Monte-Carlo simulation with FLUKA for liquid and solid targets

Introduction Monte-Carlo simulations can be used to assess isotope production on small medical cyclotrons. These simulations calculate the particle interactions with electric and magnetic fields, as well as the nuclear reactions. The results can be used to predict both yields and isotopic contaminations and can aid in the optimum design of target material and target geometry [1,2]. FLUKA is a general-purpose tool widely used in many applications from accelerator shielding to target design, calorimetry, activation, dosimetry, detector design, neutrino physics, or radiotherapy [3,4]. In this work, we applied the Monte-Carlo code FLUKA to determine the accuracy of predicting yields of various isotopes as compared to experimental yields. Material and Methods The proton beam collimation system, as well as the liquid and solid target of the TR13 cyclotron at TRIUMF, has been modeled in FLUKA. The proton beam parameters were initially taken from the cyclotron design specifications and were optimized against experimental measurements from the TR13. Data from irradiations of different targets and with different beam currents were collected in order to account for average behavior, see FIG. 1. Yields for a pencil proton beam as well as a beam spread out in direction and energy have been calculated and have been compared to experimental results obtained with the TR13. Results and Conclusion The reactions listed in TABLE 1 were assessed. For most reactions a good agreement was found in the comparison between experimental and simulated saturation yield. TABLE 1 only shows the yields simulated with a proton beam with a spread in both direction and energy. In most cases, the simulated yield is slightly larger or comparable. Only the calculated yield for 55Co was significantly lower by a factor of 4.2. This is still a good agreement considering that FLUKA was originally a high-energy physics code. It may indicate that the FLUKA internal cross-section calculation for this isotope production needs some optimization. In summary, we conclude that FLUKA can be used as a tool for the prediction of isotope production as well as for target design

Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A

Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.publishedVersionFil: Sparacino, Javier. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Sparacino, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Farias, María Gimena. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.Fil: Farias, María Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.Fil: Farias, María Gimena. Ministerio de Ciencia, Tecnología e Innovación. Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación. Fondo para la Investigación Científica y Tecnológica; Argentina.Fil: Lamberti, Pedro Walter. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina.Fil: Lamberti, Pedro Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Otras Ciencias Física

The interaction of 11Li with 208Pb

Background: 11Li is one of the most studied halo nuclei. The fusion of 11Li with 208Pb has been the subject of a number of theoretical studies with widely differing predictions, ranging over four orders of magnitude, for the fusion excitation function. Purpose: To measure the excitation function for the 11Li + 208Pb reaction. Methods: A stacked foil/degrader assembly of 208Pb targets was irradiated with a 11Li beam producing center of target beam energies from above barrier to near barrier energies (40 to 29 MeV). The intensity of the 11Li beam (chopped) was 1250 p/s and the beam on-target time was 34 hours. The alpha-decay of the stopped evaporation residues was detected in a alpha-detector array at each beam energy in the beam-off period (the beam was on for <= 5 ns and then off for 170 ns). Results: The 215At evaporation residues were associated with the fusion of 11Li with 208Pb. The 213,214At evaporation residues were formed by the breakup of 11Li into 9Li + 2n, with the 9Li fusing with 208Pb. The 214At evaporation residue appears to result from a "quasi-breakup" process. Conclusions: Most of 11Li + 208Pb interactions lead to breakup with a small fraction (<= 11%) leading to complete fusion.Comment: 25 pages, 11 figure

Measurement of two-halo neutron transfer reaction p(11^{11}Li,9^{9}Li)t at 3AA MeV

The p(\nuc{11}{Li},\nuc{9}{Li})t reaction has been studied for the first time at an incident energy of 3$A$ MeV delivered by the new ISAC-2 facility at TRIUMF. An active target detector MAYA, build at GANIL, was used for the measurement. The differential cross sectionshave been determined for transitions to the \nuc{9}{Li} ground andthe first excited states in a wide range of scattering angles. Multistep transfer calculations using different \nuc{11}{Li} model wave functions, shows that wave functions with strong correlations between the halo neutrons are the most successful in reproducing the observation.Comment: 6 pages, 3 figures, submitted to Physical Review Letter

Tests of a Laser Ion Source at the Heidelberg Electron Beam Ion Trap

A laser ion source (LIS) has been designed and successfully tested for loading the Heidelberg electron beam ion trap (H-EBIT) with ions of practically all solid-state elements. A pulsed YAG:Nd3þ laser (30 mJ, 8 ns) is used to produce plasma from a solid target. Lowly charged ions are extracted from the plasma and accelerated by a short high-voltage pulse, generating a pulsed ion beam with energy of up to 6 keV per charge. The ion beam is transported into the EBIT, decelerated and captured within it by switching the trapping electrode potentials. The electron beam further ionizes the trapped ions to the desired highly charged states. The experimental setup is described together with the source parameters measured for different target materials. X-ray spectra of up to He-like highly charged ions (Cu, Mo, Pb, Al and Ge) produced in the EBIT after injection from the LIS have been measured. The reliability and convenience of this method allows the use of the LIS to produce highly charged ions of both insulating and conducting solid elements with an EBIT as needed for different experiments

Physics of dark energy particles

We consider the astrophysical and cosmological implications of the existence of a minimum density and mass due to the presence of the cosmological constant. If there is a minimum length in nature, then there is an absolute minimum mass corresponding to a hypothetical particle with radius of the order of the Planck length. On the other hand, quantum mechanical considerations suggest a different minimum mass. These particles associated with the dark energy can be interpreted as the ``quanta'' of the cosmological constant. We study the possibility that these particles can form stable stellar-type configurations through gravitational condensation, and their Jeans and Chandrasekhar masses are estimated. From the requirement of the energetic stability of the minimum density configuration on a macroscopic scale one obtains a mass of the order of 10^55 g, of the same order of magnitude as the mass of the universe. This mass can also be interpreted as the Jeans mass of the dark energy fluid. Furthermore we present a representation of the cosmological constant and of the total mass of the universe in terms of `classical' fundamental constants.Comment: 10 pages, no figures; typos corrected, 4 references added; 1 reference added; reference added; entirely revised version, contains new parts, now 14 page

Magneto-Optic Trapping of β-Decaying 38Km, 37K From an On-Line Isotope Separator

A magneto-optic trap (MOT) can provide a well-polarized, backing-free, localized source of radioactive atoms for β-decay experiments. We have trapped approximately 6000 atoms of 38Km ( t1/2 = 0.925s) and 2000 atoms of 37K (1.226 s) produced at the TRIUMF on-line separator TISOL in a vapor-cell MOT. We have measured optical isotope shifts and deduced the nuclear charge radii, which show an unusual lack of change at the neutron number N = 20 shell closure. Plans include a search for scalar contributions to the β+- ν correlation in the 0+→0+ decay of 38Km

Progress at the Heidelberg EBIT

Two years after the relocation of the Heidelberg EBIT, several experiments are already in operation. Spectroscopic measurements in the optical region have delivered the most precise reported wavelengths for highly charged ions, in the case of the forbidden transitions of Ar XIV and Ar XV. The lifetimes of the metastable levels involved in those transitions has been determined with an error of less than 0.2%. A new, fully automatized x-ray crystal spectrometer allows systematic measurements with very high precision and reproducibility. Absolute measurements of the Lyman series of H-like ions are currently underway. Dielectronic recombination studies have yielded information on rare processes, as two-electron-one photon transitions in Ar16+, or the interference effects between dielectronic and radiative recombination in Hg77+. The apparatus can now operate at electron beam currents of more than 500 mA, and energies up to 100 keV. A further beam energy increase is planned in the near future. Ions can be extracted from the trap and transported to external experiments. Up to 4 x 107 Ar16+ ions per second can be delivered to a 1 cm diameter target at 10 m distance. Charge-exchange experiments with U64+ colliding with a cold He atomic beam have been carried out, as well as experiments aiming at the optimization of the charge state distribution of the extracted via dielectronic recombination. Two new EBITs, currently in advanced state of construction in Heidelberg, will be used for experiments at the VUV free electron laser at TESLA (Hamburg) and for the charge breeding of short-lived radioactive isotopes at the TRIUMF ISAC facility

MARK4 controls ischaemic heart failure through microtubule detyrosination.

Myocardial infarction is a major cause of premature death in adults. Compromised cardiac function after myocardial infarction leads to chronic heart failure with systemic health complications and a high mortality rate1. Effective therapeutic strategies are needed to improve the recovery of cardiac function after myocardial infarction. More specifically, there is a major unmet need for a new class of drugs that can improve cardiomyocyte contractility, because inotropic therapies that are currently available have been associated with high morbidity and mortality in patients with systolic heart failure2,3 or have shown a very modest reduction of risk of heart failure4. Microtubule detyrosination is emerging as an important mechanism for the regulation of cardiomyocyte contractility5. Here we show that deficiency of microtubule-affinity regulating kinase 4 (MARK4) substantially limits the reduction in the left ventricular ejection fraction after acute myocardial infarction in mice, without affecting infarct size or cardiac remodelling. Mechanistically, we provide evidence that MARK4 regulates cardiomyocyte contractility by promoting phosphorylation of microtubule-associated protein 4 (MAP4), which facilitates the access of vasohibin 2 (VASH2)-a tubulin carboxypeptidase-to microtubules for the detyrosination of α-tubulin. Our results show how the detyrosination of microtubules in cardiomyocytes is finely tuned by MARK4 to regulate cardiac inotropy, and identify MARK4 as a promising therapeutic target for improving cardiac function after myocardial infarction.BHF fellowship grant (FS/14/28/30713), Issac Newton Trust Grant (18.40u), and Cambridge BHF Centre of Research Excellence grants (RE/13/6/30180 and RE/18/1/34212)