Die COVID-19-Pandemie: Die Rolle von Demografie und Demograf*innen

Die COVID-19-Todesfälle sind nur die Spitze eines Eisbergs. Staatliche Maßnahmen zur Unterstützung von Familien könnten die Auswirkungen der Pandemie auf andere demografische Ereignisse, wie zum Beispiel die Fertilität, abmildern. - Bei der Bekämpfung von COVID-19 sollten politische Entscheidungsträger*innen berücksichtigen, inwiefern die Altersstruktur und Formen des Zusammenlebens die Infektionsund Todeszahlen beeinflussen können. - Auf nationaler Ebene müssen die statistischen Ämter ihre Datenerfassungssysteme verbessern, sodass auf Registerdaten besser und schneller zugegriffen werden kann. - Das Ausmaß der Übersterblichkeit variiert stark zwischen europäischen Ländern, und auch innerhalb eines Landes gibt es deutliche Unterschiede. Die genauen Gründe für den Erfolg oder Misserfolg einer Region stehen noch nicht fest, sodass in diesem Bereich mehr Forschung notwendig ist

Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy

Background: The aim of this study was to test the feasibility and safety of subretinal transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) cells into the healthy margins and within areas of degenerative retina in a swine model of geographic atrophy (GA). Methods: Well-delimited selective outer retinal damage was induced by subretinal injection of NaIO3 into one eye in minipigs (n = 10). Thirty days later, a suspension of hiPSC-derived RPE cells expressing green fluorescent protein was injected into the subretinal space, into the healthy margins, and within areas of degenerative retina. In vivo follow-up was performed by multimodal imaging. Post-mortem retinas were analyzed by immunohistochemistry and histology. Results: In vitro differentiated hiPSC-RPE cells showed a typical epithelial morphology, expressed RPE-related genes, and had phagocytic ability. Engrafted hiPSC-RPE cells were detected in 60% of the eyes, forming mature epithelium in healthy retina extending towards the border of the atrophy. Histological analysis revealed RPE interaction with host photoreceptors in the healthy retina. Engrafted cells in the atrophic zone were found in a patchy distribution but failed to form an epithelial-like layer. Conclusions: These results might support the use of hiPSC-RPE cells to treat atrophic GA by providing a housekeeping function to aid the overwhelmed remnant RPE, which might improve its survival and therefore slow down the progression of GA. Keywords: age-related macular degeneration (AMD); geographic atrophy; pig; animal model; stem cells; iPSC; RPE; retina; regenerative medicine; advanced cell therap

Factors associated with the clinical outcome of patients with relapsed/refractory CD19+acute lymphoblastic leukemia treated with ARI-0001 CART19-cell therapy

The prognosis of patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) remains poor, particularly for those relapsing after allogeneic hema-topoietic cell transplantation (alloHCT). Novel agents such as inotuzumab ozogamicin or blinatumomab achieve increased response rates, but these are generally transient unless followed by alloHCT. Chimeric antigen receptors (CAR) targeting CD19 have shown promising results in R/R ALL, and one of these products (tisagenlecleucel) has been approved for the treatment of patients with R/R ALL up to 25 years of age

Development of a Novel Anti-CD19 Chimeric Antigen Receptor : A Paradigm for an Affordable CAR T Cell Production at Academic Institutions

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed by CD8 hinge and transmembrane region, 4-1BB- and CD3z-signaling domains. We show that A3B1 CAR T cells are highly cytotoxic and specific against CD19+ cells in vitro, inducing secretion of pro-inflammatory cytokines and CAR T cell proliferation. In vivo, A3B1 CAR T cells are able to fully control disease progression in an NOD.Cg-Prkdc Il2rd/SzJ (NSG) xenograph B-ALL mouse model. Based on the pre-clinical data, we conclude that our CART19 is clearly functional against CD19+ cells, to a level similar to other CAR19s currently being used in the clinic. Concurrently, we describe the implementation of our CAR T cell production system, using lentiviral vector and CliniMACS Prodigy, within a medium-sized academic institution. The results of the validation phase show our system is robust and reproducible, while maintaining a low cost that is affordable for academic institutions. Our model can serve as a paradigm for similar institutions, and it may help to make CAR T cell treatment available to all patients

Development of a novel anti-CD19 chimeric antigen receptor: A paradigm for an affordable CAR T cell production at academic institutions

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed by CD8 hinge and transmembrane region, 4-1BB- and CD3z-signaling domains. We show that A3B1 CAR T cells are highly cytotoxic and specific against CD19+ cells in vitro, inducing secretion of pro-inflammatory cytokines and CAR T cell proliferation. In vivo, A3B1 CAR T cells are able to fully control disease progression in an NOD.Cg-Prkdcscid Il2rdtm1Wjl/SzJ (NSG) xenograph B-ALL mouse model. Based on the pre-clinical data, we conclude that our CART19 is clearly functional against CD19+ cells, to a level similar to other CAR19s currently being used in the clinic. Concurrently, we describe the implementation of our CAR T cell production system, using lentiviral vector and CliniMACS Prodigy, within a medium-sized academic institution. The results of the validation phase show our system is robust and reproducible, while maintaining a low cost that is affordable for academic institutions. Our model can serve as a paradigm for similar institutions, and it may help to make CAR T cell treatment available to all patients

Les bases neurobiològiques del pensament i la manipulabilitat del discurs

El treball vol explicar la condició de manipulabilitat del discurs, determinat per una bases neurobiològiques prèvies i condicionat per unes institucions i agents que de manera orquestrada configuren les estructures mentals tant de la societat com dels individus que la conformen.El trabajo quiere explicar la condición de manipulabilidad del discurso, determinado por unas bases neurobiológicas previas y condicionado por unas instituciones y agentes que de manera orquestrada configuran las estructuras mentales tanto de la sociedad como de los individuos que la conforman.The work wants to explain the manipulability condition of discourse, determined by previous neurobiological bases and conditioned by institutions and agents that in an orchestrated way configure the mental structures of both society and the individuals that comprise it

Les bases neurobiològiques del pensament i la manipulabilitat del discurs

El treball vol explicar la condició de manipulabilitat del discurs, determinat per una bases neurobiològiques prèvies i condicionat per unes institucions i agents que de manera orquestrada configuren les estructures mentals tant de la societat com dels individus que la conformen.El trabajo quiere explicar la condición de manipulabilidad del discurso, determinado por unas bases neurobiológicas previas y condicionado por unas instituciones y agentes que de manera orquestrada configuran las estructuras mentales tanto de la sociedad como de los individuos que la conforman.The work wants to explain the manipulability condition of discourse, determined by previous neurobiological bases and conditioned by institutions and agents that in an orchestrated way configure the mental structures of both society and the individuals that comprise it

In-fan-cia : educar de 0 a 6 años : revista de la Associació de Mestres Rosa Sensat

Se plantea el tema de la salud del niño y se muestran las enfermedades más comunes desarrolladas hasta los tres años. También se detallan las afecciones contagiosas que implican la no asistencia a la escuela para evitar contagios. Finalmente se aconseja sobre aspectos relacionados el uso de medicación en la escuela, la asistencia médica en caso de accidente o dolencia grave en el centro, las enfermedades crónicas y la ausencia del niño a la escuela por motivos de salud.CataluñaMadrid (Comunidad Autónoma). Servicio de Formación del Profesorado. CRIF Las Acacias; Calle General Ricardos, 179; 28025 Madrid; Tel. +34915250893; Fax +34914660991; [email protected]

CORESIDENCE: national and subnational data on household size and composition around the world, 1964-2021

The CORESIDENCE Database (CoDB) represents a significant advancement in the field of family studies, addressing existing data gaps and facilitating comprehensive analysis of households' composition and living arrangements at the national and subnational levels. This article introduces the CoDB, developed for the ERC project Intergenerational Coresidence in Global Perspective: Dimensions of Change. The database draws on global-scale individual microdata from four main repositories and national household surveys, encompassing over 150 million individual records representing more than 98% of the world's population. The CoDB provides datasets at the national, subnational, and subnational-harmonized levels, covering 156 countries, 3950 regions, and 1511 harmonized regions for the period 1964-2021. It includes 146 indicators on household composition and family arrangements, allowing researchers to explore intergenerational co-residence patterns, gender dynamics within households, and longitudinal trends in living arrangements. The CoDB fills an important gap in comparative household studies, enabling researchers to undertake ground breaking research at both macro and micro levels, ultimately fostering a deeper understanding of the complex dynamics of family structures and living arrangements