Los expedientes judiciales como fuente para la reconstrucción de archivos familiares. El ejemplo del archivo del antiguo marquesado de Lanzarote

Los archivos familiares son una fuente de información de primer orden para el conocimiento del pasado. Sin embargo, muchas veces el traspaso de un título nobiliario de un linaje a otro, o la desatención por parte de sus propios titulares, ha provocado su desaparición. Tal es el caso del archivo del antiguo marquesado de Lanzarote, hoy en paradero desconocido y escasamente mencionado por la historiografía. Si bien la localización de un inventario de este, realizado en 1634, nos permite conocer qué había en ese momento en el ar-chivo y nos habilita para reconstruirlo, en la medida de lo posible, junto al recurso de otras fuentes documentales como los expedientes judiciales, en los que figuran numerosas copias, trasladadas de sus originales, que fueron presentados como pruebas en pesquisas y juicios. En este estudio lo que se muestra es el valor de los archivos y expedientes judiciales para la reconstrucción de los archivos familiares desaparecidos

Behçet's disease: New insight into the relationship between procoagulant state, endothelial activation/damage and disease activity

Background: Behçet disease (BD) is associated with a prothrombotic state of unknown origin that may lead to life-threatening events. Calibrated Automated Thrombogram (CAT) and Rotational Thromboelastometry (ROTEM) are two global haemostasis assays that may reveal new insights into the physiopathological mechanisms of the disease and its procoagulant condition. Methods. 23 BD patients who had no signs or symptoms of current thrombosis and 33 age- and sex-matched controls were included in the study. We performed ROTEM and CAT tests and assessed erythrocyte count, platelet count, platelet contribution to clot formation and plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor type 1 (PAI-1), fibrinogen, C-reactive protein (CRP), thrombin-antithrombin III complex (TAT), D-dimer and E-selectin (ES). Results: Both ROTEM and CAT tests showed a hypercoagulable state in the BD patients. Plasma levels of PAI-1, fibrinogen, TAT, CRP and ES were significantly increased in this group compared to controls. The disease activity (DA) was significantly correlated with levels of ES and the maximum clot firmness, and this last one, in turn, correlated with rising levels of ES, PAI-1, CRP and fibrinogen. CAT parameters did not correlate with DA or ES. Conclusions: Both ROTEM and CAT tests reveal that patients with BD have a procoagulant state even in the absence of thrombosis. ROTEM test indicates that increased levels of fibrinogen and PAI-1 may be involved in the prothrombotic state of this pathology, while platelets do not significantly contribute. Moreover, CAT assay demonstrate that plasma from BD patients is able to generate more thrombin than controls in response to the same stimulus and that this effect is independent of the DA and the endothelial impairment suggesting the involvement of another factor in the hypercoagulable state observed in BD patients. This study also shows that endothelium activation/damage may be a contributing factor in both the procoagulant and clinical conditions of BD, as shown by the direct correlation between ES levels, ROTEM parameters and DAThis work was supported by grants from FIS PS09/00531 and FIS PI12/0183

Insights into the procoagulant profile of patients with systemic lupus erythematosus without antiphospholipid antibodies

We aimed to identify the key players in the prothrombotic profile of patients with systemic lupus erythematosus (SLE) not mediated by antiphospholipid antibodies, as well as the potential utility of global coagulation tests to characterize hemostasis in these patients. Patients with SLE without antiphospholipid antibodies and without signs of thrombosis were included. The kinetics of clot formation were determined by ROTEM®. Platelet activation markers were determined by flow cytometry. Thrombin generation associated with Neutrophil Extracellular Traps (NETs) and microparticles (MPs) was measured by calibrated automated thrombogram (CAT). The plasma levels of PAI-1 were also determined. ROTEM® showed a procoagulant profile in SLE patients. SLE patients had activated platelets and more leukocyte/platelet aggregates at basal conditions. The plasma PAI-1 and platelet aggregates correlated with several ROTEM® parameters. The thrombin generation associated withthe tissue factor (TF) content of MPs and with NETs was increased. Our results suggest the utility of global tests for studying hemostasis in SLE patients because they detect their procoagulant profile, despite having had neither antiphospholipid antibodies nor any previous thrombotic event. A global appraisal of hemostasis should, if possible, be incorporated into clinical practice to detect the risk of a thrombotic event in patients with SLE and to consequently act to prevent its occurrenceThis work was supported by grant from the FIS-FONDOS FEDER (PI19/00772, NVB). E.M.M. holds a predoctoral fellowship from Fundación Española de Trombosis y Hemostasia (FETH-SETH

Cliocanarias III

Este número de Cliocanarias ofrece un conjunto de artículos de investigación y divulgación relativos a muy diversos temas y ámbitos territoriale

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Corrupción y archivos

El valor de los archivos y de los documentos ha sido subjetivado por parte de quienes ostentan el poder en la administración. Su atención se centra fundamentalmente en aquellos documentos que les pueden reportar algún beneficio, ya sea institucional o personal, y para favorecer actuaciones ilícitas muchos documentos son adulterados en el mismo proceso de tramitación con lo que alteran la transacción en beneficio propio. Estos documentos pueden ser testimonios esenciales para depurar responsabilidades en la administración, la cual puede ser posibilitada mediante la potenciación de sistemas de archivos, políticas archivísticas y de transparencia eficaces, sancionándose su incumplimiento.The value of archives and documents has been made ​​subjectived by those in power´s administration. Their focus is focuised on those documents which may report some benefit, whether be institutional or personal. In addition, to promote illegal actions, many documents are adulterated in the process of dealing altering the transaction for its own benefit. These documents may be essential testimony of accountability in the administration, because these modes of action is occurring commodification process file, which can be changed by empowering file systems, archival policies and effective transparency, and punishes noncompliance

The Generation of Power Relationship through the Students' Oral Interaction under the Use of a Task-Based Syllabus

Social reasons prompted the authors' main purpose: to report on a qualitative research develop throughout one year with tenth graders from a public school in Bogotá, Colombia where a task-based lesson was implemented fostering an environment where oral interaction and the generation of power relationships were analyzed. Four instruments were used, namely, field notes, interviews, transcripts of classroom oral interaction and surveys. The preliminary results showed that relations were marked by the roles students played as they interacted and the use they made of the language in interacting as well as the existence of differences among students

The Generation of Power Relationship through the Students' Oral Interaction under the Use of a Task-Based Syllabus

Social reasons prompted the authors' main purpose: to report on a qualitative research develop throughout one year with tenth graders from a public school in Bogotá, Colombia where a task-based lesson was implemented fostering an environment where oral interaction and the generation of power relationships were analyzed. Four instruments were used, namely, field notes, interviews, transcripts of classroom oral interaction and surveys. The preliminary results showed that relations were marked by the roles students played as they interacted and the use they made of the language in interacting as well as the existence of differences among students

Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation

Background: There are limited data on gender-based differences in atrial fibrillation (AF) treatment and prognosis. We aimed to examine gender-related differences in medical attention in an emergency department (ED) and follow-up (FU) among patients diagnosed with an AF episode and to determine whether there are gender-related differences in clinical characteristics, therapeutic strategies, and long-term adverse events in this population. Methods: We performed a retrospective observational study of patients who presented to a tertiary hospital ER for AF from 2010 to 2015, with a minimum FU of one year. Data on medical attention received, mortality, and other adverse outcomes were collected and analyzed. Results: Among the 2013 patients selected, 1232 (60%) were female. Women were less likely than men to be evaluated by a cardiologist during the ED visit (11.5% vs. 16.6%, p = 0.001) and were less likely to be admitted (5.9% vs. 9.5%, p < 0.05). Electrical cardioversion was performed more frequently in men, both during the first episode (3.4% vs. 1.2%, p = 0.001 ) and during FU (15.9% vs. 10.6%, p < 0.001 ), despite a lower AF recurrence rate in women (9.9% vs. 18.1%). During FU, women had more hospitalizations for heart failure (26.2% vs. 16.1%, p < 0.001 ). Conclusions: In patients with AF, although there were no gender differences in mortality, there were significant differences in clinical outcomes, medical attention received, and therapeutic strategies. Women underwent fewer attempts at cardioversion, had a lower probability of being evaluated by cardiologists, and showed a higher probability of hospitalization for heart failure. Being alert to these inequities should facilitate the adoption of measures to correct themMedicin