H. (Hagay)
- Sokolenko A. (Anna)
- Sokolowska J. (Johanna)
- Soller M. (Maria)
- Soubrier F.
- Soucy P. (Penny)
- Southey M.C. (Melissa)
- Spurdle A.B. (Amanda)
- Stavropoulou A. (Alexandra)
- Stayner B. (Barbara)
- Steele L. (Linda)
- Stenmark-Askmalm M. (M.)
- Stevens K. (Kristen)
- Stoppa-Lyonnet D. (Dominique)
- Stoppa-Lyonnet D. (Dominique)
- Stormorken A. (Astrid)
- Sutter C. (Christian)
- Szabo C. (Csilla)
- Taylor A. (Amy)
- Taylor J. (James)
- Tea M.-K.
- Teo S.-H. (Soo-Hwang)
- Terry M.-B. (Mary-Beth)
- Tessier Y. (Yann)
- Teulé A. (A.)
- Thomassen M. (Mads)
- Thorne H. (Heather)
- Tibiletti M.G. (Maria Grazia)
- Tihomirova L. (Laima)
- Tirapo C. (Carole)
- Tischkowitz M. (Marc)
- Tobias E. (Ed)
- Tognazzo S. (Silvia)
- Tollenaar R.A.E.M. (Rob)
- Toulas C. (Christine)
- Tripathi V. (Vishakha)
- Tung N. (Nadine)
- Uhrhammer N. (Nancy)
- Varesco L. (Liliana)
- Varon-Mateeva R. (Raymonda)
- Vaszko T. (Tibor)
- Vennin P. (Philippe)
- Verhoef S.
- Verhoef S. (S.)
- Verny-Pierre C. (Carole)
- Viel A. (Alessandra)
- Vijai J. (Joseph)
- Vincent D. (Daniel)
- Volorio S. (Sara)
- Vénat-Bouvet L. (Laurence)
- Wachenfeldt A. (Anna) von
- Waisfisz Q. (Quinten)
- Walker L.J. (Lisa)
- Walsh C.S. (Christine)
- Wang C. (Chen)
- Wang X. (Xianshu)
- Wapenschmidt B. (Barbara)
- Watt C. (Catherine)
- Weaver J. (JoEllen)
- Weber B.H.F. (Bernhard)
- Weitzel J.N. (Jeffrey)
- Wiggins J. (Jennifer)
- Wijnen J.T. (Juul)
- Wijnen J.T. (Juul)
- Winchester L. (Lizzie)
- Yannoukakos D. (Drakoulis)
- Złowocka-Perłowska E. (Elzbieta)
- Öfverholm A. (Anna)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/04/2013
- Field of study
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat
Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
- Author
- A. B. Kconfab Spurdle
- A. De Pauw
- A. Ewart Toland
- Agnes Hardouin
- Alain Calender
- Aleksandra Toloczko Grabarek
- Alex Miron
- Alfons Meindl
- Amanda Ewart Toland
- Ana Osorio
- Andrea Gehrig
- Andrew K. Godwin
- Andrew Lee
- Anna Jakubowska
- Anne Bine Skytte
- Anne Marie Gerdes
- Annelie Liljegren
- Anneliese Fink Retter
- Annika Lindblom
- Antonis C. Antoniou
- Ava Kwong
- B. Swe Brca Melin
- Barbara Wappenschmidt
- Bent Ejlertsen
- Bernard Peissel
- Bernardo Bonanni
- Beth Y. Karlan
- Britta Fiebig
- Buys
- C. Issacs
- Carole Brewer
- Catherine Loustalot
- Cecelia M. Dorfling
- Cezary Cybulski
- Chris Jacobs
- Christi J. Van Asperen
- Christian F. Singer
- Christian Sutter
- Christine Lasset
- Christoph Engel
- Claudine Isaacs
- Conxi Lazaro
- Cora M. Aalfs
- D. E. Antoine Pauw
- D. Gareth Evans
- Daniel Barrowdale
- Daniela Zaffaroni
- David Goldgar
- Debra Frost
- Diana Eccles
- Dieter Niederacher
- Dieter Schafer
- Domchek Sm
- Dominique Stoppa Lyonnet
- Dorotehea Gadzicki
- Douglas F. Easton
- Edith Olah
- Elena Fineberg
- Elizabeth J. Van Rensburg
- Elzbieta Złowocka
- Embrace
- Embrace Hebon
- Eva Tornero
- Evgeny Imyanitov
- Fergus J. Couch
- Fiona Douglas
- Fiona Lalloo
- Flora E. Van Leeuwen
- Gemo
- Georg Pfeiler
- Georgia Chenevix Trench
- Gord Glendon
- H. Ocgn Ozcelik
- Hakan Olsson
- Hanne E. J. Meijers Heijboer
- Harsh Pathak
- Heli Nevanlinna
- Helmut Deissler
- Ignacio Blanco
- Irene L. Andrulis
- J. Margriet Collee
- Jacek Gronwald
- Jackie Cook
- Jacques Simard
- James S. Hoffman
- Jan Lubinski
- Javier Benitez
- Jenny Gross
- Joan Paterson
- John M. Esther
- John Em
- Jonathan Beesley
- Joseph Vijai
- Julian Adlard
- K. E. P. Van Roozendaal
- Karin Kast
- Karoline B. Kuchenbaecker
- Katarzyna Durda
- Katarzyna Jaworska
- Katherine L. Nathanson
- Kconfab
- Kelly Anne Phillips
- Kenneth Offit
- Kirsten B. Moysich
- Kristiina Aittomaki
- Laura Papi
- Laurence Faivre
- Lesley Mcguffog
- Linda Van Le
- Lisa Walker
- Loris Bernard
- M. B. Terry
- M. John Kennedy
- Mads Thomassen
- Marco Montagna
- Margriet J. Collee
- Maria A. Caligo
- Maria Isabel Tejada
- Marie Stenmark Askmalm
- Marie Plante
- Marion Gauthier Villars
- Marion Piedmonte
- Mark H. Greene
- Mark Robson
- Mary Beth Terry
- Mary E. Porteous
- Mary S. Beattie
- Mary Daly
- Matilde Navarro
- Matti Rookus
- Melanie Leone
- Melissa Southey
- Mercedes Duran
- Mia M. Gaudet
- Mieke Kriege
- Miguel De La Hoya
- Muy Kheng Tea
- Nancy Uhrhammer
- Neuhausen Sl
- Nicoline Hoogerbrugge
- Nina Ditsch
- Noralane Lindor
- Norbert Arnold
- O. N. Behalf Of The Consortium Of Investigators Of Modifiers Of Brca1/2
- Ocgn
- Olga M. Sinilnikova
- Orland Diez
- Oskar Th Johannsson
- Ottini Laura
- Paolo Peterlongo
- Paolo Radice
- Pascaline Berthet
- Patricia A. Ganz
- Patrick J. Morrison
- Paul D. P. Pharoah
- Penny Soucy
- Pharoah Pd
- Phuong L. Mai
- R. B. Hebon Van Der Luijt
- Radka Platte
- Ramunas Janavicius
- Raymonda Varon Mateeva
- Riccardo Dolcetti
- Rita K. Schmutzler
- Ros Eeles
- Rosemarie Davidson
- S. Daly
- Sabine Preisler Adams
- Saundra Buys
- Shirley Hodgson
- Silvia Tognazzo
- Simon A. Gayther
- Simone Heidemann
- Siranoush Manoukian
- Soo Hwang Teo
- Steve D. Ellis
- Sue Healey
- Susan J. Ramus
- Susan L. Neuhausen
- Susan M. Domchek
- Susan Peock
- Swe Brca
- Sylvie Mazoyer
- Terry M. Beth
- Thomas V. O. Hansen
- Tibor Vaszko
- Timothy R. Rebbeck
- Tomas Kirchhoff
- Tomasz Byrski
- Tomasz Huzarski
- Torben A. Kruse
- Trevor Cole
- Trinidad Caldes
- Tv Hansen
- Uffe Birk Jensen
- Ulf Kristoffersson
- Ute Hamann
- V. Shane Pankratz
- Valerie Bonadona
- Virginie Caux Moncoutier
- Wendy K. Chung
- Xianshu Wang
- Xiaoqing Chen
- Yuan Chun Ding
- Yves Jean Bignon
- Zachary Fredericksen
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2012
- Field of study
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide association study (GWAS) identified six alleles associated with risk of ovarian cancer for women in the general population. We evaluated four of these loci as potential modifiers of ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Four single-nucleotide polymorphisms (SNPs), rs10088218 (at 8q24), rs2665390 (at 3q25), rs717852 (at 2q31), and rs9303542 (at 17q21), were genotyped in 12,599 BRCA1 and 7,132 BRCA2 carriers, including 2,678 ovarian cancer cases. Associations were evaluated within a retrospective cohort approach. All four loci were associated with ovarian cancer risk in BRCA2 carriers; rs10088218 per-allele hazard ratio (HR) = 0.81 (95% CI: 0.67–0.98) P-trend = 0.033, rs2665390 HR = 1.48 (95% CI: 1.21–1.83) P-trend = 1.8 × 10−4, rs717852 HR = 1.25 (95% CI: 1.10–1.42) P-trend = 6.6 × 10−4, rs9303542 HR = 1.16 (95% CI: 1.02–1.33) P-trend = 0.026. Two loci were associated with ovarian cancer risk in BRCA1 carriers; rs10088218 per-allele HR = 0.89 (95% CI: 0.81–0.99) P-trend = 0.029, rs2665390 HR = 1.25 (95% CI: 1.10–1.42) P-trend = 6.1 × 10−4. The HR estimates for the remaining loci were consistent with odds ratio estimates for the general population. The identification of multiple loci modifying ovarian cancer risk may be useful for counseling women with BRCA1 and BRCA2 mutations regarding their risk of ovarian cancer
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
- Author
- Aalfs C M
- Aalfs Cora M
- Aben Katja K H
- Adenis Claude
- Adlard Julian
- Agata Simona
- Aghajanian Carol A
- Aghmesheh Morteza
- Agnarsson Bjarni A
- Aittomäki Kristiina
- Akloul Linda
- Alducci Elisa
- Allavena Anna
- Amor David
- Andersen Mette K
- Andrews Lesley
- Andrulis Irene L
- Antill Yoland
- Anton-Culver Hoda
- Antonenkova Natalia
- Antoniou Antonis C
- Apostolou Paraskevi
- Arason Adalgeir
- Ardern-Jones Audrey
- Ardnor Christina Edwinsdotter
- Aretini Paolo
- Armitage Shane
- Arnold Leanne
- Arnold Norbert
- Arun Banu K
- Arver Brita
- Attard Virginia
- Ausems M G E M
- Ausems Margreet G E M
- Azmi Mat Adenan Noor
- Azodi Masoud
- Bae-Jump Victoria L
- Baker Helen
- Balleine Rosemary
- Balmana Judith
- Bancroft Elizabeth
- Bandera Elisa V
- Bankier Agnes
- Bardsley Cathryn
- Barile Monica
- Barjhoux Laure
- Barkardottir Rosa B
- Barouk-Simonet Emmanuelle
- Barrowdale Daniel
- Barton David
- Barwell Julian
- Basil Jack B
- Bastick Patti
- Baumgärtner Anne
- Bean Yukie
- Becker Alexandra
- Beckmann Matthias W
- Beesley Jonathan
- Beilby John
- Belotti Muriel
- Benitez Javier
- Bennett Barbara
- Bennett Ian
- Berchuck Andrew
- Berger Andreas
- Berger Raanan
- Berlin Cheryl
- Bernard Loris
- Berry Geoffrey
- Berthet Pascaline
- Bignon Yves-Jean
- Birot Anne-Marie
- Bisogna Maria
- Bjorge Line
- Blackburn Anneke
- Blanco Ignacio
- Blank Stephanie V
- Blok M J
- Blok Marinus J
- Blom Marie-Jose
- bniak Tadeusz D
- Bogdanova Natalia
- Boggess John F
- Bogwitz Michael
- Bojesen Anders
- Bonadona Valérie
- Bonanni Bernardo
- Bonnet Françoise
- Borg Ake
- Bosch Nina
- Bourdon Violaine
- Boutry-Kryza Nadia
- Bove Betsy
- Bowtell D
- Bradshaw Nicola
- Brennan Meagan
- Bressac-de Paillerets Brigitte
- Bressac-de-Paillerets Brigitte
- Brewer Carole
- Brice Glen
- Brinton Louise A
- Bronner Myriam
- Brooks-Wilson Angela
- Brown Melissa
- Bruinsma Fiona
- Brunet Joan
- Bubien Virginie
- Buckley Michael
- Buecher Bruno
- Burgess Matthew
- Burke Jo
- Bustinza Gisela Barbany
- Butow Phyllis
- Butzow Ralf
- Buys Saundra S
- Byron John W
- Byron Keith
- Byrski Tomasz
- Caldes Trinidad
- Calender Alain
- Caligo Maria A
- Callen David
- Campbell Ian
- Capella Gabriel
- Capra Fabio
- Caron Olivier
- Carter Jonathan
- Carty Karen
- Casella Cinzia
- Castera Laurent
- Cattaneo Elisa
- Catts Zohra Ali-Kahn
- Caux-Moncoutier Virginie
- Chan Salina B
- Chan T L
- Chang-Claude Jenny
- Chauhan Deepa
- Chauhan Manisha
- Chen Ann
- Chen Xiaoqing
- Chen Zhihua
- Chenevix-Trench G
- Chiquette Jocelyne
- Christian Alice
- Chu Carol
- Chung Wendy K
- Claber Oonagh
- Claes Kathleen
- Clarke Christine
- Coetzee Gerry
- Coetzee Simon
- Cohn David E
- Colas Chrystelle
- Cole Trevor
- Collavoli Anita
- Collee J Margriet
- Collet Agnès
- Colley Alison
- Collier Rebecca
- Collonge-Rame Marie-Agnès
- Collée J M
- Concannon Patrick
- Cook Jackie
- Cook Linda S
- Cook Margaret
- Corines Marina
- Coron Fanny
- Cotton Dick
- Couch Fergus J
- Coulet Florence
- Coupier Isabelle
- Cramer Daniel W
- Crawford Gillian
- Crook Ashley
- Cui James
- Culling Bronwyn
- Cummings Margaret
- Cunningham Julie
- Cybulski Cezary
- D'Andrea Emma
- Dall'Olio Valentina
- Daly Mary B
- Damiola Francesca
- Dansonka-Mieszkowska Agnieszka
- Darder Esther
- Davidson Rosemarie
- Dawson Sarah-Jane
- de Bock G H
- de la Hoya Miguel
- de Lange J L
- De Leeneer Kim
- De Paepe Anne
- de Pauw Antoine
- deFazio A
- deFazio Anna
- Deissler Helmut
- Del Valle Jesus
- Delatycki Martin
- Delnatte Capucine
- DeMars Leslie R
- Dennis Joe
- Devilee P
- Devilee Peter
- Dicks Ed
- Dickson Rebecca
- Diez Orland
- Ding Yuan Chun
- DiSilvestro Paul A
- Ditsch Nina
- Dixon Joanne
- Dobrovic Alexander
- Doherty Jennifer A
- Dolcetti Riccardo
- Domchek Susan M
- Donaldson Alan
- Dorfling Cecilia M
- Dorkins Huw
- Douglas Fiona
- Downing Sarah
- Dreyfus Hélène
- Drummond Sarah
- du Bois Andreas
- Dudding Tracy
- Dumont Martine
- Duncan Alexis
- Dunning Alison M
- Duran Mercedes
- Durda Katarzyna
- Durell Sarah
- Dutra-Clarke Anna
- Dörk Thilo
- Dürst Matthias
- Eason Jacqueline
- Easton Douglas F
- Eccles Diana
- Eddy Charlotte
- Edkins Ted
- Edwards Robert P
- Edwards Stacey
- Eeles Ros
- Eglitis Janis
- Ehrencrona Hans
- Eilber Ursula
- Einbeigi Zakaria
- Eisenbruch Maurice
- Eisinger François
- Ejlertsen Bent
- Ekici Arif B
- Elan Camille
- Ellis Ian
- Ellis Steve
- Emanuelsson Monica
- Engel Christoph
- Engert Stefanie
- Evans D Gareth
- Faivre Laurence
- Farshid Gelareh
- Fasching Peter A
- Fassy-Colcombet Marion
- Fawcett Susan
- Feillel Viviane
- Feliubadalo Lidia
- Fellows Andrew
- Fenton Georgina
- Feroce Irene
- Ferrer Sandra Fert
- Ficarazzi Filomena
- Field Michael
- Fineberg Elena
- Fink-Retter Anneliese
- Fiorica James V
- Firgaira Frank
- Flanagan James
- Fleming Jean
- Fong Peter
- Fontaine Annette
- Foo Claire
- Forbes John
- Foretova Lenka
- Fortuzzi Stefano
- Fostira Florentia
- Foulkes William D
- Fountzilas George
- Fourme Emmanuelle
- Fournier Jean-Philippe Peyrat Joëlle
- Fournier Joëlle
- Fox Stephen
- Fredericksen Zachary
- Freedman Matt
- Frenay Marc
- French Juliet
- Fricker Jean-Pierre
- Fridley Brooke L
- Friebel Tara
- Friedlander Michael
- Friedman Eitan
- Frost Debra
- Frénay Marc
- Gadzicki Dorothea
- Gaff Clara
- Ganschow Pamela
- Ganz Patricia A
- Gao Yu-Tang
- Garber Judy
- Garcia Encarna B Gómez
- Garcia Maria Jose
- Gardner Mac
- Gattas Mike
- Gaudet Mia M
- Gauthier-Villars Marion
- Gayther Simon
- Gayther Simon A
- Gehrig Andrea
- Gentry-Maharaj Aleksandra
- Genuardi Maurizio
- George Angela
- George Peter
- Gerdes Anne-Marie
- Gertig D
- Gibson Sarah
- Giles Graham
- Gill Grantley
- Gille J J P
- Giraud Sophie
- Gismondi Viviana
- Gladieff Laurence
- Glasspool Rosalind
- Glendon Gord
- Godino Javier
- Godwin Andrew K
- Goff Sheila
- Goldblatt Jack
- Goldgar David E
- Golmard Lisa
- Goode Ellen L
- Goodman Marc T
- Goodman Selina
- Gorski Bohdan
- Green Adele C
- Greene Mark H
- Greening Sian
- Gregory Helen
- Grist Scott
- Gronwald Jacek
- Guillaud-Bataille Marine
- Guimbaud Rosine
- Gómez-Garcia E B
- Haan Eric
- Hahnen Erick
- Hall Per
- Halliday Dorothy
- Hamann Ute
- Handallou Sandrine
- Hansen Thomas V O
- Haque Eshika
- Harbst Katja
- Hardie Kate
- Hardouin Agnès
- Harrington Patricia
- Harris Marion
- Hart Steven
- Hart Stewart
- Harter Philipp
- Hasmad Hanis Nazihah
- Hayward Nicholas K
- Hayward Nick
- Hazelett Dennis
- Healey Sue
- Heidemann Simone
- Hein Alexander
- Heiniger Louise
- Heinritz Wolfram
- Heitz Florian
- Henderson Alex
- Henriksson Karin
- Herzog Josef
- Hildebrandt Michelle A T
- Hill Kathryn
- Hillemanns Peter
- Hodgson Shirley
- Hoffman James S
- Hoffman Jonathan
- Hogdall Claus
- Hogdall Estrid
- Hogervorst F B L
- Hogervorst Frans B L
- Holland Helene
- Hollestelle Antoinette
- Hoogerbrugge Nicoline
- Hooning M J
- Hooning Maartje J
- Hopper John
- Hosono Satoyo
- Houdayer Claude
- Houghton Catherine
- Hulick Peter
- Humphrey Evelyn
- Hunt Clare
- Huo Dezheng
- Hurteau Jean A
- Huzarski Tomasz
- ichert Gabriella
- Iglesias Silvia
- Imyanitov Evgeny N
- Isaacs Claudine
- Isaccs Claudine
- Iversen Edwin S
- Izatt Louise
- Izquierdo Angel
- Jacobs Chris
- Jager Agnes
- Jakubowska Anna
- James Margaret
- James Paul
- Janavicius Ramunas
- Jaworska-Bieniek Katarzyna
- Jeffers Lisa
- Jenkins Mark
- Jensen Allan
- Jensen Uffe Birk
- Jernström Helena
- Ji Bu-Tian
- Jobson Irene
- Johannsson Oskar Th
- John Esther M
- Jones Alison
- Jønson Lars
- Karlan Beth Y
- Karlsson Per
- Kast Karin
- Kauff Noah
- Kaufman Bella
- Kaulich Daphne Geschwantler
- Kefford Rick
- Kelemen Linda E
- Kellar Melissa
- Kelley Joseph L
- Kemp Zoe
- Kennedy M John
- Kets C M
- Kets Carolien M
- Khan Sofia
- Kidd Alexa
- Kiely Belinda
- Kiemeney Lambertus A
- Kientz Caroline
- Kim Sung-Won
- Kirchhoff Tomas
- Kirk Judy
- Kivuva Emma
- Kjaer Susanne Kruger
- Kleibl Zdenek
- Kluijt Irma
- Knol-Bout Jacoba P
- Koehler Jessica
- Kohut Kelly
- Kollias James
- Komenaka Ian
- Konstantopoulou Irene
- Kosel Matthew
- Kovalenko Serguei
- Krakstad Camilla
- Kriege Mieke
- Kristoffersson Ulf
- Kruse Torben A
- Kuchenbaecker Karoline B
- Kupryjanczyk Jolanta
- Kwong Ava
- Laframboise Rachel
- Laitman Yael
- Lakhani Sunil
- Lalloo Fiona
- Lambo Rosanna
- Lambrechts Diether
- Lambrechts Sandrina
- Langman Caroline
- Lasa Adriana
- Lasset Christine
- Lawrenson Kate
- Lazaro Conxi
- Le Nhu D
- Leaming Amanda
- Leary Jennifer
- Lebrun Marine
- Lee Adam
- Lee Alice W
- Lee Andrew
- Lee Annette
- Lee Janet M
- Lee Jong Won
- Lee Min Hyuk
- Lefol Cédrick
- Lejbkowicz Flavio
- Lele Shashi
- Leminen Arto
- Leroux Dominique
- Lesperance Bernard
- Lester Jenny
- Lesueur Fabienne
- Levine Douglas A
- Li Qiyuan
- Liang Dong
- Liedgren Sigrun
- Ligtenberg Marjolijn J L
- Liljegren Annelie
- Lim Jacqueline
- Lin Hui-Yi
- Lin Yvonne G
- Lindblom Annika
- Lindeman Geoff
- Lindor Noralane
- Lipton Lara
- Lissowska Jolanta
- Lobb Liz
- Loman Niklas
- Longmuir Mark
- Longy Michel
- Loud Jennifer T
- Lu Karen H
- Lubinski Jan
- Lucassen Anneke
- Lundvall Lene
- Lynch Henry T
- Léone Mélanie
- Léoné Mélanie
- Ma Edmund
- Machackova Eva
- Mai Phuong L
- Male Alison
- Mann Graham
- Manoukian Siranoush
- Mariani Paolo
- Mariette Frederique
- Marsh Deborah
- Martayan Aline
- Massuger Leon F A G
- Matsuo Keitaro
- Maugard Christine
- Mazoyer Sylvie
- McBride Donna
- McCann Emma
- McGuffog Lesley
- McGuire Valerie
- McLachlan Sue Anne
- McLaughlin John R
- McLeod Diane
- McNeish Ian
- Meijers-Heijboer H E J
- Meijers-Heijboer Hanne E J
- Meindl Alfons
- Meiser Bettina
- Meldrum Cliff
- Melin Beatrice
- Melloni Giulia
- Menendez Mireia
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- Menon Usha
- Mensenkamp A R
- Mensenkamp Arjen R
- Miedzybrodzka Zosia
- Milne Roger
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- Mitchell Gillian
- Modugno Francesmary
- Moeller Sanne Traasdahl
- Moncoutier Virginie
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- Morrison Patrick
- Morrison Patrick J
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- Nielsen Finn C
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- Nogues Catherine
- Nordling Margareta
- Noushmehr Houtan
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- O'Connell Shona
- O'Loughlin Imelda
- O'Malley David M
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- Olopade Olufunmilayo I
- Olson Sara H
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- Paul James
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- Pedersen Inge Sokilde
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- Robson Mark
- Rodriguez Gustavo C
- Rogers Mark T
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- Rookus M A
- Rookus Matti A
- Rosen Barry
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- Rossing Mary Anne
- Rothstein Joseph H
- Rouleau Etienne
- Roversi Gaia
- Rudaitis Vilius
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- Rudzki Barney
- Rudzki Bridget Robinson Barney
- Ruehl Ina
- Runnebaum Ingo B
- Russell N S
- Rzepecka Iwona K
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- Schmutzler Rita Katharina
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- Schwaab Ira
- Schwartz Peter E
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- Scott Clare
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- Scott Rodney
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- Selkirk Christina
- Sellers Thomas A
- Senter Leigha
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- Soucy Penny
- Southey Melissa
- Spindler Tassja J
- Spurdle Amanda
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- Stoppa-Lyonnet Dominique
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- Sutter Christian
- Sykes Pamela
- Szabo Csilla I
- Tancredi Mariella
- Tangen Ingvild L
- Tassell Margaret
- Taylor Amy
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- Taylor Jane
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- Tchatchou Sandrine
- Tea Muy-Kheng
- Teixeira Manuel R
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- Teo Soo-Hwang
- Terry Kathryn L
- Terry Mary Beth
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- Thames N E
- Thierry Benjamin
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- Thompson Pamela J
- Thorne Heather
- Tibiletti Maria Grazia
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- Tilanus-Linthorst Madeleine A
- Timorek Agnieszka
- Tirapo Carole
- Tischkowitz Marc
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- Tobias Ed
- Tognazzo Silvia
- Toland Amanda Ewart
- Tollenaar R A E M
- Toloczko-Grabarek Aleksandra
- Tommasi Stefania
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- Torres Diana
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- Townshend Sharron
- Trainer Alison
- Tran Lan
- Tripathi Vishakha
- Tsai Ya-Yu
- Tucker Kathy
- Tung Nadine
- Tworoger Shelley S
- Tyler Janet
- Tyrer Jonathan
- Uhrhammer Nancy
- van Altena Anne M
- van Asperen C J
- van Asperen Christi J
- van Cronenburg T C T E F
- van den Ouweland A M W
- van den Ouweland Ans M W
- van der Baan Frederieke H
- van der Hout A H
- van der Hout Annemarie H
- van der Luijt R B
- van der Luijt Rob B
- van der Pol C C
- van Deurzen C H M
- van Deurzen Carolien H M
- van Dooren Marieke F
- Van Le Linda
- van Leeuwen F E
- van Leeuwen Flora E
- Van Nieuwenhuysen Els
- van Os T A M
- van Os Theo A M
- van Rensburg Elizabeth J
- van Roozendaal K E P
- Varesco Liliana
- Varon-Mateeva Raymonda
- Vasen H F
- Vasen Hans F A
- Vaszko Tibor
- Vaur Dominique
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- Vennin Philippe
- Vergote Ignace
- Verhoef S
- Verhoef Senno
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- Viel Alessandra
- Vierkant Robert A
- Vignolo-Lutati Francesca
- Vijai Joseph
- Visvader Jane
- Volorio Sara
- von Wachenfeldt Anna
- Vratimos Athanassios
- Væth Signe
- Vénat-Bouvet Laurence
- Waisfisz Q
- Waisfisz Quinten
- Wakeley Katie
- Walker Lisa
- Walker Logan
- Walpole Ian
- Walsh Christine
- Wang Chen
- Wang Xianshu
- Wang-Gohrke Shan
- Wappenschmidt Barbara
- Warcoin Mathilde
- Ward Robin
- Waring Paul
- Warner Bev
- Warren Graham
- Watt Catherine
- Weaver JoEllen
- Webb P
- Weber Bernhard H F
- Weber Rachel Palmieri
- Weitzel Jeffrey N
- Wentzensen Nicolas
- Whiteman David C
- Whittemore Alice S
- Wicklund Kristine G
- Wiggins Jennifer
- Wijnands R
- Wijnen J T
- Wijnen Juul T
- Wilkens Lynne R
- Williams Rachael
- Wilson Judy
- Winchester Lizzie
- Winship Ingrid
- Woo Yin-Ling
- Wu Anna H
- Wu Kathy
- Wu Xifeng
- Yang Hannah
- Young Mary Ann
- Zaffaroni Daniela
- Zhang Jing
- Zheng Wei
- Zheng Yonglan
- Zidan Jamal
- Zikan Michal
- Ziogas Argyrios
- Złowocka-Perłowska Elżbieta
- Öfverholm Anna
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2015
- Field of study
Predicted breast and ovarian cancer absolute risks for <i>BRCA1</i> mutation carriers at the 5<sup>th</sup>, 10<sup>th</sup>, 90<sup>th</sup>, and 95<sup>th</sup> percentiles of the combined SNP profile distributions.
- Author
- Adam Lee (395196)
- Adriana Lasa (196672)
- Agnès Hardouin (395232)
- Alain Calender (395231)
- Alan Donaldson (239924)
- Alessandra Viel (10416)
- Alex Murray (395230)
- Alex Teulé (395273)
- Alexander Miron (28179)
- Alexandra V. Stavropoulou (387774)
- Alfons Meindl (112058)
- Alison M. Dunning (146796)
- Amanda B. Spurdle (47489)
- Amanda Ewart Toland (164514)
- Ana Osorio (81750)
- Andrea Gehrig (395248)
- Andrew K. Godwin (131285)
- Andrew Lee (74302)
- Anna Jakubowska (146752)
- Anna Marie Mulligan (146672)
- Anna P. Sokolenko (395288)
- Anne-Bine Skytte (395263)
- Anne-Marie Gerdes (395264)
- Anneliese Fink-Retter (395258)
- Annemarie H. van der Hout (395213)
- Antonis C. Antoniou (146788)
- Atocha Romero (395283)
- Ava Kwong (52115)
- Banu K. Arun (395211)
- Barbara Wappenschmidt (112030)
- Bella Kaufman (196589)
- Bent Ejlertsen (395269)
- Bernard Peissel (181321)
- Bernardo Bonanni (196561)
- Bernhard H. F. Weber (162289)
- Beth Y. Karlan (184236)
- Bjarni A. Agnarsson (154067)
- Brita Arver (395252)
- Capucine Delnatte (395234)
- Carole Brewer (196650)
- Carolien H. M. van Deurzen (395214)
- Caroline Seynaeve (95368)
- Catherine Houghton (395226)
- Catherine M. Phelan (219497)
- Catherine Nogues (395235)
- Cecilia M. Dorfling (395285)
- Chen Wang (88408)
- Christian F. Singer (308365)
- Christian Sutter (196732)
- Christine Lasset (395236)
- Christine Rappaport (395259)
- Christine Walsh (219475)
- Christoph Engel (218744)
- Claude Houdayer (395237)
- Conxi Lazaro (3405329)
- Csilla I. Szabo (395202)
- Curtis Olswold (73571)
- D. Gareth Evans (154186)
- Daniel Barrowdale (395192)
- Daniel Tessier (395291)
- Daniel Vincent (395198)
- Daphne Gschwantler-Kaulich (395260)
- David E. Cohn (395255)
- David E. Goldgar (196718)
- Debra Frost (154160)
- Dezheng Huo (151859)
- Diana M. Eccles (219472)
- Dieter Niederacher (93623)
- Dominique Leroux (395238)
- Dominique Stoppa-Lyonnet (29241)
- Dorothea Gadzicki (238732)
- Douglas F. Easton (89956)
- Drakoulis Yannoukakos (4758)
- Ed Dicks (395194)
- Edith Olah (395204)
- Eitan Friedman (196582)
- Elena Fineberg (395222)
- Elizabeth J. van Rensburg (395205)
- Elżbieta Złowocka-Perłowska (204566)
- Emma McCann (395229)
- Encarna B. Gómez Garcia (5654410)
- Esther M. John (107266)
- Etienne Rouleau (395239)
- Evgeny N. Imyanitov (395207)
- Fabienne Prieur (246641)
- Fergus J. Couch (146607)
- Finn C. Nielsen (206969)
- Fiona Douglas (154179)
- Flavio Lejbkowicz (196544)
- Flora E. van Leeuwen (248404)
- Francesca Damiola (5331)
- Frans B. L. Hogervorst (146390)
- François Bacot (395197)
- Gad Rennert (196538)
- Georg Pfeiler (395261)
- Georgia Chenevix-Trench (361)
- Giulia Melloni (395243)
- Gord Glendon (146666)
- Gustavo C. Rodriguez (395256)
- Hagay Sobol (91961)
- Hanne E. J. Meijers-Heijboer (395215)
- Hansjoerg Plendl (395250)
- Helen Gregory (395228)
- Heli Nevanlinna (83762)
- Helmut Deissler (196727)
- Hilmi Ozcelik (20185)
- Huw Dorkins (239925)
- Ian Campbell (205212)
- Ignacio Blanco (196711)
- Inge Sokilde Pedersen (395265)
- Irene L. Andrulis (107262)
- Isabelle Coupier (292499)
- Jacek Gronwald (218515)
- Jackie Cook (154176)
- Jacqueline Eason (238727)
- Jacques Simard (15589)
- Jan Lubinski (59925)
- Javier Benitez (81758)
- Jeffrey N. Weitzel (238722)
- Jennifer T. Loud (395275)
- Jenny Lester (395276)
- Joan Brunet (75020)
- Jocelyne Chiquette (21796)
- Joe Dennis (395193)
- Joellen Weaver (395282)
- Johannes J. P. Gille (395216)
- Josef Herzog (395277)
- Joseph Vijai (102398)
- Judith Balmaña (395210)
- Judy Garber (59512)
- Julian Adlard (395223)
- Julie Cunningham (395292)
- Juul T. Wijnen (154144)
- Kara Sarrel (102421)
- Karen H. Lu (395290)
- Karin Kast (112042)
- Karoline B. Kuchenbaecker (395191)
- Katarzyna Durda (146758)
- Katarzyna Jaworska (146755)
- Katherine L. Nathanson (154077)
- Kathleen Claes (203063)
- kConFab Investigators (2615518)
- Kenneth Offit (63812)
- Kerstin Rhiem (112049)
- Kristen Stevens (121411)
- Kristiina Aittomäki (89889)
- Laima Tihomirova (196713)
- Lars Jønson (395270)
- Laura Ottini (395244)
- Laura Papi (395245)
- Laurence Venat-Bouvet (395240)
- Laurent Castera (38087)
- Laurie Small (395257)
- Leigha Senter (395286)
- Lenka Foretova (162255)
- Lesley McGuffog (153865)
- Liliana Varesco (381200)
- Linda Steele (395272)
- Louise Izatt (69449)
- Lucy E. Side (395225)
- Mads Thomassen (395200)
- Marc Tischkowitz (395208)
- Marco Montagna (238698)
- Margreet G. E. M. Ausems (280984)
- Maria A. Caligo (154069)
- Maria Grazia Tibiletti (395246)
- Marie Stenmark-Askmalm (395253)
- Marinus J. Blok (395217)
- Marion Gauthier-Villars (238630)
- Marion Piedmonte (238646)
- Marjolijn J. L. Ligtenberg (395218)
- Mark H. Greene (395203)
- Mark Robson (70145)
- Mark T. Rogers (395227)
- Mary B. Daly (196724)
- Mary Beth Terry (2801)
- Mary S. Beattie (395206)
- Matthew Kosel (395195)
- Matti A. Rookus (154108)
- Melissa C. Southey (89921)
- Mercedes Duran (5651374)
- Mette K. Andersen (395271)
- Mia M. Gaudet (146621)
- Michael Friedlander (55581)
- Miguel de la Hoya (238670)
- Miquel Angel Pujana (395274)
- Muy-Kheng Tea (308359)
- Mélanie Léoné (395241)
- Nadine Tung (238710)
- Niklas Loman (26096)
- Nina Ditsch (395249)
- Noah Kauff (395268)
- Noralane M. Lindor (163048)
- Norbert Arnold (112045)
- Olga M. Sinilnikova (196738)
- Olufunmilayo I. Olopade (151873)
- Orland Diez (395209)
- Paolo Peterlongo (146602)
- Paolo Radice (146601)
- Pascal Pujol (8444)
- Pascaline Berthet (395233)
- Patricia A. Ganz (395212)
- Patrick J. Morrison (395224)
- Paul A. James (130908)
- Penny Soucy (21792)
- Per Hall (23544)
- Peter Devilee (13431)
- Phuong L. Mai (238716)
- Radka Platte (238724)
- Ramunas Janavicius (71877)
- Raymonda Varon-Mateeva (196729)
- Richard Rosenquist (262592)
- Rita Katharina Schmutzler (395199)
- Rosa B. Barkardottir (238688)
- Rosalind A. Eeles (194860)
- Sabine Preisler-Adams (395251)
- Salina B. Chan (395287)
- Sandra Orsulic (184242)
- Sanne Traasdahl Moeller (395266)
- Sara Volorio (255289)
- Saundra S. Buys (238707)
- Senno Verhoef (395219)
- Shani Shimon Paluch (395262)
- Sharon R. Sand (395278)
- Shirley Hodgson (154183)
- Silvia Tognazzo (395279)
- Simona Agata (395280)
- Siranoush Manoukian (146603)
- Soo-Hwang Teo (266270)
- Stefanie Engert (112037)
- Stephanie V. Blank (132743)
- Steve Ellis (395221)
- Steven A. Narod (230773)
- Steven Hart (395293)
- Sue Healey (41187)
- Susan J. Ramus (205214)
- Susan L. Neuhausen (238692)
- Susan L. Slager (223846)
- Susan M. Domchek (154078)
- Susan Peock (154155)
- Sylvie Mazoyer (196744)
- Tara M. Friebel (395289)
- Taru A. Muranen (395284)
- Theo A. M. van Os (395220)
- Thomas V. O. Hansen (395201)
- Tibor Vaszko (395281)
- Timothy R. Rebbeck (230766)
- Tomasz Huzarski (395242)
- Tomi Pastinen (15737)
- Torben A. Kruse (92928)
- Trinidad Caldes (3147195)
- Uffe Birk Jensen (395267)
- Ute Hamann (89879)
- Valeria Pensotti (395247)
- Vernon S. Pankratz (395294)
- Victoria L. Bae-Jump (284536)
- Wendy K. Chung (51418)
- Xianshu Wang (146610)
- Yael Laitman (196595)
- Yuan Chun Ding (322601)
- Yves-Jean Bignon (54433)
- Zachary Fredericksen (146612)
- Zakaria Einbeigi (395254)
- Publication venue
- Publication date
- Field of study
<p>The minimum, maximum and average risks are also shown. Predicted cancer risks are based on the associations of known breast or ovarian cancer susceptibility loci (identified through GWAS) with cancer risk for <i>BRCA1</i> mutation carriers and loci identified through the present study. Breast cancer risks based on the associations with: 1q32, 10q25.3, 19p13, 6q25.1, 12p11, <i>TOX3</i>, 2q35, <i>LSP1</i>, <i>RAD51L1</i> (based on HR and minor allele frequency estimates from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen-1003212-t001" target="_blank">Table 1</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen-1003212-t002" target="_blank">Table 2</a>, and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen.1003212.s016" target="_blank">Table S4</a>) and <i>TERT </i><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen.1003212-Bojesen1" target="_blank">[31]</a>. Ovarian cancer risks based on the associations with: 9p22, 8q24, 3q25, 17q21, 19p13 (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen-1003212-t001" target="_blank">Table 1</a>) and 17q21.31, 4q32.3 (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen-1003212-t002" target="_blank">Table 2</a>). Only the top SNP from each region was chosen. Average breast and ovarian cancer risks were obtained from published data <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen.1003212-Antoniou10" target="_blank">[25]</a>. The methods for calculating the predicted risks have been described previously <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003212#pgen.1003212-Antoniou11" target="_blank">[28]</a>.</p
Associations with breast or ovarian cancer risk for loci previously reported to be associated with cancer risk for <i>BRCA1</i> mutation carriers.
- Author
- Adam Lee (395196)
- Adriana Lasa (196672)
- Agnès Hardouin (395232)
- Alain Calender (395231)
- Alan Donaldson (239924)
- Alessandra Viel (10416)
- Alex Murray (395230)
- Alex Teulé (395273)
- Alexander Miron (28179)
- Alexandra V. Stavropoulou (387774)
- Alfons Meindl (112058)
- Alison M. Dunning (146796)
- Amanda B. Spurdle (47489)
- Amanda Ewart Toland (164514)
- Ana Osorio (81750)
- Andrea Gehrig (395248)
- Andrew K. Godwin (131285)
- Andrew Lee (74302)
- Anna Jakubowska (146752)
- Anna Marie Mulligan (146672)
- Anna P. Sokolenko (395288)
- Anne-Bine Skytte (395263)
- Anne-Marie Gerdes (395264)
- Anneliese Fink-Retter (395258)
- Annemarie H. van der Hout (395213)
- Antonis C. Antoniou (146788)
- Atocha Romero (395283)
- Ava Kwong (52115)
- Banu K. Arun (395211)
- Barbara Wappenschmidt (112030)
- Bella Kaufman (196589)
- Bent Ejlertsen (395269)
- Bernard Peissel (181321)
- Bernardo Bonanni (196561)
- Bernhard H. F. Weber (162289)
- Beth Y. Karlan (184236)
- Bjarni A. Agnarsson (154067)
- Brita Arver (395252)
- Capucine Delnatte (395234)
- Carole Brewer (196650)
- Carolien H. M. van Deurzen (395214)
- Caroline Seynaeve (95368)
- Catherine Houghton (395226)
- Catherine M. Phelan (219497)
- Catherine Nogues (395235)
- Cecilia M. Dorfling (395285)
- Chen Wang (88408)
- Christian F. Singer (308365)
- Christian Sutter (196732)
- Christine Lasset (395236)
- Christine Rappaport (395259)
- Christine Walsh (219475)
- Christoph Engel (218744)
- Claude Houdayer (395237)
- Conxi Lazaro (3405329)
- Csilla I. Szabo (395202)
- Curtis Olswold (73571)
- D. Gareth Evans (154186)
- Daniel Barrowdale (395192)
- Daniel Tessier (395291)
- Daniel Vincent (395198)
- Daphne Gschwantler-Kaulich (395260)
- David E. Cohn (395255)
- David E. Goldgar (196718)
- Debra Frost (154160)
- Dezheng Huo (151859)
- Diana M. Eccles (219472)
- Dieter Niederacher (93623)
- Dominique Leroux (395238)
- Dominique Stoppa-Lyonnet (29241)
- Dorothea Gadzicki (238732)
- Douglas F. Easton (89956)
- Drakoulis Yannoukakos (4758)
- Ed Dicks (395194)
- Edith Olah (395204)
- Eitan Friedman (196582)
- Elena Fineberg (395222)
- Elizabeth J. van Rensburg (395205)
- Elżbieta Złowocka-Perłowska (204566)
- Emma McCann (395229)
- Encarna B. Gómez Garcia (5654410)
- Esther M. John (107266)
- Etienne Rouleau (395239)
- Evgeny N. Imyanitov (395207)
- Fabienne Prieur (246641)
- Fergus J. Couch (146607)
- Finn C. Nielsen (206969)
- Fiona Douglas (154179)
- Flavio Lejbkowicz (196544)
- Flora E. van Leeuwen (248404)
- Francesca Damiola (5331)
- Frans B. L. Hogervorst (146390)
- François Bacot (395197)
- Gad Rennert (196538)
- Georg Pfeiler (395261)
- Georgia Chenevix-Trench (361)
- Giulia Melloni (395243)
- Gord Glendon (146666)
- Gustavo C. Rodriguez (395256)
- Hagay Sobol (91961)
- Hanne E. J. Meijers-Heijboer (395215)
- Hansjoerg Plendl (395250)
- Helen Gregory (395228)
- Heli Nevanlinna (83762)
- Helmut Deissler (196727)
- Hilmi Ozcelik (20185)
- Huw Dorkins (239925)
- Ian Campbell (205212)
- Ignacio Blanco (196711)
- Inge Sokilde Pedersen (395265)
- Irene L. Andrulis (107262)
- Isabelle Coupier (292499)
- Jacek Gronwald (218515)
- Jackie Cook (154176)
- Jacqueline Eason (238727)
- Jacques Simard (15589)
- Jan Lubinski (59925)
- Javier Benitez (81758)
- Jeffrey N. Weitzel (238722)
- Jennifer T. Loud (395275)
- Jenny Lester (395276)
- Joan Brunet (75020)
- Jocelyne Chiquette (21796)
- Joe Dennis (395193)
- Joellen Weaver (395282)
- Johannes J. P. Gille (395216)
- Josef Herzog (395277)
- Joseph Vijai (102398)
- Judith Balmaña (395210)
- Judy Garber (59512)
- Julian Adlard (395223)
- Julie Cunningham (395292)
- Juul T. Wijnen (154144)
- Kara Sarrel (102421)
- Karen H. Lu (395290)
- Karin Kast (112042)
- Karoline B. Kuchenbaecker (395191)
- Katarzyna Durda (146758)
- Katarzyna Jaworska (146755)
- Katherine L. Nathanson (154077)
- Kathleen Claes (203063)
- kConFab Investigators (2615518)
- Kenneth Offit (63812)
- Kerstin Rhiem (112049)
- Kristen Stevens (121411)
- Kristiina Aittomäki (89889)
- Laima Tihomirova (196713)
- Lars Jønson (395270)
- Laura Ottini (395244)
- Laura Papi (395245)
- Laurence Venat-Bouvet (395240)
- Laurent Castera (38087)
- Laurie Small (395257)
- Leigha Senter (395286)
- Lenka Foretova (162255)
- Lesley McGuffog (153865)
- Liliana Varesco (381200)
- Linda Steele (395272)
- Louise Izatt (69449)
- Lucy E. Side (395225)
- Mads Thomassen (395200)
- Marc Tischkowitz (395208)
- Marco Montagna (238698)
- Margreet G. E. M. Ausems (280984)
- Maria A. Caligo (154069)
- Maria Grazia Tibiletti (395246)
- Marie Stenmark-Askmalm (395253)
- Marinus J. Blok (395217)
- Marion Gauthier-Villars (238630)
- Marion Piedmonte (238646)
- Marjolijn J. L. Ligtenberg (395218)
- Mark H. Greene (395203)
- Mark Robson (70145)
- Mark T. Rogers (395227)
- Mary B. Daly (196724)
- Mary Beth Terry (2801)
- Mary S. Beattie (395206)
- Matthew Kosel (395195)
- Matti A. Rookus (154108)
- Melissa C. Southey (89921)
- Mercedes Duran (5651374)
- Mette K. Andersen (395271)
- Mia M. Gaudet (146621)
- Michael Friedlander (55581)
- Miguel de la Hoya (238670)
- Miquel Angel Pujana (395274)
- Muy-Kheng Tea (308359)
- Mélanie Léoné (395241)
- Nadine Tung (238710)
- Niklas Loman (26096)
- Nina Ditsch (395249)
- Noah Kauff (395268)
- Noralane M. Lindor (163048)
- Norbert Arnold (112045)
- Olga M. Sinilnikova (196738)
- Olufunmilayo I. Olopade (151873)
- Orland Diez (395209)
- Paolo Peterlongo (146602)
- Paolo Radice (146601)
- Pascal Pujol (8444)
- Pascaline Berthet (395233)
- Patricia A. Ganz (395212)
- Patrick J. Morrison (395224)
- Paul A. James (130908)
- Penny Soucy (21792)
- Per Hall (23544)
- Peter Devilee (13431)
- Phuong L. Mai (238716)
- Radka Platte (238724)
- Ramunas Janavicius (71877)
- Raymonda Varon-Mateeva (196729)
- Richard Rosenquist (262592)
- Rita Katharina Schmutzler (395199)
- Rosa B. Barkardottir (238688)
- Rosalind A. Eeles (194860)
- Sabine Preisler-Adams (395251)
- Salina B. Chan (395287)
- Sandra Orsulic (184242)
- Sanne Traasdahl Moeller (395266)
- Sara Volorio (255289)
- Saundra S. Buys (238707)
- Senno Verhoef (395219)
- Shani Shimon Paluch (395262)
- Sharon R. Sand (395278)
- Shirley Hodgson (154183)
- Silvia Tognazzo (395279)
- Simona Agata (395280)
- Siranoush Manoukian (146603)
- Soo-Hwang Teo (266270)
- Stefanie Engert (112037)
- Stephanie V. Blank (132743)
- Steve Ellis (395221)
- Steven A. Narod (230773)
- Steven Hart (395293)
- Sue Healey (41187)
- Susan J. Ramus (205214)
- Susan L. Neuhausen (238692)
- Susan L. Slager (223846)
- Susan M. Domchek (154078)
- Susan Peock (154155)
- Sylvie Mazoyer (196744)
- Tara M. Friebel (395289)
- Taru A. Muranen (395284)
- Theo A. M. van Os (395220)
- Thomas V. O. Hansen (395201)
- Tibor Vaszko (395281)
- Timothy R. Rebbeck (230766)
- Tomasz Huzarski (395242)
- Tomi Pastinen (15737)
- Torben A. Kruse (92928)
- Trinidad Caldes (3147195)
- Uffe Birk Jensen (395267)
- Ute Hamann (89879)
- Valeria Pensotti (395247)
- Vernon S. Pankratz (395294)
- Victoria L. Bae-Jump (284536)
- Wendy K. Chung (51418)
- Xianshu Wang (146610)
- Yael Laitman (196595)
- Yuan Chun Ding (322601)
- Yves-Jean Bignon (54433)
- Zachary Fredericksen (146612)
- Zakaria Einbeigi (395254)
- Publication venue
- Publication date
- Field of study
<p>Freq = frequency of allele 2 in unaffected <i>BRCA1</i> carriers.</p><p>HR = Per allele Hazard Ratio associated with allele 2, under a single disease risk model, unless specified.</p><p>r<sup>2</sup>: correlation between the SNP in the present study and the published SNP.</p>*<p>SNP not in <i>BRCA1</i> GWAS SNP allocation on iCOGS chip.</p>a<p>: rs13387042 was previously found to be associated only under the 2-df model.</p>b<p>: analysis under a competing risks model.</p
Analysis of associations with breast and ovarian cancer risk simultaneously (competing risks analysis) for SNPs found to be associated with breast or ovarian cancer.
- Author
- Adam Lee (395196)
- Adriana Lasa (196672)
- Agnès Hardouin (395232)
- Alain Calender (395231)
- Alan Donaldson (239924)
- Alessandra Viel (10416)
- Alex Murray (395230)
- Alex Teulé (395273)
- Alexander Miron (28179)
- Alexandra V. Stavropoulou (387774)
- Alfons Meindl (112058)
- Alison M. Dunning (146796)
- Amanda B. Spurdle (47489)
- Amanda Ewart Toland (164514)
- Ana Osorio (81750)
- Andrea Gehrig (395248)
- Andrew K. Godwin (131285)
- Andrew Lee (74302)
- Anna Jakubowska (146752)
- Anna Marie Mulligan (146672)
- Anna P. Sokolenko (395288)
- Anne-Bine Skytte (395263)
- Anne-Marie Gerdes (395264)
- Anneliese Fink-Retter (395258)
- Annemarie H. van der Hout (395213)
- Antonis C. Antoniou (146788)
- Atocha Romero (395283)
- Ava Kwong (52115)
- Banu K. Arun (395211)
- Barbara Wappenschmidt (112030)
- Bella Kaufman (196589)
- Bent Ejlertsen (395269)
- Bernard Peissel (181321)
- Bernardo Bonanni (196561)
- Bernhard H. F. Weber (162289)
- Beth Y. Karlan (184236)
- Bjarni A. Agnarsson (154067)
- Brita Arver (395252)
- Capucine Delnatte (395234)
- Carole Brewer (196650)
- Carolien H. M. van Deurzen (395214)
- Caroline Seynaeve (95368)
- Catherine Houghton (395226)
- Catherine M. Phelan (219497)
- Catherine Nogues (395235)
- Cecilia M. Dorfling (395285)
- Chen Wang (88408)
- Christian F. Singer (308365)
- Christian Sutter (196732)
- Christine Lasset (395236)
- Christine Rappaport (395259)
- Christine Walsh (219475)
- Christoph Engel (218744)
- Claude Houdayer (395237)
- Conxi Lazaro (3405329)
- Csilla I. Szabo (395202)
- Curtis Olswold (73571)
- D. Gareth Evans (154186)
- Daniel Barrowdale (395192)
- Daniel Tessier (395291)
- Daniel Vincent (395198)
- Daphne Gschwantler-Kaulich (395260)
- David E. Cohn (395255)
- David E. Goldgar (196718)
- Debra Frost (154160)
- Dezheng Huo (151859)
- Diana M. Eccles (219472)
- Dieter Niederacher (93623)
- Dominique Leroux (395238)
- Dominique Stoppa-Lyonnet (29241)
- Dorothea Gadzicki (238732)
- Douglas F. Easton (89956)
- Drakoulis Yannoukakos (4758)
- Ed Dicks (395194)
- Edith Olah (395204)
- Eitan Friedman (196582)
- Elena Fineberg (395222)
- Elizabeth J. van Rensburg (395205)
- Elżbieta Złowocka-Perłowska (204566)
- Emma McCann (395229)
- Encarna B. Gómez Garcia (5654410)
- Esther M. John (107266)
- Etienne Rouleau (395239)
- Evgeny N. Imyanitov (395207)
- Fabienne Prieur (246641)
- Fergus J. Couch (146607)
- Finn C. Nielsen (206969)
- Fiona Douglas (154179)
- Flavio Lejbkowicz (196544)
- Flora E. van Leeuwen (248404)
- Francesca Damiola (5331)
- Frans B. L. Hogervorst (146390)
- François Bacot (395197)
- Gad Rennert (196538)
- Georg Pfeiler (395261)
- Georgia Chenevix-Trench (361)
- Giulia Melloni (395243)
- Gord Glendon (146666)
- Gustavo C. Rodriguez (395256)
- Hagay Sobol (91961)
- Hanne E. J. Meijers-Heijboer (395215)
- Hansjoerg Plendl (395250)
- Helen Gregory (395228)
- Heli Nevanlinna (83762)
- Helmut Deissler (196727)
- Hilmi Ozcelik (20185)
- Huw Dorkins (239925)
- Ian Campbell (205212)
- Ignacio Blanco (196711)
- Inge Sokilde Pedersen (395265)
- Irene L. Andrulis (107262)
- Isabelle Coupier (292499)
- Jacek Gronwald (218515)
- Jackie Cook (154176)
- Jacqueline Eason (238727)
- Jacques Simard (15589)
- Jan Lubinski (59925)
- Javier Benitez (81758)
- Jeffrey N. Weitzel (238722)
- Jennifer T. Loud (395275)
- Jenny Lester (395276)
- Joan Brunet (75020)
- Jocelyne Chiquette (21796)
- Joe Dennis (395193)
- Joellen Weaver (395282)
- Johannes J. P. Gille (395216)
- Josef Herzog (395277)
- Joseph Vijai (102398)
- Judith Balmaña (395210)
- Judy Garber (59512)
- Julian Adlard (395223)
- Julie Cunningham (395292)
- Juul T. Wijnen (154144)
- Kara Sarrel (102421)
- Karen H. Lu (395290)
- Karin Kast (112042)
- Karoline B. Kuchenbaecker (395191)
- Katarzyna Durda (146758)
- Katarzyna Jaworska (146755)
- Katherine L. Nathanson (154077)
- Kathleen Claes (203063)
- kConFab Investigators (2615518)
- Kenneth Offit (63812)
- Kerstin Rhiem (112049)
- Kristen Stevens (121411)
- Kristiina Aittomäki (89889)
- Laima Tihomirova (196713)
- Lars Jønson (395270)
- Laura Ottini (395244)
- Laura Papi (395245)
- Laurence Venat-Bouvet (395240)
- Laurent Castera (38087)
- Laurie Small (395257)
- Leigha Senter (395286)
- Lenka Foretova (162255)
- Lesley McGuffog (153865)
- Liliana Varesco (381200)
- Linda Steele (395272)
- Louise Izatt (69449)
- Lucy E. Side (395225)
- Mads Thomassen (395200)
- Marc Tischkowitz (395208)
- Marco Montagna (238698)
- Margreet G. E. M. Ausems (280984)
- Maria A. Caligo (154069)
- Maria Grazia Tibiletti (395246)
- Marie Stenmark-Askmalm (395253)
- Marinus J. Blok (395217)
- Marion Gauthier-Villars (238630)
- Marion Piedmonte (238646)
- Marjolijn J. L. Ligtenberg (395218)
- Mark H. Greene (395203)
- Mark Robson (70145)
- Mark T. Rogers (395227)
- Mary B. Daly (196724)
- Mary Beth Terry (2801)
- Mary S. Beattie (395206)
- Matthew Kosel (395195)
- Matti A. Rookus (154108)
- Melissa C. Southey (89921)
- Mercedes Duran (5651374)
- Mette K. Andersen (395271)
- Mia M. Gaudet (146621)
- Michael Friedlander (55581)
- Miguel de la Hoya (238670)
- Miquel Angel Pujana (395274)
- Muy-Kheng Tea (308359)
- Mélanie Léoné (395241)
- Nadine Tung (238710)
- Niklas Loman (26096)
- Nina Ditsch (395249)
- Noah Kauff (395268)
- Noralane M. Lindor (163048)
- Norbert Arnold (112045)
- Olga M. Sinilnikova (196738)
- Olufunmilayo I. Olopade (151873)
- Orland Diez (395209)
- Paolo Peterlongo (146602)
- Paolo Radice (146601)
- Pascal Pujol (8444)
- Pascaline Berthet (395233)
- Patricia A. Ganz (395212)
- Patrick J. Morrison (395224)
- Paul A. James (130908)
- Penny Soucy (21792)
- Per Hall (23544)
- Peter Devilee (13431)
- Phuong L. Mai (238716)
- Radka Platte (238724)
- Ramunas Janavicius (71877)
- Raymonda Varon-Mateeva (196729)
- Richard Rosenquist (262592)
- Rita Katharina Schmutzler (395199)
- Rosa B. Barkardottir (238688)
- Rosalind A. Eeles (194860)
- Sabine Preisler-Adams (395251)
- Salina B. Chan (395287)
- Sandra Orsulic (184242)
- Sanne Traasdahl Moeller (395266)
- Sara Volorio (255289)
- Saundra S. Buys (238707)
- Senno Verhoef (395219)
- Shani Shimon Paluch (395262)
- Sharon R. Sand (395278)
- Shirley Hodgson (154183)
- Silvia Tognazzo (395279)
- Simona Agata (395280)
- Siranoush Manoukian (146603)
- Soo-Hwang Teo (266270)
- Stefanie Engert (112037)
- Stephanie V. Blank (132743)
- Steve Ellis (395221)
- Steven A. Narod (230773)
- Steven Hart (395293)
- Sue Healey (41187)
- Susan J. Ramus (205214)
- Susan L. Neuhausen (238692)
- Susan L. Slager (223846)
- Susan M. Domchek (154078)
- Susan Peock (154155)
- Sylvie Mazoyer (196744)
- Tara M. Friebel (395289)
- Taru A. Muranen (395284)
- Theo A. M. van Os (395220)
- Thomas V. O. Hansen (395201)
- Tibor Vaszko (395281)
- Timothy R. Rebbeck (230766)
- Tomasz Huzarski (395242)
- Tomi Pastinen (15737)
- Torben A. Kruse (92928)
- Trinidad Caldes (3147195)
- Uffe Birk Jensen (395267)
- Ute Hamann (89879)
- Valeria Pensotti (395247)
- Vernon S. Pankratz (395294)
- Victoria L. Bae-Jump (284536)
- Wendy K. Chung (51418)
- Xianshu Wang (146610)
- Yael Laitman (196595)
- Yuan Chun Ding (322601)
- Yves-Jean Bignon (54433)
- Zachary Fredericksen (146612)
- Zakaria Einbeigi (395254)
- Publication venue
- Publication date
- Field of study
<p>Analysis of associations with breast and ovarian cancer risk simultaneously (competing risks analysis) for SNPs found to be associated with breast or ovarian cancer.</p
Associations with SNPs at the novel 17q21 region with ovarian cancer risk for <i>BRCA1</i> and <i>BRCA2</i> mutation carriers.
- Author
- Adam Lee (395196)
- Adriana Lasa (196672)
- Agnès Hardouin (395232)
- Alain Calender (395231)
- Alan Donaldson (239924)
- Alessandra Viel (10416)
- Alex Murray (395230)
- Alex Teulé (395273)
- Alexander Miron (28179)
- Alexandra V. Stavropoulou (387774)
- Alfons Meindl (112058)
- Alison M. Dunning (146796)
- Amanda B. Spurdle (47489)
- Amanda Ewart Toland (164514)
- Ana Osorio (81750)
- Andrea Gehrig (395248)
- Andrew K. Godwin (131285)
- Andrew Lee (74302)
- Anna Jakubowska (146752)
- Anna Marie Mulligan (146672)
- Anna P. Sokolenko (395288)
- Anne-Bine Skytte (395263)
- Anne-Marie Gerdes (395264)
- Anneliese Fink-Retter (395258)
- Annemarie H. van der Hout (395213)
- Antonis C. Antoniou (146788)
- Atocha Romero (395283)
- Ava Kwong (52115)
- Banu K. Arun (395211)
- Barbara Wappenschmidt (112030)
- Bella Kaufman (196589)
- Bent Ejlertsen (395269)
- Bernard Peissel (181321)
- Bernardo Bonanni (196561)
- Bernhard H. F. Weber (162289)
- Beth Y. Karlan (184236)
- Bjarni A. Agnarsson (154067)
- Brita Arver (395252)
- Capucine Delnatte (395234)
- Carole Brewer (196650)
- Carolien H. M. van Deurzen (395214)
- Caroline Seynaeve (95368)
- Catherine Houghton (395226)
- Catherine M. Phelan (219497)
- Catherine Nogues (395235)
- Cecilia M. Dorfling (395285)
- Chen Wang (88408)
- Christian F. Singer (308365)
- Christian Sutter (196732)
- Christine Lasset (395236)
- Christine Rappaport (395259)
- Christine Walsh (219475)
- Christoph Engel (218744)
- Claude Houdayer (395237)
- Conxi Lazaro (3405329)
- Csilla I. Szabo (395202)
- Curtis Olswold (73571)
- D. Gareth Evans (154186)
- Daniel Barrowdale (395192)
- Daniel Tessier (395291)
- Daniel Vincent (395198)
- Daphne Gschwantler-Kaulich (395260)
- David E. Cohn (395255)
- David E. Goldgar (196718)
- Debra Frost (154160)
- Dezheng Huo (151859)
- Diana M. Eccles (219472)
- Dieter Niederacher (93623)
- Dominique Leroux (395238)
- Dominique Stoppa-Lyonnet (29241)
- Dorothea Gadzicki (238732)
- Douglas F. Easton (89956)
- Drakoulis Yannoukakos (4758)
- Ed Dicks (395194)
- Edith Olah (395204)
- Eitan Friedman (196582)
- Elena Fineberg (395222)
- Elizabeth J. van Rensburg (395205)
- Elżbieta Złowocka-Perłowska (204566)
- Emma McCann (395229)
- Encarna B. Gómez Garcia (5654410)
- Esther M. John (107266)
- Etienne Rouleau (395239)
- Evgeny N. Imyanitov (395207)
- Fabienne Prieur (246641)
- Fergus J. Couch (146607)
- Finn C. Nielsen (206969)
- Fiona Douglas (154179)
- Flavio Lejbkowicz (196544)
- Flora E. van Leeuwen (248404)
- Francesca Damiola (5331)
- Frans B. L. Hogervorst (146390)
- François Bacot (395197)
- Gad Rennert (196538)
- Georg Pfeiler (395261)
- Georgia Chenevix-Trench (361)
- Giulia Melloni (395243)
- Gord Glendon (146666)
- Gustavo C. Rodriguez (395256)
- Hagay Sobol (91961)
- Hanne E. J. Meijers-Heijboer (395215)
- Hansjoerg Plendl (395250)
- Helen Gregory (395228)
- Heli Nevanlinna (83762)
- Helmut Deissler (196727)
- Hilmi Ozcelik (20185)
- Huw Dorkins (239925)
- Ian Campbell (205212)
- Ignacio Blanco (196711)
- Inge Sokilde Pedersen (395265)
- Irene L. Andrulis (107262)
- Isabelle Coupier (292499)
- Jacek Gronwald (218515)
- Jackie Cook (154176)
- Jacqueline Eason (238727)
- Jacques Simard (15589)
- Jan Lubinski (59925)
- Javier Benitez (81758)
- Jeffrey N. Weitzel (238722)
- Jennifer T. Loud (395275)
- Jenny Lester (395276)
- Joan Brunet (75020)
- Jocelyne Chiquette (21796)
- Joe Dennis (395193)
- Joellen Weaver (395282)
- Johannes J. P. Gille (395216)
- Josef Herzog (395277)
- Joseph Vijai (102398)
- Judith Balmaña (395210)
- Judy Garber (59512)
- Julian Adlard (395223)
- Julie Cunningham (395292)
- Juul T. Wijnen (154144)
- Kara Sarrel (102421)
- Karen H. Lu (395290)
- Karin Kast (112042)
- Karoline B. Kuchenbaecker (395191)
- Katarzyna Durda (146758)
- Katarzyna Jaworska (146755)
- Katherine L. Nathanson (154077)
- Kathleen Claes (203063)
- kConFab Investigators (2615518)
- Kenneth Offit (63812)
- Kerstin Rhiem (112049)
- Kristen Stevens (121411)
- Kristiina Aittomäki (89889)
- Laima Tihomirova (196713)
- Lars Jønson (395270)
- Laura Ottini (395244)
- Laura Papi (395245)
- Laurence Venat-Bouvet (395240)
- Laurent Castera (38087)
- Laurie Small (395257)
- Leigha Senter (395286)
- Lenka Foretova (162255)
- Lesley McGuffog (153865)
- Liliana Varesco (381200)
- Linda Steele (395272)
- Louise Izatt (69449)
- Lucy E. Side (395225)
- Mads Thomassen (395200)
- Marc Tischkowitz (395208)
- Marco Montagna (238698)
- Margreet G. E. M. Ausems (280984)
- Maria A. Caligo (154069)
- Maria Grazia Tibiletti (395246)
- Marie Stenmark-Askmalm (395253)
- Marinus J. Blok (395217)
- Marion Gauthier-Villars (238630)
- Marion Piedmonte (238646)
- Marjolijn J. L. Ligtenberg (395218)
- Mark H. Greene (395203)
- Mark Robson (70145)
- Mark T. Rogers (395227)
- Mary B. Daly (196724)
- Mary Beth Terry (2801)
- Mary S. Beattie (395206)
- Matthew Kosel (395195)
- Matti A. Rookus (154108)
- Melissa C. Southey (89921)
- Mercedes Duran (5651374)
- Mette K. Andersen (395271)
- Mia M. Gaudet (146621)
- Michael Friedlander (55581)
- Miguel de la Hoya (238670)
- Miquel Angel Pujana (395274)
- Muy-Kheng Tea (308359)
- Mélanie Léoné (395241)
- Nadine Tung (238710)
- Niklas Loman (26096)
- Nina Ditsch (395249)
- Noah Kauff (395268)
- Noralane M. Lindor (163048)
- Norbert Arnold (112045)
- Olga M. Sinilnikova (196738)
- Olufunmilayo I. Olopade (151873)
- Orland Diez (395209)
- Paolo Peterlongo (146602)
- Paolo Radice (146601)
- Pascal Pujol (8444)
- Pascaline Berthet (395233)
- Patricia A. Ganz (395212)
- Patrick J. Morrison (395224)
- Paul A. James (130908)
- Penny Soucy (21792)
- Per Hall (23544)
- Peter Devilee (13431)
- Phuong L. Mai (238716)
- Radka Platte (238724)
- Ramunas Janavicius (71877)
- Raymonda Varon-Mateeva (196729)
- Richard Rosenquist (262592)
- Rita Katharina Schmutzler (395199)
- Rosa B. Barkardottir (238688)
- Rosalind A. Eeles (194860)
- Sabine Preisler-Adams (395251)
- Salina B. Chan (395287)
- Sandra Orsulic (184242)
- Sanne Traasdahl Moeller (395266)
- Sara Volorio (255289)
- Saundra S. Buys (238707)
- Senno Verhoef (395219)
- Shani Shimon Paluch (395262)
- Sharon R. Sand (395278)
- Shirley Hodgson (154183)
- Silvia Tognazzo (395279)
- Simona Agata (395280)
- Siranoush Manoukian (146603)
- Soo-Hwang Teo (266270)
- Stefanie Engert (112037)
- Stephanie V. Blank (132743)
- Steve Ellis (395221)
- Steven A. Narod (230773)
- Steven Hart (395293)
- Sue Healey (41187)
- Susan J. Ramus (205214)
- Susan L. Neuhausen (238692)
- Susan L. Slager (223846)
- Susan M. Domchek (154078)
- Susan Peock (154155)
- Sylvie Mazoyer (196744)
- Tara M. Friebel (395289)
- Taru A. Muranen (395284)
- Theo A. M. van Os (395220)
- Thomas V. O. Hansen (395201)
- Tibor Vaszko (395281)
- Timothy R. Rebbeck (230766)
- Tomasz Huzarski (395242)
- Tomi Pastinen (15737)
- Torben A. Kruse (92928)
- Trinidad Caldes (3147195)
- Uffe Birk Jensen (395267)
- Ute Hamann (89879)
- Valeria Pensotti (395247)
- Vernon S. Pankratz (395294)
- Victoria L. Bae-Jump (284536)
- Wendy K. Chung (51418)
- Xianshu Wang (146610)
- Yael Laitman (196595)
- Yuan Chun Ding (322601)
- Yves-Jean Bignon (54433)
- Zachary Fredericksen (146612)
- Zakaria Einbeigi (395254)
- Publication venue
- Publication date
- Field of study
*<p>HRs estimated under the single disease risk model.</p
Mapping of the 17q21 locus.
- Author
- Adam Lee (395196)
- Adriana Lasa (196672)
- Agnès Hardouin (395232)
- Alain Calender (395231)
- Alan Donaldson (239924)
- Alessandra Viel (10416)
- Alex Murray (395230)
- Alex Teulé (395273)
- Alexander Miron (28179)
- Alexandra V. Stavropoulou (387774)
- Alfons Meindl (112058)
- Alison M. Dunning (146796)
- Amanda B. Spurdle (47489)
- Amanda Ewart Toland (164514)
- Ana Osorio (81750)
- Andrea Gehrig (395248)
- Andrew K. Godwin (131285)
- Andrew Lee (74302)
- Anna Jakubowska (146752)
- Anna Marie Mulligan (146672)
- Anna P. Sokolenko (395288)
- Anne-Bine Skytte (395263)
- Anne-Marie Gerdes (395264)
- Anneliese Fink-Retter (395258)
- Annemarie H. van der Hout (395213)
- Antonis C. Antoniou (146788)
- Atocha Romero (395283)
- Ava Kwong (52115)
- Banu K. Arun (395211)
- Barbara Wappenschmidt (112030)
- Bella Kaufman (196589)
- Bent Ejlertsen (395269)
- Bernard Peissel (181321)
- Bernardo Bonanni (196561)
- Bernhard H. F. Weber (162289)
- Beth Y. Karlan (184236)
- Bjarni A. Agnarsson (154067)
- Brita Arver (395252)
- Capucine Delnatte (395234)
- Carole Brewer (196650)
- Carolien H. M. van Deurzen (395214)
- Caroline Seynaeve (95368)
- Catherine Houghton (395226)
- Catherine M. Phelan (219497)
- Catherine Nogues (395235)
- Cecilia M. Dorfling (395285)
- Chen Wang (88408)
- Christian F. Singer (308365)
- Christian Sutter (196732)
- Christine Lasset (395236)
- Christine Rappaport (395259)
- Christine Walsh (219475)
- Christoph Engel (218744)
- Claude Houdayer (395237)
- Conxi Lazaro (3405329)
- Csilla I. Szabo (395202)
- Curtis Olswold (73571)
- D. Gareth Evans (154186)
- Daniel Barrowdale (395192)
- Daniel Tessier (395291)
- Daniel Vincent (395198)
- Daphne Gschwantler-Kaulich (395260)
- David E. Cohn (395255)
- David E. Goldgar (196718)
- Debra Frost (154160)
- Dezheng Huo (151859)
- Diana M. Eccles (219472)
- Dieter Niederacher (93623)
- Dominique Leroux (395238)
- Dominique Stoppa-Lyonnet (29241)
- Dorothea Gadzicki (238732)
- Douglas F. Easton (89956)
- Drakoulis Yannoukakos (4758)
- Ed Dicks (395194)
- Edith Olah (395204)
- Eitan Friedman (196582)
- Elena Fineberg (395222)
- Elizabeth J. van Rensburg (395205)
- Elżbieta Złowocka-Perłowska (204566)
- Emma McCann (395229)
- Encarna B. Gómez Garcia (5654410)
- Esther M. John (107266)
- Etienne Rouleau (395239)
- Evgeny N. Imyanitov (395207)
- Fabienne Prieur (246641)
- Fergus J. Couch (146607)
- Finn C. Nielsen (206969)
- Fiona Douglas (154179)
- Flavio Lejbkowicz (196544)
- Flora E. van Leeuwen (248404)
- Francesca Damiola (5331)
- Frans B. L. Hogervorst (146390)
- François Bacot (395197)
- Gad Rennert (196538)
- Georg Pfeiler (395261)
- Georgia Chenevix-Trench (361)
- Giulia Melloni (395243)
- Gord Glendon (146666)
- Gustavo C. Rodriguez (395256)
- Hagay Sobol (91961)
- Hanne E. J. Meijers-Heijboer (395215)
- Hansjoerg Plendl (395250)
- Helen Gregory (395228)
- Heli Nevanlinna (83762)
- Helmut Deissler (196727)
- Hilmi Ozcelik (20185)
- Huw Dorkins (239925)
- Ian Campbell (205212)
- Ignacio Blanco (196711)
- Inge Sokilde Pedersen (395265)
- Irene L. Andrulis (107262)
- Isabelle Coupier (292499)
- Jacek Gronwald (218515)
- Jackie Cook (154176)
- Jacqueline Eason (238727)
- Jacques Simard (15589)
- Jan Lubinski (59925)
- Javier Benitez (81758)
- Jeffrey N. Weitzel (238722)
- Jennifer T. Loud (395275)
- Jenny Lester (395276)
- Joan Brunet (75020)
- Jocelyne Chiquette (21796)
- Joe Dennis (395193)
- Joellen Weaver (395282)
- Johannes J. P. Gille (395216)
- Josef Herzog (395277)
- Joseph Vijai (102398)
- Judith Balmaña (395210)
- Judy Garber (59512)
- Julian Adlard (395223)
- Julie Cunningham (395292)
- Juul T. Wijnen (154144)
- Kara Sarrel (102421)
- Karen H. Lu (395290)
- Karin Kast (112042)
- Karoline B. Kuchenbaecker (395191)
- Katarzyna Durda (146758)
- Katarzyna Jaworska (146755)
- Katherine L. Nathanson (154077)
- Kathleen Claes (203063)
- kConFab Investigators (2615518)
- Kenneth Offit (63812)
- Kerstin Rhiem (112049)
- Kristen Stevens (121411)
- Kristiina Aittomäki (89889)
- Laima Tihomirova (196713)
- Lars Jønson (395270)
- Laura Ottini (395244)
- Laura Papi (395245)
- Laurence Venat-Bouvet (395240)
- Laurent Castera (38087)
- Laurie Small (395257)
- Leigha Senter (395286)
- Lenka Foretova (162255)
- Lesley McGuffog (153865)
- Liliana Varesco (381200)
- Linda Steele (395272)
- Louise Izatt (69449)
- Lucy E. Side (395225)
- Mads Thomassen (395200)
- Marc Tischkowitz (395208)
- Marco Montagna (238698)
- Margreet G. E. M. Ausems (280984)
- Maria A. Caligo (154069)
- Maria Grazia Tibiletti (395246)
- Marie Stenmark-Askmalm (395253)
- Marinus J. Blok (395217)
- Marion Gauthier-Villars (238630)
- Marion Piedmonte (238646)
- Marjolijn J. L. Ligtenberg (395218)
- Mark H. Greene (395203)
- Mark Robson (70145)
- Mark T. Rogers (395227)
- Mary B. Daly (196724)
- Mary Beth Terry (2801)
- Mary S. Beattie (395206)
- Matthew Kosel (395195)
- Matti A. Rookus (154108)
- Melissa C. Southey (89921)
- Mercedes Duran (5651374)
- Mette K. Andersen (395271)
- Mia M. Gaudet (146621)
- Michael Friedlander (55581)
- Miguel de la Hoya (238670)
- Miquel Angel Pujana (395274)
- Muy-Kheng Tea (308359)
- Mélanie Léoné (395241)
- Nadine Tung (238710)
- Niklas Loman (26096)
- Nina Ditsch (395249)
- Noah Kauff (395268)
- Noralane M. Lindor (163048)
- Norbert Arnold (112045)
- Olga M. Sinilnikova (196738)
- Olufunmilayo I. Olopade (151873)
- Orland Diez (395209)
- Paolo Peterlongo (146602)
- Paolo Radice (146601)
- Pascal Pujol (8444)
- Pascaline Berthet (395233)
- Patricia A. Ganz (395212)
- Patrick J. Morrison (395224)
- Paul A. James (130908)
- Penny Soucy (21792)
- Per Hall (23544)
- Peter Devilee (13431)
- Phuong L. Mai (238716)
- Radka Platte (238724)
- Ramunas Janavicius (71877)
- Raymonda Varon-Mateeva (196729)
- Richard Rosenquist (262592)
- Rita Katharina Schmutzler (395199)
- Rosa B. Barkardottir (238688)
- Rosalind A. Eeles (194860)
- Sabine Preisler-Adams (395251)
- Salina B. Chan (395287)
- Sandra Orsulic (184242)
- Sanne Traasdahl Moeller (395266)
- Sara Volorio (255289)
- Saundra S. Buys (238707)
- Senno Verhoef (395219)
- Shani Shimon Paluch (395262)
- Sharon R. Sand (395278)
- Shirley Hodgson (154183)
- Silvia Tognazzo (395279)
- Simona Agata (395280)
- Siranoush Manoukian (146603)
- Soo-Hwang Teo (266270)
- Stefanie Engert (112037)
- Stephanie V. Blank (132743)
- Steve Ellis (395221)
- Steven A. Narod (230773)
- Steven Hart (395293)
- Sue Healey (41187)
- Susan J. Ramus (205214)
- Susan L. Neuhausen (238692)
- Susan L. Slager (223846)
- Susan M. Domchek (154078)
- Susan Peock (154155)
- Sylvie Mazoyer (196744)
- Tara M. Friebel (395289)
- Taru A. Muranen (395284)
- Theo A. M. van Os (395220)
- Thomas V. O. Hansen (395201)
- Tibor Vaszko (395281)
- Timothy R. Rebbeck (230766)
- Tomasz Huzarski (395242)
- Tomi Pastinen (15737)
- Torben A. Kruse (92928)
- Trinidad Caldes (3147195)
- Uffe Birk Jensen (395267)
- Ute Hamann (89879)
- Valeria Pensotti (395247)
- Vernon S. Pankratz (395294)
- Victoria L. Bae-Jump (284536)
- Wendy K. Chung (51418)
- Xianshu Wang (146610)
- Yael Laitman (196595)
- Yuan Chun Ding (322601)
- Yves-Jean Bignon (54433)
- Zachary Fredericksen (146612)
- Zakaria Einbeigi (395254)
- Publication venue
- Publication date
- Field of study
<p><i>Top 3 panels:</i> P-values of association (−log<sub>10</sub> scale) with ovarian cancer risk for genotyped and imputed SNPs (1000 Genomes Project CEU), by chromosome position (b.37) at the 17q21 region, for <i>BRCA1</i>, <i>BRCA2</i> mutation carriers and combined. Results based on the kinship-adjusted score test statistic (1 d.f.). <i>Fourth panel:</i> Genes in the region spanning (43.4–44.9 Mb, b.37) and the location of the most significant genotyped SNPs (in red font) and imputed SNPs (in black font). <i>Bottom panel:</i> Pairwise r<sup>2</sup> values for genotyped SNPs on iCOG array in the 17q21 region covering positions (43.4–44.9 Mb, b.37).</p
Study design for selection of the SNPs and genotyping of <i>BRCA1</i> samples.
- Author
- Adam Lee (395196)
- Adriana Lasa (196672)
- Agnès Hardouin (395232)
- Alain Calender (395231)
- Alan Donaldson (239924)
- Alessandra Viel (10416)
- Alex Murray (395230)
- Alex Teulé (395273)
- Alexander Miron (28179)
- Alexandra V. Stavropoulou (387774)
- Alfons Meindl (112058)
- Alison M. Dunning (146796)
- Amanda B. Spurdle (47489)
- Amanda Ewart Toland (164514)
- Ana Osorio (81750)
- Andrea Gehrig (395248)
- Andrew K. Godwin (131285)
- Andrew Lee (74302)
- Anna Jakubowska (146752)
- Anna Marie Mulligan (146672)
- Anna P. Sokolenko (395288)
- Anne-Bine Skytte (395263)
- Anne-Marie Gerdes (395264)
- Anneliese Fink-Retter (395258)
- Annemarie H. van der Hout (395213)
- Antonis C. Antoniou (146788)
- Atocha Romero (395283)
- Ava Kwong (52115)
- Banu K. Arun (395211)
- Barbara Wappenschmidt (112030)
- Bella Kaufman (196589)
- Bent Ejlertsen (395269)
- Bernard Peissel (181321)
- Bernardo Bonanni (196561)
- Bernhard H. F. Weber (162289)
- Beth Y. Karlan (184236)
- Bjarni A. Agnarsson (154067)
- Brita Arver (395252)
- Capucine Delnatte (395234)
- Carole Brewer (196650)
- Carolien H. M. van Deurzen (395214)
- Caroline Seynaeve (95368)
- Catherine Houghton (395226)
- Catherine M. Phelan (219497)
- Catherine Nogues (395235)
- Cecilia M. Dorfling (395285)
- Chen Wang (88408)
- Christian F. Singer (308365)
- Christian Sutter (196732)
- Christine Lasset (395236)
- Christine Rappaport (395259)
- Christine Walsh (219475)
- Christoph Engel (218744)
- Claude Houdayer (395237)
- Conxi Lazaro (3405329)
- Csilla I. Szabo (395202)
- Curtis Olswold (73571)
- D. Gareth Evans (154186)
- Daniel Barrowdale (395192)
- Daniel Tessier (395291)
- Daniel Vincent (395198)
- Daphne Gschwantler-Kaulich (395260)
- David E. Cohn (395255)
- David E. Goldgar (196718)
- Debra Frost (154160)
- Dezheng Huo (151859)
- Diana M. Eccles (219472)
- Dieter Niederacher (93623)
- Dominique Leroux (395238)
- Dominique Stoppa-Lyonnet (29241)
- Dorothea Gadzicki (238732)
- Douglas F. Easton (89956)
- Drakoulis Yannoukakos (4758)
- Ed Dicks (395194)
- Edith Olah (395204)
- Eitan Friedman (196582)
- Elena Fineberg (395222)
- Elizabeth J. van Rensburg (395205)
- Elżbieta Złowocka-Perłowska (204566)
- Emma McCann (395229)
- Encarna B. Gómez Garcia (5654410)
- Esther M. John (107266)
- Etienne Rouleau (395239)
- Evgeny N. Imyanitov (395207)
- Fabienne Prieur (246641)
- Fergus J. Couch (146607)
- Finn C. Nielsen (206969)
- Fiona Douglas (154179)
- Flavio Lejbkowicz (196544)
- Flora E. van Leeuwen (248404)
- Francesca Damiola (5331)
- Frans B. L. Hogervorst (146390)
- François Bacot (395197)
- Gad Rennert (196538)
- Georg Pfeiler (395261)
- Georgia Chenevix-Trench (361)
- Giulia Melloni (395243)
- Gord Glendon (146666)
- Gustavo C. Rodriguez (395256)
- Hagay Sobol (91961)
- Hanne E. J. Meijers-Heijboer (395215)
- Hansjoerg Plendl (395250)
- Helen Gregory (395228)
- Heli Nevanlinna (83762)
- Helmut Deissler (196727)
- Hilmi Ozcelik (20185)
- Huw Dorkins (239925)
- Ian Campbell (205212)
- Ignacio Blanco (196711)
- Inge Sokilde Pedersen (395265)
- Irene L. Andrulis (107262)
- Isabelle Coupier (292499)
- Jacek Gronwald (218515)
- Jackie Cook (154176)
- Jacqueline Eason (238727)
- Jacques Simard (15589)
- Jan Lubinski (59925)
- Javier Benitez (81758)
- Jeffrey N. Weitzel (238722)
- Jennifer T. Loud (395275)
- Jenny Lester (395276)
- Joan Brunet (75020)
- Jocelyne Chiquette (21796)
- Joe Dennis (395193)
- Joellen Weaver (395282)
- Johannes J. P. Gille (395216)
- Josef Herzog (395277)
- Joseph Vijai (102398)
- Judith Balmaña (395210)
- Judy Garber (59512)
- Julian Adlard (395223)
- Julie Cunningham (395292)
- Juul T. Wijnen (154144)
- Kara Sarrel (102421)
- Karen H. Lu (395290)
- Karin Kast (112042)
- Karoline B. Kuchenbaecker (395191)
- Katarzyna Durda (146758)
- Katarzyna Jaworska (146755)
- Katherine L. Nathanson (154077)
- Kathleen Claes (203063)
- kConFab Investigators (2615518)
- Kenneth Offit (63812)
- Kerstin Rhiem (112049)
- Kristen Stevens (121411)
- Kristiina Aittomäki (89889)
- Laima Tihomirova (196713)
- Lars Jønson (395270)
- Laura Ottini (395244)
- Laura Papi (395245)
- Laurence Venat-Bouvet (395240)
- Laurent Castera (38087)
- Laurie Small (395257)
- Leigha Senter (395286)
- Lenka Foretova (162255)
- Lesley McGuffog (153865)
- Liliana Varesco (381200)
- Linda Steele (395272)
- Louise Izatt (69449)
- Lucy E. Side (395225)
- Mads Thomassen (395200)
- Marc Tischkowitz (395208)
- Marco Montagna (238698)
- Margreet G. E. M. Ausems (280984)
- Maria A. Caligo (154069)
- Maria Grazia Tibiletti (395246)
- Marie Stenmark-Askmalm (395253)
- Marinus J. Blok (395217)
- Marion Gauthier-Villars (238630)
- Marion Piedmonte (238646)
- Marjolijn J. L. Ligtenberg (395218)
- Mark H. Greene (395203)
- Mark Robson (70145)
- Mark T. Rogers (395227)
- Mary B. Daly (196724)
- Mary Beth Terry (2801)
- Mary S. Beattie (395206)
- Matthew Kosel (395195)
- Matti A. Rookus (154108)
- Melissa C. Southey (89921)
- Mercedes Duran (5651374)
- Mette K. Andersen (395271)
- Mia M. Gaudet (146621)
- Michael Friedlander (55581)
- Miguel de la Hoya (238670)
- Miquel Angel Pujana (395274)
- Muy-Kheng Tea (308359)
- Mélanie Léoné (395241)
- Nadine Tung (238710)
- Niklas Loman (26096)
- Nina Ditsch (395249)
- Noah Kauff (395268)
- Noralane M. Lindor (163048)
- Norbert Arnold (112045)
- Olga M. Sinilnikova (196738)
- Olufunmilayo I. Olopade (151873)
- Orland Diez (395209)
- Paolo Peterlongo (146602)
- Paolo Radice (146601)
- Pascal Pujol (8444)
- Pascaline Berthet (395233)
- Patricia A. Ganz (395212)
- Patrick J. Morrison (395224)
- Paul A. James (130908)
- Penny Soucy (21792)
- Per Hall (23544)
- Peter Devilee (13431)
- Phuong L. Mai (238716)
- Radka Platte (238724)
- Ramunas Janavicius (71877)
- Raymonda Varon-Mateeva (196729)
- Richard Rosenquist (262592)
- Rita Katharina Schmutzler (395199)
- Rosa B. Barkardottir (238688)
- Rosalind A. Eeles (194860)
- Sabine Preisler-Adams (395251)
- Salina B. Chan (395287)
- Sandra Orsulic (184242)
- Sanne Traasdahl Moeller (395266)
- Sara Volorio (255289)
- Saundra S. Buys (238707)
- Senno Verhoef (395219)
- Shani Shimon Paluch (395262)
- Sharon R. Sand (395278)
- Shirley Hodgson (154183)
- Silvia Tognazzo (395279)
- Simona Agata (395280)
- Siranoush Manoukian (146603)
- Soo-Hwang Teo (266270)
- Stefanie Engert (112037)
- Stephanie V. Blank (132743)
- Steve Ellis (395221)
- Steven A. Narod (230773)
- Steven Hart (395293)
- Sue Healey (41187)
- Susan J. Ramus (205214)
- Susan L. Neuhausen (238692)
- Susan L. Slager (223846)
- Susan M. Domchek (154078)
- Susan Peock (154155)
- Sylvie Mazoyer (196744)
- Tara M. Friebel (395289)
- Taru A. Muranen (395284)
- Theo A. M. van Os (395220)
- Thomas V. O. Hansen (395201)
- Tibor Vaszko (395281)
- Timothy R. Rebbeck (230766)
- Tomasz Huzarski (395242)
- Tomi Pastinen (15737)
- Torben A. Kruse (92928)
- Trinidad Caldes (3147195)
- Uffe Birk Jensen (395267)
- Ute Hamann (89879)
- Valeria Pensotti (395247)
- Vernon S. Pankratz (395294)
- Victoria L. Bae-Jump (284536)
- Wendy K. Chung (51418)
- Xianshu Wang (146610)
- Yael Laitman (196595)
- Yuan Chun Ding (322601)
- Yves-Jean Bignon (54433)
- Zachary Fredericksen (146612)
- Zakaria Einbeigi (395254)
- Publication venue
- Publication date
- Field of study
<p>GWAS data from 2,727 <i>BRCA1</i> mutation carriers were analysed for associations with breast and ovarian cancer risk and 32,557 SNPs were selected for inclusion on the iCOGS array. A total of 11,705 <i>BRCA1</i> samples (after quality control (QC) checks) were genotyped on the 31,812 <i>BRCA1</i>-GWAS SNPs from the iCOGS array that passed QC. Of these samples, 2,387 had been genotyped at the SNP selection stage and are referred to as “stage 1” samples, whereas 9,318 samples were unique to the iCOGS study (“Stage 2” samples). Next, 17 SNPs that exhibited the most significant associations with breast and ovarian cancer were selected for genotyping in a third stage involving an additional 2,646 <i>BRCA1</i> samples (after QC).</p