2 research outputs found
Assimilation of surface-sensitive infrared radiances over land: Estimation of land surface temperature and emissivity
Heart Rate Variability, Ambient Particulate Matter Air Pollution, and Glucose Homeostasis: The Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative
Metabolic neuropathophysiology underlying the prediabetic state may confer susceptibility to the adverse health effects of ambient particulate matter <10 ΞΌm in diameter (PM10). The authors therefore examined whether impaired glucose homeostasis modifies the effect of PM10 on heart rate variability in a stratified, random sample of 4,295 Women's Health Initiative clinical trial participants, among whom electrocardiograms and fasting blood draws were repeated at 3-year intervals from 1993 to 2004. In multilevel, mixed models weighted for sampling design and adjusted for clinical and environmental covariables, PM10 exposure was inversely associated with heart rate variability. Inverse PM10βheart rate variability associations were strongest for the root mean square of successive differences in normal-to-normal RR intervals (RMSSD). Among participants with impaired fasting glucose, there were β8.3% (95% confidence interval: β13.9, β2.4) versus β0.6% (95% confidence interval: β2.4, 1.3), β8.4% (95% confidence interval: β13.8, β2.7) versus β0.3% (95% confidence interval: β2.1, 1.6), and β4.3% (95% confidence interval: β9.4, 1.0) versus β0.8% (95% confidence interval: β2.7, 1.0) decreases in the RMSSD per 10-ΞΌg/m3 increase in PM10 at high versus low levels of insulin (Pβ<β0.01), insulin resistance (Pβ<β0.01), and glucose (Pβ=β0.16), respectively. These associations were stronger among participants with diabetes and weaker among those without diabetes or impaired fasting glucose. The findings suggest that insulin and insulin resistance exacerbate the adverse effect of PM10 on cardiac autonomic control and thus risk of coronary heart disease among nondiabetic, postmenopausal women with impaired fasting glucose