Can activation of TLR3 induce apoptosis in patients with miscarriages?

Objective - to estimate influence of TLR3 activation on apoptosis proteins in endometrium in patients with miscarriages and missed abortion

TDDFT of magneto-optical response of solids

Trabajo presentado al: "Deutsche Physikalische Gesellschaft Spring Meeting" celebrado en Dresden (Alemania) del 30 de marzo al 4 de Abril de 2014.Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme (Grant Agreement PIIF-GA-2012-326435 RespSpatDisp); European Research Council Advanced Grant DYNamo (ERC-2010-AdG-267374); Spanish Grants (FIS2010-21282-C02-01 and PIB2010US-00652); Grupos Consolidados UPV/EHU del Gobierno Vasco (IT-578-13) and Ikerbasque and European Commission projects CRONOS (Grant number 280879-2 CRONOS CP-FP7).Peer reviewe

Catalytic degradation of polyethylene in the presence of synthetic aluminosilicates

Degradation of polyethylene in the presence of synthetic amorphous aluminosilicates as catalysts to form petroleum-like hydrocarbons was studiedyesBS

Poder do russo e os colonistas-mennonitas na segunda metade do século XVIII: política e práticas de colonização

The relevance of a studied problem is caused by the need of researching the realization of the colonization policy of the government in the second half of the 18th century that gives the opportunity to define the contribution of various ethnic - confessional groups to the land development of the Russian Empire. The article is devoted to the history of the invitation of the colonists (Mennonites) to Russia for the settlement in the Ekaterinoslav’s vicegerency. The article presents the main directions of the colonization policy of Catherine II, shows the colonizing activities of G. Potemkin in the Ekaterinoslav’s vicegerency reflects the implementation of the colonization policy towards Mennonite society. The authors showed that the activity of the Mennonites in the promotion of their claims to the most advantageous conditions of their arrangement in Russia led to the adoption of a decree that sanctioned special privileges and privileges for them. The article defines the importance of meeting the Russian Empress and Mennonite deputies, which led to a serious result – the announcement made by the Russian government to the Mennonite society in Danzig at the end of December 1787. This document authorized the arrival of the Mennonites to Russia, it determined the conditions for their invitation. Thus, the authors showed that an important factor in the arrival of the Mennonite colonists in Russia was their communication with the Russian authorities.La relevancia de un problema estudiado se debe a la necesidad de investigar la realización de la política de colonización del gobierno en la segunda mitad del siglo XVIII, que brinda la oportunidad de definir la contribución de varios grupos etno - confesionales al desarrollo de la tierra del país Imperio. El artículo está dedicado a la historia de la invitación de los colonos (menonitas) a Rusia para el asentamiento en la vicegerencia de Ekaterinoslavsk. El artículo presenta las principales direcciones de la política de colonización de Catalina II, muestra las actividades de colonización de G. Potemkin en la vicegerencia de Ekaterinoslavsk refleja la implementación de la política de colonización hacia la sociedad menonita. Los autores demostraron que la actividad de los menonitas en la promoción de sus reclamos a las condiciones más ventajosas de su arreglo en Rusia condujo a la adopción de un decreto que les sancionó privilegios y privilegios especiales. El artículo define la importancia de conocer a la emperatriz rusa y los diputados menonitas, lo que condujo a un resultado serio: el anuncio hecho por el gobierno ruso a la sociedad menonita en Danzig a fines de diciembre de 1787. Este documento autoriza la llegada de los menonitas a Rusia, determinó las condiciones para su invitación. Por lo tanto, los autores demostraron que un factor importante en la llegada de los colonos menonitas en Rusia fue su comunicación con las autoridades rusas.A relevância de um problema estudado é a necessidade de investigar a realização da política de colonização do governo na segunda metade do século XVIII, que brinda a oportunidade de definir a contribuição de vários grupos etno - confessionales al desarrollo de la tierra del país Imperio. O artigo é dedicado à história da invitación dos colonos (menonitas) a Rússia para o asentamiento na vitória de Ekaterinoslavsk. O artigo apresenta as direcções principais da política de colonização de Catalina II, realiza as actividades de colonização de G. Potemkin na vitória de Ekaterinoslavsk, ajuda a implementar a política de colonização da sociedade civil. Los autores demostraron que a atividade de menonitas na promoção de suas respostas às condições mais ventajosas de su arreglo em Rusia condujo a adoption de un decreto que les sancionó privilegios y privilegios especiales. El artículo define a importância de se comunicar com a polícia sobre a mulher e os homens hospitalizados, ao contrário de um ano consecutivo: o anuncio foi introduzido pelo governo ruso à sociedade civilizada em Danzig às multias de dezembro de 1787. Este documento autoriza la llegada de los menonitas a Rusia, determinó as condições para sua invitación. Por favor, los autores demoestrarson that un factor important en la llegada de los colonos menonitas en Rusia fue su comunicación con las procedens rusas

The foam-glass material for a radio frequency echoless chambers

The conducted experiment of foam glass modification by carbon nanotubes shows increased radio absorbing properties in comparison with a foam glass without additives. Addition of carbon nanodimensional tubes in number of 1,5 wt.% increases a tangent of dielectric losses angle by 2,5 times. The coefficient of electromagnetic radiation absorption in the range of frequencies of 120 - 260 GHz increases for a foam glass with carbon nanotubes (1,5 wt. %) twice in comparison with a foam glass without additives. The foam glass modified by carbon nanotubes is recommended as the effective radio absorbing material for the device of anechoic cameras. This material is fire safety, nonflammable, environmentally friendly, rather light-weight

Identification of structural motifs as tunneling two-level systems in amorphous alumina at low temperatures

One of the most accepted models that describe the anomalous thermal behavior of amorphous materials at temperatures below 1 K relies on the quantum mechanical tunneling of atoms between two nearly equivalent potential energy wells forming a two-level system (TLS). Indirect evidence for TLSs is widely available. However, the atomistic structure of these TLSs remains an unsolved topic in the physics of amorphous materials. Here, using classical molecular dynamics, we found several hitherto unknown bistable structural motifs that may be key to understanding the anomalous thermal properties of amorphous alumina at low temperatures. We show through free energy profiles that the complex potential energy surface can be reduced to canonical TLSs. The tunnel splitting predicted from instanton theory, the number density, dipole moment, and coupling to external strain of the discovered motifs are consistent with experiments.We acknowledge financial support from the Marie Curie International Incoming Fellowship (Grant Agreement PIIF-GA-2012-326435 RespSpatDisp) and the European Research Council Advanced Grant DYNamo (ERC-2010-AdG-267374), both within the 7th European Community Framework Programme. We also thank “ayuda para la Especializacion de Personal Investigador del Vicerrectorado de Investigacion UPV/EHU-2013”, Grupos Consolidados UPV/EHU del Gobierno Vasco (IT-578-13), and the Ikerbasque Foundation. This research was supported, in part, by a grant of computer time from the CUNY HPC under NSF Grants CNS-0855217, CNS-0958379, and ACI-1126113.Peer Reviewe

Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations

The presence of a high number of macrophages within solid tumors is often significantly associated with poor prognosis and predict treatment failure for chemotherapy and radiotherapy. Macrophages are innate immune cells capable of performing diverse functions depending on the different signals from the microenvironment. The classically activated macrophage is commonly present during the early stages of tumor development while alternatively activated macrophages are associated with more advanced tumors. The distinction of the antitumoral macrophages from the pro-tumoral macrophages is not absolute. However, they have different cell surface markers such as mannose receptor (MRC1 or CD206) abundantly expressed by macrophages treated with interleukin-4 (IL-4). The important roles of macrophages in cancers suggest that it is important to develop novel therapies that target these cells. In the present study, we designed a probe using Polyamidoamine (PAMAM) fifth-generation (G5) dendrimers conjugated with mannose, Cyanine 7 (Cy7), and hydrazinonicotinamide (HYNIC) for target macrophages with high expression of MRC1 in the tumor. The intracellular uptake of 99mTc-HYNIC-dendrimer-mannose-Cy7 through the interaction with MRC1 in bone marrow-derived macrophages (BMDMs) untreated or treated with lipopolysaccharides (LPS) + interferon (IFN)γ or IL-4 was analyzed. Our results show that high-density mannose dendrimers are preferentially bound by macrophages treated by IFNγ and LPS that express lower levels of MRC1 than for macrophages treated by IL-4 that express high levels of MRC1. Furthermore, the intracellular 99mTc-HYNIC-dendrimer-mannose-Cy7 uptake in BMDMs was not inhibited in the presence of free mannose or glucose. This result suggests that 99mTc-HYNIC-dendrimer-mannose-Cy7 is not internalized via macrophage MRC1. Based on these findings, we concluded that MRC1 expression does not determine the uptake of high-density mannose dendrimers