Azole interactions with multidrug therapy in pediatric oncology

Patients with cancer receive multidrug therapy. Antineoplastic agents and supportive care drugs are often administered together, leading to potential drug-drug interactions. These interactions may have significant clinical implications in terms of toxicity or a decrease in the efficacy of the treatment administered. Here, we focus on the role of azoles and their main pharmacokinetic interactions with the principal classes of drugs used in pediatric oncology. The co-administration of azoles and antineoplastic agents, corticosteroids, immunosuppressants, antacids, antiemetics, antiepileptic drugs and analgesics was investigated, and a practical guide on the management of these drugs when administered together is provided

Prosumers' Digital Business Models for Electric Vehicles: Exploring Microfoundations for a Balanced Policy Approach

Mäkinen et al. provide an indispensable view of business model opportunities for electric vehicle (EV) prosumers in the future energy market. The digitalization of energy markets has started a transformation to smart grids where information flows bi-directionally end to end between energy production and consumption. The chapter explores how prosumers can create, deliver, and capture value with EVs in future energy systems. Focusing on prosumers’ digital business models (DBMs), the chapter illustrates the complex interdependencies between various activities and actors needed in the development of an energy system. In addition to demonstrating prosumers’ EV DBMs and the current state of readiness in value creation, delivery, and capture, Mäkinen et al. develop a balanced policy approach that is based on these DBM microfoundations.acceptedVersionPeer reviewe