29 research outputs found

    Piecewise smoothed value picking regularization applied to 2-D TM and TE inverse scattering

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    The Stepwise Relaxed Value Picking (SRVP) regularization technique, proposed earlier for the iterative reconstruction of piecewise (quasi-) homogeneous objects, is a non-spatial technique, whereby the reconstruction unknowns are clustered around a limited number of-a-priori unknown-reference values. Artifacts have been observed in some 2-D and 3D complex permittivity reconstructions. This paper therefore combines the non-spatial SRVP technique with a spatial smoothing technique, whereby the reference values provided by the former-in each iteration-are employed by the latter to define separate smoothing regions. This way edges are preserved, since the spatial smoothing constraints in the cost function are active within but not across the region boundaries. This combined technique, denoted as Stepwise Relaxed Piecewise Smoothed Value Picking (SRPSVP) regularization, is formulated for the 2.5D microwave inverse scattering problem and is illustrated with reconstructions from the Institut Fresnel 2-D scattering database

    (Photo-)crosslinkable gelatin derivatives for biofabrication applications

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    Over the recent decades gelatin has proven to be very suitable as an extracellular matrix mimic for bio-fabrication and tissue engineering applications. However, gelatin is prone to dissolution at typical cell culture conditions and is therefore often chemically modified to introduce (photo-)crosslinkable functionalities. These modifications allow to tune the material properties of gelatin, making it suitable for a wide range of biofabrication techniques both as a bioink and as a biomaterial ink (component). The present review provides a non-exhaustive overview of the different reported gelatin modification strategies to yield crosslinkable materials that can be used to form hydrogels suitable for biofabrication applications. The different crosslinking chemistries are discussed and classified according to their mechanism including chain-growth and step-growth polymerization. The step-growth polymerization mechanisms are further classified based on the specific chemistry including different (photo-)click chemistries and reversible systems. The benefits and drawbacks of each chemistry are also briefly discussed. Furthermore, focus is placed on different biofabrication strategies using either inkjet, deposition or light-based additive manufacturing techniques, and the applications of the obtained 3D constructs

    Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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    Contains fulltext : 172380.pdf (publisher's version ) (Open Access
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