Abnormal haemoglobins in Cape Town

No Abstract

Zeta Function Zeros, Powers of Primes, and Quantum Chaos

We present a numerical study of Riemann's formula for the oscillating part of the density of the primes and their powers. The formula is comprised of an infinite series of oscillatory terms, one for each zero of the zeta function on the critical line and was derived by Riemann in his paper on primes assuming the Riemann hypothesis. We show that high resolution spectral lines can be generated by the truncated series at all powers of primes and demonstrate explicitly that the relative line intensities are correct. We then derive a Gaussian sum rule for Riemann's formula. This is used to analyze the numerical convergence of the truncated series. The connections to quantum chaos and semiclassical physics are discussed

Carotid intima-media thickness and its associations with type 2 diabetes mellitus in South Africans

OBJECTIVES: Carotid intima-media thickness (CIMT) is a surrogate marker of subclinical atherosclerosis and a predictor of cardiovascular events. Few studies in Africa have evaluated CIMT and its associations in people with type 2 diabetes mellitus. This study measured CIMT in a sample of mainly black South African patients with type 2 diabetes mellitus, and evaluated the association of demographic and clinical risk factors with CIMT. DESIGN: Cross-sectional study. SETTING: Kafalong Hospital, a large community hospital in Pretoria that mainly serves an urban black community. SUBJECTS: Patients with type 2 diabetes mellitus. OUTCOME MEASURES: We evaluated clinical, biochemical and CIMT ultrasound measurements in a standardised fashion. RESULTS: In 185 patients, the univariate significant predictors of mean far-wall CIMT were age [beta 0.007 (standard error 0.001)], systolic blood pressure [beta 0.001 (standard error 0.000)] and inverse serum creatinine [beta -8.15 (standard error 3.23)]. Low-density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B:A-1 ratio and apolipoprotein B:A-1 ratio > 1.2 all had p-values below 0.1, but above 0.05. Age had the largest R-squared (20%). The multivariate models did not explain more of the variation in CIMT than did age alone. CONCLUSION: Lipid parameters were related to CIMT in our study population. However, this did not reach statistical significance in this relatively small sample, and lipids added very little to the variability of CIMT compared with age alone.http://www.jemdsa.co.za/index.php/JEMDSAay201

Track E Implementation Science, Health Systems and Economics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Fundamental restructuring of Durban's public transport system : the user preference study

Paper presented at the 20th Annual South African Transport Conference 16 - 20 July 2001 "Meeting the transport challenges in Southern Africa", CSIR International Convention Centre, Pretoria, South Africa.This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document Transformation Technologies Postal Address: PO Box 560 Irene 0062 South Africa. Tel.: +27 12 667 2074 Fax: +27 12 667 2766 E-mail: [email protected] URL: http://www.doctech.co.z

Carotid intima-media thickness and its associations with type 2 diabetes mellitus in South Africans

Objectives: Carotid intima-media thickness (CIMT) is a surrogate marker of subclinical atherosclerosis and a predictor of cardiovascular events. Few studies in Africa have evaluated CIMT and its associations in people withtype 2 diabetes mellitus. This study measured CIMT in a sample of mainly black South African patients with type 2 diabetes mellitus, and evaluated the association of demographic and clinical risk factors with CIMT.Design: Cross-sectional study.Setting: Kafalong Hospital, a large community hospital in Pretoria that mainly serves an urban black community.Subjects: Patients with type 2 diabetes mellitus.Outcome measures: We evaluated clinical, biochemical and CIMT ultrasound measurements in a standardised fashion.Results: In 185 patients, the univariate significant predictors of mean far-wall CIMT were age [beta 0.007 (standard error 0.001)], systolic blood pressure [beta 0.001 (standard error 0.000)] and inverse serum creatinine [beta -8.15 (standard error 3.23)]. Low-density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B:A-1 ratio and apolipoprotein B:A-1 ratio &gt; 1.2 all had p-values below 0.1, but above 0.05. Age had the largest R-squared (20%). The multivariate models did not explain more of the variation in CIMT than did age alone.Conclusion: Lipid parameters were related to CIMT in our study population. However, this did not reach statistical significance in this relatively small sample, and lipids added very little to the variability of CIMT compared with age alone

Carotid intima-media thickness and its associations with type 2 diabetes mellitus in South Africans

OBJECTIVES: Carotid intima-media thickness (CIMT) is a surrogate marker of subclinical atherosclerosis and a predictor of cardiovascular events. Few studies in Africa have evaluated CIMT and its associations in people with type 2 diabetes mellitus. This study measured CIMT in a sample of mainly black South African patients with type 2 diabetes mellitus, and evaluated the association of demographic and clinical risk factors with CIMT. DESIGN: Cross-sectional study. SETTING: Kafalong Hospital, a large community hospital in Pretoria that mainly serves an urban black community. SUBJECTS: Patients with type 2 diabetes mellitus. OUTCOME MEASURES: We evaluated clinical, biochemical and CIMT ultrasound measurements in a standardised fashion. RESULTS: In 185 patients, the univariate significant predictors of mean far-wall CIMT were age [beta 0.007 (standard error 0.001)], systolic blood pressure [beta 0.001 (standard error 0.000)] and inverse serum creatinine [beta -8.15 (standard error 3.23)]. Low-density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B:A-1 ratio and apolipoprotein B:A-1 ratio > 1.2 all had p-values below 0.1, but above 0.05. Age had the largest R-squared (20%). The multivariate models did not explain more of the variation in CIMT than did age alone. CONCLUSION: Lipid parameters were related to CIMT in our study population. However, this did not reach statistical significance in this relatively small sample, and lipids added very little to the variability of CIMT compared with age alone.http://www.jemdsa.co.za/index.php/JEMDSAay201

Pretoriana, no. 050 & 051, Apr & Aug 1966

Voorwoord = Preface / N.A. Coetzee -- Die republikeinse strewe in die geskiedenis van Suid-Afrika / F.J. du Toit Spies & M.C. van Zyl -- Kommandant-generaal A.H. Potgieter / Jan Ploeger -- Kommandant-generaal A.W.J. Pretorius / F.A. van Jaarsveld -- President J.P. Hoffman / Jan Ploeger -- President J.N. Boshof / F.J. du Toit Spies -- President J.H. Brand / M.C. van Schoor -- President F.W. Reitz / F.J. du Toit Spies -- President M.Y. Steyn / F.J. du Toit Spies -- Administrateur N.C. Gey van Pittius / W.J. de Kock -- President L.J. Meyer / Anoniem -- President S. Parker / W.S. Robertson -- Administrateur G.J. van Niekerk / W.J. de Kock -- President M.W. Pretorius / F.A. van Jaarsveld -- President W.C. Janse van Rensburg / H.M. Rex -- President T.F. Burgers / M.C. van Zyl -- President S.J.P. Kruger / J.I. Rademeyer -- Staatspresident C.R. Swar