Swinging and tumbling of elastic capsules in shear flow

The deformation of an elastic micro-capsule in an infinite shear flow is studied numerically using a spectral method. The shape of the capsule and the hydrodynamic flow field are expanded into smooth basis functions. Analytic expressions for the derivative of the basis functions permit the evaluation of elastic and hydrodynamic stresses and bending forces at specified grid points in the membrane. Compared to methods employing a triangulation scheme, this method has the advantage that the resulting capsule shapes are automatically smooth, and few modes are needed to describe the deformation accurately. Computations are performed for capsules both with spherical and ellipsoidal unstressed reference shape. Results for small deformations of initially spherical capsules coincide with analytic predictions. For initially ellipsoidal capsules, recent approximative theories predict stable oscillations of the tank-treading inclination angle, and a transition to tumbling at low shear rate. Both phenomena have also been observed experimentally. Using our numerical approach we could reproduce both the oscillations and the transition to tumbling. The full phase diagram for varying shear rate and viscosity ratio is explored. While the numerically obtained phase diagram qualitatively agrees with the theory, intermittent behaviour could not be observed within our simulation time. Our results suggest that initial tumbling motion is only transient in this region of the phase diagram.Comment: 20 pages, 7 figure

The Universal Gaussian in Soliton Tails

We show that in a large class of equations, solitons formed from generic initial conditions do not have infinitely long exponential tails, but are truncated by a region of Gaussian decay. This phenomenon makes it possible to treat solitons as localized, individual objects. For the case of the KdV equation, we show how the Gaussian decay emerges in the inverse scattering formalism.Comment: 4 pages, 2 figures, revtex with eps

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy

The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and neonatal tissues and declining thereafter. We have systematically studied the expression of the human IGF-II/M6P receptor protein in tissues from 10 human fetuses and infants (age 23 weeks gestation to 24 months postnatal). We have asked 1) whether there is differential expression among different organs, and 2) whether or not the human IGF-II/M6P receptor is developmentally regulated from 23 weeks gestation to 24 months postnatal. Protein was extracted from human tissues using a buffer containing 2% sodium dodecyl sulfate and 2% Triton X-100. Aliquots of the protein extracts were analyzed by sodium dodecyl sulfate- polyacrylamide gel electrophoresis and immunoblotting using an anti-IGF- II/M6P receptor antiserum (no. 66416) and 125I-protein A or an immunoperoxidase stain. IGF-II/M6P receptor immunoreactivity was detected in all tissues studied with the highest amount of receptor being expressed in heart, thymus, and kidney and the lowest receptor content being measured in brain and muscle. The receptor content in ovary, testis, lung, and spleen was intermediate. The apparent molecular weight of the IGF-II/M6P receptor (220,000 kilos without reduction of disulfide bonds) varied among the different tissues: in brain the receptor was of lower molecular weight than in other organs. Immunoquantitation experiments employing 125I-protein A and protein extracts from human kidney at different ages revealed a small, albeit not significant, difference of the receptor content between fetal and postnatal tissues: as in other species, larger amounts of receptor seemed to be present in fetal than in postnatal organs. In addition, no significant difference of the receptor content between human fetal liver and early postnatal liver was measured employing 125I-protein A- immunoquantitation in three fetal and five postnatal liver tissue samples. The distribution of IGF-binding protein (IGEBP) species, another abundant and major class of IGF binding principles, was also measured in human fetal and early postnatal lung, liver, kidney, muscle, and brain using Western ligand blotting with 125I-IGF-II: as with IGF-II/M6P receptor immunoreactivity there was differential expression of the different classes of IGFBPs in the various organs

Chronisches Schmerzsyndrom des Beckens: Neurostimulation, Neuromodulation und Akupunktur

Zusammenfassung: Das chronische Schmerzsyndrom des Beckens ("chronic pelvic pain syndrome", CPPS) ist gemäß den Richtlinien der "European Association of Urology" charakterisiert als ein nicht-maligner Schmerz, der in Bezug auf die Strukturen des weiblichen oder männlichen Beckens über einen Zeitraum von mindestens 6Monaten wahrgenommen wird, ohne dass eine Infektion oder offensichtliche anderweitige Pathologie vorliegt. Das CPPS beeinträchtigt die Lebensqualität von Millionen von Menschen weltweit und hat einen ähnlich großen Einfluss wie andere chronische Krankheiten, z.B. Diabetes mellitus, Morbus Crohn oder kongestive Herzinsuffizienz. Trotz mehrerer etablierter Erstlinientherapien stellt die Behandlung des CPPS eine große Herausforderung dar, da viele Patienten therapierefraktär bleiben. Unkonventionelle Behandlungsmethoden wie Neurostimulation, Neuromodulation und Akupunktur können beim CPPS eine ausgezeichnete Wirkung zeigen und haben ein vorteilhaftes Nebenwirkungsprofil. So sollten diese vielversprechenden Therapieverfahren im klinischen Alltag vermehrt eingesetzt werde

Iodidobis(≠5-penta-methyl-cyclo-penta-dien-yl)titanium(III)

In the title complex mol-ecule, [Ti(C10H15) 2I], the paramagnetic Ti(III) atom is coordinated by two penta-methyl-cyclo-penta-dienyl (Cp*) ligands and one iodide ligand. The two Cp*ligands are in a staggered orientation. The coordination geometry at the titanium atom can be described as distorted trigonal-planar

Figures of merit of thermoelectric and bolometric thermal radiation sensors

Figures of merit condensing the performance parameters of radiation sensors such as responsivity, noise equivalent power, and time constant in a single number can be useful for rating the performance of a particular sensor in comparison to other ones or to fundamental performance limits. The classification system and the figures of merit of radiation sensors introduced by R. C. Jones are revisited for thermal radiation sensors with the focus on thermopiles and bolometers. As a result it is stated that radiation thermopiles and bolometers should be classified differently: type III detectors for thermopiles vs. type II detectors for bolometers. Modified figures of merit are suggested and relations between them given. The figures of merit are applied in an overview on state-of-the-art thermopiles and bolometers operated at room temperature

Influence of the temperature on the depinning transition of driven interfaces

We study the dynamics of a driven interface in a two-dimensional random-field Ising model close to the depinning transition at small but finite temperatures T using Glauber dynamics. A square lattice is considered with an interface initially in (11)-direction. The drift velocity v is analyzed for the first time using finite size scaling at T = 0 and additionally finite temperature scaling close to the depinning transition. In both cases a perfect data collapse is obtained from which we deduce beta = 1/3 for the exponent which determines the dependence of v on the driving field, nu = 1 for the exponent of the correlation length and delta = 5 for the exponent which determines the dependence of v on T.Comment: 5 pages, Latex, Figures included, to appear in Europhys. Let

Dynamics of Competitive Evolution on a Smooth Landscape

We study competitive DNA sequence evolution directed by {\it in vitro} protein binding. The steady-state dynamics of this process is well described by a shape-preserving pulse which decelerates and eventually reaches equilibrium. We explain this dynamical behavior within a continuum mean-field framework. Analytical results obtained on the motion of the pulse agree with simulations. Furthermore, finite population correction to the mean-field results are found to be insignificant.Comment: 4 pages, 2 figures, revised, to appear in Phys. Rev. Let