On the benefits of phase shift keying to optical telecommunication systems

Les avantages de la modulation de phase vis-à-vis la modulation d’intensité pour les réseaux optiques sont claires et accepté par la communauté scientifique des télécommunications optiques. Surtout, la modulation de phase montre une meilleure sensibilité au bruit, ainsi qu’une plus grande tolérance aux effets non-linéaires que la modulation d’intensité. Nous présentons dans cette thése un étude qui vise à développer les avantages de la modulation de phase. Nous attaquons d’abord la complexité du récepteur en détection directe, en proposant une nouvelle configuration dont la complexité est comparable à celle du récepteur pour la modulation d’intensité traditionnel, mais avec des meilleures performances. Cette solution pourrait convenir pour les réseaux métropolitains (et même d’accès) à haut débit binaire. Nous passons ensuite à l’examen de la possibilité d’utiliser des amplificateur à semi-conducteur (SOA) au lieu des amplificateurs à fibre dopée à l’erbium pour fournir amplification optique aux signaux modulés en phase. Les non-linéarité des SOA sont étudiées, et un compensateur simple et très efficace est proposé. Les avantages des amplificateurs à semi-conducteur par rapport à ceux à fibre sont bien connus. Surtout, la méthode que nous proposons permettrait l’integrabilité des SOA avec d’autres composants de réseau (par exemple, le récepteur nommé cidessus), menant à des solutions technologiques de petite taille et efficaces d’un point de vue énergétique. Il y a deux types de systèmes pour signaux modulés en phase: basé sur la détection directe, ou sur les récepteurs cohérents. Dans le dernière partie de ce travail, nous nous concentrons sur cette dernière catégorie, et nous comparons deux solutions possibles pour la mise à niveau des réseaux terrestres actuel. Nous comparons deux configurations dont les performances sont très comparables en termes de sensibilité au bruit, mais nous montrons comment la meilleure tolérance aux effets non linéaires (en particuliers dans les systèmes à débit mixte) fait que une solution soit bien plus efficace que l’autre.The advantages of phase modulation (PM) vis-à-vis intensity modulation for optical networks are accepted by the optical telecommunication community. PM exhibits a higher noise sensitivity than intensity modulation, and it is more tolerant to the effects of fiber nonlinearity. In this thesis we examine the challenges and the benefits of working with different aspects of phase modulation. Our first contribution tackles the complexity of the direct detection noncoherent receiver for differentially encoded quadrature phase shift keying. We examine a novel configuration whose complexity is comparable to that of traditional receivers for intensity modulation, yet outperforming it. We show that under severe nonlinear impairments, our proposed receiver works almost as well as the conventional receiver, with the advantage of being much less complex. We also show that the proposed receiver is tolerant to chromatic dispersion, and to detuning of the carrier frequency. This solution might be suitable for high-bit rates metro (and even access) networks. Our second contribution deals with the challenges of using semiconductor optical amplifiers (SOAs) instead of typical erbium doped fiber amplifiers (EDFAs) to provide amplification to phase modulated signals. SOAs nonlinearities are investigated, and we propose a simple and very effective feed-forward compensator. Above all, the method we propose would permit the integrability of SOAs with other network components (for example, the aforementioned receiver) achieving small size, power efficient sub-systems. Phase modulation paves the way to high spectral efficiency, especially when paired with digital coherent receivers. With the digital coherent receiver, the degree of freedom offered by polarization can be exploited to increase the channel bit rate without increasing its spectral occupancy. In the last part of this work we focus on polarization multiplexed signaling paired with coherent reception and digital signal processing. Our third contribution provides insight on the strategies for upgrading current terrestrial core networks to high bit rates. This is a particularly challenging scenario, as phase modulation has to coexist with previously installed intensity modulated channels. We compare two configurations which have received much attention in the literature. These solutions show comparable performance in terms of back-to-back noise sensitivity, and yet are not equivalent. We show how the superior tolerance to nonlinear fiber propagation (and particularly to cross phase modulation induced by the presence of intensity modulated channels) makes one of them much more effective than the other

Pilot-Symbols Aided Carrier Phase Recovery for 100G PM-QPSK Digital Coherent Receivers

A feed-forward pilot-symbols aided carrier phase recovery scheme is described. The approach relies on pilot symbols that are time-division multiplexed with the transmitted data. The main advantage of the proposed solution is that of avoiding the phase ambiguity problem after a cycle slip. For homogeneous PM-QPSK transmission the proposed scheme outperforms blind carrier recovery with differential decoding

Empirical Modeling and Simulation of Phase Noise in Long-haul Coherent Optical Transmission Systems

An empirical phase noise channel model suitable for performance evaluation of high spectrally efficient modulations in 100G long-haul coherent optical transmission systems using polarization-division multiplexed and wavelength-division multiplexing channels is presented. The derivation of the model is worked out by exploiting the similarity between the power spectral density of the carrier extracted from the analysis of propagation measurements and the Lorentzian spectrum that is usually adopted to describe instabilities of semiconductor lasers. The proposed channel model is characterized by only two parameters: the linewidth of the carrier and the signal-to-noise ratio. We show that in the case of quadrature phase-shift keying transmission a good agreement exists between quantitative measures of performance extracted by processing experimental data and those obtained from simulations based on the use of the empirical model

Mind the Age Gap! How Problematic Internet Use Affects Adults’ and Emerging Adults’ Well-Being and Prosocial Consumer Behavior

While much has been reported about the negative consequences of the pervasive presence of information and communications technologies in consumers’ everyday lives, the present research enriches the literature on problematic internet use by applying the cognitive-behavioral model in a consumer context, creating a bridge between marketing and psychology research, with novel insights and directions for future research. By means of a moderated mediation model tested on hundreds of consumers, the authors explore whether problematic internet use influences well-being through the mediation of prosocial consumer behavior and the moderation of online-social support. The results show that problematic internet use can indirectly affect individual well-being by affecting consumer choice. Managerial and theoretical implications are addressed

On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships

Recent studies demonstrated that post-herpetical and inflammatory pain can be locally managed by morphine gels, empirically chosen. Aiming to rationalize the selection of the most suitable opioid for the cutaneous delivery, we studied the in vitro penetration through human epidermis of eight opioids, evidencing the critical modifications of the morphinan core. Log P, log D, solid-state features and solubility were determined. Docking simulations were performed using supramolecular assembly made of ceramide VI. The modifications on position 3 of the morphinan core resulted the most relevant in determining both physicochemical characteristics and diffusion pattern. The 3-methoxy group weakened the cohesiveness of the crystal lattice structure and increased the permeation flux (J). Computational studies emphasized that, while permeation is essentially controlled by molecule apolarity, skin retention depends on a fine balance of polar and apolar molecular features. Moreover, ChemPLP scoring the interactions between the opioids and ceramide, correlated with both the amount retained into the epidermis (Qret) and J. The balance of the skin penetration properties and the affinity potency for μ-receptors evidenced hydromorphone as the most suitable compound for the induction of local analgesia

Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands

Inhibition of adenosine A2A receptors has been shown to elicit a therapeutic response in preclinical animal models of Parkinson's disease (PD). We previously identified the triazolo-9H-purine, ST1535, as a potent A2A R antagonist. Studies revealed that ST1535 is extensively hydroxylated at the ω-1 position of the butyl side chain. Here, we describe the synthesis and evaluation of derivatives in which the ω-1 position has been substituted (F, Me, OH) in order to block metabolism. The stability of the compounds was evaluated in human liver microsomes (HLM), and the affinity for A2A R was determined. Two compounds, (2-(3,3-dimethylbutyl)-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-6-amine (3 b) and 4-(6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl)-2-methylbutan-2-ol (3 c), exhibited good affinity against A2A R (Ki =0.4 nM and 2 nM, respectively) and high in vitro metabolic stability (89.5 % and 95.3 % recovery, respectively, after incubation with HLM for two hours)

Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models

Abstract The EGFR tyrosine kinase inhibitor osimertinib has been approved for the first-line treatment of EGFR-mutated Non-Small Cell Lung Cancer (NSCLC) patients. Despite its efficacy, patients develop resistance. Mechanisms of resistance are heterogeneous and not fully understood, and their characterization is essential to find new strategies to overcome resistance. Ceramides are well-known regulators of apoptosis and are converted into glucosylceramides (GlcCer) by glucosylceramide synthase (GCS). A higher content of GlcCers was observed in lung pleural effusions from NSCLC patients and their role in osimertinib-resistance has not been documented. The aim of this study was to determine the therapeutic potential of inhibiting GCS in NSCLC EGFR-mutant models resistant to osimertinib in vitro and in vivo. Lipidomic analysis showed a significant increase in the intracellular levels of glycosylceramides, including GlcCers in osimertinib resistant clones compared to sensitive cells. In resistant cells, the GCS inhibitor PDMP caused cell cycle arrest, inhibition of 2D and 3D cell proliferation, colony formation and migration capability, and apoptosis induction. The intratumoral injection of PDMP completely suppressed the growth of OR xenograft models. This study demonstrated that dysregulation of ceramide metabolism is involved in osimertinib-resistance and targeting GCS may be a promising therapeutic strategy for patients progressed to osimertinib