Mixed Data and Classification of Transit Stops

An analysis of the characteristics and behavior of individual bus stops can reveal clusters of similar stops, which can be of use in making routing and scheduling decisions, as well as determining what facilities to provide at each stop. This paper provides an exploratory analysis, including several possible clustering results, of a dataset provided by the Regional Transit Service of Rochester, NY. The dataset describes ridership on public buses, recording the time, location, and number of entering and exiting passengers each time a bus stops. A description of the overall behavior of bus ridership is followed by a stop-level analysis. We compare multiple measures of stop similarity, based on location, route information, and ridership volume over time

Application of ERTS-A data to agricultural practices in the Mississippi Delta region

There are no author-identified significant results in this report

Chaplygin Gas Cosmology - Unification of Dark Matter and Dark Energy

The models that unify dark matter and dark energy based upon the Chaplygin gas fail owing to the suppression of structure formation by the adiabatic speed of sound. Including string theory effects, in particular the Kalb-Ramond field, we show how nonadiabatic perturbations allow a successful structure formation.Comment: 7 pages, presented by N. B. at IRGAC 2006, Barcelona, 11-15 July 2006, typos corrected, concluding paragraph slightly expanded, final version, accepted in J. Phys. A, special issu

FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling

<p>Abstract</p> <p>Background</p> <p>Cytoplasmic viral double-stranded RNA (dsRNA) is detected by a class of ubiquitous cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation antigen-5 (MDA5), which initiate a signaling cascade via their common adaptor called interferon-β (IFN-β) promoter stimulator-1 (IPS-1). This leads to the production of proinflammatory and antiviral cytokines, the type I Interferons, via mainly nuclear factor kappa B (NF-κB) and interferon response factor-3 (IRF3) transcription factors. Fas-associated death domain (FADD) protein, receptor-interacting protein (RIP1), caspase-8 and tumor necrosis factor receptor (TNFR)-associated death domain (TRADD) protein, all traditionally associated with death receptor signaling, are also involved in RIG-I/MDA5 signaling pathway. We previously showed that FLIP (Flice-like inhibitory protein), also designated as <it>cflar </it>(CASP8 and FADD-like apoptosis regulator), negatively regulates lipopolysaccharide (LPS)-induced toll-like receptor 4 (TLR4) signaling in endothelial cells and mouse embryonic fibroblasts (MEFs) and protected against TLR4-mediated apoptosis.</p> <p>Results</p> <p>In this study, we investigated the role of FLIP in cellular response to cytoplasmic polyinosinic:polycytidylic acid, poly(I:C), a synthetic analog of dsRNA. <it>C</it>onsistent with the previously described role of FADD in RIG-I/MDA5-mediated apoptosis, we found that FLIP^-/-MEFs were more susceptible to killing by cytoplasmic poly(I:C). However, FLIP^-/-MEFs also exhibited markedly increased expression of NF-κB-and IRF3- dependent genes in response to cytoplasmic poly(I:C). Importantly, reconstitution of FLIP in FLIP^-/-MEFs reversed the hyper-activation of IRF3- and NF-κB-mediated gene expression. Further, we found that caspase-8 catalytic activity was not required for cytoplasmic poly(I:C)-mediated NF-κB and IRF3 signaling.</p> <p>Conclusions</p> <p>These results provide evidence for a crucial dual role for FLIP in antiviral responses to cytoplasmic dsRNA: it protects from cytoplasmic dsRNA-mediated cell death while down-regulating IRF3-and NF-κB-mediated gene expression. Since the pathogenesis of several viral infections involves a heightened and dysregulated cytokine response, a possible therapy could involve modulating FLIP levels.</p

Ghost Condensate Busting

Applying the Thomas-Fermi approximation to renormalizable field theories, we construct ghost condensation models that are free of the instabilities associated with violations of the null-energy condition.Comment: 9 pages, minor corrections, a reference added, the discussion on consistency of the Thomas-Fermi approximation expanded, to appear in JCA

Laboratory Efficacy of Chemical Repellents for Reducing Blackbird Damage in Rice and Sunflower Crops

Nonlethal alternatives are needed to manage blackbird (Icterids) damage to rice and sunflower production in the United States. We evaluated 4 registered fungicides on rice seeds (i.e., Allegiance® FL, Thiram 42-S, Trilex®, and Vitavax® 200 preplant seed treatments) and 2 foliar pesticides on sunflower seeds (CobaltTM insecticide and Flock Buster bird repellent) as candidate blackbird repellents. Red-winged blackbirds (Agelaius phoeniceus) preferred untreated rice relative to rice treated with Thiram (P \u3c 0.001) and Vitavax (P \u3c 0.001), and untreated sunflower relative to sunflower treated with Cobalt (P \u3c 0.001). Blackbirds preferred untreated sunflower relative to sunflower treated with Flock Buster repellent on day 1 of a 4-day preference test (P \u3c 0.001). We observed no difference in consumption of treated versus untreated rice during the Allegiance preference test (P = 0.928), and blackbirds preferred rice treated with Trilex relative to untreated rice (P = 0.003). Although repellency was positively related to tested concentrations of Thiram (P = 0.010), Trilex (P = 0.026), and Vitavax (P \u3c 0.001), maximum repellency was \u3c50% during our concentration-response tests of these seed treatments. Repellency was also positively related to tested concentrations of Cobalt (P \u3c 0.001), and we observed \u3e80% repellency of sunflower treated with Cobalt at ≥50% of the label rate. We observed no concentration-response relationship for the Allegiance seed treatment (P = 0.341) and Flock Buster repellent (P = 0.952). We recommend implementation of supplemental field studies to compare laboratory efficacy, repellency, and chemical residues of effective avian repellents throughout periods of needed crop protection

The Effect of European Starlings and Ambient Air Temperature on \u3cem\u3eSalmonella enterica\u3c/em\u3e Contamination within Cattle Feed Bunks

European starlings (Sturnus vulgaris) are a known risk factor for the occurrence of microorganisms that are pathogenic to cattle and humans in concentrated animal feeding operations (CAFOs). Starling use of CAFOs is known to vary in response to weather; starling control operations on CAFOs often are timed to coincide with favorable environmental conditions to maximize take. The totality of this information suggests that disease risks in CAFOs associated with starlings may be influenced by environmental factors, such as temperature. In this study, we assessed the risk of Salmonella enterica contamination of cattle feed by modeling the interaction between starling numbers and ambient air temperatures using data previously reported from Texas CAFOs. We compared these interaction models to the previously published additive models for S. enterica contamination of cattle feed using an information-theoretic approach to model selection that ranked and weighted models in terms of their support by the data, using bias-adjusted Akaike’s Information Criterion (AICc) and Akaike weights (Wi). Our results indicate that the interaction between European starlings and ambient air temperature better explained the occurrence of S. enterica in cattle feed than any of the previously reported models. Specifically, the risk of S. enterica contamination of cattle feed by starlings was greatest when winter temperatures were highest (10°C). Thus, we conclude that the risk of S. enterica contamination of cattle feed by starlings will be worst on the few winter days when daytime high temperatures are above freezing and large numbers of birds are present. Because these conditions will be most common in the late winter and early spring, we recommend that starling control operations on feedlots and dairies be conducted as early in the winter as possible to mitigate the risks of disease created by large foraging flocks of starlings

The effect of European starlings and ambient air temperature on \u3ci\u3eSalmonella enterica\u3c/i\u3e contamination within cattle feed bunks

European starlings (Sturnus vulgaris) are a known risk factor for the occurrence of microorganisms that are pathogenic to cattle and humans in concentrated animal feeding operations (CAFOs). Starling use of CAFOs is known to vary in response to weather; starling control operations on CAFOs often are timed to coincide with favorable environmental conditions to maximize take. The totality of this information suggests that disease risks in CAFOs associated with starlings may be influenced by environmental factors, such as temperature. In this study, we assessed the risk of Salmonella enterica contamination of cattle feed by modeling the interaction between starling numbers and ambient air temperatures using data previously reported from Texas CAFOs. We compared these interaction models to the previously published additive models for S. enterica contamination of cattle feed using an information-theoretic approach to model selection that ranked and weighted models in terms of their support by the data, using bias-adjusted Akaike’s Information Criterion (AICc) and Akaike weights (Wi). Our results indicate that the interaction between European starlings and ambient air temperature better explained the occurrence of S. enterica in cattle feed than any of the previously reported models. Specifically, the risk of S. enterica contamination of cattle feed by starlings was greatest when winter temperatures were highest (10°C). Thus, we conclude that the risk of S. enterica contamination of cattle feed by starlings will be worst on the few winter days when daytime high temperatures are above freezing and large numbers of birds are present. Because these conditions will be most common in the late winter and early spring, we recommend that starling control operations on feedlots and dairies be conducted as early in the winter as possible to mitigate the risks of disease created by large foraging flocks of starlings

Field Method for Analyzing Birds for Avicide 3-Chloro-P-Toluidine Hydrochloride

We developed a fast and simple method to detect presence or absence of DRC-1339 (CPTH: 3-Chloro-p-toluidine Hydrochloride) in birds that fed on DRC-1339 bait sites. We compared the effectiveness of the colorimetric method to the previously published analytical method using birds collected from DRC-1339 bait sites in Louisiana and Texas. We also conducted tests with caged red-winged blackbirds (Agelaius phoeniceus) to determine if time from consumption of DRC-1339-treated bait to death and time from death to colorimetric analysis affected test results. The colorimetric assay was effective in detecting the presence or absence of DRC-1339 in birds collected from bait sites. In the tests with caged birds, the method resulted in the detection of four grains of treated rice consumed up to 120 minutes post consumption, but failed to detect 1 grain of treated rice consumed at 120 minutes. Frozen samples of 4 treated consumed rice grains could be detected up to 90 days post collection