3 research outputs found
ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΠ·Π° ΠΏΡΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΈΠ»ΠΈ ΡΠ΅Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³Π΅ΡΠΏΠ΅ΡΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ
Based on the analysis of foreign and domestic literature, the article presents the features of infectious mononucleosis caused by the main pathogens from the Herpesviridae family, course of the disease at various phases of the infectious process. The article identifies clinical and laboratory manifestations characteristic of each pathogen. The authors discuss the issues related to the lack of the unified terminology for describing chronic herpes virus infection. The article discusses the causes of persistent herpes virus infections, risk factors for the adverse course and outcome of herpes virus infections.ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π°Π½Π½ΡΡ
Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΠΎΠΉ ΠΈ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΠ·Π°, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»ΡΠΌΠΈ ΠΈΠ· ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° Herpesviridae, ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ°Π·Π°Ρ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΡΠ΄Π΅Π»Π΅Π½Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΠ·Π°, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠ΅ Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ. ΠΡΠ½ΠΎΡΡΡΡΡ Π½Π° ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ Π²ΠΎΠΏΡΠΎΡΡ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ Π΅Π΄ΠΈΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠΈΠ½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π΄Π»Ρ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈ ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠ΅ΠΉ Π³Π΅ΡΠΏΠ΅ΡΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. ΠΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΏΡΠΈΡΠΈΠ½ ΠΏΠ΅ΡΡΠΈΡΡΠ΅Π½ΡΠΈΠΈ Π³Π΅ΡΠΏΠ΅ΡΠ²ΠΈΡΡΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ, ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΈΡΡ
ΠΎΠ΄Π° Π³Π΅ΡΠΏΠ΅ΡΠ²ΠΈΡΡΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ
Infectious mononucleosis in children: Clinical and laboratory characteristics depending on the disease etiology and phase of infection
Objective. To assess the association between clinical and laboratory characteristics of infectious mononucleosis (IM) and disease etiology and phase of infection. Patients and methods. This prospective observational study was conducted at Z.A.Bashlyaeva Children's City Clinical Hospital, Moscow Healthcare Department and included 107 children with IM. Laboratory testing was performed at the Department of Virological Diagnostics, National Medical Research Center for Hematology, Ministry of Health of the Russian Federation. Results. IM is a polyetiologic disease. So far, researcher have failed to find a significant correlation between clinical manifestations of IM and its etiology and phase of infection. Patients with IM caused by primary monoinfection with EpsteinβBarr virus (EBV) are at high risk of developing chronic EBV infection. Neutrophilia is a typical laboratory sign of IM during the acute phase of it. Conclusion. The improvement of IM diagnosis with a detailed evaluation of clinical and laboratory criteria, as well as risk assessment of unfavorable outcome are currently impossible without the identification of both disease etiology and phase of infection. Β© 2020, Dynasty Publishing House. All rights reserved
Clinical manifestations of infectious mononucleosis in primary or reactivated herpes virus infection [ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΠ·Π° ΠΏΡΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ ΠΈΠ»ΠΈ ΡΠ΅Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³Π΅ΡΠΏΠ΅ΡΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ]
Based on the analysis of foreign and domestic literature, the article presents the features of infectious mononucleosis caused by the main pathogens from the Herpesviridae family, course of the disease at various phases of the infectious process. The article identifies clinical and laboratory manifestations characteristic of each pathogen. The authors discuss the issues related to the lack of the unified terminology for describing chronic herpes virus infection. The article discusses the causes of persistent herpes virus infections, risk factors for the adverse course and outcome of herpes virus infections. Β© 2020 National Academy of Pediatric Science and Innovation. All rights reserved