12 research outputs found
Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease
- Author
- A Gorog D
- Abadier R
- Acheatel R
- Al-Joundi B
- Albert M
- Albirini A
- Albisu Di Gennaro J
- Alcocer Gamba M
- Alexandersen P
- Alexeeva N
- Almassi H
- Altunkeser B
- Amerena J
- Amin J
- Ando K
- Apostolova E
- Appel Kf
- Appel M
- Ardissino D
- Arif I
- Armstrong P
- Asbill B
- Aslam A
- Aviles R
- Azocar J
- Bacon J
- Baden M
- Bakbak A
- Bakhai A
- Ballantyne C
- Bang L
- Barbarash O
- Barr C
- Barter Philip J.
- Basson M
- Batchelor W
- Beaudry Y
- Benatar J
- Benton R
- Bernhardi D
- Berrouschot J
- Betteridge J
- Bhagwat R
- Bhargava A
- Bhargava R
- Bhatia P
- Binder R
- Bitzur R
- Blain L
- Blombery P
- Boldueva S
- Borghi C
- Bourhaial H
- Brautigam D
- Brewer H. Bryan
- Brodmann M
- Broncel M
- Bronzwaer P
- Brown K
- Bruckert E
- Brunskill J
- Brønnum-Schou J
- Bucci M
- Bugan W
- Butman S
- Caccavo A
- Cahill T
- Canto J
- Carmichael P
- Castano L
- Cecil J
- Chan K
- Chandler G
- Chandrika Parameswaran A
- Chang K
- Chehayeb R
- Chen J
- Cheng S
- Chenier M
- Chiang Ce
- Chizhov P
- Cho B
- Chorin E
- Cinteza M
- Claudio J
- Cohen K
- Cohn J
- Coleman C
- Collis W
- Colombo H
- Colombo T
- Colquhoun D
- Comerota A
- Conde Diego
- Constantinescu M
- Cooke D
- Copaci I
- Coste P
- Cottin Y
- Coulson W
- Crater T
- Cremer P
- Crenshaw B
- Croaning J
- Crowley K
- Dalby Aj
- Davalos J
- de Groot M
- De los Rios Ibarra M
- De Luca G
- De Melker E
- De Wolf L
- Deen C
- Degregorio M
- Dehart D
- Dehning M
- Delforge M
- Dena V
- Desai V
- Desantis J
- Devedzhiev T
- Devlin G
- Di Lorenzo L
- Dietrich D
- Dillon W
- Dimov B
- Dion D
- Donahoe S
- Dorsel T
- Dosh K
- Doshi A
- Downey H
- Drexel H
- Durr S
- Dy J
- Dyczek A
- Dzupina A
- Earl J
- Edwards R
- El-Ahdab F
- Elbaz M
- Eliaschewitz F
- Elliott J
- Ellison W
- Ennis B
- Erkan A
- Erlinge D
- Evans J
- Fabec D
- Fairlamb J
- Fajardo-Campos P
- Faludi P
- Fanghanel G
- Fazekas F
- Felten W
- Fernandez-Ortiz A
- Finnell Jb
- Flores E
- Foucauld J
- Fox Keith A. A.
- Francis A
- Franken M
- French W
- Fuentes Jiménez F
- Fujii K
- Fujimoto K
- Fujinaga H
- Fukunaga M
- Gamez Jm
- Garcia Puig J
- Gaudet D
- Ge J
- Geisler T
- Gelernt M
- Genest J
- Geohas C.
- George W
- Georgeson S
- Gergel V
- Giannitsis E
- Gibson C. Michael
- Gilchrist I
- Gilmore R
- Gimple L
- Glenny J
- Gniot J
- Goldscher D
- Goodman Shaun G.
- Goodwin T
- Gorog D
- Gosse P
- Gottlieb S
- Goudev A
- Graf R
- Granger Christopher
- Gratsiansky N
- Guarnieri T
- Guasparini G
- Gudipati R
- Guerra Lopez A
- Guerra Jl
- Guizar Sanchez C
- Gupta D
- Gurbel P
- Gurevich V
- Haddad T
- Hala T
- Hamer B
- Hammett C
- Hamoud S
- Han S
- Hansen O
- Hanusch U
- Harding S
- Hart H
- Hearne S
- Henry S
- Hermiller J
- Hernandez García Jm
- Herrman Jp
- Herzog W
- Higa N
- Higashikata T
- Hirschl M
- Hoch J
- Hong B
- Horowitz J
- Hoshizaki H
- Hosokawa S
- Hotchkiss D
- Howes L
- Hranai M
- Hsieh I
- Huber K
- Hubert C
- Hunter J
- Hussein O
- Hwang K
- Ichikawa S
- Ilavská A
- Imberti D
- Imholz B
- Islam A
- Isserman S
- Janik M
- Jarasuniene D
- Jellis C
- Jeong J
- Jeong Mh
- Jerabek O
- Jetty P
- Jukema Jw
- Kadel C
- Kahn B
- Kancz S
- Kandath David
- Karalis I
- Karpenko O
- Karunaratne H
- Katus H
- Katzan I
- Kavaliauskiene R
- Kawamitsu K
- Kawka-Urbanek T
- Kaydashev I
- Kazatani Y
- Keenan G
- Keltai M
- Kereiakes D
- Khan F
- Khan M
- Khan T
- Kichukov K
- Kim D
- Kimura K
- Kirtane A
- Kis E
- Knutson T
- Kooy A
- Koren M
- Korn D
- Kosinski E
- Kouz Simon
- Kovalenko V
- Kozina M
- Kozlowski L
- Kracoff O
- Kramer J
- Krantzler J
- Krichmar P
- Krum H
- Krzyzanowski M
- Kuchar J
- Kuramochi T
- Kus W
- Kutner M
- Labonte R
- Labroo A
- Lader E
- Lafitte S
- Lahoud R
- Lai W
- Lakatos F
- Lamas G
- Lanno R
- Lappe J
- Laszloczky A
- Lau E
- Lavoie Jp
- Lazov P
- Leibowitz D
- Leiter L
- Leiva-Pons Jose L.
- Lenderink T
- Lesnik J
- Li H
- Li Weimin
- Li X
- Lieber I
- Lincoff A. Michael
- Lindgren L
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- Llamas Esperon G
- Lobo Marquez L
- Loftus I
- Loh I
- Lok D
- Lonn E
- Lotun K
- Loussararian A
- Loy J
- Luquez H
- Ma C
- Ma W
- Machkova M
- Machova V
- Madder R
- Maffei L
- Magro M
- Mahaffey K
- Mahal S
- Maislos F
- Maixing A
- Markov V
- Marple R
- Mascarenhas V
- Mason Denise
- Masri B
- Masutani M
- Matei C
- Mathis C
- Matuska J
- Maynard K
- Maynard R
- Mays M
- Mcerlean Ellen
- Mcguire Darren K.
- Melucci M
- Menon Venu
- Merkely B
- Miller G
- Miller M
- Miller S
- Min D
- Mincheva V
- Minescu B
- Miracle S
- Mirek-Bryniarska E
- Moccetti T
- Momiyama Y
- Montalescot Gilles
- Montano E
- Monteleone P
- Montenegro R
- Mooe T
- Morel O
- Moretto T
- Moriarty K
- Morris F
- Mos L
- Motiejuniene L
- Moursi M
- Mulkay A
- Muneer B
- Murray A
- Münzel T
- Nadar V
- Nakamura T
- Natour M
- Nault P
- Navas J
- Nawaz S
- Nevarez Ruiz L
- Newton D
- Nicholls Stephen J.
- Nicolau Jose C.
- Nielsen H
- Nieto Iglesias Lj
- Nissen
- Nortje H
- Ochean V
- Ogawa H
- Ohshima K
- Okopien B
- Olsson A
- Ongen Z
- Oroszlan T
- Ozaki R
- Ozaki Y
- O’Keefe D
- Pagel-Langenickel I
- Panchal V
- Pandey S
- Park G
- Parkhomenko A
- Parvanova Z
- Paster R
- Peart B
- Peeters A
- Peichert D
- Penev P
- Perez Vargas E
- Pesant Yves
- Peterson S
- Petrochenkova N
- Pintó Sala X
- Piper P
- Plomp J
- Poi K
- Poirier P
- Polasek P
- Pollock S
- Poock J
- Prado A
- Prashad R
- Preston S
- Prodafikas J
- Proietto J
- Pruna C
- Pytlewski G
- Quadrel M
- Quinlan E
- Rader Daniel
- Raev D
- Raikhel M
- Rama P
- Ramlachan P
- Rangé G
- Rao V
- Rasmussen T
- Raugaliene R
- Rees A
- Reichert P
- Ren H
- Renkin J
- Rhee M
- Ridker P
- Rieker W
- Riesmeyer Jeffrey S.
- Rocco M
- Rogers W
- Rohatgi A
- Ronner E
- Rosenthal S
- Rubba P
- Ruotolo Giacomo
- Rynkiewicz A
- Saaiman J
- Sabatino K
- Sakota S
- Saku K
- Sakuragi S
- Salazar J
- Salvioni A
- Sandoval J
- Sarkar S
- Schiff E
- Schmedtje J
- Schramm E
- Schuchard T
- Schäufele T
- Sciborski R
- Seals A
- Seaworth J
- Senn T
- Sethi P
- Shah P
- Shah S
- Sharma J
- Sheu W
- Shimizu M
- Shimomura H
- Shortal B
- Shukla D
- Shyu K
- Siachos A
- Silvain J
- Simon H
- Simpson R
- Singal D
- Singer O
- Singh N
- Sipos A
- Siqueira Bodart J
- Slade K
- Slapikas R
- Smejkalova O
- Snyder H
- Soni A
- Soots M
- Soufer J
- Spencer R
- Srivastava S
- St-Maurice F
- Stahl L
- Stamate C
- Standley J
- Staniloae C
- Steg G
- Stegman B
- Steinhubl S
- Stellbrink C
- Stephens M
- Steven E. Del Valle M
- Stobschinski de Alba C
- Stoyanov M
- Strain J
- Stroes E
- Studeny M
- Sueyoshi A
- Sullivan D
- Supryadkina T
- Suryanarayana P
- Suzuki M
- Sweet M
- Syan R
- Szakal I
- Szocs A
- Szántai G
- Sánchez Álvarez J
- Taguchi S
- Tahirkheli Naeem
- Takahashi N
- Talano J
- Tall Alan R.
- Tanabe J
- Tanabe K
- Tardif Jc
- Tashiro H
- Teklinski A
- Tengmark Bo
- Theron H
- Tishler S
- Tong Yc
- Torosyan N
- Toursarkissian N
- Traboulssi M
- Tran D
- Treasure C
- Trenk D
- Troquay R
- Tsujita K
- Tyden P
- Tzekova M
- Uchino K
- Ueda O
- Ueng K
- Uhliar R
- Valter I
- van Cleeff M
- van Eck J
- Van Leendert R
- Van-Zyl L
- Vangel S
- Vangerow Burkhard
- Vanwelden J
- Vazquez-Tanus J
- Velimsky T
- Venter T
- Verhave G
- Vinanska D
- Violante Ortiz R
- Visona A
- Vo A
- Vodnansky P
- Vogel C
- vom Dahl J
- Vora N
- Wali A
- Weerakkody Govinda
- Weinstein D
- Weiss R
- Weisz G
- West S
- Westendorp I
- Whitaker J
- White H
- White L
- Widimsky P
- Wiersma J
- Wierzbicka K
- Wilson S
- Wittes J
- Wollaert B
- Wolski Kathy
- Wong B
- Xu D
- Yagensky A
- Yamagishi M
- Yasuda S
- Yeo W
- Yeoman G
- Yeung V
- Young C
- Younis L
- Yu C
- Z Jafar M
- Zakhary B
- Zayas-Torres C
- Zebrack J
- Zelman R
- Zhu J
- Ziada K
- Zrazhevsky K
- Zólyomi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease.
METHODS:
In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Patients were randomly assigned to receive either evacetrapib at a dose of 130 mg or matching placebo, administered daily, in addition to standard medical therapy. The primary efficacy end point was the first occurrence of any component of the composite of death from cardiovascular causes, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina.
RESULTS:
At 3 months, a 31.1% decrease in the mean LDL cholesterol level was observed with evacetrapib versus a 6.0% increase with placebo, and a 133.2% increase in the mean HDL cholesterol level was seen with evacetrapib versus a 1.6% increase with placebo. After 1363 of the planned 1670 primary end-point events had occurred, the data and safety monitoring board recommended that the trial be terminated early because of a lack of efficacy. After a median of 26 months of evacetrapib or placebo, a primary end-point event occurred in 12.9% of the patients in the evacetrapib group and in 12.8% of those in the placebo group (hazard ratio, 1.01; 95% confidence interval, 0.91 to 1.11; P=0.91).
CONCLUSIONS:
Although the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers, treatment with evacetrapib did not result in a lower rate of cardiovascular events than placebo among patients with high-risk vascular disease. (Funded by Eli Lilly; ACCELERATE ClinicalTrials.gov number, NCT01687998 .)
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- Abo‐Auda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- Arias‐Mendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- Biering‐Sørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- Costa‐Vitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- Crespo‐Leiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen Hans‐Dirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
- Filippatos Gerasimos
- Fisher Daniel
- Florea Viorel
- Flores Ana Maria De Leon
- Floresta Agata Marina
- Fonseca Candida
- Fonseca Cândida
- Forman Steven
- Forster Tamas
- Fortes Jose Augusto Ribas
- Fourie Nyda
- Franchi Francesco
- Frank Theodore
- Frankenstein Lutz
- Freire Ramon Bover
- Fremont Richard
- French John
- Friedman Keith
- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
- Fuente Galan Luis
- Fuente Ricardo Alfonso Leon
- Fujii Kenshi
- Fujii Shigeru
- Fujiwara Wakaya
- Fukuzawa Shigeru
- Fulop Peter
- Gabriel George
- Gajardo Victor Areli Saavedra
- Galinier Michel
- Ganeshram Vedampattu
- Ganji Jagadeesh
- Garrido Marcelo Alejandro
- Gass Alan
- Gaudet Daniel
- Geltman Edward
- Gemignani Anthony
- Genth‐Zotz Sabine
- Georges Jean‐Louis
- Giamouzis Grigorios
- Gianfagna Robert
- Giannetti Nadia
- Gilmore Richard
- Giorgeto Flavio Eduardo
- Giraldo Clara Ines Saldarriaga
- Giuca Alina
- Giudici Vittorio
- Glover Jason
- Gogia Harinder
- Gohara Seiichiro
- Gola Zbigniew
- Goloshchekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Goncharov Ivan
- Gonsorcik Jozef
- Gonzalez Ricardo Garcia
- Gonzalez Salvador Leon
- Gordon Brian
- Gorodeski Eiran
- Gottlieb Stephen
- Goudev Assen
- Goudev Assen R.
- Gray Wayne
- Grazette Luanda
- Greco Oswaldo
- Grewal Gurinder
- Groote Pascal De
- Gueffet Jean‐Pierre
- Guerrero Rodolfo Andres Ahuad
- Gupta Dinesh
- Gupta Milan
- Guray Umit
- Haddad Tariq
- Haehling Stephan
- Hajko Erik
- Hal John
- Halpern Stephen
- Hametz Craig
- Hamilton Andrew
- Han Qinghua
- Han Yajun
- Handel Franklin
- Hara Hisao
- Harris John
- Hart Hamish
- Hart Terence
- Hartleib Michael
- Hasni Syed
- Hata Yoshiki
- Hattler Brack
- Hearne Steven
- Hedgepeth Chester
- Heilman Karl
- Heitner John
- Henderson David
- Herczeg Bela
- Hermans Walter
- Herzog William
- Hidaka Takayuki
- Hidalgo Mario Yanez
- Higashino Yorihiko
- Hiroi Shitoshi
- Hominal Miguel Angel
- Horacek Thomas
- Houra Marek
- Houston Brian
- Howlett Jonathan G.
- Huang He
- Huber Kurt
- Huelsmann Martin
- Hullin Roger
- Hunter Vernon
- Huynh Thao
- Ibañez Julio
- Ibrahim Hassan
- Indolfi Ciro
- Inomata Takayuki
- Iseki Harukazu
- Ishikawa Masahiro
- Isnard Richard
- Isshiki Takaaki
- Itchhaporia Dipti
- Ito Hiroshi
- Jackson Bruce
- Jacob Binu
- Jadbabaie Farid
- Jaeger Cristiano Pederneiras
- Jaffrani Naseem
- Jalaf Margarita Gertrudis Vejar
- Janik Matthew
- Jankowski Piotr
- Janmohamed Munir
- Jarasuniene Dalia
- Jattin Fernando Manzur
- Javier Julian
- Jeppesen Jorgen
- Jerabek Ondrej
- Jimenez Juan Francisco Delgado
- Jofre Christian Paolo Pincetti
- Jondeau Guillaume
- Jones Alonzo
- Joseph Susan
- Juanatey Jose Ramon Gonzalez
- Judkins Christopher
- Kadel Christoph
- Kadokami Toshiaki
- Kafara Mariusz
- Kai Hisashi
- Kaiser‐Nielsen Peter
- Kajinami Kouji
- Kalarus Zbigniew
- Kalecinska‐Krystkiewicz Ewa
- Kalra Paul
- Kaluski Edo
- Kanda Junji
- Kania Grzegorz
- Kao John
- Karavidas Apostolos
- Karim Amin
- Karlstrom Patric
- Karpenko Oleksandr
- Karvounis Haralambos
- Kasai Toshio
- Kassiotis Christos
- Katz Richard
- Kawakami Hideo
- Kawamitsu Katsunori
- Kawasaki Tomohiro
- Kazemi Navid
- Kazinczy Rita
- Kearney Leighton
- Keeling Philip
- Kellnerova Ivana
- Khalife Wissam
- Kida Keisuke
- Killat Holger
- Kindel Carlos Conejeros
- King Anthony
- Kirma Cevat
- Kitaoka Hiroaki
- Klimsa Zdenek
- Klug Eric
- Kobalava Zhanna
- Kochiadakis George
- Koga Tokushi
- Koike Akihiro
- Koizumi Tomomi
- Koldas Zehra Lale
- Koleckar Pavel
- Komiyama Nobuyuki
- Kondo Nicholas
- Konieczynska Malgorzata
- Kono Alan
- Koo Charles
- Kopaczewski Jerzy
- Korczyk Dariusz
- Koren Michael
- Korzh Oleksii
- Kosmacheva Elena
- Kostenko Viktor
- Kotelnikov Mikhail
- Kowalski Robert
- Kracz Igor
- Krantz Mori
- Krishnamoorthy Arun
- Krupicka Jiri
- Kryza Radim
- Kubota Toru
- Kulibaba Elena
- Kulynych Oleksii
- Kurtz Christopher E.
- Kwan Michael
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- Lang Chim
- Lang Christopher
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- Suter Thomas M.
- Suzuki Masahiro
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- Tallet Julio
- Tanabe Jun
- Tanaka Takahiro
- Tang Huifang
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- Tartiere Jean‐Michel
- Tatebe Shunsuke
- Taylor Justin
- Teerlink John R.
- Terasaki Toshiro
- Terasawa Akihiro
- Tereschenko Sergey
- Timofeev Alexander
- Tisheva‐ Gospodinova Snezhanka
- Tocchetti Carlo Gabriele
- Todorov Georgi
- Tognon Alexandre
- Tomcsanyi Janos
- Tomcsanyi Janos
- Toth Kalman
- Treasure Charles
- Trebacz Jaroslaw
- Trevelyan Jasper
- Triana Miguel Urina
- Trichon Benjamin
- Trochu Jean Noel
- Tsabedze Nqoba
- Tsao Lana
- Tseluyko Vira
- Tsioufis Konstantinos
- Tsujimoto Mitsuru
- Tuncer Mustafa
- Turgut Okan Onur
- Tyl Petr
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- Tziakas Dimitrios
- Ueda Yasunori
- Ueno Hideki
- Uhliar Rudolf
- Ujino Keiji
- Uretsky Barry
- Usui Makoto
- Utsu Noriaki
- Vaccari Christopher
- Vakaliuk Igor
- Van Eck Jacob
- Van Kesteren Henricus
- Van Zyl Louis
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
- Vasallo Javier
- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
- Velikov Chavdar
- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu Olga‐Cristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- Wozakowska‐Kaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594).
Conclusions:
GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects.
- Author
- Abdulhakim Ee
- Abraham G
- Adamiec R
- Adler A
- Alpizar-Salazar M
- Altorjay A
- Andre I
- Anzà C
- Appolinario J
- Archambeaud F
- Armstrong P
- Astrup A
- Augusztin G
- Avezum A
- Baar M
- Babes A
- Banasiak W
- Barnett Ah
- Baro Fm
- Barrios Merino A
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- Beermann J
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- Bodmer C
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- Bosello O
- Bringer J
- Brohet C
- Brophy J
- Brunetiere C
- Bugan V
- Caixas A
- Campbell Iw
- Campbell L
- Carey D
- Carrageta M
- Carrillo-Ortega E
- Caterson Id
- Caterson Id
- Cencarik J
- Cepelak V
- Cerny P
- Charpentier G
- Chiariello M
- Chowdhury T
- Chrusciel P
- Cifkova R
- Cifkova R
- Cleland J
- Cocaul-André M
- Colquhoun D
- Colquhoun D
- Cook Rc
- Cordera R
- Costa e Forti A
- Costa e Forti A
- Coucke F
- Coutinho W
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- Creteanu G
- Csala L
- Csaszar A
- Cuatrecasas Cambra G
- Czuriga I
- Dabadie H
- Dagenais G
- Dammann Hg
- Dan Ga
- de Albuquerque Dc
- de Godoy Matos Af
- de la Torre Casares Ml
- Dendale P
- Derlaga B
- Di Mario U
- Diehm C
- Dinneen S
- Dinnyes J
- Ditschuneit H
- Dominguez Escribano Jr
- Dominguez H
- Donnachie H
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- Dragulescu Si
- Drexler H
- Dubreuil A
- Duran Garcia S
- Escobar-Jimenez L
- Esteva de Antonio I
- Estour B
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- Formiguera Sala X
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- Gessek J
- Gessner S
- Gibault T
- Giorgino R
- Gonsorcik J
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- Graur M
- Gross Jl
- Guthersohn A
- Gyimesi A
- Hainer V
- Halimi S
- Halmy L
- Halmy L
- Halpern A
- Hamann A
- Hancu N
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- Hanefeld M
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- Herzner A
- Hespel Jp
- Heufelder Ae
- Heun Kc
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- Hillis Gs
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- Howarth Dj
- Hughes E
- Issa Sayegh M
- Jackson S
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- Janik K
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- Janosi A
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- Kamensky G
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- Laville M
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- Lecerf Jm
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- Linhart A
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- Liziczai I
- Louvet Jp
- Macek V
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- Madero Ma
- Maggioni Ap
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- Maisch B
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- Majercak I
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- Piepiorka M
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- Pocock S
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- Polaszewska-Muszynska M
- Ponikowski P
- Povolny J
- Proietto J
- Pupek-Musialik D
- Radoi M
- Raja A
- Ranetti A
- Reckless J
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- Repetto G
- Ricart W
- Richard F
- Richelsen B
- Riecansky I
- Ritz P
- Roberts D
- Roberts-Thomson P
- Robinson J
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- Rodriguez G
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- Rubio Ma
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- Saldate C
- Sanchez-Castillo Cp
- Santeusanio F
- Santini F
- Sarmiento R
- Sawicki A
- Scheen A
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- Schlienger Jl
- Schmidt E
- Schmitt B
- Scholze J
- Schoors D
- Schreckenberg A
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- Sharma Am
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- Shaw J
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- Thomas Ho
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- Tinahones F
- Tirgoviste Ci
- TORP-PEDERSEN C
- Torp-Pedersen C
- Totoian I
- Toubro S
- Toubro S
- Trojnar R
- Tykarski A
- Uhliar R
- Urbanek R
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- Urhammer S
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- Van Crombrugge P
- VAN GAAL Lf
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- Zuniga-Guajardo S
- Zuniga-Perez Lemaur M
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2010
- Field of study
BACKGROUND: The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established. METHODS: We enrolled in our study 10,744 overweight or obese subjects, 55 years of age or older, with preexisting cardiovascular disease, type 2 diabetes mellitus, or both to assess the cardiovascular consequences of weight management with and without sibutramine in subjects at high risk for cardiovascular events. All the subjects received sibutramine in addition to participating in a weight-management program during a 6-week, single-blind, lead-in period, after which 9804 subjects underwent random assignment in a double-blind fashion to sibutramine (4906 subjects) or placebo (4898 subjects). The primary end point was the time from randomization to the first occurrence of a primary outcome event (nonfatal myocardial infarction, nonfatal stroke, resuscitation after cardiac arrest, or cardiovascular death). RESULTS: The mean duration of treatment was 3.4 years. The mean weight loss during the lead-in period was 2.6 kg; after randomization, the subjects in the sibutramine group achieved and maintained further weight reduction (mean, 1.7 kg). The mean blood pressure decreased in both groups, with greater reductions in the placebo group than in the sibutramine group (mean difference, 1.2/1.4 mm Hg). The risk of a primary outcome event was 11.4% in the sibutramine group as compared with 10.0% in the placebo group (hazard ratio, 1.16; 95% confidence interval [CI], 1.03 to 1.31; P=0.02). The rates of nonfatal myocardial infarction and nonfatal stroke were 4.1% and 2.6% in the sibutramine group and 3.2% and 1.9% in the placebo group, respectively (hazard ratio for nonfatal myocardial infarction, 1.28; 95% CI, 1.04 to 1.57; P=0.02; hazard ratio for nonfatal stroke, 1.36; 95% CI, 1.04 to 1.77; P=0.03). The rates of cardiovascular death and death from any cause were not increased. CONCLUSIONS: Subjects with preexisting cardiovascular conditions who were receiving long-term sibutramine treatment had an increased risk of nonfatal myocardial infarction and nonfatal stroke but not of cardiovascular death or death from any cause. (Funded by Abbott; ClinicalTrials.gov number, NCT00234832.
Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
- Author
- 3rd Allison J.
- Abe N
- Abedini S
- Abraham G
- Acker Kv
- Adelberger V
- Adhikari P
- Agarwal N
- Ahmed F
- Aiello A
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- Aldigier Jc
- Allemann Y
- Almeida F
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- Anderson J
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- Bazzi A
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- Berrizbeitia M
- Bevilacqua Mt
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- Chouinard G
- Chowdhury S
- Christiansen Js
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- Chua T
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- Cocchi R
- Comas A
- Comlekci A
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- Connery L
- Constam En
- Cooperman M
- Corona V
- Corsi A
- Coucke F
- Cournoyer S
- Cozzolino D
- Craig W
- Culak J
- Cunha R
- Cusachs Ar
- Dö
- D&apos
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- da Costa AG
- da Silva GF
- da Silva PM
- Dani S
- Darko D
- Dattani D
- David S
- de Jong A
- de Paula RB
- De Pellegrin A
- de Roa ER
- De Teresa E
- de Zeeuw D
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- dell Valle MH
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- Zanette G
- Zangroniz P
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- Zimmermann U
- Zinman B
- Zushi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
Background
This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 dia- betes and chronic kidney disease, cardiovascular disease, or both.
Methods
In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting\u2013enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level.
Results
The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P=0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pres- sures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, 656 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P<0.001 for both comparisons).
Conclusions
The addition of aliskiren to standard therapy with renin\u2013angiotensin system block- ade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- Abbott J. Dawn
- Abdullah S.
- Abib E.
- Ables L. R.
- Abrantes J. A. M.
- Acosta R.
- Adams A.
- Adams F.
- Adroer Martori R.
- Agafina A. S.
- Agaiby J. M.
- Aggarwala G.
- Agraou B.
- AguilarSalinas C. A.
- Ahmad A.
- Ajala B.
- Akdeniz B.
- Akhtar N.
- Akright L.
- Aksentiev S.
- Al-Zoebi A.
- Alappat P.
- Albert M.
- Alfieri A. D.
- Alhakim M.
- Allaw M. A.
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- Altafullah I. M.
- Alvarado O. P.
- Alvarez C. A.
- Alvarez J. G.
- Alvarez M. S.
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- Alzand B.
- Amarenco P.
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- Andersen J. L.
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- Anderson Patricia
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- Andrassy P.
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUN
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M.
- Aboufakher R.
- Abrahamsen T. E.
- Accini Mendoza J. L.
- Acheatel R.
- Ackermann D.
- Adamkova V.
- Adams M.
- Adlam D.
- Aggarwal R.
- Aggarwal S.
- Ahsan A.
- Ainsworth P.
- Airody Govinda R.
- Akai A.
- Ako J.
- Al-Bahrani A.
- Al-Joundi T.
- Aldegather J.
- Aldrete Velasco J. A.
- Alfieri A.
- Alt I.
- Alzohaili O.
- Amerena J.
- Amin J.
- Amoedo R.
- Amuchastegui M.
- Anderson T.
- Andreka P.
- Andreotti F.
- Angoulvant D.
- Ansell B.
- Antalik L.
- Antkowiak-Piatyszek K.
- Appel K.
- Arakawa T.
- Arana Londoño C.
- Ardissino D.
- Ardito W. R.
- Arkhipov M.
- Arsenescu-Georgescu C.
- Asamoah N.
- Ascaso Gimilio J. F.
- Atar S.
- Atassi K.
- Athyros V.
- Auerbach E.
- Awtry E.
- Baass A.
- Badariene J.
- Badat A.
- Badila E.
- Bae J.
- Baigent C.
- Bain S.
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- Baldari D.
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- Banach M.
- Bandh S.
- Banerjee S.
- Banik M.
- Banikova A.
- Barbarash O.
- Barcinas R.
- Barnum O.
- Barroso de Souza W. K.
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- Barton J.
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- Beltrame J.
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
peer reviewedBACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets. © 2017 Massachusetts Medical Society
Cardiorenal end points in a trial of aliskiren for type 2 diabetes.
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- Glorioso N
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- Gonzalez JM
- Gonzalez R
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- Gouet D
- Goumenos D
- Graf HJ
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- Haase F
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- Herrada B
- Herrmann HJ
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- Hiremath J
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- Ibrik O
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- Iglesias JN
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- Kaneko S
- Kang S
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- Katayama SS
- Katz L
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- Kilbane A.
- Kim S
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- Kitiyakara C
- Klaff L
- Klausmann G
- Klepzig C
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- Koleny D
- Komroskova M
- Kooy A
- Kooy A
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- Koranyi L
- Kovalchuck AA
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- Krishnan U
- Krzesinski JM
- Kumar J
- Kumar S
- Kuschnir E
- Kvapil M
- Kwak I
- Kwon Y
- Labutiniene IP
- Lachance P
- Lachin JM
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- Lanier D
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- Ledger G
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- Leendert RJ
- Lehmann G
- Leimbach W
- Leira VM
- Leiter L
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- Lembo G
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- Leotta S
- Lerman S
- Lervang HH
- Leurs PB
- Levenson D
- Levinson L
- Li H
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- Lieverse AG
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- Limone PP
- Lin H
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- Liu B
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- Lopez I
- Lopez JM
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- Lv X
- Ma J
- Maddux A
- Maeda Y
- Maggioni A
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- Mamish Z
- Mancebo JG
- Mannarino E
- Marchionni N
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- Marre M
- Marre M
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- Massari P
- Mateos C
- Mathieu C
- Matsubayashi S
- Matsumoto A
- Mayer G
- McGill J
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- Mediavilla JD
- Medina B
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- Medina F
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- Middleton A
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- Miglinas M
- Milesi R
- Minehart C
- Mion D Jr
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- Modi KK
- Mohan V
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- Monterroso V
- Morosetti M
- Mos L
- Mostard G
- Moustafa M
- Mueller G
- Muirhead N
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- Muros T
- Nadal JJ
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- Nanclares MS
- Narayan P
- Narimiya M
- Ng TG
- Nickenig G
- Nickenig G
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- Niepen PV
- Nierop PR
- Nolen T
- Nour K
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- O'Hare P
- Oerter E
- Oestergaard O
- Ogawa Y
- Oh H
- Oigman W
- Okamoto H
- Olivan J
- Olsen H
- Onishi Y
- Ontiveros C
- Ooi TC
- Orias M
- Oroszlan T
- Ott P
- Ovize M
- Pagkalos E
- Pan C
- Pandey S
- Papadakis I
- Pappas S
- Paragh G
- Parra J
- Parre\uf1o Lde T
- Parving HH1
- Pascual J
- Pastrnakova E
- Paulweber B
- Pedersen TR
- Pedrinelli R
- Pella D
- Pencz I
- Penfornis A
- Peral JL
- Perez JS
- Pernalete N
- Perrild H
- Persson F
- Persu A
- Perticone F
- Petrillo A
- Petrulioniene Z
- Pettersson P
- Pfeffer MA
- Phillips A
- Piatti P
- Pichette V
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- Piskorz D
- Podgorski G
- Pollock J
- Polonia DJ
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- Porta A
- Portnay G
- Poteliuniene V
- Povedano ST
- Powell C
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- Prager R
- Prasad J
- Providencia DL
- Puig JG
- Qi X
- Qiu M
- Quarello F
- Querejeta R
- Quinonez M
- Rambausek M
- Ranjith N
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- Rayner BL
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- Rekhi A
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- Ricart W
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- Roberts J
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- Rosenblit P
- Rossing P
- Ruddy M
- Rudofsky G
- Ruige J
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- Ruilope L
- Ruiz-Rivera L
- Rusculleda M
- S\ue1nchez V
- Saari M
- Saavedra A
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- Sadler L
- Sahay R
- Sala J
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- Sarro M
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- Savela K
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- Schmitt H
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- Szentivanyi M
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- Takeda H
- Tanaka S
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- Tildesley H
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- Turcios E
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- van den Meiracker AH
- van der Zwaan C
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- van Loon BJ
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- Varthakavi P
- Vasconcelos MP
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- Villafuerte B
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- Vinciguerra A
- Viswanathan V
- Vita N
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- Vodnansky P
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- Voors AA
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- Vosskuehler A
- Vriese AD
- Wahl T
- Wang H
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- Wassermann A
- Watschinger B
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- Weisnagel SJ
- Weiss L
- Weiss L
- Wellmann H
- Widimsky P
- Wiesweg CK
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- Wittmann I
- Woittiez AJ
- Wong KS
- Wong KS
- Woo V
- Woolley A
- Wu CJ
- Wu KD
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- Wuethrich R
- Wuethrich R
- Wynne A
- Wyss F
- Xia W
- Xiang Z
- Xu G
- Xu M
- Xu X
- Yajnik C
- Yalouris A
- Yamada K
- Yamada T
- Yan J
- Yan L
- Yan S
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- Yang TC
- Yang W
- Yeoh LY
- Yuan Z
- Zabuliene L
- Zamora B
- Zamorano JL
- Zanella M
- Zanella MT
- Zanette G
- Zangroniz P
- Zaoui P
- Zhan X
- Zhang H
- Zhang J
- Zhang M
- Zhong H
- Zhong L
- Zhou Z
- Zhu D
- Zigrang W
- Zimmermann U
- Zinman B
- Zushi S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2012
- Field of study
BACKGROUND: This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both.
METHODS: In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level.
RESULTS: The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P=0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, 656 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P<0.001 for both comparisons).
CONCLUSIONS: The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful
Stress neuropeptide levels in adults with chest pain due to coronary artery disease: potential implications for clinical assessment
- Author
- A. A. Ermolaev
- A. A. Fomin
- A. A. Grace
- A. A. J. Adgey
- A. A. J. Adgey
- A. A. J. Adgey
- A. Abdelfattah
- A. Affatato
- A. Aiello
- A. Albuquerque
- A. Albuquerque
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleixo
- A. Aleksic
- A. Aleksova
- A. Alexandrescu
- A. Altamirano
- A. Alvarez-San Gabriel
- A. Anzoletti Boscolo
- A. Arias
- A. Ariza Sole
- A. Ariza Sole
- A. Ariza Sole
- A. Asif
- A. Aurelio
- A. Bellemain-Appaix
- A. Berezin
- A. Beyaztas
- A. Birdane
- A. Birdane
- A. Birdane
- A. Birdane
- A. Birdane
- A. Bittlinsky
- A. Botelho
- A. Botelho
- A. Botelho
- A. Boytsov
- A. Brzozowska-Czarnek
- A. C. C. Carvalho
- A. C. C. Carvalho
- A. C. C. Carvalho
- A. C. Ferreira
- A. C. Van Rossum
- A. C. Van Rossum
- A. C. Van Rossum
- A. Cabiati
- A. Calabro
- A. Campanile
- A. Campo
- A. Cattabiani
- A. Cavusoglu
- A. Cavusoglu
- A. Cequier Fillat
- A. Chaib
- A. Chernova
- A. Comella
- A. Condac
- A. Conti
- A. Contine
- A. Correia
- A. Cristea
- A. De Caterina
- A. De Miguel
- A. Dibra
- A. Diego
- A. Dominguez-Rodriguez
- A. Drumond
- A. Drumond
- A. Drumond
- A. Drumond
- A. Dushpanova
- A. Erglis
- A. Erglis
- A. F. Simoes Marques Assuncao Caetano
- A. Fareed
- A. Faustino
- A. Faustino
- A. Faustino
- A. Faustino
- A. Fernandez-Ortiz
- A. Fernandez-Ortiz
- A. Fernandez-Ortiz
- A. Fiarresga
- A. Fruntelata
- A. Fruntelata
- A. G. Aroutunov
- A. G. Fruntelata
- A. G. Nikishin
- A. G. Nikishin
- A. G. Rebuzzi
- A. Garcia Escudero
- A. Garcia Quintana
- A. Geppert
- A. Gnanaraj
- A. Gonella
- A. Goodkova
- A. Grave
- A. Grave
- A. Hirsch
- A. Hirsch
- A. Hirsch
- A. Horvath
- A. I. Hassan
- A. I. Suceveanu
- A. I. Suceveanu
- A. Ibatov
- A. Ibatov
- A. Iniguez
- A. Ionac
- A. Izzo
- A. Izzo
- A. Izzo
- A. J. Aleksandra Jovelic
- A. J. Palomino Doza
- A. J. Six
- A. Jegou
- A. Jovelic
- A. Kalinauskas
- A. Kasai
- A. Kastrati
- A. Kawamura
- A. Kokotos
- A. Konopka
- A. Kral
- A. Kruger
- A. L. Bartorelli
- A. L. Volkova
- A. Lallo
- A. Leitao
- A. Leitao
- A. Leitao Marques
- A. Leitao Marques
- A. Leitao Marques
- A. Leitao Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Leitao-Marques
- A. Linhart
- A. Linhart
- A. Llacer
- A. Lopez-March
- A. Lousinha
- A. Lousinha
- A. M. Abdelbary
- A. M. Fareed
- A. M. Leitao Marques
- A. M. Leitao-Marques
- A. M. Leitao-Marques
- A. M. Leitao-Marques
- A. M. Leone
- A. M. Ramirez Rodriguez
- A. M. Van Der Laan
- A. M. Van Der Laan
- A. Maisel
- A. Manerba
- A. Martinez Martinez
- A. Marzari
- A. Mayr
- A. Medina Fernandez Aceytuno
- A. Melnikov
- A. Menozzi
- A. Mercadier
- A. Mosterd
- A. Mousa
- A. Mysiak
- A. N. Kitsiou
- A. Naggar
- A. Nardelli
- A. Neji
- A. Neskovic
- A. Neskovic
- A. Omura
- A. Palazzuoli
- A. Pani
- A. Parspour
- A. Pereira
- A. Pereira
- A. Perez De Prado
- A. Pernat
- A. Peterschroeder
- A. Peterschroeder
- A. Petris
- A. Proclemer
- A. Proclemer
- A. Pullara
- A. Reda
- A. Reggiani
- A. Rialan
- A. Rincon De Arellano
- A. Rodrigues
- A. Rodriguez
- A. Rodriguez-Gonzalez
- A. Rodriguez-Gonzalez
- A. Rusali
- A. S. Mullasari
- A. S. Postadzhiyan
- A. Samborska-Sablik
- A. Sanchez Gonzalez
- A. Sanchez-Grande-Flecha
- A. Sanchez-Grande-Flecha
- A. Sarantopoulos
- A. Scafa Udriste
- A. Scafa Udriste
- A. Schaefer
- A. Schmidt
- A. Schoemig
- A. Schratter
- A. Schratter
- A. Sciahbasi
- A. Shotan
- A. Shpektor
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Silva
- A. Stojkovic
- A. Stojkovic
- A. Stojkovic
- A. Stojkovic
- A. Suarez-Barrientos
- A. Suceveanu
- A. Suceveanu
- A. Suzuki
- A. Swiatkowski
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. T. Timoteo
- A. Tomlin
- A. Toste
- A. Toste
- A. Toste
- A. Unalir
- A. Unalir
- A. Urbanik
- A. V. Starodubova
- A. V. Timofeev
- A. Van Der Laan
- A. Viertel
- A. Vorlat
- A. Weaver
- A. Y. A. Goodkova
- A. Y. Suvorov
- A. Yukawa
- A. Zhivkov
- A.- C. Martin
- B. B. Ong
- B. B. Ong
- B. Berdaoui
- B. Berta
- B. Brockmeyer
- B. Del Taglia
- B. Doka
- B. E. Backus
- B. Finkov
- B. Fontanella
- B. Franci
- B. G. Branko Gligic
- B. Getaldic
- B. Gligic
- B. Gok
- B. Gorenek
- B. Gorenek
- B. Gorenek
- B. Gorenek
- B. Gorenek
- B. Ibanez
- B. Ibanez
- B. Ibanez Cabeza
- B. J. Bouma
- B. Jedaida
- B. Merkely
- B. Merkely
- B. Merkely
- B. Metzler
- B. Meuris
- B. Minescu
- B. Moquet
- B. Putnikovic
- B. Putnikovic
- B. Ruiz-Mateos
- B. Ruiz-Mateos
- B. Sasko
- B. Schei
- B. Silva
- B. Silva
- B. Silva
- B. Silva
- B. Silva
- B. Smith
- B. Sredniawa
- B. Steuerova
- B. Timuralp
- B. Trimarco
- B. Valente
- B. Vega
- B. Vogel
- B. Vogel
- B. Wasan
- B. Xu
- C. A. Den Uil
- C. Acebal
- C. Acebal
- C. Aguiar
- C. Aguiar
- C. Aguiar
- C. Andrioaia
- C. Andrys
- C. Arsenescu-Georgescu
- C. Autore
- C. B. Dias
- C. B. Dias
- C. Bonanad
- C. C. Fang
- C. Cabades
- C. Caiati
- C. Calisto
- C. Calisto
- C. Calisto
- C. Calisto
- C. Cardwell
- C. Carriere
- C. Cavallini
- C. Cherfils
- C. Ciccarese
- C. Ciurea
- C. Cosson
- C. Cozma
- C. Crowe
- C. Cuellas
- C. Demirustu
- C. Demirustu
- C. Demirustu
- C. Demirustu
- C. Dubois
- C. Dubois
- C. Dubois
- C. Enjuanes-Grau
- C. Enjuanes-Grau
- C. Faustino
- C. Ferrari
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fonseca
- C. Fresco
- C. Fresco
- C. G. Owens
- C. Garcia-Garcia
- C. Ginghina
- C. Grasso
- C. Hassager
- C. Hassager
- C. Hernandez
- C. Hernandez Garcia
- C. Hernandez Garcia
- C. Hernandez Luis
- C. Hernandez Luis
- C. Hernandez Luis
- C. Homorodean
- C. I. Santos De Sousa
- C. I. Stoicescu
- C. J. Mc Cann
- C. J. Terkelsen
- C. J. Vrints
- C. Jorge
- C. Jorge
- C. Jorge
- C. Jorge
- C. L. Huang
- C. L. Yu
- C. Lombardi
- C. Macarie
- C. Macarie
- C. Macaya
- C. Macaya
- C. Martinez-Sanchez
- C. Michalakeas
- C. Moretti
- C. Morley
- C. Mornos
- C. Mornos
- C. Mueller
- C. Navarro
- C. Olariu
- C. P. G. Carlos Pena Gil
- C. Papadopoulos
- C. Paulo
- C. Paulo
- C. Pena-Gil
- C. Perigaud
- C. Poggioni
- C. Pop
- C. Pop
- C. Pop
- C. Pop
- C. Ronco
- C. Rubio-Iglesias-Garcia
- C. Rubio-Iglesias-Garcia
- C. Santos
- C. Sinescu
- C. Sinescu
- C. Spaulding
- C. Tapia
- C. Tapia Ballesteros
- C. Tapia Ballesteros
- C. Tapia Ballesteros
- C. Teodorescu
- C. Tessa
- C. Thalhammer
- C. Trani
- C. Udroiu
- C. Vignali
- C. Villa
- C. Wibberley
- C.- H. Tang
- D. Ardissino
- D. Becker
- D. Becker
- D. Blondhaim
- D. Bonnefont-Rousselot
- D. Brieger
- D. Caeiro
- D. Caeiro
- D. Caeiro
- D. Caeiro Pereira
- D. Constantinescu
- D. Cozma
- D. Cruz
- D. D. Ionescu
- D. D. Ionescu
- D. D. Ionescu
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- Y. Cavusoglu
- Y. Cavusoglu
- Y. Cavusoglu
- Y. Cavusoglu
- Y. Chen
- Y. D. Kim
- Y. D. Tang
- Y. D. Tang
- Y. Eki
- Y. Endo
- Y. H. Nam
- Y. Ishibashi
- Y. J. Wu
- Y. J. Wu
- Y. J. Yang
- Y. J. Yany
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- Y. N. Belenkov
- Y. Ohishi
- Y. Sato
- Y. Simova
- Y. T. F. N. Jao
- Y. Takeda
- Y. Van Belleghem
- Y. Zhang
- Y. Zhao
- Z. Babic
- Z. Babic
- Z. C. H. Cherneva
- Z. Dridi
- Z. K. Wu
- Z. Kalarus
- Z. Keca
- Z. Monhart
- Z. Motovska
- Z. Pagava
- Z. Perisic
- Z. Perisic
- Z. Perisic
- Z. Plazonic
- Z. Plazonic
- Z. Radovanovic
- Z. S. Jenei
- Z. Sablik
- Z. Vasiljevic
- Z. Y. Zhao
- Z. Y. Zhao
- Z.- S. Chen
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/10/2010
- Field of study
: Substance P (SP) and neuropeptide Y (NPY) are neuropeptides
involved in nociception. The study of biochemical markers of pain in
communicating critically ill coronary patients may provide insight for pain
assessment and management in critical care. Purpose of the study was to
to explore potential associations between plasma neuropeptide levels and
reported pain intensity in coronary critical care adults, in order to test the
reliability of SP measurements for objective pain assessment in critical
care
Eplerenone in patients with systolic heart failure and mild symptoms.
- Author
- Abreu Á
- Adamopoulos S
- Adgey AA
- Agostoni P
- Ahremark U
- Al Khaja N
- Al Mohammad A
- Almahmeed WA
- Alonso Garcia A
- Ambrosio GB
- Ambrovicova V
- Anand IS
- Anderson JL
- Andersson B
- Andrade A
- Anguita M
- Arnold JM
- Aroutyunov GP
- Aschermann M
- Attali P
- Axelsson U
- Banerjee P
- Barlow M
- Bayram Llamas E
- Bazargani N
- Bazylevych A
- Berglund S
- Berk MR
- Bertolet BD
- Bhagavatula KS
- Bisognano JD
- Bittolo Bon G
- Blonder RD
- Boehm M
- Boffa G
- Boman K
- Bonneau A
- Boreux JL
- Bousser JP
- Breburda CS
- Brecka D
- Bridges AB
- Brooks N
- Bruch L
- Cacciavillani L
- Calvillo JC
- Canaday DB
- Capodilupo RC
- Capucci A
- Cardoso JC
- Carrageta M
- Chae SC
- Charlier FP
- Chiariello M
- Chockalingam K
- Choiunard MD
- Cirrincione V
- Collier T
- Colucci WS
- Connolly EC
- Cornel JH
- Cross DB
- Cruz Diaz A
- Czibok C
- Dahiya RJ
- Dahlstrom U
- Daniëls MC
- Dargie HJ
- De Keulenaer G
- de Kluiver EP
- de Swart JB
- De Teresa E
- Delgado Leal L
- Dendale P
- Denvir MA
- Desai N
- Ding ZP
- Dion D
- Dirkali A
- Dluzniewski M
- Drexler H
- Drexler H
- Dunlap SH
- Dunselman PH
- Dutoit L
- Dyadyk OI
- Dzyak GV
- Egdell RM
- Engelhardt H
- Erbs S
- Essandoh LK
- Estrada Gomez MM
- Filipovsky J
- Flores AR
- Foerster A
- Fonseca C
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- Ignatenko GA
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- PERRONE FILARDI PASQUALE
- Pertseva TO
- Petersen Aranguren F
- Philbin E
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- Tamburino C
- Tavazzi L
- Terrosu P
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- Trabulo M
- Treasure CB 2nd
- Trochu JN
- Tseluyko VI
- Tykhonova SA
- Uhliar R
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- van Veldhuisen DJ
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- Voronkov LG
- Wachter R
- Waich S.T.
- Wander GS
- Wencker D
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- Wilhelmsen L
- Willems FF
- Willenbrock R
- Williams SG
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- Winkel E
- Winkelmann BR
- Winkler R
- Wiseman AH
- Wlsh MN
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- Yeo DP
- Yu CM
- Zaboulis C
- Zannad F
- Zannad F
- Zoiopoulos LY
- Zámolyi K
- Édes I
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M
- Aboufakher R
- Abrahamsen Te
- Accini Mendoza Jl
- Acheatel R
- Ackermann D
- Adamkova V
- Adams M
- Adlam D
- Aggarwal R
- Aggarwal S
- Ahsan A
- Ainsworth P
- Airody Govinda R
- Akai A
- Ako J
- Al-Bahrani A
- Al-Joundi T
- Aldegather J
- Aldrete Velasco Ja
- Alfieri A
- Alt I
- Alzohaili O
- Amerena J
- Amin J
- Amoedo R
- Amuchastegui M
- Anderson T
- Andreka P
- Andreotti F
- Angoulvant D
- Ansell B
- Antalik L
- Antkowiak-Piatyszek K
- Appel K
- Arakawa T
- Arana Londoño C
- Ardissino D
- Ardito Wr
- Arkhipov M
- Arsenescu-Georgescu C
- Asamoah N
- Ascaso Gimilio Jf
- Atar S
- Atassi K
- Athyros V
- Auerbach E
- Awtry E
- Baass A
- Badariene J
- Badat A
- Badila E
- Bae J
- Baigent C
- Bain S
- Baird I
- Baker J
- Balbay Y
- Baldari D
- Ballantyne C
- Bammert A
- Banach M
- Bandh S
- Banerjee S
- Banik M
- Banikova A
- Barbarash O
- Barcinas R
- Barnum O
- Barroso de Souza Wk
- Bart B
- Barton J
- Bata I
- Batalla E
- Bayat J
- Bazzoni Ruiz Ae
- Bednarkiewicz Z
- Beer Hj
- Begg A
- Beltrame J
- Bendermacher P
- Benton R
- Berger C
- Bergeron J
- Bergler-Klein J
- Berglund S
- Berlacher P
- Bernstein M
- Bertolet B
- Bertolim Precoma D
- Bhagwat R
- Bhargava R
- Bhushan R
- Biasucci Lm
- Bilianou H
- Blagden M
- Blaha V
- Blasko P
- Blicharski T
- Blignaut S
- Blokhin A
- Blumberg E
- Bodanese Lc
- Bokern M
- Bolshakova O
- Bonaca Mp
- Bonnet B
- Bosiljanoff P
- Boswijk D
- Botero Lopez R
- Bourhaial H
- Bousboulas S
- Brabec T
- Brezina B
- Bronnum-Schou J
- Brotanek J
- Broughton R
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- Brown Wv
- Bubnova M
- Budoff M
- Burgess L
- Burianova H
- Burrough B
- Butler R
- Buysschaert I
- Bystryk L
- Capps N
- Cappuccio F
- Cardona Muñoz Eg
- Carhart R
- Cariou B
- Carr K
- Case C
- Castellanos Bueno R
- Catez E
- Caulfield M
- Cayla G
- Cech V
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- Cheek Hb
- Chehayeb R
- Chen J
- Chen X
- Chen Y
- Chenu P
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- Christofides E
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- Civeira Murillo F
- Cizinsky S
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- Zarich S
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- Zilahi Z
- Zrazhevskiy K
- Östergren J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets