Hill, Jack Warren Oral History Interview: Old China Hands Oral History Project

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Walvoord, Jeane Oral History Interview: Old China Hands Oral History Project I and II

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Veldman, Harold E and Pearl Oral History Interview: Old China Hands Oral History Project

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Veldman, Jeannette Oral History Interview: Old China Hands Oral History Project I and II

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Diary Entry of Geisje Vander Haar Visscher

Geisje Vander Haar Visscher\u27s diary contains an entry on page 13, in which she made a reference to both Albertus C. Van Raalte and to Mrs. Christina Van Raalte. An entry for 1849 on p. 10 said that the Van Raaltes often came to visit the Vander Haars. The 1856 reference is about the High School and bringing it into a better condition. This is a reference to the Pioneer School. She also said Mr. Van Vleck had come to the school. She thought that Mrs. Van Vleck was a lovely person. The Vander Haar apparently got to know the Van Vlecks well.https://digitalcommons.hope.edu/vrp_1850s/1334/thumbnail.jp

Occupational Therapy Interventions for ADLs in Adults Post-TBI with Visual Symptoms: A Systematic Review

PURPOSE: Traumatic brain injury (TBI) is a leading cause of death and injury in the United States. In fact, it is estimated that 1.5 million Americans experience them every year (CDC, 2022). Visual impairments may be a symptom following TBI (Richman, 2014). This affects an individual’s ability to perform activities of daily living (ADLs) such as dressing, hygiene, and functional mobility, including the reading required for these activities. The purpose of this systematic review was to synthesize the evidence and intervention options within the scope of occupational therapy for adults post-TBI experiencing visual symptoms. DESIGN: We conducted a systematic review of the literature from 2002 to 2022 that included adults 18 years and older post TBI, had a measurable ADL outcome, and were within the scope of occupational therapy. METHOD: We reviewed 163 articles and abstracts from CINAHL, Cochrane, PubMed, and Scopus databases. Eighty-seven articles were retrieved for full review and seven met inclusion criteria. U.S. Preventative Task Force levels of certainty and grade definitions were used to describe the strength of evidence. RESULTS: Articles were themed by intervention type: oculomotor and compensatory scanning training, and training in device use. Five articles ranging from Level I-III evidence focused on oculomotor and compensatory scanning training and provide moderate strength of evidence to improve ADL performance post-TBI. Oculomotor and compensatory scanning training dosages ranged from 20 to 90 minutes sessions 1-2 times a week, for 4 to 11 weeks. Two articles, one each of Level II and III evidence, addressed training in device use, providing low strength of evidence to improve ADL performance post-TBI. These devices may include the BrainPort Vision Pro, prisms, a dichoptic device, or a cheiroscope with 4-10 hours of training. CONCLUSION: Based on moderate strength of evidence, we recommend routine use of oculomotor and compensatory scanning training for individuals experiencing visual symptoms post-TBI. Device use training should be done on a case-by-case basis due to low strength of evidence. Many of the interventions in this systematic review were exercise- rather than occupation-based. Rote eye exercises without link to occupation may be considered outside the occupational therapy scope of practice, therefore integration with occupation and collaboration with an eye care professional is important. Practitioners should consider collaborating with researchers to design occupation-based interventions that can be tested with larger sample sizes to determine effective interventions to improve ADL performance in adults post-TBI experiencing visual symptoms. Professional development can ensure occupational therapists have advanced training and education in oculomotor and compensatory scanning. IMPACT STATEMENT: Current research supports oculomotor and compensatory scanning training for adults post-TBI experiencing visual symptoms. Future research should continue to explore occupation-based interventions for this population to maximize visual function for performance of everyday activities. REFERENCES: Centers for Disease Control and Prevention. (2022, January 6). Multiple cause of death data on CDC wonder. Centers for Disease Control and Prevention. https://wonder.cdc.gov/mcd.html Richman, E. (2014, March). Traumatic brain injury and visual disorders: What every ophthalmologist should know. American Academy of Ophthalmology; EyeNet Magazine. https://www.aao.org/eyenet/article/traumatic-brain-injury-visual-disorders-what-every-2https://digitalcommons.unmc.edu/cahp_ot_sysrev/1001/thumbnail.jp

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth in response to the nutrient and energy status of the cell, and its deregulation is common in human cancers. Little is known about the overall architecture and subunit organization of this essential signaling complex. We have determined the three-dimensional (3D) structure of the fully assembled human mTORC1 by cryo-electron microscopy (cryo-EM). Our analyses reveal that mTORC1 is an obligate dimer with an overall rhomboid shape and a central cavity. The dimeric interfaces are formed by interlocking interactions between the mTOR and raptor subunits. Extended incubation with FKBP12-rapamycin compromises the structural integrity of mTORC1 in a stepwise manner, leading us to propose a model in which rapamycin inhibits mTORC1-mediated phosphorylation of 4E-BP1 and S6K1 through different mechanisms.National Institutes of Health (U.S.) (Grant AI47389)National Institutes of Health (U.S.) (Grant CA103866)United States. Dept. of Defense (W81XWH-07-1-0448)W. M. Keck Foundatio

Erythropoietin mediated bone formation is regulated by mTOR signaling

The role of erythropoietin (Epo) and Epo/Epo receptor (EpoR) signaling pathways for production of red blood cells are well established. However, little is known about Epo/EpoR signaling in non‐hematopoietic cells. Recently, we demonstrated that Epo activates JAK/STAT signaling in hematopoietic stem cells (HSCs), leading to the production of bone morphogenetic protein 2 (BMP2) and bone formation and that Epo also directly activates mesenchymal cells to form osteoblasts in vitro. In this study, we investigated the effects of mTOR signaling on Epo‐mediated osteoblastogenesis and osteoclastogenesis. We found that mTOR inhibition by rapamycin blocks Epo‐dependent and ‐independent osteoblastic phenotypes in human bone marrow stromal cells (hBMSCs) and ST2 cells, respectively. Furthermore, we found that rapamycin inhibits Epo‐dependent and ‐independent osteoclastogenesis in mouse bone marrow mononuclear cells and Raw264.7 cells. Finally, we demonstrated that Epo increases NFATc1 expression and decreases cathepsin K expression in an mTOR‐independent manner, resulting in an increase of osteoclast numbers and a decrease in resorption activity. Taken together, these results strongly indicate that mTOR signaling plays an important role in Epo‐mediated bone homeostasis. J. Cell. Biochem. 113: 220–228, 2012. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89548/1/23347_ftp.pd

Placental microbial–metabolite profiles and inflammatory mechanisms associated with preterm birth

There is growing emphasis on the potential significance of the placental microbiome and microbiome–metabolite interactions in immune responses and subsequent pregnancy outcome, especially in relation to preterm birth (PTB). This review discusses in detail the pathomechanisms of placental inflammatory responses and the resultant maternal–fetal allograft rejection in both microbial-induced and sterile conditions. It also highlights some potential placental-associated predictive markers of PTB for future investigation. The existence of a placental microbiome remains debatable. Therefore, an overview of our current understanding of the state and role of the placental microbiome (if it exists) and metabolome in human pregnancy is also provided. We critical evaluate the evidence for a placental microbiome, discuss its functional capacity through the elaborated metabolic products and also describe the consequent and more established fetomaternal inflammatory responses that stimulate the pathway to preterm premature rupture of membranes, preterm labour and spontaneous PTB