The potential role of kelp forests on iodine speciation in coastal seawater

Funding: FCK would like to thank the TOTAL Foundation (Paris) and the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland) for their support. MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions. JG acknowledges support from an SDSU Research Foundation Summer Undergraduate Research Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Some aspects of the iodine metabolism of the giant kelp Macrocystis pyrifera (phaeophyceae)

We are grateful to the Total Foundation (Paris) and to the MASTS pooling initiative (Marine Alliance for Science and Technology for Scotland, funded by the Scottish Funding Council and contributing institutions; grant reference HR09011), both for their funding support to FCK. We thank Prof. Matt Edwards (SDSU department of Biology) and his students for help in collecting specimens and for the use of equipment.Peer reviewedPostprin

The influence of marine algae on iodine speciation in the coastaocean

Funding Information: This work was supported in part by grant CHE-1664657 from the National Science Foundation to CJC and FCK, the TOTAL Foundation (Paris) and the UK Natural Environment Research Council grants (NE/D521522/1, NE/ J023094/1, Oceans 2025 / WP 4.5) to FCK. We are also grateful for funding from the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland). We thank Dr. M. L. Carter, SIO for help with collection of water samples at Scripps Pier, César O. Almeda-Jáuregui, CICESE for Ocean Data View plots and Dr. Avery Tatters, USC for the initial culture of Lingulodinium polyedra. A fellowship from the Hanse-Wissenschaftskolleg to CJC is also gratefully acknowledged.Peer reviewedPublisher PD

Kelp forest canopy biomass from 2014–2015 as estimated from Landsat imagery, and expressed as biomass in wet kg.

<p>The grey box represents the time frame of this study.</p

Mean concentrations of iodide, total reducible iodine and iodate (by difference) in surface waters at the Scripps Pier, La Jolla, CA between January and July 2015.

<p>Mean concentrations of iodide, total reducible iodine and iodate (by difference) in surface waters at the Scripps Pier, La Jolla, CA between January and July 2015.</p

Results of a 3-way Model I analysis of variance testing variation in iodate concentrations among sample locations relative to the Point Loma kelp forest, sample depths (surface and 10 m) and seasons.

<p>Results of a 3-way Model I analysis of variance testing variation in iodate concentrations among sample locations relative to the Point Loma kelp forest, sample depths (surface and 10 m) and seasons.</p

Pooled iodate concentrations (mean ± standard deviation) as a function of season at five locations within the Pt. Loma kelp forest.

<p>The dotted line represents the mean iodate concentration at the Scripps Pier control site.</p

Results of a 3-way Analysis of Covariance testing variation in iodide concentration among sample locations relative to the Point Loma kelp forest and its relationship with wind speed and water temperature.

<p>Results of a 3-way Analysis of Covariance testing variation in iodide concentration among sample locations relative to the Point Loma kelp forest and its relationship with wind speed and water temperature.</p

Hydroxyurea to lower transcranial Doppler velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort

In summary, the NOHARM trial provides additional evidence for the safety and efficacy of short-term hydroxyurea treatment for SCA in sub-Saharan Africa within a clinical trial setting. Data from both the blinded treatment phase and the open-label treatment phase demonstrate clinical and hematological benefits of hydroxyurea in a malarial endemic region, including evidence of reduced TCD velocities and primary stroke prevention. Additional TCD screening programs and clinical trials are urgently needed in sub-Saharan Africa to document the feasibility and benefits of hydroxyurea treatment for children with conditional or even abnormal TCD velocities, given the challenges of providing chronic blood transfusions. To help prevent primary stroke in this high-risk population, future studies should also focus on optimal dosing strategies and monitoring regimens, in an effort to determine the overall feasibility and safety of introducing hydroxyurea therapy for SCA widely across sub-Saharan Africa