The prevalence of arterial hypertension in school-age children of Yekaterinburg

This article presents the prevalence of arterial hypertension between school-age children and the frequency of current pathological state in 31,1% cases. The parameters of physical development were evaluated and the developmental abnormality was demonstrated in 41.5% of school-age children. It was noticed that the leader abnormality of the physical development is increasing of the body mass index.В работе определена распространенность артериальной гипертензии среди школьников, показана встречаемость данной патологии в 31,1% случаев. Проведена оценка параметров физического развития, продемонстрировано отклонение в развитии у 41,5% детей школьного возраста. Отмечено, что ведущим отклонением в физическом развитии современных школьников является увеличение индекса массы тела

Polycystic ovary syndrome: personalized therapy options

The article presents the results of a controlled clinical trial to develop the most effective program for the management of patients with polycystic ovary syndrome (PCOS) and cholestasis among 30 women in 2019-2020 in the Center of Surgery Gynecology in Yekaterinburg. There was found that use of combined oral contraceptives with ursodeoxycholic acid drugs reduces the chances of PCOS symptoms by 82.5%, odds ratio (OR): 0,175 [95% CI: 0,029–1,065].В статье представлены результаты сравнительного клинического исследования по разработке наиболее эффективной программы ведения пациенток с синдромом поликистозных яичников (СПКЯ) и холестазом среди 30 женщин в 2019-2020 гг. на базе Центра оперативной гинекологии «Женская клиника» г. Екатеринбурга. Было выявлено, что использование комбинированных оральных контрацептивов совместно с препаратами урсодезоксихолевой кислоты снижает шансы появления симптомов СПКЯ на 82,5%, отношение шансов (ОШ): 0,175 [95% ДИ: 0,029–1,065]

Identification of signs of alcohol abuse in employees of a small company design and production profile (pilot study)

The article presents the results of a study to identify signs of alcohol abuse among workers of a small company with a design and production profile in the city of Yekaterinburg and risk factors for the formation of alcohol dependence. According to the results of the questioning of 25 employees, 28% of the respondents showed signs of alcohol dependence syndrome. The main factors that increase psychological stress, contributing to alcohol abuse: long business trips, lack of vacations during the year, conflict relationships in the team and dissatisfaction with the work performedВ статье представлены результаты исследования по выявлению признаков злоупотребления алкоголем у работников малой компании проектно-производственного профиля города Екатеринбурга и факторов риска формирования алкогольной зависимости. По результатам анкетирования 25 сотрудников, у 28% опрошенных выявлены признаки синдрома зависимости от алкоголя. Определены основные факторы, повышающие психологическое напряжение, способствующее злоупотреблению алкоголем: длительные командировки, отсутствие отпусков в течение года, конфликтные отношения в коллективе и неудовлетворенность выполняемой работо

The relationship between heart failure, serum iron and severity of the condition in COVID-19 patients

The aim of the study - to reveal the relationship between signs of heart failure and serum iron level in patients with COVID-19.Цель исследования - выявление взаимосвязи между признаками сердечной недостаточности и уровнем сывороточного железа у пациентов с COVID-1

Philosophy - hermeneutics of history

Considering the fact that we live in an era of radical change and at risk of erroneous actions, especially important for us of a reflexive knowledge of philosophy, giving the methodology and axiology of the life path. The methodology and axiology of the life act is vital for pragmatic and tehnologicheskogo a time of change. We need not only the theory of philosophy, to answer the question "stoimosti", "Suchness" of the world philosophy of innovation, success, answering the questions of self-knowledge, self-actualization. In the theory of philosophy implicitly contains the logic of pragmatic, creative transformation of human life and society. It is important to correctly interpret theoretical knowledge of philosophy and pass the art of hermeneutics susceptible mind of the students. Basic concepts: philosophy as hermeneutics of history. The methodology and axiology of philosophy in the aspect of neuro-linguistic script reference life situations of our time.Учитывая факт того, что мы живем в эпоху радикальных перемен и подвержены риску ошибочных поступков, особо актуально для нас рефлексивное знание философии, дающее методологию и аксиологию жизненного пути. Методология и аксиология жизненного поступка жизненно важны для прагматического и техникологического времени перемен. Сейчас нужна не только теория философии, отвечающей на вопрос «чтойности», «таковости» мира философия инновации, успеха, отвечающая на вопросы самопознания, самореализации человека. В самой теории философии имплицитно содержится логика прагматического, творческого преображения жизни человека и общества. Важно верно истолковать теоретическое знание философии и передать искусство герменевтики восприимчивому уму студентов. Основные понятия: философия как герменевтика истории. Методология и аксиология философии в аспекте нейролингвистического сценария референтной жизненной ситуации нашего времени

Assessment of readiness for revaccination against covid19

The aim of the study - to identify factors influencing readiness for revaccination against COVID-19Цель исследования - выявление факторов, влияющих на готовность к ревакцинации против НКВ

Toxic Kidney Damage in Rats Following Subchronic Intraperitoneal Exposure to Element Oxide Nanoparticles

Chronic diseases of the urogenital tract, such as bladder cancer, prostate cancer, reproductive disorders, and nephropathies, can develop under the effects of chemical hazards in the working environment. In this respect, nanosized particles generated as by-products in many industrial processes seem to be particularly dangerous to organs such as the testes and the kidneys. Nephrotoxicity of element oxide particles has been studied in animal experiments with repeated intraperitoneal injections of Al2O3, TiO2, SiO2, PbO, CdO, CuO, and SeO nanoparticles (NPs) in total doses ranging from 4.5 to 45 mg/kg body weight of rats. NPs were synthesized by laser ablation. After cessation of exposure, we measured kidney weight and analyzed selected biochemical parameters in blood and urine, characterizing the state of the excretory system. We also examined histological sections of kidneys and estimated proportions of different cells in imprint smears of this organ. All element oxide NPs under investigation demonstrated a nephrotoxic effect following subchronic exposure. Following the exposure to SeO and SiO2 NPs, we observed a decrease in serum creatinine and urea, respectively. Exposure to Al2O3 NPs caused an increase in urinary creatinine and urea, while changes in total protein were controversial, as it increased under the effect of Al2O3 NPs and was reduced after exposure to CuO NPs. Histomorphological changes in kidneys are associated with desquamation of the epithelium (following the exposure to all NPs except those of Al2O3 and SiO2) and loss of the brush border (following the exposure to all NPs, except those of Al2O3, TiO2, and SiO2). The cytomorphological evaluation showed greater destruction of proximal sections of renal tubules. Compared to the controls, we observed statistically significant alterations in 42.1% (8 of 19) of parameters following the exposure to PbO, CuO, and SeO NPs in 21.1% (4 of 19)—following that, to CdO and Al2O3 NPs—and in 15.8% (3 of 19) and 10.5% (2 of 19) of indicators, following the exposure to TiO2 and SiO2 nanoparticles, respectively. Histomorphological changes in kidneys are associated with desquamation of epithelium and loss of the brush border. The cytomorphological evaluation showed greater destruction of proximal sections of renal tubules. The severity of cyto- and histological structural changes in kidneys depends on the chemical nature of NPs. These alterations are not always consistent with biochemical ones, thus impeding early clinical diagnosis of renal damage. Unambiguous ranking of the NPs examined by the degree of their nephrotoxicity is difficult. Additional studies are necessary to establish key indicators of the nephrotoxic effect, which can facilitate early diagnosis of occupational and nonoccupational nephropathies