Pregnant patient presenting with headache and medulloblastoma and hydrocephalous: a case report

Medulloblastoma, a primitive neuroectodermal tumor (PNET), is a second most brain tumor in children, accounting for about 20% of cases but is very rare in adults, 1% of all cancers in adults with only one third of cases occur in women and even less in pregnant women. It is primarily a cerebellar tumor. Symptoms include nausea, vomiting, loss of coordination, morning headache, seizures and personality changes. Treatment is surgical removal of tumor followed by radiotherapy. A grand-multipara presented in casualty with 30 weeks pregnancy & complains of headache, visual disturbances & disorientation. MRI findings were suggestive of medulloblastoma with hydrocephalus. Ventriculo-peritoneal shunting was done followed by termination of pregnancy. She delivered vaginally a live female child. After 15 days, her definitive neurosurgery was done. The uniqueness of this case is its rarity and symptoms of which are often masked by symptoms of pregnancy as syncope during pregnancy could be due to hypoglycemia, anxiety, orthostatic hypotension or cardiac causes

Financial Performance Of Axis Bank And Kotak Mahindra Bank In The Post Reform Era: Analysis On CAMEL Model

The objective of this study is to Analyze the Financial Position and Performance of the Axis and Kotak Mahindra Bank in India based on their financial characteristics. We have chosen the CAMEL model and t-test which measures the performance of bank from each of the important parameter like capital adequacy, asset quality, management efficiency, earning quality, liquidity and Sensitivity. The present study is conducted analyze the consistency of the profitability of the Axis and Kotak Mahindra bank’s. It is analyses that the ratio of credit deposit is maximum of Kotak Mahindra Bank Ltd and it shows efficient management of the bank. The ratio of earning per share is maximum for Axis Bank Ltd i.e. 50.28 and the ratio of return on Assets is minimum for Axis Bank Ltd. The CAMELS’ analysis and t-test concludes that there is no significance difference between the Axis and Kotak Mahindra bank’s financial performance but the Kotak Mahindra bank performance is slightly less compared with Axis Bank

Confinement study of an SU(4) gauge theory with fermions in multiple representations

We discuss the phase diagnostics used in our finite-temperature study of an SU(4) gauge theory with dynamical fermions in both the fundamental and two-index antisymmetric representations. Beyond the usual Polyakov loop diagnostics of confinement, we employ several Wilson flow phase diagnostics. The first, what we call the "flow anisotropy", is known in the literature: the deconfinement transition introduces anisotropy between the spatial and temporal directions, to which the flow is extremely sensitive. The second, the "long flow time Polyakov loop," is related but novel. While we do not claim to fully understand this diagnostic, we have empirically found it to be useful as an unusually sharp diagnostic of phase.Comment: 7 pages, 6 figures. Presented at Lattice 2017, the 35th International Symposium on Lattice Field Theory, Granada, Spain, 18-24 June 201

Assessment of the pharmacokinetics, safety, and tolerability of levothyroxine sodium in healthy Indian volunteers

Background: Few studies have assessed the pharmacokinetics of various marketed formulations of levothyroxine available in the Indian market. Here, we assessed the pharmacokinetics and safety of Thyronorm® 100 in healthy Indian volunteers.Methods: The primary and secondary objectives were to determine the pharmacokinetic profile and to monitor safety and tolerability of 600 µg of levothyroxine, respectively. Eligible subjects received a single oral dose of 6×100 µg of levothyroxine, and pharmacokinetic profiles were monitored up to 432 hours post-dose. Safety assessments included exposure of study drug and incidence of adverse events (AEs) and serious AEs. The mean plasma concentration of LT4 versus time profile was presented on both untransformed and log-transformed scales.Results: Of 20 enrolled subjects, 1 was discontinued due to an AE of pain, unrelated to study drug. The mean [standard deviation (SD)] age and body mass index of subjects were 35.7 (6.33) years and 25.0 (3.0) kg/m2, respectively. Following baseline correction, the mean maximum observed drug concentration (Cmax) and area under the plasma concentration-time curve measured to the last quantifiable concentration (AUC0-t) of free thyroxine were found to be 68.4 (12.09) ng/ml and 6760.0 (2065.05) ng×hr/ml, respectively, with an elimination half-life (t1/2) of 205.6 (180.26) hrs and a residual area of 24.6%. The median time to first observed maximum drug concentration (Tmax) was 2.5 (1.5-2.5) hrs.Conclusions: These parameters were in accordance with those of other marketed formulations and confirmed the pharmacokinetics and safety of Thyronorm® 100 in healthy volunteers from India

Halotolerant Plant Growth Promoting Bacilli from Sundarban Mangrove Mitigate the Effects of Salinity Stress on Pearl Millet (Pennisetum glaucum L.) Growth

Pearl millet (Pennisetum glaucum L.) is one of the major crops in dry and saline areas across the globe. During salinity stress, plants encounter significant changes in their physio and biochemical activities, leading to decreased growth and yield. Bacillus species are used as biofertilizers and biopesticides for pearl millet and other crops to promote growth and yield. The use of Bacillus in saline soils has been beneficial to combat the negative effect of salinity on plant growth and yield. In this context, the present study emphasizes the use of two Bacillus species, i.e. Bacillus megaterium JR-12 and B. pumilus GN-5, which helped in alleviating the impact of salinity stress on the growth activities in salt-stressed pearl millet. Pearl millet seeds were treated with two strains, B. megaterium JR-12 and B.pumilus GN-5, individually and in combination under 50, 100 and 150 mM of sodium chloride stress. The treated plants showed higher plant height, biomass accumulation, and photosynthetic apparatus than the non-treated plants. Additionally, the treated plants showed increased osmoprotectant levels under salinity stress compared to control plants. The antioxidant enzyme content was improved post-inoculation, indicating the efficient stress-alleviating potential of both strains of Bacillus species. Moreover, inoculation of these microbes significantly increased plant growth attributes in plants treated with a combination of Bp-GN-5 + Bm-JR-12 and the reduction rates of plant growth were found to be alleviated to 9.12%, 20.30% and 33%, respectively. Overall, the results of the present study suggested that these microbes could have a higher potential to improve the productivity of pearl millet under salinity stress

One step Purification and Characterisation of Abrin Toxin from Abrus Precatorius Seeds

Abrin is a plant toxin obtained from Abrus precatorius seeds. It belongs to the type II ribosomal inactivating proteins (RIPs) consisting of two chains namely, catalytically active A chain and sugar binding B chain linked by a single disulphide bond.  Due to high toxicity of abrin, its exposure or consumption can lead to serious public health problems. In the present work, we have extracted and purified the abrin toxin from Abrus precatorius seeds. The toxin was purified using a single step anion exchange chromatography. The purified protein was characterized by SDS-PAGE and MALDI- TOF to confirm its purity. The toxicity of purified abrin toxin was also confirmed by injecting the toxin in mice.  The purified protein was further used to raise antibodies in mice and characterized by indirect Enzyme Linked Immunosorbent Assay. The results of present study established the use of single step ion exchange chromatography to purify abrin toxin for further development of its detection system

Study the effect of metformin, voglibose alone and in combination on body mass index in non-diabetic obese Indian subjects- A hospital based study

Background: Early detection and therapy of the obese adolescent with a family history of type 2 diabetes may interrupt the cycle of weight gain and insulin resistance that leads to glucose intolerance in adulthood. Materials & Methods: The objective of our study was to observe the effect of metformin and voglibose on BMI, as it provides a simple and convenient anthropometric index for classification of obesity. 60 non diabetic obese subjects were selected on the basis of inclusion and exclusion criteria, and divided into three groups of 20 subjects each. The first group received metformin 500 mg BD, second group received voglibose 0.3 mg and the third group received a combination of metformin 500 mg and voglibose 0.3mg. For the comparison we applied paired and unpaired t test. Paired t test was applied for intra group comparison and unpaired t test was applied for inter group comparison. Results: After six months of treatment with Metformin 500 mg BD alone, Voglibose 0.3mg BD alone and Metformin 500 mg with Voglibose 0.3 mg BD in combination, all three groups showed statistically significant reduction in BMI values from baseline. When we compared results of metformin group with voglibose group there was no statistically significant difference. But when we compared results of metformin alone with metformin and voglibose combination and voglibose alone with metformin and voglibose combination, the combination group showed statistically significant reduction in BMI base line values. Conclusion: Therefore, it can be concluded that Metformin + Voglibose combination is very effective in reducing body weight, but further long term studies with large sample size are needed to assess the safety and efficacy of Metformin+ Voglibose combination in treatment of obesity in non-diabetic population

A concurrent parallel study to compare the efficacy and safety of oral iron chelators, defrasirox and defriprone in patients of beta thalassaemia major

Background: This study was planned to evaluate all the cases of β thalassaemia major, already receiving one of the oral iron chelators for a comparison among the efficacy, safety and economy of deferasirox and deferiprone to establish the better option in an Indian scenario.Methods: We identified two groups of patients: 38 treated with deferasirox and 35 treated with deferiprone. Laboratory parameters such as serum ferritin, creatinine, SGPT, Hb, CBC and urine were recorded at the time of inclusion and at 1, 3 and 6 months after the inclusion. The primary outcome variable was serum Ferritin level at the start and at the end of study. Serum ferritin level was carried out by microparticle enzyme linked immunoassay.Results: Before the study, the mean hemoglobin level was 7.32±1.50mg/dL ranged from 4 to 10.8 in deferasirox group and 7.54±1.15mg/dL ranged from 5.5 to 8.8 in deferiprone group. At the time of inclusion, study population was characterized by a mean serum ferritin value of 4735.11±450.01 SE in deferasirox and 4315.97±340.75 SE in deferiprone group. After one month the mean serum ferritin increases to 4578.66±371.96 in deferasirox and 4388.82±316.16 in deferiprone group. After three month the mean serum ferritin reduces to 4295.60±377.37 in deferasirox and 3988.88±349.84 in Deferiprone group.Conclusions: Thus, we conclude that deferasirox and deferiprone are well tolerated, have few adverse effects and almost have a comparable effect in lowering of the patient's serum ferritin level. Deferiprone is more cost effective but needs a strict control on compliance owing to requirement in three divided doses per day

Ageratum enation virus Infection Induces Programmed Cell Death and Alters Metabolite Biosynthesis in Papaver somniferum

A previously unknown disease which causes severe vein thickening and inward leaf curl was observed in a number of opium poppy (Papaver somniferum L.) plants. The sequence analysis of full-length viral genome and associated betasatellite reveals the occurrence of Ageratum enation virus (AEV) and Ageratum leaf curl betasatellite (ALCB), respectively. Co-infiltration of cloned agroinfectious DNAs of AEV and ALCB induces the leaf curl and vein thickening symptoms as were observed naturally. Infectivity assay confirmed this complex as the cause of disease and also satisfied the Koch’s postulates. Comprehensive microscopic analysis of infiltrated plants reveals severe structural anomalies in leaf and stem tissues represented by unorganized cell architecture and vascular bundles. Moreover, the characteristic blebs and membranous vesicles formed due to the virus-induced disintegration of the plasma membrane and intracellular organelles were also present. An accelerated nuclear DNA fragmentation was observed by Comet assay and confirmed by TUNEL and Hoechst dye staining assays suggesting virus-induced programmed cell death. Virus-infection altered the biosynthesis of several important metabolites. The biosynthesis potential of morphine, thebaine, codeine, and papaverine alkaloids reduced significantly in infected plants except for noscapine whose biosynthesis was comparatively enhanced. The expression analysis of corresponding alkaloid pathway genes by real time-PCR corroborated well with the results of HPLC analysis for alkaloid perturbations. The changes in the metabolite and alkaloid contents affect the commercial value of the poppy plants