926 research outputs found

    Importing Corruption Culture from Overseas: Evidence from Corporate Tax Evasion in the United States

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    This paper studies how cultural norms and enforcement policies influence illicit corporate activities. Using confidential IRS audit data, we show that corporations with owners from countries with higher corruption norms engage in higher amounts of tax evasion in the U.S. This effect is strong for small corporations and decreases as the size of the corporation increases. In the mid-2000s, the United States implemented several enforcement measures which significantly increased tax compliance. However, we find that these enforcement efforts were less effective in reducing tax evasion by corporations whose owners are from countries with higher corruption norms. This suggests that cultural norms can be a challenge to legal enforcement.

    The Effects of Dance-Based Exercise on Body Composition, Physical Fitness, and Cognitive Function in Older Adults

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    Regular physical activity is widely recommended and has many benefits for older adults to maintain health and physical fitness. The excellent exercise program in older adults should include crucial components such as physical fitness and cognitive function. PURPOSE: To determine the effects of dance-based exercise training compared with traditional chair-based exercise on body composition, physical fitness, and cognitive function in the older adults. METHODS: Fourteen older adults (female: 11, male: 3), aged 71.2±8.0 years, were assigned into two groups: dance-based exercise (DE; n=8) and traditional chair-based exercise (TE; n=6). Both forms of exercise training were provided twice a week during 8 weeks and were performed for 60 min per session. Each session included 30 min main exercises, a 10 min warm-up, a 10 min cool-down, and short breaks between the different exercises or movements adding another 10 min. The intensity of two different types of exercise programs was adjusted (60-80% of maximal heart rate) by a physical activity tracker, which recorded heart rates (HR) during the exercise session. The DE program focused on elementary spins (longitudinal turns), shifts of center of gravity (COG), single-leg stances, skips and hops, different steps (i.e., mambo, cha cha, grapevine, jazz square) to challenge the balance system. Height (cm), body mass (kg), waist circumference (cm), hip circumference (cm), percent body fat (%), blood pressure (mmHg), resting HR (b·min-1), muscular strength (kg), balance ability (s), and cognitive function (score) were measured pre- and post-intervention, and the results were analyzed utilizing a repeated measures two-way ANOVA (p\u3c 0.05). RESULTS: Balance ability (one-leg standing with eyes open, left leg) was significantly increased only in DE (13.2±17.8 to 21.6±19.5 s, p=.007). Systolic blood pressure was significantly decreased only in TE (142.0±16.4 to 127.0±13.8 mmHg, p=.024). Waist circumference (p=.006) and 30-second chair stand (p=.004) were significantly improved in both groups. There was no significant difference in other variables after 8 weeks of training. CONCLUSION: The results indicate that dance-based exercise is an effective exercise regimen compared to the traditional chair-based exercise to improve balance ability and lower body muscular strength in older adults

    Screening of Vietnamese medicinal plants for NF-ÎșB signaling inhibitors: Assessing the activity of flavonoids from the stem bark of Oroxylum indicum

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    AbstractEthnopharmacological relevanceSeventeen plants used in Vietnamese traditional medicine for the treatment of inflammatory disorders were screened for NF-ÎșB inhibitory activity. Oroxylum indicum, which exhibited activity, was investigated in detail.Materials and methodsForty plant extracts from 17 species were prepared by maceration using dichloromethane and methanol and were tested (10”g/mL) to evaluate their ability to inhibit NF-ÎșB activation using TNF-α-stimulated HEK-293 cells stably transfected with a NF-ÎșB-driven luciferase reporter. The active extract of Oroxylum indicum was subsequently fractionated by different chromatographic techniques. After isolation, all single compounds were identified by spectroscopic methods and assessed for NF-ÎșB inhibitory effects.ResultsThe dichloromethane extracts obtained from Chromolaena odorata leaves and the stem bark of Oroxylum indicum showed distinct inhibitory effects on NF-ÎșB activation at a concentration of 10”g/mL. The active extract of Oroxylum indicum was subjected to further phytochemical studies resulting in identification of four flavonoid aglyca and six flavonoid glycosides. Pharmacological evaluation of the obtained compounds identified oroxylin A as the most active substance (IC50=3.9”M, 95% CI: 3.5–4.4”M), while chrysin and hispidulin showed lower activity with IC50=7.2”M (95% CI: 6.0–8.8”M) and 9.0”M (95% CI: 7.9–10.2”M), respectively. Interestingly, in this study the activity of baicalein (IC50=28.1”M, 95% CI: 24.6–32.0”M) was weak. The isolated glycosides showed no inhibitory activity when tested at a concentration of 30”M. Quantification of the four active flavonoids in extracts and plant materials suggested that oroxylin A contributes to the NF-ÎșB inhibitory activity of the stem barks of Oroxylum indicum to a greater extent than baicalein which was thought to be responsible for the anti-inflammatory activity of this plant.ConclusionsThe screening presented in this study identified the dichloromethane extracts of Chromolaena odorata and Oroxylum indicum as promising sources for NF-ÎșB inhibitors. Hispidulin, baicalein, chrysin and oroxylin A, isolated from Oroxylum indicum, were identified as inhibitors of NF- ÎșB activation

    NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways.

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    While sensory representations in the brain depend on context, it remains unclear how such modulations are implemented at the biophysical level, and how processing layers further in the hierarchy can extract useful features for each possible contextual state. Here, we demonstrate that dendritic N-Methyl-D-Aspartate spikes can, within physiological constraints, implement contextual modulation of feedforward processing. Such neuron-specific modulations exploit prior knowledge, encoded in stable feedforward weights, to achieve transfer learning across contexts. In a network of biophysically realistic neuron models with context-independent feedforward weights, we show that modulatory inputs to dendritic branches can solve linearly nonseparable learning problems with a Hebbian, error-modulated learning rule. We also demonstrate that local prediction of whether representations originate either from different inputs, or from different contextual modulations of the same input, results in representation learning of hierarchical feedforward weights across processing layers that accommodate a multitude of contexts

    Proton transfer and esterification reactions in EMIMOAc-based acidic ionic liquids

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    Acetate-based ionic liquids (such as 1-ethyl-3-methylimidazolium acetate, EMIMOAc) have potential applications for CO2 absorption and electrochemical reduction, chemical separations and extractions, and Fischer esterification of alcohols, amines, and starch. Both strong and weak organic acids can be dissolved in EMIMOAc and yield interesting proton-rich acidic ionic liquid solutions. We have used GCMS vapor pressure measurements, spectroscopic methods, calorimetry, and viscosity/conductivity measurements to investigate the properties and reactions of various acids dissolved in EMIMOAc. Unique proton transfer and esterification reactions are observed in many of these acidic solutions with carboxylic acids or sulfonic acids as solutes. Some acids react with the acetate anion to produce acetic acid, which provides a measure of acid strength in ionic liquid solvents. In addition, we observed an esterification reaction that might involve the imidazolium cation and the acetate anion to yield methyl acetate

    THE IMPACT OF INNOVATION ON ECONOMIC GROWTH: THE SPILLOVER EFFECT OF FOREIGN DIRECT INVESTMENT

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    Purpose of the study: Innovation is seen as the key to improving quality and productivity, thereby promoting competition and economic growth. This study analyzes the impact of innovation on economic growth through various measures, such as research and development spending, the number of researchers, number of patents as well as trademark registrations. Research results are evidence to recommend policies for intellectual-based economic growth. Methodology: Literature review and empirical analysis conducted in the study. The empirical method is a two-step System Generalize Methods of Moments (GMM), aiming at reliable results. Accessing the World Bank Database, research data from 64 developed and developing countries are collected from 2006 to 2014. Main Findings: The empirical findings show that innovation plays a crucial contribution in promoting economic growth, similar to national openness and government spending on education. This study also finds a positive impact on foreign investment flows and their spillover role in enhancing the correlation between innovation and economic growth. Applications of this study: The findings of this study focus on the contributions of innovation, foreign direct investment inflows, and other macro factors that can be enforced to improve economic growth by policymakers. Novelty/Originality of this study: The study uses different measures of innovation, including inputs such as the number of researchers, research and development expenditure, and outputs as the number of patents and number of trademark registrations. Empirical findings are found consistently, thus confirming that innovation is very important for economic growth. The study also shows convincing evidence confirming the positive contribution of foreign direct investment as well as its spillover effect on innovation and economic growth

    System for Performing Single Query Searches of Heterogeneous and Dispersed Databases

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    The present invention is a distributed computer system of heterogeneous databases joined in an information grid and configured with an Application Programming Interface hardware which includes a search engine component for performing user-structured queries on multiple heterogeneous databases in real time. This invention reduces overhead associated with the impedance mismatch that commonly occurs in heterogeneous database queries

    POLLUTION OF GROUNDWATER BY LEACHATE FROM DONG THANH LANDFILL DISPOSAL SITE

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    Joint Research on Environmental Science and Technology for the Eart

    Quality of care for patients with type 2 diabetes in general practice according to patients' ethnic background: a cross-sectional study from Oslo, Norway

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    <p>Abstract</p> <p>Background</p> <p>In recent decades immigration to Norway from Asia, Africa and Eastern Europe has increased rapidly. The aim of this study was to assess the quality of care for type 2 diabetes mellitus (T2DM) patients from these ethnic minority groups compared with the care received by Norwegians.</p> <p>Methods</p> <p>In 2006, electronic medical record data were screened at 11 practices (49 GPs; 58857 patients). 1653 T2DM patients cared for in general practice were identified. Ethnicity was defined as self-reported country of birth. Chi-squared tests, one-way ANOVAs, multiple regression, linear mixed effect models and generalized linear mixed models were used.</p> <p>Results</p> <p>Diabetes was diagnosed at a younger age in patients from the ethnic minority groups (South Asians (SA): mean age 44.9 years, Middle East/North Africa (MENA): 47.2 years, East Asians (EA): 52.0 years, others: 49.0 years) compared with Norwegians (59.7 years, p < 0.001). HbA1c, systolic blood pressure (SBP) and s-cholesterol were measured in >85% of patients in all groups with minor differences between minority groups and Norwegians. A greater proportion of the minority groups were prescribed hypoglycaemic medications compared with Norwegians (≄79% vs. 72%, p < 0.001). After adjusting for age, gender, diabetes duration, practice and physician unit, HbA1c (geometric mean) for Norwegians was 6.9% compared to 7.3-7.5% in the minority groups (p < 0.05). The proportion with poor glycaemic control (HbA1c > 9%) was higher in minority groups (SA: 19.6%, MENA: 18.9% vs. Norwegians: 5.6%, p < 0.001. No significant ethnic differences were found in the proportions reaching the combined target: HbA1c ≀ 7.5%, SBP ≀ 140 mmHg, diastolic blood pressure (DBP) ≀ 85 mmHg and total s-cholesterol ≀5.0 mmol/L (Norwegians: 25.5%, SA: 24.9%, MENA: 26.9%, EA: 26.1%, others:17.5%).</p> <p>Conclusions</p> <p>Mean age at the time of diagnosis of T2DM was 8-15 years younger in minority groups compared with Norwegians. Recording of important processes of care measures is high in all groups. Only one in four of most patient groups achieved all four treatment targets and prescribing habits may be sub-optimal. Patients from minority groups have worse glycaemic control than Norwegians which implies that it might be necessary to improve the guidelines to meet the needs of specific ethnic groups.</p
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