Fascist di-visions of enjoyment and the perverse remainder: A psychoanalytic study

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Under the shade of escalating violence and fundamentalism, our epoch's diffused aura of liberalism supposedly tolerates difference, by exorcising the evil phantasms of totalitarianism, in favour of a liberal and humane post-modem order. Consequently, behind contemporary versions of evil, one demonises modem 'fascists', 'totalitarian threats', and 'Hitlers'. As if not obscure enough, fascist evil has been equivocally linked with perversion. Considering this link a tenebrous enigma, my thesis suggests that psychoanalysis can successfully elucidate its problematic and feeble basis, by reappraising previous narratives from a number of different discourses that inscribe the liaison between fascism and perversion in their representational stage. In a first approach, the present study dissects texts as heterogeneous, as film, social theory, political philosophy, and psychoanalysis. This is to show that, despite the divergent speculative angle that each discourse espouses, perversion is a common exegetic thread, intertextually sewing their narratives. The objective of my criticism that goes through psychoanalysis, without, however, exempting it from this criticism, is to reveal that both fascism and perversion implicate the non-symbolisable kernel in politics, which becomes the source of their mystification. My thesis argues that the fascist does not take the same discursive position, as the pervert does, regarding this symbolic gap. The first is interested in domination, drawn from the superiority of his ideology's master signifier, whereas the latter is interested in excavating the emptiness of any master signifier and in constantly provoking prefabricated knowledge, similarly to the hysteric. Apart from the level of discourse, on the ethical level, I disengage the view that sees Sade and the Nazi officer, as emblematic figures of a Kantian ethical gesture. Considering the imaginary hypostasis of their ethical performance, I argue that personal interests, fantasies and desires, determine the austerity of their ethical duty. Yet, the fantasies of Sade and Nazism are incongruent, insomuch as they are organised by antithetical ideals. Finally, I develop a new rhetoric, de-pathologised and de-ideologised, regarding the structure of the so-called pervert, introducing new vocabularies and directions for psychoanalytic research that further distance the pervert, or whom I call the extra-ordinary subject, from fascist politics and, instead, expose his diachronic "fascist" isolation from the social edifice. This reveals the fruitful alternatives that can stem from a 'return to Freud cum Lacan, which supports a flexible on-going reformulation of psychoanalytic knowledge

Fascist di-visions of enjoyment and the perverse remainder : a psychoanalytic study

Under the shade of escalating violence and fundamentalism, our epoch's diffused aura of liberalism supposedly tolerates difference, by exorcising the evil phantasms of totalitarianism, in favour of a liberal and humane post-modem order. Consequently, behind contemporary versions of evil, one demonises modem 'fascists', 'totalitarian threats', and 'Hitlers'. As if not obscure enough, fascist evil has been equivocally linked with perversion. Considering this link a tenebrous enigma, my thesis suggests that psychoanalysis can successfully elucidate its problematic and feeble basis, by reappraising previous narratives from a number of different discourses that inscribe the liaison between fascism and perversion in their representational stage. In a first approach, the present study dissects texts as heterogeneous, as film, social theory, political philosophy, and psychoanalysis. This is to show that, despite the divergent speculative angle that each discourse espouses, perversion is a common exegetic thread, intertextually sewing their narratives. The objective of my criticism that goes through psychoanalysis, without, however, exempting it from this criticism, is to reveal that both fascism and perversion implicate the non-symbolisable kernel in politics, which becomes the source of their mystification. My thesis argues that the fascist does not take the same discursive position, as the pervert does, regarding this symbolic gap. The first is interested in domination, drawn from the superiority of his ideology's master signifier, whereas the latter is interested in excavating the emptiness of any master signifier and in constantly provoking prefabricated knowledge, similarly to the hysteric. Apart from the level of discourse, on the ethical level, I disengage the view that sees Sade and the Nazi officer, as emblematic figures of a Kantian ethical gesture. Considering the imaginary hypostasis of their ethical performance, I argue that personal interests, fantasies and desires, determine the austerity of their ethical duty. Yet, the fantasies of Sade and Nazism are incongruent, insomuch as they are organised by antithetical ideals. Finally, I develop a new rhetoric, de-pathologised and de-ideologised, regarding the structure of the so-called pervert, introducing new vocabularies and directions for psychoanalytic research that further distance the pervert, or whom I call the extra-ordinary subject, from fascist politics and, instead, expose his diachronic "fascist" isolation from the social edifice. This reveals the fruitful alternatives that can stem from a 'return to Freud cum Lacan, which supports a flexible on-going reformulation of psychoanalytic knowledge.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Fascist di-visions of enjoyment and the perverse remainder : a psychoanalytic study

Under the shade of escalating violence and fundamentalism, our epoch's diffused aura of liberalism supposedly tolerates difference, by exorcising the evil phantasms of totalitarianism, in favour of a liberal and humane post-modem order. Consequently, behind contemporary versions of evil, one demonises modem 'fascists', 'totalitarian threats', and 'Hitlers'. As if not obscure enough, fascist evil has been equivocally linked with perversion. Considering this link a tenebrous enigma, my thesis suggests that psychoanalysis can successfully elucidate its problematic and feeble basis, by reappraising previous narratives from a number of different discourses that inscribe the liaison between fascism and perversion in their representational stage. In a first approach, the present study dissects texts as heterogeneous, as film, social theory, political philosophy, and psychoanalysis. This is to show that, despite the divergent speculative angle that each discourse espouses, perversion is a common exegetic thread, intertextually sewing their narratives. The objective of my criticism that goes through psychoanalysis, without, however, exempting it from this criticism, is to reveal that both fascism and perversion implicate the non-symbolisable kernel in politics, which becomes the source of their mystification. My thesis argues that the fascist does not take the same discursive position, as the pervert does, regarding this symbolic gap. The first is interested in domination, drawn from the superiority of his ideology's master signifier, whereas the latter is interested in excavating the emptiness of any master signifier and in constantly provoking prefabricated knowledge, similarly to the hysteric. Apart from the level of discourse, on the ethical level, I disengage the view that sees Sade and the Nazi officer, as emblematic figures of a Kantian ethical gesture. Considering the imaginary hypostasis of their ethical performance, I argue that personal interests, fantasies and desires, determine the austerity of their ethical duty. Yet, the fantasies of Sade and Nazism are incongruent, insomuch as they are organised by antithetical ideals. Finally, I develop a new rhetoric, de-pathologised and de-ideologised, regarding the structure of the so-called pervert, introducing new vocabularies and directions for psychoanalytic research that further distance the pervert, or whom I call the extra-ordinary subject, from fascist politics and, instead, expose his diachronic "fascist" isolation from the social edifice. This reveals the fruitful alternatives that can stem from a 'return to Freud cum Lacan, which supports a flexible on-going reformulation of psychoanalytic knowledge.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing

An increasing body of literature from genome-wide association studies and human whole-genome sequencing highlights the identification of large numbers of candidate regulatory variants of potential therapeutic interest in numerous diseases. Our relatively poor understanding of the functions of non-coding genomic sequence, and the slow and laborious process of experimental validation of the functional significance of human regulatory variants, limits our ability to fully benefit from this information in our efforts to comprehend human disease. Humanized mouse models (HuMMs), in which human genes are introduced into the mouse, suggest an approach to this problem. In the past, HuMMs have been used successfully to study human disease variants; e.g., the complex genetic condition arising from Down syndrome, common monogenic disorders such as Huntington disease and β-thalassemia, and cancer susceptibility genes such as BRCA1. In this commentary, we highlight a novel method for high-throughput single-copy site-specific generation of HuMMs entitled High-throughput Human Genes on the X Chromosome (HuGX). This method can be applied to most human genes for which a bacterial artificial chromosome (BAC) construct can be derived and a mouse-null allele exists. This strategy comprises (1) the use of recombineering technology to create a human variant–harbouring BAC, (2) knock-in of this BAC into the mouse genome using Hprt docking technology, and (3) allele comparison by interspecies complementation. We demonstrate the throughput of the HuGX method by generating a series of seven different alleles for the human NR2E1 gene at Hprt. In future challenges, we consider the current limitations of experimental approaches and call for a concerted effort by the genetics community, for both human and mouse, to solve the challenge of the functional analysis of human regulatory variation

Development of model systems for b-thalassaemia

Oral presentation is available onlin

The therapeutic potential of genome editing for β-thalassemia.

The rapid advances in the field of genome editing using targeted endonucleases have called considerable attention to the potential of this technology for human gene therapy. Targeted correction of disease-causing mutations could ensure lifelong, tissue-specific expression of the relevant gene, thereby alleviating or resolving a specific disease phenotype. In this review, we aim to explore the potential of this technology for the therapy of β-thalassemia. This blood disorder is caused by mutations in the gene encoding the β-globin chain of hemoglobin, leading to severe anemia in affected patients. Curative allogeneic bone marrow transplantation is available only to a small subset of patients, leaving the majority of patients dependent on regular blood transfusions and iron chelation therapy. The transfer of gene-corrected autologous hematopoietic stem cells could provide a therapeutic alternative, as recent results from gene therapy trials using a lentiviral gene addition approach have demonstrated. Genome editing has the potential to further advance this approach as it eliminates the need for semi-randomly integrating viral vectors and their associated risk of insertional mutagenesis. In the following pages we will highlight the advantages and risks of genome editing compared to standard therapy for β-thalassemia and elaborate on lessons learned from recent gene therapy trials

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Under the shade of escalating violence and fundamentalism, our epoch's diffused aura of liberalism supposedly tolerates difference, by exorcising the evil phantasms of totalitarianism, in favour of a liberal and humane post-modem order. Consequently, behind contemporary versions of evil, one demonises modem 'fascists', 'totalitarian threats', and 'Hitlers'. As if not obscure enough, fascist evil has been equivocally linked with perversion. Considering this link a tenebrous enigma, my thesis suggests that psychoanalysis can successfully elucidate its problematic and feeble basis, by re-appraising previous narratives from a number of different discourses that inscribe the liaison between fascism and perversion in their representational stage. In a first approach, the present study dissects texts as heterogeneous, as film, social theory, political philosophy, and psychoanalysis. This is to show that, despite the divergent speculative angle that each discourse espouses, perversion is a common exegetic thread, intertextually sewing their narratives. The objective of my criticism that goes through psychoanalysis, without, however, exempting it from this criticism, is to reveal that both fascism and perversion implicate the non-symbolisable kernel in politics, which become

Animal models of beta-hemoglobinopathies: utility and limitations

The structural and functional conservation of hemoglobin throughout mammals has made the laboratory mouse an exceptionally useful organism in which to study both the protein and the individual globin genes. Early researchers looked to the globin genes as an excellent model in which to examine gene regulation - bountifully expressed and displaying a remarkably consistent pattern of developmental activation and silencing. In parallel with the growth of research into expression of the globin genes, mutations within the β-globin gene were identified as the cause of the β-hemoglobinopathies such as sickle cell disease and β-thalassemia. These lines of enquiry stimulated the development of transgenic mouse models, first carrying individual human globin genes and then substantial human genomic fragments incorporating the multigenic human β-globin locus and regulatory elements. Finally, mice were devised carrying mutant human β-globin loci on genetic backgrounds deficient in the native mouse globins, resulting in phenotypes of sickle cell disease or β-thalassemia. These years of work have generated a group of model animals that display many features of the β-hemoglobinopathies and provided enormous insight into the mechanisms of gene regulation. Substantive differences in the expression of human and mouse globins during development have also come to light, revealing the limitations of the mouse model, but also providing opportunities to further explore the mechanisms of globin gene regulation. In addition, animal models of β-hemoglobinopathies have demonstrated the feasibility of gene therapy for these conditions, now showing success in human clinical trials. Such models remain in use to dissect the molecular events of globin gene regulation and to identify novel treatments based upon the reactivation of developmentally silenced γ-globin. Here, we describe the development of animal models to investigate globin switching and the β-hemoglobinopathies, a field that has paralleled the emergence of modern molecular biology and clinical genetics