Predictores de deterioro neurologico precoz en pacientes con enfermedad vascular cerebral isquemica

Determinar prevalencia y construir modelo de predicción de deterioro neurológico precoz en pacientes con Enfermedad cerebrovascular (ECV) isquémico. Material y método: Estudio observacional, analítico, transversal, se evaluó 191 pacientes con ECV isquémico distribuidos en 2 grupos: Grupo I (13 pacientes con deterioro neurológico precoz y Grupo II (178 pacientes sin Deterioro Neurológico precoz). Se investigó la influencia de: edad, sexo, Hipertensión Arterial, diabetes mellitus tipo 2, presión Arterial Sistólica , score de la Escala de Glasgow (ECG), nitrógeno ureico en la sangre (BUN) , creatinina sérica, razón BUN /creatinina, hemoglobina, glucosa, lipoproteínas de alta densidad, triglicéridos, sodio, potasio, proteína C reactiva (PCR), en el desarrollo de Deterioro Neurológico Precoz (DNP). Se aplicó el Test de Chi cuadrado y se calculó el Odds Ratio para asociación significativa entre las variables, y análisis multivariado de regresión logística binaria para evaluar simultáneamente los factores de riesgo ajustado. Resultados: Las variables clínicas con asociación significativa a DNP tras un ECV isquémico fueron: sexo OR = 0,20 (P=0,041), puntuación ECG al tercer día OR= 0,70 (p=0,002) y nivel de potasio a la admisión OR= 2,53 (P=0,030), controlando el resto de variables. El modelo tuvo un rendimiento diagnóstico de 80,53%. Conclusiones: Prevalencia de DNP en pacientes con ECV isquémica fue 6.8%. El modelo de predicción para DNP en pacientes con ECV isquémica estuvo integrado por las variables: sexo, score de ECG al tercer día, y niveles de K a la admisión con rendimiento diagnóstico de 80,53%.Determine prevalence and make a predictive model of early neurological deterioration in patients with ischemic cerebrovascular disease (CVD). Method: It was conducted an observational, analytical, cross-sectional study, evaluated 191 patients with ischemic CVD, which were divided into two groups. Group I (13 patients with early neurological deterioration and Group II (178 patients without early neurological deterioration); the influence of :sex, Arterial hypertension, diabetes mellitus type 2, systolic blood pressure, score of the Glasgow Coma Scale (GCS), blood urea nitrogen (BUN) , serum creatinine, BUN / creatinine ratio, hemoglobin, glucose, High density lipoprotein (HDL), triglycerides, sodium, potassium, C-reactive protein were investigated in the development of early Neurological deterioration (END). Chi square was applied and Odds Ratio’s result shows significant association between the variables test, it is also performed the multivariate analysis of logistic binary regression where evaluated simultaneously the risk factors in study. Results: The clinical variables with significant association to early neurological impairment after ischemic cerebrovascular disease were: sex OR = 0.20 (P = 0.041), ECG score in the third day OR = 0.70 (p = 0.002) and the level of potassium admission OR = 2.53 (P = 0.030), controlling the other variables. The model had a 80.53% diagnostic performance. Conclusions: The prevalence of DNP in patients with ischemic CVD was 6.8%. The prediction model for DNP for patients with ischemic CVD consisted of variables: sex, ECG score on the third day, and potassium levels to admission diagnostic yield of 80.53%

Colitis pseudomembranosa enfoque anatomopatológico: A propósito de un caso: Pseudomembranosa colitis. anatomopathological approach: A purpose of a case

Pseudomembranous colitis is a serious digestive disease that develops in a context clinical-epidemiological quite predictable and most of the time, fatal. We present the case of a Elderly patient suffering left hip fracture, enters the hospital center and develops infection urinary, receiving broad-spectrum antibiotic therapy. Progressively, complications are installed respiratory, digestive and septic, being operated surgically to correct a clinical picture of intestinal obstruction, performing a sigmoidectomy. The macro and microscopic findings corresponded to a typical pseudomebranous colitis. The patient dies five days after the surgery. The entity is reviewed, with emphasis on the pathological findings, in order to make diagnoses safer and faster in future cases.   DOI 10.25176/RFMH.v18.n4.1739La Colitis pseudomembranosa es una enfermedad digestiva grave que se desarrolla en un contexto clínico-epidemiológico bastante predecible y la mayoría de las veces, fatal. Presentamos el caso de una paciente anciana que sufre fractura de cadera izquierda, ingresa al centro hospitalario y desarrolla infección urinaria, recibiendo terapia antibiótica de amplio espectro. Progresivamente, se instalan complicaciones respiratorias, digestivas y sépticas, siendo intervenida quirúrgicamente para corregir un cuadro clínico de obstrucción intestinal, realizándosele una sigmoidectomía. Los hallazgos macro y microscópicos correspondieron a una típica Colitis pseudomebranosa. La paciente fallece cinco días después de la cirugía. Se revisa la entidad, con énfasis en los hallazgos patológicos, a efectos de realizar diagnósticos más seguros y rápidos en casos futuros.   DOI 10.25176/RFMH.v18.n4.173

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets

Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at root s = 13 TeV, and correspond to an integrated luminosity of 35.9 fb(-1). The spectra of total transverse hadronic energy of candidate events are examined for deviations from the standard model predictions. No statistically significant excess is observed over the expected background. The first cross section limits on new physics processes resulting in such events are set. The results are interpreted as upper limits on the rate of gluino pair production, utilizing a simplified stealth supersymmetry model. The excluded gluino masses extend up to 1.7 TeV, for a neutralino mass of 200 GeV and exceed previous mass constraints set by analyses targeting events with isolated photons.Peer reviewe

Measurement of b jet shapes in proton-proton collisions at root s=5.02 TeV

We present the first study of charged-hadron production associated with jets originating from b quarks in proton-proton collisions at a center-of-mass energy of 5.02 TeV. The data sample used in this study was collected with the CMS detector at the CERN LHC and corresponds to an integrated luminosity of 27.4 pb(-1). To characterize the jet substructure, the differential jet shapes, defined as the normalized transverse momentum distribution of charged hadrons as a function of angular distance from the jet axis, are measured for b jets. In addition to the jet shapes, the per-jet yields of charged particles associated with b jets are also quantified, again as a function of the angular distance with respect to the jet axis. Extracted jet shape and particle yield distributions for b jets are compared with results for inclusive jets, as well as with the predictions from the pythia and herwig++ event generators.Peer reviewe

Bose-Einstein correlations of charged hadrons in proton-proton collisions at s\sqrt s = 13 TeV

Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at $\sqrt{s}$ = 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at $\sqrt{s}$ = 7 TeV, as well as with theoretical predictions.[graphic not available: see fulltext]Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at $\sqrt{s} =$ 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at $\sqrt{s} =$ 7 TeV, as well as with theoretical predictions