Isolated deep earthquakes beneath the North Island of New Zealand

Seismicity shallows towards the south along the Tonga-Kermadec-Hikurangi margin, deep and intermediate seismicity being absent altogether in the South Island of New Zealand. Beneath the Taranaki region of the North Island the maximum depth of the main seismicity is 250 km, but very rare events occur directly below at 600 km. These could be associated with a detached slab or a vertical, aseismic continuation of the subducted Pacific Plate. Six small events that occurred in the 1990s were recorded extensively by digital instruments of the New Zealand National Network (NZNN) and temporary deployments. We relocate these events by a joint hypocentre determination (JHD) method and find their focal mechanisms using first motions and relative amplitudes of P and S arrivals. The earthquakes relocate to a remarkably uniform depth of 603 +/- 3 kmrelative error (+/- 10 km absolute error) in a line 30- km long orientated 40 NE, roughly parallel to the strike of the intermediate- depth seismicity. The only consistent component of the focal mechanisms is the tension axis: all lie close to horizontal and tend to align with the line of hypocentres. We interpret this deep seismic zone as a detached sliver of plate lying horizontally with the same orientation as the main subducted plate above. Volume change caused by a phase change controlled by the pressure at 600 km and temperature in the sliver produces a pattern of strain that places the sliver under tension along its lengt

Recent Insights into the Pathogenesis of Type AA Amyloidosis

The amyloidoses are a group of life-threatening diseases in which fibrils made of misfolded proteins are deposited in organs and tissues. The fibrils are stable, insoluble aggregates of precursor proteins that have adopted an antiparallel β-sheet structure. In type AA, or reactive, amyloidosis, the precursor protein of the fibrils is serum amyloid A (SAA). SAA is a 104-amino-acid protein that is produced in the liver in response to proinflammatory cytokines. Although the protein that is produced by the liver contains 104 amino acids, only the N-terminal 66–76 amino acids are found in amyloid fibrils. Furthermore, SAA has been shown to have an α-helical structure primarily. Thus, for SAA to be incorporated into an amyloid fibril, two processes have to occur: C-terminal cleavage and conversion into a β-sheet. Only a minority of patients with elevated SAA levels develop amyloidosis. Factors that contribute to the risk of amyloidosis include the duration and degree of SAA elevation, polymorphisms in SAA, and the type of autoinflammatory syndrome. In the Hyper-IgD syndrome, amyloidosis is less prevalent than in the other autoinflammatory diseases. In vitro work has shown that the isoprenoid pathway influences amyloidogenesis by farnesylated proteins. Although many proteins contain domains that have a potential for self-aggregation, amyloidosis is only a very rare event. Heat shock proteins (HSPs) are chaperones that assist other proteins to attain, maintain, and regain a functional conformation. In this review, recent insights into the pathogenesis of amyloidosis are discussed, in addition to a new hypothesis for a role of HSPs in the pathogenesis of type AA

Особливості функціонування оцінних дієслівних лексем у публіцистичному дискурсі

Стаття присвячена дослідженню семантико-стилістичних особливостей оціночної дієслівної лексики в публіцистичному дискурсі, виділенню тематичних груп інгерентно та адгерентно оціночної дієслівної лексики, а також визначенню основних типів сенсибилізації оціночних дієслів-прагмем. Ключові слова: публіцистичний дискурс, дискурс, прагмема, іформема, дієслова інгерентної оцінки, адгерентно оціночні дієслова, дієслівна прагмема, сенсибілізація, лінгвістичні сенсибілізатори.Статья посвящена исследованию семантико-стилистических особенностей оценочной глагольной лексики в публицистическом дискурсе, выделению тематических групп ингерентно и адгерентно оценочной глагольной лексики, а также определению основных типов сенсибилизации оценочных глаголов-прагмем. Ключевые слова: публицистический дискурс, прагмема, информема, глаголы ингерентной оценки, адгерентно оценочные глаголы, глагольная прагмема, сенсибилизация, лингвистические сенсибилизаторы.The article is dedicated to study of the semantic-stylistic features of estimated verbal vocabulary in publicistic discourse, to allocation of thematic groups ingerentno and angerentno estimated verbal vocabulary, and also to definition of the basic types of a sensubulisation of estimated verbs-pragmem. Keywords: Publicistic discourse, pragmems, informem, the ingerentno estimated verbs, the angerentno estimated verbs, verbal pragmems, a sensubulisation, linguistic sensubulisator

Пов’язка для лікування гнійно-некротичних ран у хворих на цукровий діабет

Разработана и клинически апробирована повязка для лечения гнойно-некротических ран у больных сахарным диабетом. Её использование способствует значительному улучшению результатов лечения и эффективной реабилитации этой категории больных.Developed and clinically tested for the treatment of necrotic wounds in diabetic patients. Its use greatly improve the results of treatment and effective rehabilitation of these patients

Low-ILUC-risk rapeseed biodiesel:potential and indirect GHG emission effects in Eastern Romania

Indirect land-use change (ILUC) can have a severe impact on the greenhouse gas (GHG) balance of biofuels. Mitigating ILUC risk is important to avoid additional GHG emissions compared to fossil fuels. This is possible by making surplus land available through land demand reduction and using this for low-ILUC-risk biodiesel production. For a case study in Eastern Romania, we calculated the rapeseed biodiesel potential and the GHG emissions of four measures to make surplus land available in 2020. Four scenarios varying in assumptions on productivity and sustainability in the agricultural sector show the variation in the potential of these measures. We find that using surplus land to produce low-ILUC-risk rapeseed biodiesel has a potential of 3-64 PJ, 1-28% of the projected Romanian transport diesel consumption. The main contribution to this potential comes from yield improvements in crop and livestock production. Average GHG emissions of the ILUC mitigation measures are -11 to 22 g CO2-eq MJ−1 (maximum total lifecycle emissions are 34 g CO2-eq MJ−1; 60% reduction from fossil fuel reference). This means ILUC mitigation is possible without necessarily missing the GHG emission reduction target, provided that the entire agricultural sector is sustainably intensified, going beyond a focus on biofuel production alone

Projecting socio-economic impacts of bioenergy:Current status and limitations of ex-ante quantification methods

The socio-economic effects of bio-energy are not unequivocally positive, although it is one of the main arguments for supporting its expansion. An ex-ante quantification of the impacts is necessary for transparently presenting the benefits and burdens of bioenergy before they occur, and for minimising unwanted outcomes. In this article, the status, limitations, and possibilities for improvements in ex-ante quantitative research methods for investigating socio-economic impacts of bioenergy are mapped. For this, a literature review to identify relevant indicators, analyse the latest quantitative ex-ante research methods, and to assess their ability and suitability to measure these indicators was performed. The spatial aggregation of existing analyses was specifically considered because quantitative information on different spatial scales shows the geographic distribution of the effects. From the 236 indicators of socio-economic impacts spread over twelve impact categories that were found in this review, it becomes evident that there are clear differences in the ex-ante quantification of these indicators. The review shows that some impact categories receive more attention in ex-ante quantification studies, such as project-level economic feasibility and national-level macroeconomic impacts, while other relevant indicators have not been ex-ante quantified, such as community impacts and public acceptance. Moreover, a key blind spot regarding food security impacts was identified in the aggregation level at which food security impacts are quantified, which does not match the level at which the impacts occur. The review also shows that much more can be done in terms of ex-ante quantification of these impacts. Specifically, spatial disaggregation of models and model collaboration can extend the scope of socio-economic analyses. This is demonstrated for food security impacts, which shows the potential for future household-level analysis of food security impacts on all four pillars of food security

Imaging along-strike variations in mechanical properties of the Gofar transform fault, East Pacific Rise

Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 119 (2014): 7175–7194, doi:10.1002/2014JB011270.A large part of global plate motion on mid-ocean ridge transform faults (RTFs) is not accommodated as major earthquakes. When large earthquakes do occur, they often repeat quasiperiodically. We focus here on the high slip rate (∼14 cm/yr) Gofar transform fault on the equatorial East Pacific Rise. This fault is subdivided into patches that slip during Mw 5.5–6 earthquakes every 5 to 6 years. These patches are separated by rupture barriers that accommodate slip through swarms of smaller events and/or aseismic creep. We performed an imaging study to investigate which spatiotemporal variations of the fault zone properties control this segmentation in mechanical behavior and could explain the specific behavior of RTFs at the global scale. We adopt a double-difference approach in a joint inversion of active air gun shots and microseismicity recorded for 1 year. This data set includes the 2008 Mw 6 Gofar earthquake. The along-strike P wave velocity structure reveals an abrupt transition between the barrier area, characterized by a damaged fault zone of 10–20% reduced Vp and a nearly intact fault zone in the asperity area. The importance of the strength of the damage zone on the mechanical behavior is supported by the temporal S wave velocity changes which suggest increased damage within the barrier area, during the week preceding the Mw 6 earthquake. Our results support the conclusion that extended highly damaged zones are the key factor in limiting the role of major earthquakes to accommodate plate motion along RTFs.The material presented here is based on work supported by the National Science Foundation grants 1232725 and 0242117.2015-03-2

Impact of cumulative complications on 1-year treatment-related healthcare costs in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

BACKGROUND: The aim of this study was to evaluate the impact of all minor and major complications on treatment-related healthcare costs in patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of colorectal peritoneal metastases (PMs). METHOD: Patients with histologically proven colorectal PMs who underwent CRS + HIPEC from March 2006 to October 2019 in a tertiary referral centre were retrospectively identified from a prospectively maintained database. Patients were divided into six subgroups according to the severity of the complications, which were scored using the comprehensive complication index (CCI) (CCI 0-9.9, CCI 10-19.9, CCI 20-29.9, CCI 30-39.9, CCI 40-49.9, and CCI 50 or higher). Treatment-related healthcare costs up to 1 year after CRS + HIPEC were obtained from the financial department. Differences in costs and survival outcomes were compared using the chi-squared test and Kruskal-Wallis H test. RESULTS: A total of 142 patients were included (CCI 0-9.9, 53 patients; CCI 10-19.9, 0 patients; CCI 20-29.9, 45 patients; CCI 30-39.9, 14 patients; CCI 40-49, 9 patients; and CCI 50 or higher, 21 patients). Median (interquartile range) treatment-related healthcare costs increased significantly and exponentially for the CCI 30-39, CCI 40-49, and CCI 50 or higher groups (€48 993 (€44 262-€84 805); €57 167 (€43 047-€67 591); and €82 219 (€55 487-€145 314) respectively) compared with those for the CCI 0-9.9 and CCI 20-29.9 groups (€33 856 (€24 433-€40 779) and €40 621 (€31 501-€58 761) respectively, P < 0.010). CONCLUSION: Treatment-related healthcare costs increase exponentially as more complications develop among patients who undergo CRS + HIPEC for the treatment of colorectal PMs. Anastomotic leakages after CRS + HIPEC lead to an increase of 295 per cent of treatment-related healthcare costs