Climate change management: a resilience strategy for flood risk using Blockchain tools

This work aims to offer a contribution in the analysis and management, from an economic and financial point of view, of the flood risk, and extended to the hydrogeological risk, from the perspective of a public administration. As main responsible actor for containing the phenomenon through the maintenance of the territory, public administration is responsible for the cost of restoring of the services that have been damaged by this type of phenomenon. The assets of which the public administration must ensure the restoration are all public infrastructures (i.e. transportation, energy and water supply system, communication) together with the damage suffered by private property, if these affect services to be guaranteed to the population. In this work, the authors propose possible strategies that a public administration can put in place to deal with flood risk. Three main strategies are analysed: an absolute passivity that provides for the payment of damages as they occur (i.e. business-as-usual scenario), a classic insurance scheme, a resilient and innovative insurance scheme. The economic–financial profiles of these strategies proposed in this work put an emphasis on how the assumption of a time horizon can change the convenience of one strategy compared to the others. This study highlights the key role of the quantification of flood risk mitigation measure from an engineering perspective, and their potential issues to pursue these objectives in connection to the regulatory framework of the public administrations. This synergy is supported by the potential use of Blockchain-based tools. Within the paper is highlighted the key role that such platform IT data management platform could have within risk analysis and management schemes, both as a data collection tool and as certification of the various steps necessary to complete the process

COVID-19 Effects on Cultural Heritage: The Case of Villa Adriana and Villa D'Este

The paper aims to provide a clarification of assessing insurance risk related to an asset owned by a subject under public law and, more specifically, to an economic cultural asset. This study is aligned with key aspects proposed by the EU for the protection of the cultural heritage from natural disasters. In the first place, given the peculiarity of the material inherent to cultural heritage, a motivation underlies the search for the correlation between the latter and the commonality. Secondly, it appeared necessary to verify the differences, similarities and importance of the economic management of cultural heritage in order to understand the social, economic, material and intangible importance of an asset managed in an economic way within a social axis (municipality). The third reason relates to the general severity and the risk and subsequent damage that a hazard, such as a pandemic outbreak (COVID-19), can cause on one or more cultural heritage. In the final analysis, perhaps the most meaningful aspect underlies the verification of the possible consequences in the analysis of summations of losses generated by a hazard in order to allow a prospect of what could be the consequences of such a catastrophic scenario

Non-Incomes Risk Mitigation Mechanisms for Cultural Heritage: Role of Insurances Facing Covid-19 in the Italian Context

Abstract The economic cultural heritages are exposed to several natural and nowadays biological hazards, which, in addition to causing potential structural damage, can lead to severe loss deriving from financial non-incomes. The paper aims to highlight the role of insurance in mitigating financial damages and losses, specifically explaining the key role of insurance in mitigating biological hazards like Covid-19. The paper is part of broader research by the authors and uses the assumptions and results already obtained previously in the context of the case study relating to the asset of Villa Adriana and Villa D'Este

What constitutes clinically significant binge eating? Association between binge features and clinical validators in college-age women

Objective: To investigate the association between binge features and clinical validators. Method: The Eating Disorder Examination assessed binge features in a sample of 549 college-age women: loss of control (LOC) presence, binge frequency, binge size, indicators of impaired control, and LOC severity. Clinical validators were self-reported clinical impairment and current psychiatric comorbidity, as determined via a semistructured interview. Results: Compared with women without LOC, those with LOC had significantly greater odds of reporting clinical impairment and comorbidity (ps \u3c 0.001). Among women with LOC (n = 252), the indicators of impaired control and LOC severity, but not binge size or frequency, were associated with greater odds of reporting clinical impairment and/or comorbidity (ps \u3c 0.05). Dicussion: Findings confirm that the presence of LOC may be the hallmark feature of binge eating. Further, dimensional ratings about the LOC experienceand possibly the indicators of impaired controlmay improve reliable identification of clinically significant binge eating. (c) 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013

An examination of the Clinical Impairment Assessment among women at high risk for eating disorder onset

Identifying measures that reliably and validly assess clinical impairment has important implications for eating disorder (ED) diagnosis and treatment. The current study examined the psychometric properties of the Clinical Impairment Assessment (CIA) in women at high risk for ED onset. Participants were 543 women (20.6 +/- 2.0 years) who were classified into one of three ED categories: clinical ED, high risk for ED onset, and low risk control. Among high risk women, the CIA demonstrated high internal consistency (alpha = 0.93) and good convergent validity with disordered eating attitudes (rs = 0.27-0.68, ps \u3c 0.001). Examination of the CIA\u27s discriminant validity revealed that CIA global scores were highest among women with a clinical ED (17.7 +/- 10.7) followed by high risk women (10.6 +/- 8.5) and low risk controls (3.0 +/- 3.3), respectively (p \u3c 0.001). High risk women reporting behavioral indices of ED psychopathology (objective and/or subjective binge episodes, purging behaviors, driven exercise, and ED treatment history) had higher CIA global scores than those without such indices (ps \u3c 0.05), suggesting good criterion validity. These data establish the first norms for the CIA in a United States sample. The CIA is psychometrically sound among high risk women, and heightened levels of impairment among these individuals as compared to low risk women verify the relevance of early intervention efforts. (C) 2012 Elsevier Ltd. All rights reserved

De-inked paper sludge and mature compost as high-valuecomponents of soilless substrate to support tree growth

The recycled paper industry produces tons of waste whose disposal is a cost for industry and the environment. This research examines the suitability of de-inked paper sludge (DPS), after pelletization, as a sustainable alternative component to a peat-based growing media, creating ideal root conditions for tree development (e.g. high water storage, low compaction). DPS, tested on Lepidium sativum L. germination, did not show toxicity effects. Three species, Quercus ilex L., Lagerstroemia indica L. and Prunus serrulata “Kanzan”, were planted in 40 cm Ø pots filled with a control (peat, pumice and zeolite) and the experimental substrate (compost, DPS pellets, pumice and zeolite). After two years in the nursery, the trees were planted in situ. The physical and chemical properties of substrates were analyzed. Plant morphological and physiological parameters were monitored: trunk diameter, leaf dry matter, leaf nitrogen, chlorophyll, and photosynthetic efficiency. The new substrate showed higher Corg (+135%), total N (+73%) and easily available water (+19%), compared to the control substrate used in the nursery. In this new substrate, the trees showed similar radial growth values to the control in the nursery and after transplanting in situ improved their photosynthetic performance in terms of quantum yield of photosystem II (+36%, and +29% in P. serrulata and L. indica, respectively) and electron transport rate (+39%, +25%, and +32% in P. serrulata, Q. ilex and L. indica, respectively). Pelletization represents an attractive amendment for growing media, which enhances the plant’s physiological health status. This study proposes alternative recovery methods for paper industry waste with low environmental impact. As the process is developed locally, it should also contribute to reducing energy-related CO2 emissions from transport. Pelletization represents an attractive novelty in the use of DPS as amendment for growing media, which enhances the plant’s physiological health status. This study proposes alternative recovery methods for paper industry waste with low environmental impact. As the process is developed locally, it should also contribute to reducing energy-related CO2 emissions from transport

Wavelength locking of silicon photonics multiplexer for DML-based WDM transmitter

We present a wavelength locking platform enabling the feedback control of silicon (Si) microring resonators (MRRs) for the realization of a 4 × 10 Gb/s wavelength-division-multiplexing (WDM) transmitter. Four thermally tunable Si MRRs are employed to multiplex the signals generated by four directly modulated lasers (DMLs) operating in the L-band, as well as to improve the quality of the DMLs signals. Feedback control is achieved through a field-programmable gate array controller by monitoring the working point of each MRR through a transparent detector integrated inside the resonator. The feedback system provides an MRR wavelength stability of about 4 pm (0.5 GHz) with a time response of 60 ms. Bit error rate (BER) measurements confirm the effectiveness and the robustness of the locking system to counteract sensitivity degradations due to thermal drifts, even under uncooled operation conditions for the Si chip

Bullous systemic lupus erythematosus associated with lupus nephritis: report of two cases

Bullous systemic lupus erythematosus is recognized as a distinct entity related to autoimmunity to type VII collagen. In some cases, the flare of bullous disease coincides with the exacerbation of systemic lupus erythematosus, and especially lupus nephritis. Two cases of young female patients with vesiculobullous eruption on sun-exposed and non-exposed areas associated to lupus nephritis are described. Diagnosis was proved by characteristic histopathology and direct immunofluorescence. Corticosteroids and dapsone therapy may be effective.O lúpus eritematoso sistêmico bolhoso é reconhecido como entidade distinta relacionada à auto-imunidade contra colágeno VII. Em alguns casos, a presença de doença bolhosa coincide com a exacerbação do lúpus eritematoso sistêmico, especialmente da nefrite lúpica. São descritos dois casos de mulheres jovens com erupção vésico-bolhosa em áreas expostas e não expostas ao sol associada à nefrite lúpica. O diagnóstico foi comprovado pela histopatologia e imunofluorescência direta características. O tratamento com corticosteróide e dapsona costuma ser eficiente.Sociedade Brasileira de DermatologiaComplexo Hospitalar Heliópolis Serviço de ReumatologiaUNIFESPComplexo Hospitalar Heliópolis Serviço de DermatologiaUNIFESPSciEL

An atlas of Mediterranean seismicity

We present a description of the characteristics of the seismic deformation occurring in the Alpine Mediterranean Belt, and outline its association with tectonic and geologic features. We map seismic activity using several catalogues. Hypocentral data are retrieved from the Catalog of the International Seismological Center, the most comprehensive compilation of global data. Earthquake size and source geometry are instead evaluated from catalogs of earthquake mechanisms. These include seismic moment tensor catalogs (mainly the Harvard CMT Catalog, the Euro-Mediterranean Regional Centroid-Moment Tensors – RCMT Catalog and the regional moment tensor determination in the European-Mediterranean area – ETH Catalog) and a recent extensive compilation of solutions available in literature (EMMA) that provides consistency-controlled fault-plane solutions where mechanisms based on waveform fitting are missing. The study area follows the Africa-Eurasia margin from the Central Atlantic to Iran, and it has been divided into several provinces for the sake of presentation and graphic purposes. For each province, a brief geologic and tectonic description complements the outline of the pattern of seismicity, illustrated by several maps. Focal mechanisms are also grouped together to yield average mechanisms and enable synoptic views. A comprehensive bibliography is referenced. A CD-ROM accompanying this issue contains, besides maps, figures and results of local comparisons and summation of moment tensors with easy access via sensible maps, also an updated version of the EMMA focal mechanism database. Rather than an attempt at presenting a comprehensive seismotectonic model of the Mediterranean, this contribution aims to offer a panoramic view of the active tectonics as imaged by seismicity and focal mechanisms. Its scope may be seen as similar to that of an atlas, as a broad reference and a support for more specific studies

Ldrb toxin with in vitro and in vivo antitumor activity as a potential tool for cancer gene therapy

Due to the high prevalence of cancer in recent years, it is necessary to develop new and more effective therapies that produce fewer side effects. Development of gene therapy for cancer based on the use of suicide genes that can damage the tumor cell, without requiring a prodrug for its lethal effect, is one of the recent foci of gene therapy strategies. We evaluated the cytotoxic impact of the LdrB toxin from Escherichia coli k12 as a possible tool for cancer gene therapy. For that, colorectal and breast cancer cells were transfected under the control of a TRE3G promoter inducible by doxycycline. Our results showed that ldrB gene expression induced a drastic inhibition of proliferation in vitro, in both 2D and 3D experimental models. Moreover, unlike conventional chemotherapy, the ldrB gene induced a severe loss of proliferation in vivo without any side effects in our animal model. This antitumor outcome was modulated by cell cycle arrest in the G0/G1 phase and apoptotic death. Scanning electronic microscopy demonstrates that the LdrB toxin conserves its pore-forming ability in HCT-116 cells as in E. coli k12. Taken together, our results provide, for the first time, a proof of concept of the antitumor capacity of the ldrB gene in colorectal and breast cancer.This research was supported by the Fundación Mutua Madrileña (project FMM-AP16683-2017), Consejería de Salud Junta de Andalucía (PI-0089-2017), the MNat Scientitc Unit of Excellence (UCE.PP2017.0f), and from the Chair “Doctors Galera-Requena in cancer stem cell research”