786 research outputs found
One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies
Objective
To investigate the parameters of mosaicism and the biological mechanisms leading to healthy pregnancies from mosaic embryo transfers.
Design
Prospective study.
Setting
IVF center and associated research laboratory.
Patient(s)
Fifty-nine patients.
Intervention(s)
Embryos underwent blastocyst-stage preimplantation genetic testing for aneuploidy by next-generation sequencing. Trophectoderm biopsies containing 20%â80% abnormal cells were deemed mosaic, and corresponding blastocysts were transferred. Mosaic embryos donated to research were examined for karyotype concordance in multiple biopsies and assessed for cell proliferation and death by immunofluorescence and computational quantitation.
Main Outcome Measure(s)
Chemical start of pregnancy, implantation, fetal heartbeat, and birth.
Result(s)
Globally, mosaic embryos showed inferior clinical outcomes compared with euploid embryos. Aneuploid cell percentage in trophectoderm biopsies did not correlate with outcomes, but type of mosaicism did, as embryos with single mosaic segmental aneuploidies fared better than all other types. Mosaic blastocysts generated from oocytes retrieved at young maternal ages (?34 years) showed better outcomes than those retrieved at older maternal ages. Mosaic embryos displayed low rates of karyotype concordance between multiple biopsies and showed significant elevation of cell proliferation and death compared with euploid embryos.
Conclusion(s)
After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type. If a patient has mosaic embryos available that were generated at different ages, preference should be given to those made at younger ages. Intrablastocyst karyotype discordance and differential cell proliferation and death might be reasons that embryos classified as mosaic can result in healthy pregnancies and babies
739 observed NEAs and new 2-4m survey statistics within the EURONEAR network
We report follow-up observations of 477 program Near-Earth Asteroids (NEAs)
using nine telescopes of the EURONEAR network having apertures between 0.3 and
4.2 m. Adding these NEAs to our previous results we now count 739 program NEAs
followed-up by the EURONEAR network since 2006. The targets were selected using
EURONEAR planning tools focusing on high priority objects. Analyzing the
resulting orbital improvements suggests astrometric follow-up is most important
days to weeks after discovery, with recovery at a new opposition also valuable.
Additionally we observed 40 survey fields spanning three nights covering 11 sq.
degrees near opposition, using the Wide Field Camera on the 2.5m Isaac Newton
Telescope (INT), resulting in 104 discovered main belt asteroids (MBAs) and
another 626 unknown one-night objects. These fields, plus program NEA fields
from the INT and from the wide field MOSAIC II camera on the Blanco 4m
telescope, generated around 12,000 observations of 2,000 minor planets (mostly
MBAs) observed in 34 square degrees. We identify Near Earth Object (NEO)
candidates among the unknown (single night) objects using three selection
criteria. Testing these criteria on the (known) program NEAs shows the best
selection methods are our epsilon-miu model which checks solar elongation and
sky motion and the MPC's NEO rating tool. Our new data show that on average 0.5
NEO candidates per square degree should be observable in a 2m-class survey (in
agreement with past results), while an average of 2.7 NEO candidates per square
degree should be observable in a 4m-class survey (although our Blanco
statistics were affected by clouds). At opposition just over 100 MBAs (1.6
unknown to every 1 known) per square degree are detectable to R=22 in a 2m
survey based on the INT data, while our two best ecliptic Blanco fields away
from opposition lead to 135 MBAs (2 unknown to every 1 known) to R=23.Comment: Published in Planetary and Space Sciences (Sep 2013
Monte Carlo radiative transfer for the nebular phase of Type Ia supernovae
We extend the range of validity of the ARTIS 3D radiative transfer code up to hundreds of days after explosion, when Type Ia supernovae (SNe Ia) are in their nebular phase. To achieve this, we add a non-local thermodynamic equilibrium population and ionization solver, a new multifrequency radiation field model, and a new atomic data set with forbidden transitions. We treat collisions with non-thermal leptons resulting from nuclear decays to account for their contribution to excitation, ionization, and heating. We validate our method with a variety of tests including comparing our synthetic nebular spectra for the well-known one-dimensional W7 model with the results of other studies. As an illustrative application of the code, we present synthetic nebular spectra for the detonation of a sub-Chandrasekhar white dwarf (WD) in which the possible effects of gravitational settling of 22Ne prior to explosion have been explored. Specifically, we compare synthetic nebular spectra for a 1.06 Mâ WD model obtained when 5.5 Gyr of very efficient settling is assumed to a similar model without settling. We find that this degree of 22Ne settling has only a modest effect on the resulting nebular spectra due to increased 58Ni abundance. Due to the high ionization in sub-Chandrasekhar models, the nebular [Ni II] emission remains negligible, while the [Ni III] line strengths are increased and the overall ionization balance is slightly lowered in the model with 22Ne settling. In common with previous studies of sub-Chandrasekhar models at nebular epochs, these models overproduce [Fe III] emission relative to [Fe II] in comparison to observations of normal SNe Ia
Atmospheric Acetaldehyde: Importance of Air-Sea Exchange and a Missing Source in the Remote Troposphere.
We report airborne measurements of acetaldehyde (CH3CHO) during the first and second deployments of the National Aeronautics and Space Administration (NASA) Atmospheric Tomography Mission (ATom). The budget of CH3CHO is examined using the Community Atmospheric Model with chemistry (CAM-chem), with a newly-developed online air-sea exchange module. The upper limit of the global ocean net emission of CH3CHO is estimated to be 34 Tg a-1 (42 Tg a-1 if considering bubble-mediated transfer), and the ocean impacts on tropospheric CH3CHO are mostly confined to the marine boundary layer. Our analysis suggests that there is an unaccounted CH3CHO source in the remote troposphere and that organic aerosols can only provide a fraction of this missing source. We propose that peroxyacetic acid (PAA) is an ideal indicator of the rapid CH3CHO production in the remote troposphere. The higher-than-expected CH3CHO measurements represent a missing sink of hydroxyl radicals (and halogen radical) in current chemistry-climate models
Mass Transfer by Stellar Wind
I review the process of mass transfer in a binary system through a stellar
wind, with an emphasis on systems containing a red giant. I show how wind
accretion in a binary system is different from the usually assumed Bondi-Hoyle
approximation, first as far as the flow's structure is concerned, but most
importantly, also for the mass accretion and specific angular momentum loss.
This has important implications on the evolution of the orbital parameters. I
also discuss the impact of wind accretion, on the chemical pollution and change
in spin of the accreting star. The last section deals with observations and
covers systems that most likely went through wind mass transfer: barium and
related stars, symbiotic stars and central stars of planetary nebulae (CSPN).
The most recent observations of cool CSPN progenitors of barium stars, as well
as of carbon-rich post-common envelope systems, are providing unique
constraints on the mass transfer processes.Comment: Chapter 7, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
Oxidation of mercury by bromine in the subtropical Pacific free troposphere
Mercury is a global toxin that can be introduced to ecosystems through atmospheric deposition. Mercury oxidation is thought to occur in the free troposphere by bromine radicals, but direct observational evidence for this process is currently unavailable. During the 2013 Nitrogen, Oxidants, Mercury and Aerosol Distributions, Sources and Sinks campaign, we measured enhanced oxidized mercury and bromine monoxide in a free tropospheric air mass over Texas. We use trace gas measurements, air mass back trajectories, and a chemical box model to confirm the origin and chemical history of the sampled air mass. We find the presence of elevated oxidized mercury to be consistent with oxidation of elemental mercury by bromine atoms in this subsiding upper tropospheric air mass within the subtropical Pacific High, where dry atmospheric conditions are conducive to oxidized mercury accumulation. Our results support the role of bromine as the dominant oxidant of mercury in the upper troposphereNational Science Foundation (U.S.) (Grants 121701 and, 1215712
Falsification Of The Atmospheric CO2 Greenhouse Effects Within The Frame Of Physics
The atmospheric greenhouse effect, an idea that many authors trace back to
the traditional works of Fourier (1824), Tyndall (1861), and Arrhenius (1896),
and which is still supported in global climatology, essentially describes a
fictitious mechanism, in which a planetary atmosphere acts as a heat pump
driven by an environment that is radiatively interacting with but radiatively
equilibrated to the atmospheric system. According to the second law of
thermodynamics such a planetary machine can never exist. Nevertheless, in
almost all texts of global climatology and in a widespread secondary literature
it is taken for granted that such mechanism is real and stands on a firm
scientific foundation. In this paper the popular conjecture is analyzed and the
underlying physical principles are clarified. By showing that (a) there are no
common physical laws between the warming phenomenon in glass houses and the
fictitious atmospheric greenhouse effects, (b) there are no calculations to
determine an average surface temperature of a planet, (c) the frequently
mentioned difference of 33 degrees Celsius is a meaningless number calculated
wrongly, (d) the formulas of cavity radiation are used inappropriately, (e) the
assumption of a radiative balance is unphysical, (f) thermal conductivity and
friction must not be set to zero, the atmospheric greenhouse conjecture is
falsified.Comment: 115 pages, 32 figures, 13 tables (some typos corrected
The "lessons" of the Australian "heroin shortage"
Heroin use causes considerable harm to individual users including dependence, fatal and nonfatal overdose, mental health problems, and blood borne virus transmission. It also adversely affects the community through drug dealing, property crime and reduced public amenity. During the mid to late 1990s in Australia the prevalence of heroin use increased as reflected in steeply rising overdose deaths. In January 2001, there were reports of an unpredicted and unprecedented reduction in heroin supply with an abrupt onset in all Australian jurisdictions. The shortage was most marked in New South Wales, the State with the largest heroin market, which saw increases in price, dramatic decreases in purity at the street level, and reductions in the ease with which injecting drug users reported being able to obtain the drug. The abrupt onset of the shortage and a subsequent dramatic reduction in overdose deaths prompted national debate about the causes of the shortage and later international debate about the policy significance of what has come to be called the "Australian heroin shortage". In this paper we summarise insights from four years' research into the causes, consequences and policy implications of the "heroin shortage"
- âŠ