Analyzing the Improvements of Energy Management Systems for Hybrid Electric Vehicles Using a Systematic Literature Review: How Far Are These Controls from Rule-Based Controls Used in Commercial Vehicles?

Featured Application This work is useful for researchers interested in the study of energy management systems for hybrid electric vehicles. In addition, it is interesting for institutions related to the market of this type of vehicle. The hybridization of vehicles is a viable step toward overcoming the challenge of the reduction of emissions related to road transport all over the world. To take advantage of the emission reduction potential of hybrid electric vehicles (HEVs), the appropriate design of their energy management systems (EMSs) to control the power flow between the engine and the battery is essential. This work presents a systematic literature review (SLR) of the more recent works that developed EMSs for HEVs. The review is carried out subject to the following idea: although the development of novel EMSs that seek the optimum performance of HEVs is booming, in the real world, HEVs continue to rely on well-known rule-based (RB) strategies. The contribution of this work is to present a quantitative comparison of the works selected. Since several studies do not provide results of their models against commercial RB strategies, it is proposed, as another contribution, to complete their results using simulations. From these results, it is concluded that the improvement of the analyzed EMSs ranges roughly between 5% and 10% with regard to commercial RB EMSs; in comparison to the optimum, the analyzed EMSs are nearer to the optimum than commercial RB EMSs

Angiosarcoma del muslo: diagnóstico diferencial

Se presenta un caso de angiosarcoma de partes blandas en un paciente de 92 años localizado en extremidad inferior de seis meses de evolución. Estos tipos de tumores muestran probabilidades de ser confundidos con hematomas, incluso con estudios de Resonancia Nuclear. Se destaca la ayuda que ofrece para el diagnóstico la arteriografía, así como la agresividad de dichos tumores y los posibles abordajes terapéuticos actuales.A case of angiosarcoma is presented. The patient was 92 years old. The tumor was present 6 months before diagnosis. The tumor was diagnosed by MRN as haematoma of the muscle. Arteriography is a good diagnostic tool before the biopsy in that type of lesions. Alternative treatments of such letal neoplasms are discussed

Development of a passive mini-direct ethanol fuel cell : effect of mea assembly parameters by hot pressure.

This paper presents preliminary results on the design, construction and evaluation of a passive mini direct ethanol fuel cell (DEFC), capillary fed with 2 mol l-1 aqueous ethanol, at a rate of 2.03 μL min-1, and air oxygen in the cathode through an air vent. Parameters such as pressure, temperature and time of manufacturing a membrane-electrode assembly (MEA) by hot-pressure were evaluated. As the electrode holder used a 0.25 cm2 carbon tissue which was deposited on the catalytic layer (C. L.) for both the anode (0.8 mg cm-2 of PtRu/C) and the cathode (0.8 mg cm-2 of Pt/C), Nafi on® 115 membranes were used as the electrolyte. The results show, an average power density of 302 μWcm2 under the best conditions used, a catalytic layer with a Nafi on percentage of 50% at 25 °C. A temperature of 125 °C, a pressure of 49.2 Kg/cm2, and 90 seconds duration were used to obtain the MEA

Cotilo recubierto con hidroxiapatita de la artroplastia Omnifit: resultados a medio plazo

Las cúpulas acetabulares roscadas han mostrado malos resultados en períodos medios de evolución. Aunque la sujeción inmediata es excelente, con el paso del tiempo se ha comprobado la ausencia de fijación, mostrando un alto porcentaje de movilizaciones. Una alternativa para evitar esos fracasos es el recubrimiento de estos cotilos con hidroxiapatita. Hemos revisado clínica y radiográficamente 36 casos de artroplastias Omnifit con cotilo roscado y recubierto de hidroxiapatita, con un tiempo medio de seguimiento de 58 meses. Diez pacientes presentaban dolor en región inguinal. Sólo el 63,9% de los cotilos se encontraban radiográficamente integrados, habiendo sufrido una clara movilización seis que precisaron cirugía de revisión acetabular; otros siete mostraban signos radiológicos de probable inestabilidad. El recubrimiento con hidroxiapatita no asegura una buena fijación en los cotilos roscados Omnifit por lo que recomendamos componentes acetabulares implantados a presión con posibilidad de sujeción adicional con tornillos.The threaded acetabular cups have shown mid-term bad results. Though the immediate fixation is excellent, as time goes by it has been proven the absence of fixation, appearing a high percentage of mobilizations. An alternative to avoid those failures is the hydroxyapatite coated implant. We have analysed clinically and radiographically 36 cases of Omnifit arthroplasties with cup threaded and coated with hydroxyapatite with an average time of follow-up of 58 months. Ten patients had pain in the hip. Only 63.9% of the acetabular cups were found to be radiographically integrated, six having suffered a clear mobilization requiring surgical review. Seven showed radiological signs of probable instability. The hydroxytapatite coatings does not assure a good fixation in the Omnifit threaded cups, therefore we recommend press fit acetabular components with the possibility of additional fixation with screws

Development of a Passive Mini-Direct Ethanol Fuel Cell: Effect of Mea Assembly Parameters by Hot Pressure

This paper presents preliminary results on the design, construction and evaluation of a passive mini direct ethanol fuel cell (DEFC), capillary fed with 2 mol l-1 aqueous ethanol, at a rate of 2.03 μL min-1, and air oxygen in the cathode through an air vent. Parameters such as pressure, temperature and time of manufacturing a membrane-electrode assembly (MEA) by hot-pressure were evaluated. As the electrode holder used a 0.25 cm2 carbon tissue which was deposited on the catalytic layer (C. L.) for both the anode (0.8 mg cm-2of PtRu/C) and the cathode (0.8 mg cm -2of Pt/C), Nafi on® 115 membranes were used as the electrolyte. The results show, an average power density of 302 μWcm2 under the best conditions used, a catalytic layer with a Nafi on percentage of 50% at 25 °C. A temperature of 125 °C, a pressure of 49.2 Kg/cm2, and 90 seconds duration were used to obtain the MEA

Development and evaluation of a nanofiber membrane in vitro as a therapeutic alternative for the post treatment in breast cancer cell in a murine model

Worldwide female breast cancer is the most commonly diagnosed cancer, with an estimated 2.3 million new cases in 2020, reason for the need of targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles of gold (AuNps) exhibit cytotoxic properties against certain types of cancer cell lines. Nanofibers have been use in the drug delivery systems due to its degradability and high surface area. We proposed a membrane with nanometric fibers using polivinilic alcohol (PVA) and chitosan (Qts) loaded with AuNps and Doxorubicin (Doxo) with the purpose of diminish tumor regression. PVA-Qts membrane was develop with electrospinning, the injection, voltage, distance and relative humidity parameters were standardized and it were characterized by Microscopic Atomic Force. The cytotoxicity with a median lethal dose (DL50) in two cell lines, breast adenocarcinoma murine (4T1) and murine fibroblast (NiH3T3) as a healthy control were evaluated. AuNps had a size of 3 nanometers (nm) with a Z potential of 13.2 mVolts and a DL50 of 75 µM in the cell line 4T1. Doxo was decrease in 95% with a final concentration of 0.03 mg/cm2. Both doses were loaded in the PVA-Qts solution. PVA-Qts-Doxo and PVA-Qts-AuNps-Doxo decrease the viability in 4T1 in 24 hours with a 15%, 72 hours with a 28%, the first with 60% and the latter with 82%. PVA-Qts-Doxo and PVA-Qts-AuNps-Doxo in NiH3T3 diminish incrementing with the time reaching a 40% in 120 hours. Finally, The viability for 4T1 cultured on PVA-Qts-Doxo was minor than in NiH3T3. The amount of Doxo in the membrane synthetized was 95% less than the employ doses, demonstrating that the fiber improves the delivery of the chemotherapeutic in a palatine time

Anatomy of the Human Optic Nerve: Structure and Function

The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key points of the ON are the optic nerve head and chiasm. This chapter will include a detailed and updated review of the ON different parts: RGC axons, glial cells, connective tissue of the lamina cribrosa and the septum and the blood vessels derivate from the central retina artery and from the ciliary system. There will be an up-to-date description about the superficial nerve fibre layer, including their organization, and about prelaminar, laminar and retrolaminar regions, emphasizing the axoplasmic flow, glial barriers, biomechanics of the lamina cribrosa and the role of the macro- and microglia in their working

Early Postoperative Monitoring of the Liver Graft

Liver transplantation (LT) is a common current technique for end-stage liver disease. Complications after the surgical procedure, though uncommon, can be of very different origin and can also be severe enough to lead to liver and multiorgan failure and finally graft loss and/or recipient’s death. Intensivists and the surgical team must be familiarized with these early complications to detect them as soon as possible in order to use the best diagnostic tools and take the best therapeutic measures to restore anatomical integrity and organ function to optimize the liver graft. In this chapter, we present an updated state of the art for efficiently tackling with all different, most usual complications that an LT patient can present during early postoperative period

Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients

Differences in gene expression patterns have been documented not only in Multiple Sclerosis patients versus healthy controls but also in the relapse of the disease. Recently a new gene expression modulator has been identified: the microRNA or miRNA. The aim of this work is to analyze the possible role of miRNAs in multiple sclerosis, focusing on the relapse stage. We have analyzed the expression patterns of 364 miRNAs in PBMC obtained from multiple sclerosis patients in relapse status, in remission status and healthy controls. The expression patterns of the miRNAs with significantly different expression were validated in an independent set of samples. In order to determine the effect of the miRNAs, the expression of some predicted target genes of these were studied by qPCR. Gene interaction networks were constructed in order to obtain a co-expression and multivariate view of the experimental data. The data analysis and later validation reveal that two miRNAs (hsa-miR-18b and hsa-miR-599) may be relevant at the time of relapse and that another miRNA (hsa-miR-96) may be involved in remission. The genes targeted by hsa-miR-96 are involved in immunological pathways as Interleukin signaling and in other pathways as wnt signaling. This work highlights the importance of miRNA expression in the molecular mechanisms implicated in the disease. Moreover, the proposed involvement of these small molecules in multiple sclerosis opens up a new therapeutic approach to explore and highlight some candidate biomarker targets in MS