Effects of foundation mass on dynamic responses of beams subjected to moving oscillators

This paper aims at the effects of foundation mass on the dynamic responses of beams subjected to moving oscillators. To achieve this aim, experiments were performed for a beam resting on the foundation considering effects of the foundation model including linear elastic spring, shear layer, viscous damping. In addition, special effects of mass density of foundation during vibration were established to obtain the characteristic parameter of the influence of foundation mass based on natural circular frequency of the structure system determined from FFT plots of the time history of acceleration data. Furthermore, the experimental parameters were used to analyze the influence of the foundation mass on the dynamic response of the beam subjected to moving oscillator. Comparisons between experimental and simulated results showed that the foundation mass showed significant effects on the dynamic characteristic response of the beam system. It increased the general vibrating mass of the structure system. Hence, it decreased of the natural frequency of the structural system and caused a significant increase on the dynamic response of the beam when compared with the case without considering the foundation mass. Finally, the relationships between the foundation properties and the parameters of foundation mass were derived and discussed

The influence of foundation mass on dynamic response of track-vehicle interaction

The influence of foundation mass on the dynamic response of track-vehicle interaction is studied in this paper. The moving vehicle is modeled as a two-axle mass-spring-damper four-degrees-of-freedom system. A new dynamic foundation model, called "Dynamic foundation model" including linear elastic spring, shear layer, viscous damping and foundation mass parameter, is used to analyze the dynamic response of the track-vehicle interaction. The railway track on the new dynamic foundation model subjected to a moving vehicle is regarded as an integrated system. By means of the finite element method and dynamic balance principle, the governing equation of motion for railway track-vehicle-foundation interaction is derived and solved by the step-by-step integration method. The accuracy of the algorithm is verified by comparing the numerical results with the other numerical results in the literature. The influence of foundation mass parameter on the dynamic response of railway track-vehicle interaction is investigated. The numerical results show that with the new dynamic foundation model the foundation mass effects more significantly on the dynamic response of track-vehicle interaction. The study shows that the new dynamic foundation model describes the true behavior of soil in the analysis of dynamic response of structures on the foundation

How Digital Natives Learn and Thrive in the Digital Age: Evidence from an Emerging Economy

As a generation of ‘digital natives,’ secondary students who were born from 2002 to 2010 have various approaches to acquiring digital knowledge. Digital literacy and resilience are crucial for them to navigate the digital world as much as the real world; however, these remain under-researched subjects, especially in developing countries. In Vietnam, the education system has put considerable effort into teaching students these skills to promote quality education as part of the United Nations-defined Sustainable Development Goal 4 (SDG4). This issue has proven especially salient amid the COVID−19 pandemic lockdowns, which had obliged most schools to switch to online forms of teaching. This study, which utilizes a dataset of 1061 Vietnamese students taken from the United Nations Educational, Scientific, and Cultural Organization (UNESCO)’s “Digital Kids Asia Pacific (DKAP)” project, employs Bayesian statistics to explore the relationship between the students’ background and their digital abilities. Results show that economic status and parents’ level of education are positively correlated with digital literacy. Students from urban schools have only a slightly higher level of digital literacy than their rural counterparts, suggesting that school location may not be a defining explanatory element in the variation of digital literacy and resilience among Vietnamese students. Students’ digital literacy and, especially resilience, also have associations with their gender. Moreover, as students are digitally literate, they are more likely to be digitally resilient. Following SDG4, i.e., Quality Education, it is advisable for schools, and especially parents, to seriously invest in creating a safe, educational environment to enhance digital literacy among students

Finite element model for vibration and buckling of functionally graded sandwich beams based on a refined shear deformation theory

Finite element model for vibration and buckling of functionally graded sandwich beams based on a refined shear deformation theory is presented. The core of sandwich beam is fully metal or ceramic and skins are composed of a functionally graded material across the depth. Governing equations of motion and boundary conditions are derived from the Hamilton’s principle. Effects of power-law index, span-to-height ratio, core thickness and boundary conditions on the natural frequencies, critical buckling loads and load–frequency curves of sandwich beams are discussed. Numerical results show that the above-mentioned effects play very important role on the vibration and buckling analysis of functionally graded sandwich beams

Security risks from climate change and environmental degradation: implications for sustainable land use transformation in the Global South

Climate change and environmental degradation remain the most complex challenges that present and future generations of humankind face and raise several security risks that have received relatively little attention in the literature. This paper aims to review the evidence of security risks arising from these challenges in the Global South and to provide forward-looking perspectives on how to increase the resilience of affected individuals and communities. We see diverse land use strategies as a key element to drive a transformation towards greater sustainability and resilience. We propose that rural land use in the Global South should be geared towards the promotion of resource and biodiversity conservation, the development of agroforestry, tree-based farming systems, the diversification of crops, and the utilization of climate-resilient cultivars, and neglected and under-utilized plants. These actions would contribute to addressing the security risks stemming from the interconnected challenges of climate change and environmental degradation

Seasonal variation of phytoplankton in My Thanh River, Mekong delta, Vietnam

A study on the seasonal variation of phytoplankton composition was conducted at the upper, middle, and lower parts of the My Thanh River, which supplies an important source of water for aquaculture. Qualitative and quantitative samples of phytoplankton were collected monthly at both high and low tide. The results showed that a total of 171 phytoplankton (algae) species were recorded, belonging to 59 genera and 5 phyla. Diatoms were the most abundant group with the highest species number, followed by green algae. The other phyla possessed a lower number of species. The species composition was more diverse in the rainy season and at high tide at most of the sampling sites. The mean density of algae varied from 30,900-43,521 ind.L^-1^. The density of diatoms was higher in the middle and lower parts. At the same time, euglenoids displayed the highest density in the upper part, showing a difference in the dominant algae group under the influence of salinity. Salinity was found to be significantly positively correlated (p<0.01) with diatoms, whereas it was negatively correlated (p<0.05) with blue-green algae and euglenoids. The algae composition was quite diverse, with the H' index ranging from 2.0-3.3, showing the water quality was slightly to moderately polluted

Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

<p>Abstract</p> <p>Background</p> <p>The positive transcription elongation factor, P-TEFb, comprised of cyclin dependent kinase 9 (Cdk9) and cyclin T1, T2 or K regulates the productive elongation phase of RNA polymerase II (Pol II) dependent transcription of cellular and integrated viral genes. P-TEFb containing cyclin T1 is recruited to the HIV long terminal repeat (LTR) by binding to HIV Tat which in turn binds to the nascent HIV transcript. Within the cell, P-TEFb exists as a kinase-active, free form and a larger, kinase-inactive form that is believed to serve as a reservoir for the smaller form.</p> <p>Results</p> <p>We developed a method to rapidly quantitate the relative amounts of the two forms based on differential nuclear extraction. Using this technique, we found that titration of the P-TEFb inhibitors flavopiridol, DRB and seliciclib onto HeLa cells that support HIV replication led to a dose dependent loss of the large form of P-TEFb. Importantly, the reduction in the large form correlated with a reduction in HIV-1 replication such that when 50% of the large form was gone, HIV-1 replication was reduced by 50%. Some of the compounds were able to effectively block HIV replication without having a significant impact on cell viability. The most effective P-TEFb inhibitor flavopiridol was evaluated against HIV-1 in the physiologically relevant cell types, peripheral blood lymphocytes (PBLs) and monocyte derived macrophages (MDMs). Flavopiridol was found to have a smaller therapeutic index (LD₅₀/IC₅₀) in long term HIV-1 infectivity studies in primary cells due to greater cytotoxicity and reduced efficacy at blocking HIV-1 replication.</p> <p>Conclusion</p> <p>Initial short term studies with P-TEFb inhibitors demonstrated a dose dependent loss of the large form of P-TEFb within the cell and a concomitant reduction in HIV-1 infectivity without significant cytotoxicity. These findings suggested that inhibitors of P-TEFb may serve as effective anti-HIV-1 therapies. However, longer term HIV-1 replication studies indicated that these inhibitors were more cytotoxic and less efficacious against HIV-1 in the primary cell cultures.</p