Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Research data supporting "The Missing N1 or Jittered P2: Electrophysiological Correlates of Pattern-Glare in the Time and Frequency Domain"

EEG, ERP, Behavioural responses and questionnaire data

Data from: Newly discovered morphology of the Silurian sea spider Haliestes and its implications

The three-dimensionally preserved Haliestes dasos from the Silurian (Wenlock) Lagerstätte is the most complete fossil sea spider and the oldest unambiguous pycnogonid known from the fossil record. The discovery of two new specimens to add to the holotype reveals new features including proximal annulations of the appendages and segmentation of the trunk end, critical details for comparison with pycnogonids from the Devonian (Emsian) Hunsrück Slate and for the interpretation of the evolutionary significance of Palaeozoic genera. There is some evidence of sexual dimorphism. H. dasos was nektobenthic and its morphology indicates an unusual mode of feeding compared to living pycnogonids. The new morphological features of H. dasos are closely similar to those in Palaeoisopus problematicus from the Hunsrück Slate and it clearly belongs, together with that species, in stem Pycnogonida and not the crown group

Data from: Newly discovered morphology of the Silurian sea spider Haliestes and its implications

The three-dimensionally preserved Haliestes dasos from the Silurian (Wenlock) Lagerstätte is the most complete fossil sea spider and the oldest unambiguous pycnogonid known from the fossil record. The discovery of two new specimens to add to the holotype reveals new features including proximal annulations of the appendages and segmentation of the trunk end, critical details for comparison with pycnogonids from the Devonian (Emsian) Hunsrück Slate and for the interpretation of the evolutionary significance of Palaeozoic genera. There is some evidence of sexual dimorphism. H. dasos was nektobenthic and its morphology indicates an unusual mode of feeding compared to living pycnogonids. The new morphological features of H. dasos are closely similar to those in Palaeoisopus problematicus from the Hunsrück Slate and it clearly belongs, together with that species, in stem Pycnogonida and not the crown group

Process evaluation of the sedation and weaning in children (SANDWICH) multicentre stepped wedge, cluster randomised controlled trial

Data from interviews and focus groups undertaken with clinical staff working in United Kingdom (UK) paediatric intensive care units (PICUs), with a role in weaning children from mechanical ventilation. Data were collected between July 2019 and March 2020. Participants included nurses (bedside, senior clinical management, and advanced nurse practitioners), medical staff (medical trainees and consultant intensivists), allied health professionals (physiotherapists, pharmacists and nursing assistants) and members of the hospital/unit research teams. Data address their understanding and experience of the SANDWICH trial. Note this data forms the basis of the following published paper: "Delivery of a novel intervention to facilitate liberation from mechanical ventilation in paediatric intensive care: a process evaluation" (2023). Owing to the sensitive nature of the data created during this study, data is available via restricted access. Data is embargoed until 1 November 2025. Thereafter, it is available via restricted access conditions. To request access after the embargo period, please contact RDM Team at Queen’s University Belfast Email: [email protected]

Additional file 3 of A systematic analysis of splicing variants identifies new diagnoses in the 100,000 Genomes Project

Additional file 3. Table S2. Candidate variants

Additional file 1: Table A. of Variation in Prosthetic Joint Infection and treatment strategies during 4.5Â years of follow-up after primary joint arthroplasty using administrative data of 41397 patients across Australian, European and United States hospitals

Individual hospitals contributing data by region. Table B. Included secondary procedure codes to identify surgical treatment for PJI. (DOCX 16Â kb

Additional file 2 of Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

Additional file 2: Table 1. Description of total serum N-glycan UHPLC measured peaks. Table 2. Description of total serum derived traits. Table 3. Summary statistics for the associations between N-glycan traits and response to ICI treatment. Table 4. Summary statistics for the associations between N-glycan traits and progression-free survival. Table 5. Summary statistics for the associations between N-glycan traits and overall survival. Table 6. Summary statistics for the N-glycans shift at follow up with respect to the pre-treatment relative abundances