317 research outputs found
Mid-Infrared Photometry and Spectra of Three High Mass Protostellar Candidates at IRAS 18151-1208 and IRAS 20343+4129
We present arcsecond-scale mid-ir photometry (in the 10.5 micron N band and
at 24.8 microns), and low resolution spectra in the N band (R~100) of a
candidate high mass protostellar object (HMPO) in IRAS 18151-1208 and of two
HMPO candidates in IRAS 20343+4129, IRS 1 and IRS 3. In addition we present
high resolution mid-ir spectra (R~80000) of the two HMPO candidates in IRAS
20343+4129. These data are fitted with simple models to estimate the masses of
gas and dust associated with the mid-ir emitting clumps, the column densities
of overlying absorbing dust and gas, the luminosities of the HMPO candidates,
and the likely spectral type of the HMPO candidate for which [Ne II] 12.8
micron emission was detected (IRAS 20343+4129 IRS 3). We suggest that IRAS
18151-1208 is a pre-ultracompact HII region HMPO, IRAS 20343+4129 IRS 1 is an
embedded young stellar object with the luminosity of a B3 star, and IRAS
20343+4129 IRS 3 is a B2 ZAMS star that has formed an ultracompact HII region
and disrupted its natal envelope.Comment: 40 pages, 8 figures, 3 tables. Accepted for publication in
Astrophysical Journal (Part 1
Trumpler 20 - an old and rich open cluster
We show that the open cluster Trumpler 20, contrary to the earlier findings,
is actually an old Galactic open cluster. New CCD photometry and
high-resolution spectroscopy are used to derive the main parameters of this
cluster. At [Fe/H]=-0.11 for a single red giant star, the metallicity is
slightly subsolar. The best fit to the color-magnitude diagrams is achieved
using a 1.3 Gyr isochrone with convective overshoot. The cluster appears to
have a significant reddening at E(B-V)=0.46 (for B0 spectral type), although
for red giants this high reddening yields the color temperature exceeding the
spectroscopic T_eff by about 200 K. Trumpler 20 is a very rich open cluster,
containing at least 700 members brighter than M_V=+4. It may extend over the
field-of-view available in our study at 20'x20'.Comment: 7 pages, 5 figures; accepted for publication in MNRA
Model-Independent Diagnostics of Highly Reddened Milky Way Star Clusters: Age Calibration
The next generation near- and mid-infrared Galactic surveys will yield a
large number of new highly obscured star clusters. Detailed characterization of
these new objects with spectroscopy is time-consuming. Diagnostic tools that
will be able to characterize clusters based only on the available photometry
will be needed to study large samples of the newly found objects. The
brightness difference between the red clump and the main-sequence turn-off
point have been used as a model-independent age calibrator for clusters with
ages from a few 10 to 10 yr in the optical. Here we apply for the
first time the method in the near-infrared. We calibrated this difference in
-band, which is likely to be available for obscured clusters, and we apply
it to a number of test clusters with photometry comparable to the one that will
be yielded by the current or near-future surveys. The new calibration yields
reliable ages over the range of ages for which the red clump is present in
clusters. The slope of the relation is smoother than that of the corresponding
-band relation, reducing the uncertainty in the age determinations with
respect to the optical ones.Comment: 5 pages, 5 eps figure, accepted for publication in Astronomy and
Astrophysic
Episodic mass loss in binary evolution to the Wolf-Rayet phase: Keck and HST proper motions of RY Scuti's nebula
Binary mass transfer via Roche-lobe overflow (RLOF) is a key channel for
producing stripped-envelope Wolf-Rayet (WR) stars and may be critical to
account for SN Ib/c progenitors. RY Scuti is an extremely rare example of a
massive binary star caught in this brief but important phase. Its toroidal
nebula indicates equatorial mass loss during RLOF, while the mass-gaining star
is apparently embedded in an opaque accretion disk. RY Scuti's toroidal nebula
has two components: an inner ionised double-ring system, and an outer dust
torus that is twice the size of the ionised rings. We present two epochs of
Lband Keck NGS-AO images of the dust torus, plus three epochs of HST images of
the ionised gas rings. Proper motions show that the inner ionised rings and the
outer dust torus came from two separate ejection events roughly 130 and 250 yr
ago. This suggests that RLOF in massive contact binaries can be accompanied by
eruptive and episodic burst of mass loss, reminiscent of LBVs. We speculate
that the repeating outbursts may arise in the mass gainer from instabilities
associated with a high accretion rate. If discrete mass-loss episodes in other
RLOF binaries are accompanied by luminous outbursts, they might contribute to
the population of extragalactic optical transients. When RLOF ends for RY
Scuti, the overluminous mass gainer, currently surrounded by an accretion disk,
will probably become a B[e] supergiant and may outshine the hotter mass-donor
star that should die as a Type Ib/c supernova.Comment: 15 pages, 7 figures, submitted to MNRA
Quantum Griffiths effects and smeared phase transitions in metals: theory and experiment
In this paper, we review theoretical and experimental research on rare region
effects at quantum phase transitions in disordered itinerant electron systems.
After summarizing a few basic concepts about phase transitions in the presence
of quenched randomness, we introduce the idea of rare regions and discuss their
importance. We then analyze in detail the different phenomena that can arise at
magnetic quantum phase transitions in disordered metals, including quantum
Griffiths singularities, smeared phase transitions, and cluster-glass
formation. For each scenario, we discuss the resulting phase diagram and
summarize the behavior of various observables. We then review several recent
experiments that provide examples of these rare region phenomena. We conclude
by discussing limitations of current approaches and open questions.Comment: 31 pages, 7 eps figures included, v2: discussion of the dissipative
Ising chain fixed, references added, v3: final version as publishe
A Small Molecule Inhibitor of PDK1/PLC gamma 1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a protein complex with 3-phosphoinositide-dependent protein kinase 1 (PDK1). In an effort to define novel strategies to inhibit PLCγ1-dependent signals we tested here whether a newly identified and highly specific PDK1 inhibitor, 2-O-benzyl-myo-inositol 1,3,4,5,6-pentakisphosphate (2-O-Bn-InsP5), could affect PDK1/PLCγ1 interaction and impair PLCγ1-dependent cellular functions in cancer cells. Here, we demonstrate that 2-O-Bn-InsP5 interacts specifically with the pleckstrin homology domain of PDK1 and impairs formation of a PDK1/PLCγ1 complex. 2-O-Bn-InsP5 is able to inhibit the epidermal growth factor-induced PLCγ1 phosphorylation and activity, ultimately resulting in impaired cancer cell migration and invasion. Importantly, we report that 2-O-Bn-InsP5 inhibits cancer cell dissemination in zebrafish xenotransplants. This work demonstrates that the PDK1/PLCγ1 complex is a potential therapeutic target to prevent metastasis and it identifies 2-O-Bn-InsP5 as a leading compound for development of anti-metastatic drugs
Influence of the environment on polycyclic aromatic hydrocarbon emission in star-forming regions
We investigate the emission properties of polycyclic aromatic hydrocarbons (PAHs) in various metallicity environments with the Infrared Spectrograph on board Spitzer. Local giant H II regions are used as references as they enable access to the distinct interstellar medium components that contribute to the mid-infrared spectrum of star-forming galaxies: photodissociation regions (PDRs), photoionized gas, stellar clusters, and embedded regions. Three objects are considered: NGC 3603 in the Milky Way, 30 Doradus in the Large Magellanic Cloud, and N 66 in the Small Magellanic Cloud. From the variations of the PAH/14 μm ratio, we find that PAHs are destroyed in the ionized gas for a radiation field such that [Ne iii]/[Ne ii] >~ 3. From the variations of the PAH/Huα ratio, we find that the PAH emission sources in the giant H II regions follow the same photodestruction law regardless of metallicity. We then compare these results with observations of starburst galaxies, Hii galaxies, and blue compact dwarf galaxies (BCDs). While the integrated mid-infrared spectra of BCDs are reminiscent of a warm dusty ionized gas, we observe a significant contribution to the PAH emission in starburst galaxies that is not arising from PDRs
Gewalt in der Schule
Vortrag auf der Tagung Bindung, Trauma und soziale Gewalt , 3.-5.12.2004 in Frankfurt am Main
BAG3: a multifaceted protein that regulates major cell pathways
Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain (110–124 amino acids). BAG3 is the only member of the family to be induced by stressful stimuli, mainly through the activity of heat shock factor 1 on bag3 gene promoter. In addition to the BAG domain, BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. These multifaceted interactions underlie BAG3 ability to modulate major biological processes, that is, apoptosis, development, cytoskeleton organization and autophagy, thereby mediating cell adaptive responses to stressful stimuli. In normal cells, BAG3 is constitutively present in a very few cell types, including cardiomyocytes and skeletal muscle cells, in which the protein appears to contribute to cell resistance to mechanical stress. A growing body of evidence indicate that BAG3 is instead expressed in several tumor types. In different tumor contexts, BAG3 protein was reported to sustain cell survival, resistance to therapy, and/or motility and metastatization. In some tumor types, down-modulation of BAG3 levels was shown, as a proof-of-principle, to inhibit neoplastic cell growth in animal models. This review attempts to outline the emerging mechanisms that can underlie some of the biological activities of the protein, focusing on implications in tumor progression
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