The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents

WOS: 000305708000012PubMed ID: 22570955The prevalence of obesity among children and adolescents has been rapidly increasing in recent years. Obese individuals are at risk for vitamin D deficiency. The aim of this study was to investigate the relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. A total of 106 children and adolescents (48 prepubertal and 58 pubertal) between 8 and 16 years of age were included in the study. Fasting blood glucose, insulin, lipid profile, calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D [25(OH) D] levels, as well as blood glucose and insulin concentrations at 120 min of oral glucose tolerance test were measured. Insulin resistance was calculated using the homeostasis model assessment. Daily vitamin D intake was questioned. Serum 25(OH) D level was normal in only 3.8%, insufficient in 34.0%, and deficient in 62.2% of the subjects. There was a statistically significant rate of 25(OH) D deficiency in the pubertal group compared with that in the prepubertal group. Those subjects with 25(OH) D deficiency were found to have greater insulin resistance. Vitamin D deficiency is common among obese children and adolescents. Low vitamin D levels in obese individuals may accelerate the development of metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease by further increasing insulin resistance

Are there any risks of hyperglycaemia during acute febrile illness at pediatric emergency department?

WOS: 00027048990097

Heuristic methods for the capacitated stochastic lot-sizing problem under the static-dynamic uncertainty strategy

We consider a lot-sizing problem in a single-item single-stage production system facing non-stationary stochastic demand in a finite planning horizon. Motivated by common practice, the set-up times need to be determined and frozen once and for all at the beginning of the horizon while decisions on the exact lot sizes can be deferred until the setup epochs. This operating scheme is referred to as the static dynamic uncertainty strategy in the literature. It has been shown that a modified base stock policy is optimal for a capacitated system with minimum lot size restrictions under the static-dynamic uncertainty strategy. However, the optimal policy parameters require an exhaustive search, for which the computational time grows exponentially in the number of periods in the planning horizon. In order to alleviate the computational burden for real-life size problems, we developed and tested seven different heuristics for computational efficiency and solution quality. Our extensive numerical experiments showed that average optimality gaps less than 0.1% and maximum optimality gaps below 4% can be attained in reasonable running times by using a combination of these heuristics. (C) 2019 Published by Elsevier Ltd

INVISIBLE INGESTED FOREIGN BODY: ALUMINUM CAN TOP

WOS: 000338476500008PubMed ID: 2456588

Many admissions to the emergency departments with recurrent syncope attacks and seizures in an adolescent boy

WOS: 000266780700022PubMed ID: 19337751A 16-year-old boy presented with tonic-clonic seizure after he woke up early in the morning. He had experienced 5-6 episodes of syncope, fatigue, weakness and somnolence one year before admission. On admission, physicial examination was normal and first line laboratory tests were normal except capillary blood glucose which was 16 mg/dl