Arsenic in drinking water wells on the Bolivian high plain: field monitoring and effect of salinity on removal efficiency of iron-oxides-containing filters

In the rural areas around Oruro (Bolivia), untreated groundwater is used directly as drinking water. This research aimed to evaluate the general drinking water quality, with focus on arsenic (As) concentrations, based on analysis of 67 samples from about 16 communities of the Oruro district. Subsequently a filter using Iron Oxide Coated Sand (IOCS) and a filter using a Composite Iron Matrix (CIM) were tested for their arsenic removal capacity using synthetic water mimicking real groundwater. Heavy metal concentrations in the sampled drinking water barely exceeded WHO guidelines. Arsenic concentrations reached values up to 964 mu g L-1 and exceeded the current WHO provisional guideline value of 10 mu g L-1 in more than 50% of the sampled wells. The WHO guideline of 250 mg L-1 for chloride and sulphate was also exceeded in more than a third of the samples, indicating high salinity in the drinking waters. Synthetic drinking water could be treated effectively by the IOCS- and CIM-based filters reducing As to concentrations lower than 10 mu g L-1. High levels of chloride and sulphate did not influence As removal efficiency. However, phosphate concentrations in the range from 4 to 24 mg L-1 drastically decreased removal efficiency of the IOCS-based filter but had no effects on removal efficiency of the CIM-based filter. Results of this study can be used as a base for further testing and practical implementation of drinking water purification in the Oruro region

HST Imaging of Globular Clusters in the Edge--on Spiral Galaxies NGC 4565 and NGC 5907

We present a study of the globular cluster systems of two edge-on spiral galaxies, NGC4565 and NGC5907, from WFPC2 images in the F450W and F814W filters. The globular cluster systems of both galaxies appear to be similar to the Galactic globular cluster system. In particular, we derive total numbers of globular clusters of N_{GC}(4565)= 204+/-38 {+87}{-53} and N_{GC}(5907)=170+/-41 {+47}{-72} (where the first are statistical, the second potential systematic errors) for NGC4565 and NGC5907, respectively. This determination is based on a comparison to the Milky Way system, for which we adopt a total number of globular clusters of 180+/-20. The specific frequency of both galaxies is S_N~0.6: indistinguishable from the value for the Milky Way. The similarity in the globular cluster systems of the two galaxies is noteworthy since they have significantly different thick disks and bulge-to-disk ratios. This would suggest that these two components do not play a major role in the building up of a globular cluster system around late-type galaxies.Comment: Accepted for publication in the Astronomical Journal, 17 pages incl 5 figures, AAS style two columns. Also available at http://www.eso.org/~mkissler, Color version of figure 1 only available at http://www.eso.org/~mkissler (B/W version included

International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multi-centre cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within two weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1400 participants from 143 active centres in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modelling, treatment effects and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS. ClinicalTrials.gov Identifier: NCT01582763

Interstellar Polarization in M31

The wavelength dependence of interstellar polarization due to dust in M31 has been observed along four sightlines. Only one sightline had been measured previously.The globular clusters, S78, S150, S233 and Baade 327 were used as point sources to probe the interstellar dust in M31. The Serkowski law produces good fits for all the sightlines although the relationship between K and lambda(max) may be different from that found in the Galaxy. The results of this study imply that the slope K/lambda(max) may be significantly larger in M31. The Serkowski curves are significantly narrower than those of the same lambda(max) in the Galaxy and may require extreme modifications to the size distributions of silicate particles. The fits for the four sightlines reveal values of lambda(max) ranging from 4800 to 5500 A. These are consistent with average values of lambda(max) measured in the Galaxy and the Magellanic Clouds. The range measured for M31 corresponds to R(V) values of 2.7 to 3.1. The range in R(V) seen in the Galaxy is 2.5 to 5.5 implying, for this small sample, that the average size ofinterstellar grains in M31 is typically smaller than that seen for Galactic grains if the nature of the grains is the same. Also, the polarization efficiency for these sightlines is large although some bias is expected since sightlines known to have significant interstellar polarization were selected for the sample.Comment: 13 pages, 2 figures, AJ in press (June

Human Skeletal myopathy myosin mutations disrupt myosin head sequestration

Myosin heavy chains encoded by MYH7 and MYH2 are abundant in human skeletal muscle, and important for muscle contraction. However, it is unclear how mutations in these genes disrupt myosin structure and function leading to skeletal muscle myopathies termed myosinopathies. Here, we used multiple approaches to analyse the effects of common MYH7 and MYH2 mutations in the light meromyosin region of myosin (LMM). Analyses of expressed and purified MYH7 and MYH2 LMM mutant proteins combined with in-silico modelling showed that myosin coiled-coil structure and packing of filaments in vitro are commonly disrupted. Using muscle biopsies from patients, and Mant-ATP chase protocols to estimate the proportion of myosin heads that were super-relaxed, together with X-ray diffraction measurements to estimate myosin head order we found that basal myosin ATP consumption was increased and the myosin super-relaxed state was decreased in vivo. In addition, myofibre mechanics experiments to investigate contractile function showed myofibre contractility was not affected. These findings indicate that the structural remodelling associated with LMM mutations induces a pathogenic state in which formation of shutdown heads is impaired, thus increasing myosin head ATP demand in the filaments, rather than affecting contractility. These key findings will help design future therapies for myosinopathies

Crowdsourcing hypothesis tests: Making transparent how design choices shape research results

To what extent are research results influenced by subjective decisions that scientists make as they design studies? Fifteen research teams independently designed studies to answer fiveoriginal research questions related to moral judgments, negotiations, and implicit cognition. Participants from two separate large samples (total N > 15,000) were then randomly assigned to complete one version of each study. Effect sizes varied dramatically across different sets of materials designed to test the same hypothesis: materials from different teams renderedstatistically significant effects in opposite directions for four out of five hypotheses, with the narrowest range in estimates being d = -0.37 to +0.26. Meta-analysis and a Bayesian perspective on the results revealed overall support for two hypotheses, and a lack of support for three hypotheses. Overall, practically none of the variability in effect sizes was attributable to the skill of the research team in designing materials, while considerable variability was attributable to the hypothesis being tested. In a forecasting survey, predictions of other scientists were significantly correlated with study results, both across and within hypotheses. Crowdsourced testing of research hypotheses helps reveal the true consistency of empirical support for a scientific claim.</div

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI &lt;18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For school&#x2;aged children and adolescents, we report thinness (BMI &lt;2 SD below the median of the WHO growth reference) and obesity (BMI &gt;2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Impact of Energy and Climate Policies on Electricity Generation - Analysis based on Large-scale Unit Commitment Modeling

Electricity generation systems in Europe are undergoing dramatic changes, largely driven by changing energy and climate policies. In this dissertation, three evolutions are dealt with in particular: (1) the deployment of intermittent renewables in electricity systems such as wind and solar photovoltaics, (2) the integration of electricity markets and (3) the mitigation of CO2 emissions from the electricity sector. The focus of this dissertation is on the technical and cost-related aspects of electricity generation systems, taking an operational viewpoint (i.e., no investment decisions are studied in this work). The dissertation presents several case studies inspired by realistic and large-scale electricity systems. Concerning the deployment of intermittent renewables, the impact of variable renewable generation on cycling of conventional power plants is studied, as well as the impact of remote renewables—such as offshore wind—on grid congestions. Regarding the integration of electricity markets, this dissertation investigates the benefits of integrating reserve markets and discusses the flow-based market coupling implemented in Central Western European day-ahead markets. Finally, concerning CO2 emission abatement in the electricity sector, the impact of a CO2 emission price on the generation of electricity is studied, together with the policy interaction between the European emission trading system and the deployment of renewables. A unit commitment model has been developed and is used in this dissertation. This model, referred to as the LUSYM model, is a state-of-the-art deterministic unit commitment model, formulated as a tight and compact mixed-integer program and able to solve large-scale electricity systems within reasonable run times. The model includes power plant constraints, renewables curtailment, load curtailment, storage units, transmission grid constraints and reserve constraints. Benchmarking simulations show that the LUSYM model is competitive or outperforms commercial unit commitment packages in terms of optimality of simulation results and/or run times. All the case studies presented in this dissertation, providing qualitative and quantitative insights, indicate that electricity systems are indeed evolving in the direction envisioned by policy makers (at least when it comes to the deployment of renewables, the integration of electricity markets and the reduction of CO2 emissions). However, this dissertation also demonstrates that changing energy and climate policies pose new challenges to electricity systems, such as maintaining the system balance with a large share of intermittent generation. In this respect, unit commitment modeling plays an important role in evaluating policies and their impact on electricity generation systems, in order to develop effective and efficient policies.status: publishe