Military Construction, Veterans Affairs, and Related Agencies: FY2010 Appropriations

This report discusses the President's Fiscal Year (FY) 2010 budget request for the Military Construction, Veterans Affairs, and Related Agencies appropriations bill, which provides funding for the planning, design, construction, alteration, and improvement of facilities used by active and reserve military components worldwide

Edwardsiella Comparative Phylogenomics Reveal the New Intra/Inter-Species Taxonomic Relationships, Virulence Evolution and Niche Adaptation Mechanisms

Edwardsiella bacteria are leading fish pathogens causing huge losses to aquaculture industries worldwide. E. tarda is a broad-host range pathogen that infects more than 20 species of fish and other animals including humans while E. ictaluri is host-adapted to channel catfish causing enteric septicemia of catfish (ESC). Thus, these two species consist of a useful comparative system for studying the intricacies of pathogen evolution. Here we present for the first time the phylogenomic comparisons of 8 genomes of E. tarda and E. ictaluri isolates. Genome-based phylogenetic analysis revealed that E. tarda could be separate into two kinds of genotypes (genotype I, EdwGI and genotype II, EdwGII) based on the sequence similarity. E. tarda strains of EdwGI were clustered together with the E. ictaluri lineage and showed low sequence conservation to E. tarda strains of EdwGII. Multilocus sequence analysis (MLSA) of 48 distinct Edwardsiella strains also supports the new taxonomic relationship of the lineages. We identified the type III and VI secretion systems (T3SS and T6SS) as well as iron scavenging related genes that fulfilled the criteria of a key evolutionary factor likely facilitating the virulence evolution and adaptation to a broad range of hosts in EdwGI E. tarda. The surface structure-related genes may underlie the adaptive evolution of E. ictaluri in the host specification processes. Virulence and competition assays of the null mutants of the representative genes experimentally confirmed their contributive roles in the evolution/niche adaptive processes. We also reconstructed the hypothetical evolutionary pathway to highlight the virulence evolution and niche adaptation mechanisms of Edwardsiella. This study may facilitate the development of diagnostics, vaccines, and therapeutics for this under-studied pathogen

Expulsion, Censure, Reprimand, and Fine: Legislative Discipline in the House of Representatives

This report discusses the Rehabilitation Act of 1973, which is the nation's major program providing comprehensive vocational rehabilitation (VR) services to help persons with physical and mental disabilities become employable and achieve full integration into society

Advance Appropriations for Veterans' Health Care: Issues and Options for Congress

This report discusses issues regarding authorization of an advanced appropriation for certain medical care accounts of the Veterans Health Administration

Fiscal Year 2016

This report discusses budget issues for the Department of Veterans Affairs (VA), which provides a range of benefits and services to veterans who meet certain eligibility rules

109th Congress

This report provides an overview of major issues facing veterans' health care during the 109th Congress. The report's primary focus is on veterans and not military retirees

Fiscal Year 2010

This report focuses on funding for the Veterans Health Administration (VHA). The VHA is primarily a direct service provider of primary care, specialized care, and related medical and social support services to veterans through the nation's largest integrated health care system. Eligibility for VA health care is based primarily on previous military service, disability, and income

Fiscal Year 2014

This report focuses on funding for the Veterans Health Administration (VHA). The VHA is primarily a direct service provider of primary care, specialized care, and related medical and social support services to veterans through the nation's largest integrated health care system. Eligibility for VA health care is based primarily on previous military service, disability, and income

Health Care for Veterans: Answers to Frequently Asked Questions

This report provides responses to frequently asked questions about health care provided to veterans through the VHA