COMMON VARIABLE IMMUNODEFICIENCY

Common variable immunodeficiency is the most commonly seen primary immune deficiency condition in adults, characterized by impaired B cell differentiation. The patient is diagnosed with common variable immunodeficiency by recurrent bacterial infections usually accompanied by chronic lung diseases, gastrointestinal/liver diseases, granulomatous diseases, autoimmunity, lymphoid hyperplasia, splenomegaly or malignancies. Serum IgG concentration is significantly low along with low IgA and/or IgM concentrations. Intravenous immunoglobulin (IVIG) is the first choice of treatment. Immunoglobulin treatment ameliorates recurrent infections and associated complications such as autoimmune diseases and pulmonary injury. The main cause of death in patients with common variable immunodeficiency is chronic lung diseases or malignancies, because acute bacterial infections is usually prevented by IVIG therapy

Changes in left ventricular outflow and intraventricular flow patterns in hypertension and controls: a Doppler echocardiographic study.

Objective - It has been previously reported that intraventricular flow patterns in some hypertensive patients with left ventricular hypertrophy, change to patterns similar to flow profiles of hypertrophic cardiomyopathy. The purpose of the study was to assess left ventricular outflow and mid-septal intraventricular flow patterns in hypertensive and normotensive patients

Apelin: A new biomarker in fatty liver disease

Apelin is a peptide known for its insulin-sensitizing effect. This study aimed to examine the relationship between apelin and fatty liver disease. Non-diabetic patients were evaluated by ultrasound in this prospective, single-center, case-control study between 1 April 2020 and 1 April 2021. Serum apelin levels were measured, and the relationship with ultrasonography results and degree of hepatosteatosis was examined. Statistical analysis was carried out using NCSS 2007. This study was conducted with 80 non-diabetic participants, 53 females and 27 males. The mean age of the cases was 40.55 +/- 13.82 (interquartile range = 27-51) years, and their mean body mass index (BMI) was 29.34 +/- 7.44 (interquartile range = 23.4-35.2) kg/m(2). There was no hepatosteatosis according to ultrasound in 42% (n = 34) of the cases. When patients with or without hepatosteatosis were compared, there was no difference in terms of gender, alanine aminotransferase (ALT), and hemoglobin levels, whereas fasting blood glucose (FBG), HOMA-IR, triglycerides, LDL-cholesterol, BMI, creatinine, and age were higher in the group with hepatosteatosis. Apelin was found to be lower in patients with non-diabetic hepatosteatosis than in those without hepatosteatosis (p = .001). As the degree of fatty liver increased, the apelin level decreased further. There was also a negative correlation between apelin and age. However, the relationship between apelin and hepatosteatosis was independent of age. In non-diabetic patients with fatty liver disease, compared to those without fatty liver disease, serum apelin level was lower and was negatively correlated with the degree of steatosis, independent of age

Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family

Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father, a 51-year-old mother, two sons aged 23 and 21 years, and a 15-year-old daughter. According to the results of MBL2 rs1800450 variant analysis performed, the father had homozygous mutant, the mother had homozygous normal, and the three children had heterozygous mutant genotype. When we compared the clinical parameters and genotypes, MBL2 gene polymorphism plays a very important role in COVID-19 susceptibility and severe disease. The family, which makes up our study, is the proof of this situation, and it contains important implications for host factors and COVID-19

Risk factors for coronary heart disease in patients with spinal cord injury in Turkey.

Objective: To compare the standard risk factors for coronary heart: disease (CHD), defined in National Cholesterol Education Program II (NCEP II) of Turkish spinal cord injury (SCI) patients with healthy controls, discuss the results according to the findings in Turkish population, and SCI patients in the literature