Optically beamformed beam-switched adaptive antennas for fixed and mobile broadband wireless access networks

In this paper, a 3-bit optical beamforming architecture based in 2×2 optical switches and dispersive media is proposed and demonstrated. The performance of this photonic beamformer is experimentally demonstrated at 42.7 GHz in both transmission and reception modes. The progress achieved for realizing these architectures with integrated optics is also reported. Due to its advanced features (i.e., potential fast-switching, huge bandwidth, and immunity to electromagnetic interference), the architecture is a very promising alternative to traditional beamforming technologies for implementing beamformed base-station antennas in fixed and mobile broad-band wireless access networks operating in the millimeter-wave band. The study presented here has been carried out in the frame of the IST 2000-25390 OBANET project

Next-generation sequencing in a series of 80 fetuses with complex cardiac malformations and/or heterotaxy.

Herein, we report the screening of a large panel of genes in a series of 80 fetuses with congenital heart defects (CHDs) and/or heterotaxy and no cytogenetic anomalies. There were 49 males (61%/39%), with a family history in 28 cases (35%) and no parental consanguinity in 77 cases (96%). All fetuses had complex CHD except one who had heterotaxy and midline anomalies while 52 cases (65%) had heterotaxy in addition to CHD. Altogether, 29 cases (36%) had extracardiac and extra-heterotaxy anomalies. A pathogenic variant was found in 10/80 (12.5%) cases with a higher percentage in the heterotaxy group (8/52 cases, 15%) compared with the non-heterotaxy group (2/28 cases, 7%), and in 3 cases with extracardiac and extra-heterotaxy anomalies (3/29, 10%). The inheritance was recessive in six genes (DNAI1, GDF1, MMP21, MYH6, NEK8, and ZIC3) and dominant in two genes (SHH and TAB2). A homozygous pathogenic variant was found in three cases including only one case with known consanguinity. In conclusion, after removing fetuses with cytogenetic anomalies, next-generation sequencing discovered a causal variant in 12.5% of fetal cases with CHD and/or heterotaxy. Genetic counseling for future pregnancies was greatly improved. Surprisingly, unexpected consanguinity accounts for 20% of cases with identified pathogenic variants