Spectral analysis and experimental study of lateral capillary dynamics for flip-chip applications

This article presents a study on the dynamics of lateral motion of a liquid meniscus confined by a pad and a chip moving parallel to the pad. This problem is a typical flip-chip case study, whose use is widespread in industrial assembly. The proposed model describing this dynamics is built upon two coupled physics: the Navier-Stokes equation governing the liquid flow between the pad and the chip, and the Newton's law describing the motion of the chip. This coupled problem is solved with a spectral method based on Chebyshev polynomials, by assuming a linear analytical expression of the lateral stiffness of the meniscus in the cases of circular and square pads. The theoretical results are benchmarked with literature results and thoroughly experimentally validated. From these results, we propose a map giving the characteristic time of the chip dynamics according to only two non-dimensional parameters, constructed with the physical (density, surface tension, and viscosity), geometrical (pad area and gap), or dynamical (chip mass) parameters of the problem

Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice

Genome-wide association studies linked diacylglycerol kinase eta and iota to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized female mice lacking Dgkh alone, Dgki alone, and double Dgkh/Dgki-knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survived to weaning when raised by wild-type (WT) females. Poor survival under the care of dKO mothers was unrelated to pup genotype. Moreover, pups from dKO dams survived when fostered by WT dams, suggesting the poor survival rate of dKO-raised litters was related to impaired maternal care by dKO dams. Nest building was similar between WT and dKO dams; however, some dKO females failed to retrieve any pups in a retrieval assay. Pups raised by dKO dams had smaller or absent milk spots and reduced weight, indicative of impaired nursing. Unlike WT females, postpartum dKO females showed erratic, panicked responses to cage disturbances. Virgin dKO females showed behavioral signs of anxiety and mania, which were not seen in mice lacking either Dgkh or Dgki alone. Our research indicates that combined deletion of Dgkh and Dgki impairs maternal behavior in the early postpartum period, and suggests female dKO mice model symptoms of mania and anxiety

Spectral analysis and experimental study of lateral capillary dynamics for flip-chip applications

status: publishe

Mapping the Oxford Shoulder Score onto the EQ-5D utility index

Purpose In order to enable cost-utility analysis of shoulder pain conditions and treatments, this study aimed to develop and evaluate mapping algorithms to estimate the EQ-5D health index from the Oxford Shoulder Score (OSS) when health outcomes are only assessed with the OSS. Methods 5437 paired OSS and EQ-5D questionnaire responses from four national multicentre randomised controlled trials investigating different shoulder pathologies and treatments were split into training and testing samples. Separate EQ-5D-3L and EQ-5D-5L analyses were undertaken. Transfer to utility (TTU) regression (univariate linear, polynomial, spline, multivariable linear, two-part logistic-linear, tobit and adjusted limited dependent variable mixture models) and response mapping (ordered logistic regression and seemingly unrelated regression (SUR)) models were developed on the training sample. These were internally validated, and their performance evaluated on the testing sample. Model performance was evaluated over 100-fold repeated training–testing sample splits. Results For the EQ-5D-3L analysis, the multivariable linear and splines models had the lowest mean square error (MSE) of 0.0415. The SUR model had the lowest mean absolute error (MAE) of 0.136. Model performance was greatest in the mid-range and best health states, and lowest in poor health states. For the EQ-5D-5L analyses, the multivariable linear and splines models had the lowest MSE (0.0241–0.0278) while the SUR models had the lowest MAE (0.105–0.113). Conclusion The developed models now allow accurate estimation of the EQ-5D health index when only the OSS responses are available as a measure of patient-reported health outcome

Far Infrared to identify venous impairment after breast cancer surgery -

info:eu-repo/semantics/publishe