IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein

http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000100011&lng=es&nrm=isoIP3 increase and de novo synthesis of scoparone are produced in the hypersensitive response (HR) of lemon seedlings against the fungus Alternaria alternata. To elucidate whether a G-protein and/or a protein tyrosine kinase (PTK) are involved in signal transduction leading to the production of such a defensive response, we studied the HR in this plant system after treatment with G-protein activators alone and PTK inhibitors in the presence of fungal conidia. No changes in the level of IP3 were detected in response to the treatment with the G-protein activators cholera toxin or mastoparan, although the HR was observed in response to these compounds as determined by the scoparone synthesis. On the contrary, the PTK inhibitors lavendustin A and 2,5-dihidroxy methyl cinnamate (DHMC) not only prevented the IP3 changes observed in response to the fungal inoculation of lemon seedlings but also blocked the development of the HR. These results suggest that the IP3 changes observed in response to A. alternata require a PTK activity and are the result of a G-protein independent Phospholipase C activity, even though the activation of a G-protein can also lead to the development of a HR. Therefore, it appears that more than one signaling pathway may be activated for the development of HR in lemon seedlings: one involving a G-protein and the other involving a PTK-dependent PLC

El Storytelling de la publicidad relacionada al COVID-19 y las percepciones de los jóvenes de 18 a 25 años: Caso #NOESDEPATAS de Pilsen Callao

Pilsen Callao es una cervecera peruana que se caracteriza por su forma de percibir la amistad entre las personas. Esta tesis busca analizar las percepciones de los jóvenes acerca del storytelling de la marca Pilsen Callao luego de ver su publicidad sobre la Covid-19. Se ha realizado una investigación de tipo exploratorio, abordada desde un enfoque cualitativo, puesto que se realizaron grupos focales con jóvenes de 18 a 25 años y análisis de contenido del propio spot publicitario. Dentro de los resultados, se identificaron diferentes elementos emocionales del storytelling que son de suma importancia para la investigación. Además, las percepciones que tuvieron en los jóvenes fueron altamente positivas, pues Pilsen Callao supo utilizar sus recursos para que el spot publicitario tenga un cambio en los jóvenes y ellos puedan sentirse identificados con lo que observaban en la publicidad.Pilsen Callao is a Peruvian brewery that is characterized by its way of perceiving friendship between people. This thesis seeks to analyze the perceptions of young people about the storytelling of Pilsen Callao brand after seeing its advertising about Covid-19. An exploratory type of research has been carried out, approached from a qualitative approach, since focus groups were carried out with young people between 18 and 25 years of age and content analysis of the advertising spot itself. Within the results, different emotional elements of storytelling were identified that are of the utmost importance for the investigation. In addition, the perceptions that they had in young people were highly positive, since Pilsen Callao knew how to use its resources so that the advertisement produced a change among young people and they can feel identified with what they saw in advertisement

Depresión y ansiedad en falla cardíaca: ¿existen diferencias según el grupo muscular rehabilitado? Ensayo clínico aleatorizado (Strong Hearts Trial)

Introduction: heart failure is considered the disease of the millennium, its mortality is increasing worldwide. The population with heart failure and depressive disease has a prevalence of 25%.Objective: to determine the differences in strength training for upper versus lower limbs as a treatment to decrease levels of depression and anxiety in patients with heart failure.Methods: 3-year randomised controlled trial with 920 heart failure patients in three groups (aerobic exercise, aerobic exercise plus upper limb training and aerobic exercise plus lower limb training). Haematological samples were taken to determine blood glucose levels and lipid profile. In addition, tests were performed for aerobic capacity, maximum heart rate, anthropometry, depression, anxiety, and clinical and hemodynamic parameters. The tests were performed before and after 24 60-minute training sessions, three times a week, for two months.Results: depression levels were reduced by 52% in the operated groups, as well as 59% in the anxiety levels.Conclusions: when comparing the effects of lower limb strength training versus upper limb strength training on depression and anxiety levels, aerobic exercise plus upper limb strength training proved to be the most effective in reducing them.Introducción: la insuficiencia cardíaca es considerada la enfermedad del milenio, su mortalidad va en aumento en el mundo. La población con insuficiencia cardíaca y enfermedad depresiva se presenta con una prevalencia del 25%. Objetivo: determinar las diferencias en el entrenamiento de fuerza para miembros superiores versus inferiores como tratamiento para disminuir los niveles de depresión y ansiedad en pacientes con falla cardíaca.Métodos: ensayo controlado aleatorizado de tres años con 920 pacientes con falla cardíaca distribuidos en tres grupos (ejercicio aeróbico, ejercicio aeróbico más entrenamiento miembros superiores y ejercicio aeróbico más entrenamiento de miembros inferiores). Se realizaron muestras hematológicas para determinar los niveles de glucemia y el perfil lipídico. Además, pruebas para capacidad aeróbica, frecuencia cardíaca máxima, antropometría, depresión, ansiedad y parámetros clínicos y hemodinámicos. Las pruebas se realizaron antes y después de 24 sesiones de entrenamiento de 60 minutos, tres veces por semana, durante dos meses. Resultados: se disminuyeron los niveles de depresión en un 52% en los grupos intervenidos, al igual que un 59% en los niveles de ansiedad. Conclusiones: al comparar los efectos del entrenamiento de fuerza para miembros inferiores versus miembros superiores ante los niveles de depresión y ansiedad el ejercicio aeróbico más entrenamiento de fuerza en miembro superior resultó ser el más efectivo para disminuirlos

Early impact of the COVID-19 pandemic on paediatric cancer care in Latin America

Although previous studies have suggested that the complications and mortality rate related to COVID-19 are substantially lower in the paediatric population,1 it is reasonable to consider that children with underlying conditions such as cancer will be at increased risk of severe disease...Fil: Vasquez, Liliana. Universidad de San Martín de Porres; Perú. Organización Panamericana de la Salud; PerúFil: Sampor, Claudia. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; ArgentinaFil: Villanueva, Gabriela. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; ArgentinaFil: Maradiegue, Essy. Instituto Nacional de Enfermedades Neoplasicas; PerúFil: Garcia Lombardi, Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Gomez García, Wendy. Hospital Infantil Dr. Robert Reid Cabral; República DominicanaFil: Moreno, Florencia. Ministerio de Salud. Instituto Nacional del Cáncer; ArgentinaFil: Diaz, Rosdali. Instituto Nacional de Enfermedades Neoplasicas; PerúFil: Cappellano, Andrea M.. Universidade Federal de Sao Paulo; BrasilFil: Portilla, Carlos Andres. Universidad del Valle; ColombiaFil: Salas, Beatriz. Hospital del Niño Manuel Ascencio Villarroel; BoliviaFil: Nava, Evelinda. Hospital de Niños Jesus Garcia Coello; VenezuelaFil: Brizuela, Silvia. Instituto de Previsión Social ; ParaguayFil: Jimenez, Soledad. Hospital Solca Núcleo de Loja; EcuadorFil: Espinoza, Ximena. Hospital de Niños Dr. Roberto del Río; ChileFil: Gassant, Pascale Yola. Hôpital Saint-Damien; HaitíFil: Quintero, Karina. Children's Hospital Dr Jose Renan Esquivel; PanamáFil: Fuentes Alabi, Soad. Hospital Nacional de Niños Benjamin Bloom; El SalvadorFil: Velasquez, Thelma. No especifíca;Fil: Fu, Ligia. Hospital Escuela de Tegucigalpa; HondurasFil: Gamboa, Yessika. National Children's Hospital; Costa RicaFil: Quintana, Juan. Clinica Las Condes; ChileFil: Castiglioni, Mariela. Hospital Pereira Rossell; UruguayFil: Nuñez, Cesar. Children's Cancer Hospital; Estados UnidosFil: Moreno, Arturo. Hospital Universitario de Puebla; MéxicoFil: Luna Fineman, Sandra. State University of Colorado at Boulder; Estados UnidosFil: Luciani, Silvana. Pan American Health Organization; Estados UnidosFil: Chantada, Guillermo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Hospital Sant Joan de Deu Barcelona; Españ

New Alien Mediterranean Biodiversity Records (August 2022)

In this Collective Article on alien and cryptogenic diversity in the Mediterranean Sea we report a total of 19 species belonging to nine Phyla and coming from nine countries. Several of these records concern fish species, and of particular interest are the first records of: Terapon puta for Italian waters; Pteragopus trispilus from Malta; Plotosus lineatus from Cyprus; and the northernmost Mediterranean record of Lagocephalus sceleratus. The northernmost Mediterranean record was also reported for the sea urchin Diadema setosum. The portunid crab Thalamita poissonii was recorded for the first time in Libya. The copepod Pseudodiaptomus marinus was recorded for the first time in the Marmara Sea. The polychaete Branchiomma luctuosum was recorded for the first time from the Mediterranean coast of France. The alien anemone Diadumene lineata was recorded for the first time from Slovenia. The macroalgae Sargassum furcatum was recorded for the first time from Italy. The new Mediterranean records here reported help tracing abundance and distribution of alien and cryptic species in the Mediterranean Sea

American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

10.1002/acr.23834ARTHRITIS CARE & RESEARCH715579-59

Global variations in diabetes mellitus based on fasting glucose and haemogloblin A1c

Fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) are both used to diagnose diabetes, but may identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening had elevated FPG, HbA1c, or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardised proportion of diabetes that was previously undiagnosed, and detected in survey screening, ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the agestandardised proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global gap in diabetes diagnosis and surveillance.peer-reviewe

La responsabilidad social en países andinos: un enfoque de negocios

La Responsabilidad Social Empresarial (RSE), no es un tema nuevo pero en la actualidad se ha convertido en una estrategia de negocios que le permite a las empresas mejorar a su interior y así obtener mas beneficios externos ya que cuenta con mayor credibilidad y más aún con proyectos sostenibles en pro del la comunidad y de factores tales como el ambiente, los clientes entre otros. Este trabajo de investigación busca dar a conocer como alrededor de los negocios las empresas si pueden llegar a ser responsables socialmente, dando a conocer inicialmente los fundamentos teóricos del tema y posteriormente realizando un análisis a tres multinacionales con presencia en Colombia y simultáneamente en otros países de América Latina, tal como lo son Unilever, Telefónica y Coca Cola. Estos casos específicos, en su diagnóstico, dejan ver de una forma u otra como a través de los compromisos que han asumido estas empresas, los proyectos sostenibles que se han desarrollado a su interior han permitido mejorar aspectos de la comunidad que necesitada de estas soluciones muestran interés generando resultados que se dan por la gestión que se define con la ética de la misma empresa. Esto permite ver como de esta forma se puede preservar los recursos ambientales y culturales para las generaciones futuras, respetando la diversidad y promoviendo la disminución de las desigualdades sociales.The Corporate Social Responsibility (CSR) is not a new issue but now it has become a business strategy that enables companies to improve their internal and external benefits more because they have more credibility and more with sustainable projects for the community and factors such as the environment, customers and others. This research seeks to raise awareness about the business as the companies if they can be socially responsible by publicizing initially theoretical foundations of the subject and then conducting an analysis to three multinationals with a presence in Colombia and other countries simultaneously Latin America, as are Unilever, Telefónica and Coca Cola. These specific cases in his diagnosis let see in one way or another and through the commitments they have made these companies, sustainable projects that have been developed to have improved its internal aspects of the community who need these solutions show interest generating results that are given by the management that defines the ethics of the same company. This allows seeing how these events can preserve the environmental and cultural resources for future generations, respecting diversity and promoting the reduction of social inequalities

Síntesis y estudio de las propiedades estructurales y magnéticas del estroncio-rutenato de tierra rara Sr2RuHoO6

Se ha realizado un estudio de las propiedades estructurales, morfológicas, magnéticas y ópticas de la perovskita Sr2HoRuO6. El análisis de Rietlved de los patrones de difracción de rayos X reveló que este material óxido cristaliza en una estructura de perovskita monoclínica, grupo espacial P21/n (#14), con parámetros de red a = 5.7719 Å, b = 5.8754 Å, c = 8.1651 Å y ángulo β = 90.034°. La caracterización morfológica mediante microscopía electrónica de barrido (SEM) muestra una topografía superficial uniforme con granos fuertemente interconectados de tamaño similar (D ≈ 0.74 μm), que varían en forma y orientación. El análisis semicuantitativo de la composición se realizó mediante Electron Energy Dispersion Spectra (EDX), a partir del cual se puede establecer que la composición de las muestras es del 99% de acuerdo con la composición estequiométrica esperada. Las curvas de susceptibilidad magnética en función de la temperatura revelaron la característica ferrimagnética de este material, con una temperatura de Néel TN = 14 K. Mediante el ajuste de susceptibilidad magnética de tipo Curie-Weiss se determinó que el momento magnético efectivo es de 11,36 μB. Este valor está de acuerdo con el esperado a partir de las reglas de Hund (11.28 μB). El espectro de reflectancia difusa sugiere que este material se comporta como un semiconductor con Eg= 1.38 eV, que está de acuerdo con los resultados de estructura de bandas y cálculos de la densidad de estados electrónicos obtenidos como parte adicional para la publicación del presente trabajo en una revista científica.Abstract: A study of the structural, morphological, magnetic and optic properties of the Sr2HoRuO6 perovskite has been performed. Rietlved analysis from x-ray diffraction patterns revealed that this oxide material crystallizes in a monoclinic perovskite structure, P21/n (# 14) space group, with lattice parameters a=5.7719 Å, b=5.8754 Å, c=8.1651 Å and angle β=90.034°. The morphological characterization by Scanning Electron Microscopy (SEM) shows an uniform surface topography with strongly interconnected grains of similar size (D ≈ 0.74 μm), which vary in shape and orientation. Semi-quantitative analysis of the composition was performed by Electron Energy Dispersion Spectra (EDX), from which it can be established that the composition of the samples is 99% in accordance with the expected stoichiometric composition. Curves of magnetic susceptibility as a function of temperature revealed the ferrimagnetic feature of this material with Néel temperature TN=14 K. Through the Curie-Weiss magnetic susceptibility adjustment the effective magnetic moment was determined to be 11.36 μB. This value is in agreement with that expected from the Hund’s rules (11.28 μB). The diffuse reflectance spectrum suggests that this material behaves as a semiconductor with Eg=1.38 eV, which is in accordance with results of band structure and density of states calculations performed as an additional part for the publication of this work in a scientific journal.Maestrí