Pharmacological correction of endothelial dysfunction using ademethionin and taurine

It is noted that ademethionine and taurine have an endothelioprotective effect because of their ability to decrease hyperhomocysteinemia The investigated drugs showed pronounced endothelioprotective activity and can be recommended for further pre-clinical studie

Process optimization of liquid-liquid extraction reformate from solvent teg at the installation of LG-35 / 8-300B JSC "Naftan"

Industrial complex for producing aromatic hydrocarbons is a chemical-technological system composed of interconnected industrial catalytic reforming and dearomatisation catalysate. Studying the process of extraction of aromatic hydrocarbons from products of catalytic reforming is an important and actual scientific task. The plant type LG-35 / 8-300B "Naftan" for aromatic hydrocarbons extraction, solvent TEG with a water content of 4-10% by weight is used

Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models

During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same of female rats was performed by bilateral ovarioectomy and further intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7. The deficiency of nitric oxide as a result of the NO-synthase blockade was accompanied by the impairment of the endotheliumdependent and independent vasodilatation estimated in the pharmacological tests, which was expressed in the increasing coefficient of endothelial dysfunctio

Objective Function Development Based on the Parameters of a Regional Terminal Network

The article is devoted to the development of the objective function for calculating the parameters of a terminal network in a region. The key parameters of a terminal network, as logistic system, are described. The factors influencing the parameters of a terminal network are analyzed, and the objective function, concerning the value and qualitative aspects for determining the transport and spatial/quantitative parameters proposed. The level of service quality for the clients is also taken into account. The heuristic solution method, and the results of the approach are demonstrated with the help of an application example concerning different combinations of distribution.Der Artikel widmet sich der Modellierung eines Transportnetzes, das, unter Beachtung der Lage der Distributionszentren und der Lage der Kunden, minimale Gesamtlogistikkosten ergibt. Diese setzen sich wiederum aus den Transport- und aus den Standortkosten hinsichtlich der Lager- und Betriebskosten der Distributionszentren zusammen. Darüber hinaus wird auch die Maximierung beziehungsweise das Niveau der Servicequalität für die Kunden einbezogen. Das heuristische Lösungsverfahren wird anschließend an einem Anwendungsbeispiel hinsichtlich unterschiedlicher Kombinationen von Distributionszentren erprobt und hinsichtlich der Zielerreichung dokumentiert

Pancreatogenic infections: importance of microbiological monitoring and penetration of antimicrobial chemotherapeutic agents into the pancreas when defining therapeutic approach

The review provides the information on the spectrum of microorganisms initiating the development of clinical and morphological forms of pancreatogenic infections. It is shown that when analyzing pathological conditions, no features in the microbiological landscape of the secondary infection in the pancreas and the surrounding extraperitoneal cellular tissue are registere

Effect of antagonist mineralocorticoid receptors Eplerenon on the dynamics of QT interval dispersion in patients with acute elderly aged

Currently, there is an increase in the frequency of cardiovascular diseases, including acute coronary syndrome (ACS), while in the Russian Federation due to ACS there is a high mortality rate from sudden cardiac death (SCD). The aim of the work is a comparative analysis of the effect of mineralocorticoid receptor antagonists (MRA) of eplerenone on the predictors of SCD development in patients with ST elevation myocardial infarction (STEMI) with a moderately abnormal ejection fraction(EF) of the left ventricle (LV) in the early stages of the diseas

Assessment of senior dental students and dental residents in matters of antimicrobial chemotherapy

This article highlights the results of the study designed to assess knowledge of senior dental students of medical schools and dental residents on the main issues of antibiotic therapy and the empirical use of antimicrobials for treatment of respiratory disorde

Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction

For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environmen

Parameterization of the turbulent diffusion coefficient of industrial emissions

Turbulent diffusion of industrial emissions is one of the main transport mechanisms that determine the spatial distribution of pollutants in the atmospheric boundary layer. One of the famous ways to study the basic laws of the spatial distribution of the contaminant is a mathematical modeling of the transport of particles in the air. A diffusive-convective transport model had got wide recognition. A parameter of the diffusive-convective transport model is a vertical eddy diffusion coefficient k[z]. In the simulation of vertical transport impurities the parameterization of turbulent diffusion coefficient is often used in the form: k[z]=k[pr] * z. A parameter k[pr] essentially depends on roughness and temperature heterogeneity of the underlying surface, convective flow and disperse composition impurities. Due to the complexity of the turbulence diffusion processes, adequate description of the vertical transporting is not possible without the involvement of the models, based on experimental materials. In this paper we propose the parameter describing the turbulent diffusion of industrial emissions determinate like solving an inverse problem on the distribution of the contaminant measured along a certain direction from a point source. The content of harmful substances in the air is relatively small, especially at a considerable distance from the source. Therefore, to measure the distribution of the contaminant it is advisable to use the method of moss-biomonitors, exposure time of which is determined by the length growth of moss and it is a year or more. The method is widely used to study air pollution by heavy metals (HM)