Effect of local treatments of convection upon the solar p-mode excitation rates

We compute, for several solar models, the rates P at which the solar radial p modes are expected to be excited. The solar models are computed with two different local treatments of convection : the classical mixing-length theory (MLT hereafter) and Canuto, Goldmann and Mazzitelli(1996, CGM hereafter)'s formulation. For one set of solar models (EMLT and ECGM models), the atmosphere is gray and assumes Eddington's approximation. For a second set of models (KMLT and KCGM models), the atmosphere is built using a T(tau) law which has been obtained from a Kurucz's model atmosphere computed with the same local treatment of convection. The mixing-length parameter in the model atmosphere is chosen so as to provide a good agreement between synthetic and observed Balmer line profiles, while the mixing-length parameter in the interior model is calibrated so that the model reproduces the solar radius at solar age. For the MLT treatment, the rates P do depend significantly on the properties of the atmosphere. On the other hand, for the CGM treatment, differences in P between the ECGM and the KCGM models are very small compared to the error bars attached to the seismic measurements. The excitation rates P for modes from the EMLT model are significantly under-estimated compared with the solar seismic constraints. The KMLT model results in intermediate values for P and shows also an important discontinuity in the temperature gradient and the convective velocity. On the other hand, the KCGM model and the ECGM model yield values for P closer to the seismic data than the EMLT and KMLT models. We conclude that the solar p-mode excitation rates provide valuable constraints and according to the present investigation cleary favor the CGM treatment with respect to the MLT.Comment: 4 pages, 3 figures, proceedings of the SOHO14/GONG 2004 workshop "Helio- and Asteroseismology: Towards a Golden Future" from July 12-16 2004 at New Haven CT (USA

Influence of local treatments of convection upon solar p mode excitation rates

We compute the rates P at which acoustic energy is injected into the solar radial p modes for several solar models. The solar models are computed with two different local treatments of convection: the classical mixing-length theory (MLT hereafter) and Canuto et al (1996)'s formulation (CGM hereafter). Among the models investigated here, our best models reproduce both the solar radius and the solar luminosity at solar age and the observed Balmer line profiles. For the MLT treatment, the rates P do depend significantly on the properties of the atmosphere whereas for the CGM's treatment the dependence of P on the properties of the atmosphere is found smaller than the error bars attached to the seismic measurements. The excitation rates P for modes associated with the MLT models are significantly underestimated compared with the solar seismic constraints. The CGM models yield values for P closer to the seismic data than the MLT models. We conclude that the solar p-mode excitation rates provide valuable constraints and according to the present investigation clearly favor the CGM treatment with respect to the MLT, although neither of them yields values of P as close to the observations as recently found for 3D numerical simulations.Comment: 11 pages, 7 figures, accepted for publication in Astronomy & Astrophysic

Effect of convective outer layers modeling on non-adiabatic seismic observables of delta Scuti stars

The identification of pulsation modes in delta Scuti stars is mandatory to constrain the theoretical stellar models. The non-adiabatic observables used in the photometric identification methods depend, however,on convection modeling in the external layers. Our aim is to determine how the treatment of convection in the atmospheric and sub-atmospheric layers affects the mode identification, and what information about the thermal structure of the external layers can be obtained from amplitude ratios and phase lags in Str\"omgren photometric bands. We derive non-adiabatic parameters for delta Scuti stars by using, for the first time, stellar models with the same treatment of convection in the interior and in the atmosphere. We compute classical non-gray mixing length models, and as well non-gray ``Full Spectrum of Turbulence'' models. Furthermore, we compute the photometric amplitudes and phases of pulsation by using the colors and the limb-darkening coefficents as derived from the same atmosphere models used in the stellar modeling. We show that the non-adiabatic phase-lag is mainly sensitive to the thermal gradients in the external layers, (and hence to the treatment of convection), and that this sensitivity is also clearly reflected in the multi-color photometric phase differences.Comment: 14 pag. 19 figs. accepted for publication in Astronomy and Astrophysic

Impact of granulation effects on the use of Balmer lines as temperature indicators

Balmer lines serve as important indicators of stellar effective temperatures in late-type stellar spectra. One of their modelling uncertainties is the influence of convective flows on their shape. We aim to characterize the influence of convection on the wings of Balmer lines. We perform a differential comparison of synthetic Balmer line profiles obtained from 3D hydrodynamical model atmospheres and 1D hydrostatic standard ones. The model parameters are appropriate for F,G,K dwarf and subgiant stars of metallicity ranging from solar to 1/1000 solar. The shape of the Balmer lines predicted by 3D models can never be exactly reproduced by a 1D model, irrespective of its effective temperature. We introduce the concept of a 3D temperature correction, as the effective temperature difference between a 3D model and a 1D model which provides the closest match to the 3D profile. The temperature correction is different for the different members of the Balmer series and depends on the adopted mixing-length parameter in the 1D model. Among the investigated models, the 3D correction ranges from -300K to +300K. Horizontal temperature fluctuations tend to reduce the 3D correction. Accurate effective temperatures cannot be derived from the wings of Balmer lines, unless the effects of convection are properly accounted for. The 3D models offer a physically well justified way of doing so. The use of 1D models treating convection with the mixing-length theory do not appear to be suitable for this purpose. In particular, there are indications that it is not possible to determine a single value of the mixing-length parameter which will optimally reproduce the Balmer lines for any choice of atmospheric parameters.Comment: 6 pages, 3 figures, accepted for publication in A&

A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer

BACKGROUND: The detection of circulating tumour cells (CTCs) has been linked with poor prognosis in advanced breast cancer. Relatively few studies have been undertaken to study the clinical relevance of CTCs in early-stage breast cancer. METHODS: In a prospective study, we evaluated CTCs in the peripheral blood of 82 early-stage breast cancer patients. Control groups consisted of 16 advanced breast cancer patients and 45 healthy volunteers. The CTC detection was performed using ErbB2/EpCAM immunomagnetic tumour cell enrichment followed by multimarker quantitative PCR (QPCR). The CTC status and common clinicopathological factors were correlated to relapse-free, breast cancer-related and overall survival. RESULTS: Circulating tumour cells were detected in 16 of 82 (20%) patients with early-stage breast cancer and in 13 out of 16 (81%) with advanced breast cancer. The specificity was 100%. The median follow-up time was 51 months (range: 17 -60). The CTC positivity in early-stage breast cancer patients resulted in significantly poorer relapse-free survival (log rank test: P ¼ 0.003) and was an independent predictor of relapse-free survival (multivariate hazard ratio ¼ 5.13, P ¼ 0.006, 95% CI: 1.62 -16.31). CONCLUSION: The detection of CTCs in peripheral blood of early-stage breast cancer patients provided prognostic information for relapse-free survival

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Background: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell membranes, thus slowing elimination and prolonging their effects. Recent evidence suggests, instead, that they induce prolonged desensitization of the κ opioid receptor. Methods To evaluate these hypotheses, we measured relevant physicochemical properties of nor-BNI, GNTI and JDTic, and the timecourse of brain and plasma concentrations in mice after intraperitoneal administration (using LC-MS-MS). Results: In each case, plasma levels were maximal within 30 min and declined by >80% within four hours, correlating well with previously reported transient effects. A strong negative correlation was observed between plasma levels and the delayed, prolonged timecourse of κ antagonism. Brain levels of nor-BNI and JDTic peaked within 30 min, but while nor-BNI was largely eliminated within hours, JDTic declined gradually over a week. Brain uptake of GNTI was too low to measure accurately, and higher doses proved lethal. None of the drugs were highly lipophilic, showing high water solubility (> 45 mM) and low distribution into octanol (log D7.4 7% unbound). JDTic showed P-gp-mediated efflux; nor- BNI and GNTI did not, but their low unbound brain uptake suggests efflux by another mechanism. Conclusions: The negative plasma concentration-effect relationship we observed is difficult to reconcile with simple competitive antagonism, but is consistent with desensitization. The very slow elimination of JDTic from brain is surprising given that it undergoes active efflux, has modest affinity for homogenate, and has a shorter duration of action than nor-BNI under these conditions. We propose that this persistence may result from entrapment in cellular compartments such as lysosomes

A systematic review of methods to assess intake of fruits and vegetables among healthy European adults and children: a DEDIPAC (DEterminants of DIet and Physical Activity) study

Evidence suggests that health benefits are associated with consuming recommended amounts of fruits and vegetables (F&V), yet standardised assessment methods to measure F&V intake are lacking. The current review aims to identify methods to assess F&V intake among children and adults in pan-European studies and inform the development of the DEDIPAC (DEterminants of DIet and Physical Activity) toolbox of methods suitable for use in future European studies. A literature search was conducted using three electronic databases and by hand-searching reference lists. English-language studies of any design which assessed F&V intake were included in the review. Studies involving two or more European countries were included in the review. Healthy, free-living children or adults. The review identified fifty-one pan-European studies which assessed F&V intake. The FFQ was the most commonly used (n 42), followed by 24 h recall (n 11) and diet records/diet history (n 7). Differences existed between the identified methods; for example, the number of F&V items on the FFQ and whether potatoes/legumes were classified as vegetables. In total, eight validated instruments were identified which assessed F&V intake among adults, adolescents or children. The current review indicates that an agreed classification of F&V is needed in order to standardise intake data more effectively between European countries. Validated methods used in pan-European populations encompassing a range of European regions were identified. These methods should be considered for use by future studies focused on evaluating intake of F&V