Clinical quiz.

J Pediatr Gastroenterol Nutr. 2005 Oct;41(4):483-4, 484. Clinical quiz. Prior AC, Selores M, Pina R, Dias JA, Costa FM, Vale L, Gomes L. Department of Pediatrics, Hospital Geral de Santo António, Portugal. PMID: 16205521 [PubMed - indexed for MEDLIN

Single neutral heavy lepton production at electron-muon colliders

New heavy Majorana and Dirac neutrinos production at future electron-muon colliders are investigated. The production of a single heavy neutrino is shown to be more relevant than pair production when comparing cross sections and neutrino mass ranges. The process $e^\pm \mu^\mp \longrightarrow {\nu} \ell^{\pm} W^{\mp}$ is studied including on-shell and off-shell heavy neutrino effects. Distributions are calculated including hadronization effects and experimental cuts that suppress background, in order to have a clear signal for heavy neutral leptons.Comment: 4 pages, 14 jpg figures, Published Phys.Lett B494 (2000) 273-27

Efficient α-methylenation Of Carbonyl Compounds In Ionic Liquids At Room Temperature

The application of several 1-butyl-3-methylimidazolium (BMIM) salt ionic liquids as solvent in the α-methylenation of carbonyl compounds at room temperature is reported. The ionic liquid [BMIM][NTf 2] gave a clean reaction in a short time and good yields of several α-methylene carbonyl compounds. This ionic liquid was reused without affecting the reaction rates or yields over seven runs. © Georg Thieme Verlag Stuttgart.17578Stiger, K.D., Mar-Tang, R., Bartlet, P.A., (1999) J. Org. Chem, 64, p. 8409Weingarten, M.D., Skudlarek, J., Sikorski, J.A., (2006), PCT Int. Appl. WO 2006004903Mori, K., Yajima, A., Takikawa, H., (1996) Liebigs. Ann, p. 891Picman, A.K., (1986) Biochem. Syst. Ecol, 14, p. 255Schmidt, T.J., (1999) Curr. Org. Chem, 3, p. 577Basavaiah, D., Rao, A.J., Satyanarayana, T., (2003) Chem. Rev, 103, p. 811Kagan, H.B., Riant, O., (1992) Chem. 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Commun, p. 2041Hon, Y.S., Chang, F.-J., Lu, L., Lin, W.C., (1998) Tetrahedron, 54, p. 5233Hon, Y.S., Chen, H.F., (2007) Tetrahedron Lett, 48, p. 8611Hon, Y.S., Hsieh, C.H., (2006) Tetrahedron, 41, p. 9713Hon, Y.S., Hsieh, C.H., Liu, Y.W., (2005) Tetrahedron, 61, p. 2713Hon, Y.S., Liu, Y.W., Hsieh, C.H., (2004) Tetrahedron, 60, p. 4837For the total synthesis of brevetoxin B (second to last step), see: (a) Nicolaou, K. C.Rutjes, F. P. J. T.Theodorakis, E. A.Tiebes, J.Sato, M.Untersteller, E. J. Am. Chem. Soc. 1995, 117, 1173Nicolaou, K.C., Reddy, K.R., Skokotas, G., Fuminori, S., Xiao, X.-Y., (1992) J. Am. Chem. Soc, 114, p. 7935. , See also: bCrimmins, M.T., Stanton, M.G., Allwein, S.P., (2002) J. Am. Chem. Soc, 124, p. 5958. , For the total synthesis of laulimalide, see: cAhmed, A., Hoegenauer, E.K., Enev, V.S., Hanbauer, M., Kaehlig, H., Ohler, E., Mulzer, J., (2003) J. Org. 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Catal, 49, p. 153Jain, N., Kumar, A., Chauban, S., Chauban, S.M.S., (2005) Tetahedron, 61, p. 1015Cassol, C.C., Eberling, G., Ferrera, B., Dupont, J., (2006) Adv. Synth. Catal, 324, p. 243Dupont, J., (2004) J. Braz. Chem. Soc, 15, p. 341Rosa, J.N., Afonso, C.A.M., Santos, A.G., (2001) Tetrahedron, 57, p. 4189Kumar, A., Pawar, S.S., (2003) J. Mol. Catal. A: Chem, 208, p. 33Marsh, K.N., Boxall, J.A., Lichtenthaler, R., (2004) Fluid Phase Equilibria, 219, p. 93Jiang, Y.-Y., Wang, G.-N., Zhou, Z., Wu, Y.-T., Geng, J., Zhang, Z.-B., (2008) Chem. Commun, p. 505Pihko, P.M., Erkkila, A., (2006) J. Org. Chem, 71, p. 2538Spectroscopic Data for Ethyl 3-Methylene-2-oxo-4-phenylbutanoate (1) 1H NMR (300 MHz, CDCl3, δ, 1.36 (t, 3 H, J, 9 Hz, 3.65 (s, 2 H, 4.35 (q, 2 H, J, 9 Hz, 5.98 (s, 1 H, 6.23 (s, 1 H, 7.25 (m, 5 H, 13C NMR (75.5 MHz, CDCl3, δ, 14.0, 35.7, 62.2, 126.5, 128.6, 129.2, 133.1, 137.6, 144.4, 163.9, 188.1. MS: m/z, 218 (5, M, 189 (4, 145 (43, 117 (100, 115 (76, 91 (40, 65 (18, 51 (19, Spectroscopic Data for Ethyl 2-Methylene-3-oxo-3-phenylpropionate(2) 1H NMR (300 MHz, CDCl3, δ, 1.10 (t, 3 H, J, 7.1 Hz, 4.19 (q, 2 H, J, 7.2 Hz, 6.2 (s, 1 H, 6.65 (s, 1 H, 7.44 (d, 2 H, J, 7.2 Hz, 7.52 (t, 1 H, J, 7.3 Hz, 7.84 (d, 2 H, J, 7.2 Hz, 13C NMR (75.5 MHz, CDCl3, δ, 14.0, 61.5, 128.5, 129.4, 131.3, 133.5, 136.3, 141.5, 164.0, 193.0. MS: m/z, 204 11, MYamauchi, M., Katayama, S., Watanabe, T., (1982) Synthesis, p. 935Hon, Y.-S., Hsu, T.-R., Chen, C.-Y., Lin, Y.-H., Chang, F.-J., Hsieh, C.-H., Szu, P.-H., (2003) Tetrahedron, 59, p. 1509Chatani, N., Kamitani, A., Oshita, M., Fukumoto, Y., Murai, S., (2001) J. Am. Chem. Soc, 123, p. 1268

Advanced code-division multiplexers for superconducting detector arrays

Multiplexers based on the modulation of superconducting quantum interference devices are now regularly used in multi-kilopixel arrays of superconducting detectors for astrophysics, cosmology, and materials analysis. Over the next decade, much larger arrays will be needed. These larger arrays require new modulation techniques and compact multiplexer elements that fit within each pixel. We present a new in-focal-plane code-division multiplexer that provides multiplexing elements with the required scalability. This code-division multiplexer uses compact lithographic modulation elements that simultaneously multiplex both signal outputs and superconducting transition-edge sensor (TES) detector bias voltages. It eliminates the shunt resistor used to voltage bias TES detectors, greatly reduces power dissipation, allows different dc bias voltages for each TES, and makes all elements sufficiently compact to fit inside the detector pixel area. These in-focal-plane code-division multiplexers can be combined with multi-gigahertz readout based on superconducting microresonators to scale to even larger arrays.Comment: 8 pages, 3 figures, presented at the 14th International Workshop on Low Temperature Detectors, Heidelberg University, August 1-5, 2011, proceedings to be published in the Journal of Low Temperature Physic

Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water

The transport of live fish is a routine practice in aquaculture and constitutes a considerable source of stress to the animals. The addition of anesthetic to the water used for fish transport can prevent or mitigate the deleterious effects of transport stress. This study investigated the effects of the addition of eugenol (EUG) (1.5 or 3.0 mu L L-1) and essential oil of Lippia alba (EOL) (10 or 20 mu L L-1) on metabolic parameters (glycogen, lactate and total protein levels) in liver and muscle, acetylcholinesterase activity (AChE) in muscle and brain, and the levels of protein carbonyl (PC), thiobarbituric acid reactive substances (TBARS) and nonprotein thiol groups (NPSH) and activity of glutathione-S-transferase in the liver of silver catfish (Rhamdia quelen; Quoy and Gaimard, 1824) transported for four hours in plastic bags (loading density of 169.2 g L-1). The addition of various concentrations of EUG (1.5 or 3.0 mu L L-1) and EOL (10 or 20 mu L L-1) to the transport water is advisable for the transportation of silver catfish, since both concentrations of these substances increased the levels of NPSH antioxidant and decreased the TBARS levels in the liver. In addition, the lower liver levels of glycogen and lactate in these groups and lower AChE activity in the brain (EOL 10 or 20 mu L L-1) compared to the control group indicate that the energetic metabolism and neurotransmission were lower after administration of anesthetics, contributing to the maintenance of homeostasis and sedation status.Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS/PRONEX) [10/0016-8]; Conselho Nacional de Pesquisa e Desenvolvimento Cientifico (CNPq) [470964/2009-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); CNPqinfo:eu-repo/semantics/publishedVersio

Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes

Este trabajo proporcionó la primera idea de que la deleción del Cr13 tiene valor pronóstico pe-yorativo en MM. Proporcionó las primeras pistas del valor de la FISH en MM, que sigue siendo la herramienta fundamental para evaluar el pronóstico en estos pacientes en todo el mundo[EN]Recent observations indicate that chromosome aberrations are important prognostic factors in patients with multiple myeloma (MM) treated with high-dose chemotherapy. Nevertheless, the inherent problems of conventional cytogenetics have hampered the systematic evaluation of this parameter in series of patients treated with conventional chemotherapy. Fluorescence in situ hybridization (FISH) analysis is an attractive alternative for evaluation of numerical chromosomal changes. In the present study, we analyze the relationship between aneuploidies of 15 different chromosomes assessed by FISH and prognosis in a series of 63 patients with MM treated with conventional chemotherapy. After a median follow-up of 61 months (range, 6 to 109), 49% of patients are still alive with a median survival of 33 months. The overall incidence of numerical chromosome abnormalities was 70%. This incidence significantly increased when seven or more chromosomes were analyzed (53 patients), reaching 81%. Trisomies of chromosomes 6, 9, and 17 were associated with prolonged survival (P = .033, P = .035, and P = .026, respectively); by contrast, overall survival (OS) was lower in cases with monosomy 13 (as assessed by deletion of Rb gene, P = .0012). From the clinical point of view, loss of Rb gene was associated with a poor performance status; low hemoglobin levels; high creatinine, C-reactive protein, and lactic dehydrogenase serum levels; high percentage of bone marrow plasma cells (BMPC); extensive bone lytic lesions; and advanced clinical stage. Other chromosome abnormalities such as trisomy of chromosome 9 and 17 were associated with good prognostic features including high hemoglobin levels, early clinical stage, beta2microglobulin less than 6 micro/mL, and low percentage of BMPC. A multivariate analysis for OS showed that S-phase PC greater than 3% (P = .010) and beta2microglobulin serum levels greater than 6 micro/mL (P = .024), together with monosomy of chromosome 13 (P = .031) and nontrisomy of chromosome 6 (P = .048) was the best combination of independent parameters for predicting survival in patients with MM. According to these results, chromosomal analysis is of great use in patients with MM at diagnosis to have a correct prognostic evaluation for clinical decision making.Hospital Universitario de Salamanca Universidad de SalamancaHospital Universitario de Salamanc

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters